Olfactory bulb α2-adrenoceptor activation promotes rat pup odor-preference learning via a cAMP-independent mechanism

Learning and Memory

Volumn 19, Issue 11, 2012, Pages 499-502

  Shakhawat, Amin M D ^a   Harley, Carolyn W ^a   Yuan, Qi ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; NORADRENALIN; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; FEMALE; MALE; MITRAL CELL; NEWBORN; NONHUMAN; ODOR; OLFACTORY BULB; PAIRED ASSOCIATE LEARNING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY STIMULATION; STIMULUS RESPONSE;

ANIMALS; CONDITIONING, CLASSICAL; CYCLIC AMP; LEARNING; ODORS; OLFACTORY BULB; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA;

EID: 84869211426     PISSN: 10720502     EISSN: 15495485     Source Type: Journal    
DOI: 10.1101/lm.027359.112     Document Type: Article

References (25)

1. Camp LL, Rudy JW. 1988. Changes in the categorization of appetitive and aversive events during postnatal development of the rat. Dev Psychobiol 21: 25-42.
2. Cui W, Smith A, Darby-King A, Harley CW, McLean JH. 2007. A temporal-specific and transient cAMP increase characterizes odorant classical conditioning. Learn Mem 14: 126-133. (Pubitemid 46495189)
3. Doucette W, Gire DH, Whitesell J, Carmean V, Lucero MT, Restrepo D. 2011. Associative cortex features in the first olfactory brain relay station. Neuron 69: 1176-1187.
4. Grimes MT, Harley CW, Darby-King A, McLean JH. 2012. PKA increases in the olfactory bulb act as unconditioned stimuli and provide evidence for parallel memory systems: Pairing odor with increased PKA creates intermediate- and long-term, but not short-term,memories. Learn Mem 19: 107-115.
5. Harley CW, Darby-King A, McCann J, McLean JH. 2006. β1-adrenoceptor or α1-adrenoceptor activation initiates early odor preference learning in rat pups: Support for the mitral cell/cAMP model of odor preference learning. Learn Mem 13: 8-13. (Pubitemid 43200813)
6. Hayar A, Heyward PM, Heinbockel T, Shipley MT, Ennis M. 2001. Direct excitation of mitral cells via activation of α1-noradrenergic receptors in rat olfactory bulb slices. J Neurophysiol 86: 2173-2182. (Pubitemid 34000581)
7. Johanson IB, Teicher MH. 1980. Classical conditioning of an odor preference in 3-day-old rats. Behav Neural Biol 29: 132-136. (Pubitemid 11240047)
8. Kucharski D, Hall WG. 1987. New routes to early memories. Science 238: 786-788. (Pubitemid 18005234)
9. Langdon PE, Harley CW, McLean JH. 1997. Increased β adrenoceptor activation overcomes conditioned olfactory learning deficits induced by serotonin depletion. Brain Res Dev Brain Res 102: 291-293. (Pubitemid 27435949)
10. Lethbridge R, Hou Q, Harley CW, Yuan Q. 2012. Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat. PLoS One 7: e35024. doi: 10.1371/journal.pone.0035024.
11. McLean JH, Darby-King A, Sullivan RM, King SR. 1993. Serotonergic influence on olfactory learning in the neonate rat. Behav Neural Biol 60: 152-162. (Pubitemid 23284706)
12. McLean JH, Harley CW, Darby-King A, Yuan Q. 1999. pCREB in the neonate rat olfactory bulb is selectively and transiently increased by odor preference-conditioned training. Learn Mem 6: 608-618. (Pubitemid 30033388)
13. Moriceau S, Raineki C, Holman JD, Holman JG, Sullivan RM. 2009. Enduring neurobehavioral effects of early life trauma mediated through learning and corticosterone suppression. Front Behav Neurosci 3: 22. doi: 10.3389/nruto.08.022.2009.
14. Nai Q, Dong HW, Hayar A, Linster C, Ennis M. 2009. Noradrenergic regulation of GABAergic inhibition of main olfactory bulb mitral cells varies as a function of concentration and receptor subtype. J Neurophysiol 101: 2472-2484.
15. Nai Q, Dong HW, Linster C, Ennis M. 2010. Activation of α11 and α12 noradrenergic receptors exert opposing effects on excitability of main olfactory bulb granule cells. Neuroscience 169: 882-892.
16. Pandipati S, Gire DH, Schoppa NE. 2010. Adrenergic receptor-mediated disinhibition of mitral cells triggers long-term enhancement of synchronized oscillations in the olfactory bulb. J Neurophysiol 104: 665-674.
17. Sullivan RM, Hall WG. 1988. Reinforcers in infancy: Classical conditioning using stroking or intra-oral infusions of milk as UCS. Dev Psychobiol 21: 215-223.
18. Sullivan RM, Leon M. 1986. Early olfactory learning induces an enhanced olfactory bulb response in young rats. Brain Res 392: 278-282. (Pubitemid 16086504)
19. Sullivan RM, McGaugh JL, Leon M. 1991. Norepinephrine-induced plasticity and one-trial olfactory learning in neonatal rats. Brain Res Dev Brain Res 60: 219-228.
20. Sullivan RM, Landers M, Yeaman B, Wilson DA. 2000a. Good memories of bad events in infancy. Nature 407: 38-39.
21. Sullivan RM, Stackenwalt G, Nasr F, Lemon C, Wilson DA. 2000b. Association of an odor with activation of olfactory bulb noradrenergic β-receptors or locus coeruleus stimulation is sufficient to produce learned approach responses to that odor in neonatal rats. Behav Neurosci 114: 957-962.
22. Yuan Q. 2009. Theta bursts in the olfactory nerve paired with b-adrenoceptor activation induce calcium elevation in mitral cells: A mechanism for odor preference learning in the neonate rat. Learn Mem 16: 676-681.
23. Yuan Q, Harley CW, Bruce JC, Darby-King A, McLean JH. 2000. Isoproterenol increases CREB phosphorylation and olfactory nerve-evoked potentials in normal and 5-HT-depleted olfactory bulbs in rat pups only at doses that produce odor preference learning. Learn Mem 7: 413-421. (Pubitemid 32003248)
24. Yuan Q, Harley CW, Darby-King A, Neve RL, McLean JH. 2003a. Early odor preference learning in the rat: Bidirectional effects of cAMP response element-binding protein (CREB) and mutant CREB support a causal role for phosphorylated CREB. J Neurosci 23: 4760-4765. (Pubitemid 36706204)
25. 2Areceptor colocalization and cAMP coregulation: A new model of norepinephrine-induced learning in the olfactory bulb. Learn Mem 10: 5-15.