EMR-based medication adherence metric markedly enhances identification of nonadherent patients

American Journal of Managed Care

Volumn 18, Issue 10, 2012, Pages

  Singer, Shepherd Roee ^a   Hoshen, Moshe ^a   Shadmi, Efrat ^a,b   Leibowitz, Morton ^a   Flaks Manov, Natalie ^a   Bitterman, Haim ^a   Balicer, Ran D ^a,c  

^a CLALIT HEALTH SERVICES   (Israel)

^b UNIVERSITY OF HAIFA   (Israel)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; ELECTRONIC MEDICAL RECORD; FEMALE; HEALTH CARE PLANNING; HUMAN; MALE; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PRESCRIPTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TREATMENT REFUSAL; BLOOD; MEDICATION COMPLIANCE; MIDDLE AGED; RECEIVER OPERATING CHARACTERISTIC; STATISTICS AND NUMERICAL DATA;

CHOLESTEROL, LDL; DRUG PRESCRIPTIONS; ELECTRONIC HEALTH RECORDS; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; RETROSPECTIVE STUDIES; ROC CURVE;

EID: 84869210923     PISSN: 10880224     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353(5):487-497. (Pubitemid 41127293)
2. Liberopoulos EN, Florentin M, Mikhailidis DP, Elisaf MS. Compliance with lipid-lowering therapy and its impact on cardiovascular morbidity and mortality. Expert Opin Drug Saf. 2008;7(6):717-225.
3. Esposti LD, Saragoni S, Benemei S, et al. Adherence to antihypertensive medications and health outcomes among newly treated hypertensive patients. Clinicoecon Outcomes Res. 2011;3:47-54.
4. Cannon GW, Sauer BC, Hayden CL, et al. Merging Veterans Affairs rheumatoid arthritis registry and pharmacy data to assess methotrexate adherence and disease activity in clinical practice. Arthritis Care Res (Hoboken). 2011;63(12):1680-1690.
5. Fitzgerald AA, Powers JD, Ho PM, et al. Impact of medication nonadherence on hospitalizations and mortality in heart failure. J Card Fail. 2011;17(8):664-669.
6. Corrao G, Conti V, Merlino L, Catapano AL, Mancia G. Results of a retrospective database analysis of adherence to statin therapy and risk of nonfatal ischemic heart disease in daily clinical practice in Italy. Clin Ther. 2010;32(2):300-310.
7. Pittman DG, Chen W, Bowlin SJ, Foody JM. Adherence to statins, subsequent healthcare costs, and cardiovascular hospitalizations. Am J Cardiol. 2011;107(11):1662-1666.
8. Aubert RE, Yao J, Xia F, Garavaglia SB. Is there a relationship between early statin compliance and a reduction in healthcare utilization? Am J Manag Care. 2010;16(6):459-466.
9. Dragomir A, Côté R, White M, Lalonde L, Blais L, Bérard A, Perreault S. Relationship between adherence level to statins, clinical issues and health-care costs in real-life clinical setting. Value Health. 2010;13(1):87-94.
10. Andrade SE, Kahler KH, Frech F, Chan KA. Methods for evaluation of medication adherence and persistence using automated databases. Pharmacoepidemiol Drug Saf. 2006;15(8):565-574. (Pubitemid 44336271)
11. Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997; 50(1):105-116. (Pubitemid 27089212)
12. Shah NR, Hirsch AG, Zacker C, et al. Predictors of first-fill adherence for patients with hypertension. Am J Hypertens. 2009;22(4):392-396.
13. Shah NR, Hirsch AG, Zacker C, Taylor S, Wood GC, Stewart WF. Factors associated with first-fill adherence rates for diabetic medications: a cohort study. J Gen Intern Med. 2009;24(2):233-237.
14. Fischer MA, Stedman MR, Lii J, et al. Primary medication nonadherence: analysis of 195,930 electronic prescriptions. J Gen Intern Med. 2010;25(4):284-290.
15. Fischer MA, Choudhry NK, Brill G, et al. Trouble getting started: predictors of primary medication nonadherence Am J Med. 2011;124 (11):1081.e9-22.
16. Karter AJ, Parker MM, Moffet HH, Ahmed AT, Schmittdiel JA, Selby JV. New prescription medication gaps: a comprehensive measure of adherence to new prescriptions. Health Serv Res. 2009;44(5, pt 1):1640-1661.
17. Rosen B, Porath A, Pawlson LG, Chassin MR, Benbassat J. Adherence to standards of care by health maintenance organizations in Israel and the USA. Int J Qual Health Care. 2011;23(1):15-25.
18. Insull W. The problem of compliance to cholesterol altering therapy. J Intern Med. 1997;241(4):317-325. (Pubitemid 27223997)
19. Maron DJ, Fazio S, Linton MF. Current perspectives on statins. Circulation. 2000;101(2):207-213. (Pubitemid 30044262)
20. Cholesterol Reference Method Laboratory Network. LDL Cholesterol Certification Protocol for Manufacturers. http://www.cdc.gov/labstandards/pdf/ crmln/MFRLDLJune2006final.pdf. Published June 2006. Accessed December 28, 2011.
21. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982;143(1):29-36. (Pubitemid 12142173)
22. Karter AJ, Parker MM, Adams AS, et al. Primary non-adherence to prescribed medications. J Gen Intern Med. 2010;25(8):763.
23. Chodick G, Shalev V, Gerber Y, et al. Long-term persistence with statin treatment in a not-for-profit health maintenance organization: a population-based retrospective cohort study in Israel. Clin Ther. 2008;30(11):2167-2179.
24. Chaudhry HJ, McDermott B. Recognizing and improving patient nonadherence to statin therapy. Curr Atheroscler Rep. 2008;10(1):19-24. (Pubitemid 351385595)
25. Peterson AM, Nau DP, Cramer JA, Benner J, Gwadry-Sridhar F, Nichol M. A checklist for medication compliance and persistence studies using retrospective databases. Value Health. 2007;10(1):3-12. (Pubitemid 46161090)