Prostaglandin E2 Represses Interleukin 1 Beta-Induced Inflammatory Mediator Output from Pregnant Human Myometrial Cells Through the EP2 and EP4 Receptors 1

Biology of Reproduction

Volumn 87, Issue 1, 2012, Pages 7-

  Mosher, Andrea A ^a   Rainey, Kelly J ^a   Giembycz, Mark A ^a   Wood, Stephen ^a   Slater, Donna M ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Ccl2; Csf2; Cxcl8; Ep2; Ep4; Human myometrial cells; Inflammation; Pge2; Pregnancy

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROSTAGLANDIN E RECEPTOR 1; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 3; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; SMALL INTERFERING RNA; AUTACOID; CCL2 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; PTGER2 PROTEIN, HUMAN; PTGER4 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN MYOMETRIAL CELL; HUMAN TISSUE; INFLAMMATION; MYOMETRIUM; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE;

BASE SEQUENCE; CELLS, CULTURED; CHEMOKINE CCL2; DINOPROSTONE; FEMALE; GENE KNOCKDOWN TECHNIQUES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-8; MYOMETRIUM; PREGNANCY; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84869205185     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.112.100099     Document Type: Article

References (49)

1. Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel LA, Nien JK. Inflammation in preterm and term labour and delivery. Semin Fetal Neonatal Med 2006; 11: 317-326.
2. Bollapragada S, Youssef R, Jordan F, Greer I, Norman J, Nelson S. Term labor is associated with a core inflammatory response in human myometrium and cervix. Am J Obstet Gynecol 2009; 200: 104.e1-104.e11.
3. Thomson AJ, Telfer JF, Young A, Campbell S, Stewart CJR, Cameron IT, Greer IA, Norman JE. Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process. Hum Reprod 1999; 14: 229-236.
4. Young A, Thomson AJ, Ledingham MA, Jordan F, Greer IA, Norman JE. Immunolocalization of proinflammatory cytokines in myometrium, cervix, and fetal membranes during human parturition at term. Biol Reprod 2002; 66: 445-449.
5. Osman I, Young A, Ledingham MA, Thomson AJ, Jordan F, Greer IA, Norman JE. Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Mol Hum Reprod 2003; 9: 41-45.
6. Romero R, Mazor M, Brandt F, Sepulveda W, Avila C, Cotton DB, Dinarello CA. Interleukin-1 alpha and interleukin-1 beta in preterm and term human parturition. Am J Reprod Immunol 1992; 27: 117-123.
7. Bry K, Hallman M, Teramo K, Waffarn F, Lappalainen U. Granulocytemacrophage colony-stimulating factor in amniotic fluid and in airway specimens of newborn infants. Pediatr Res 1997; 41: 105-109.
8. Mittal P, Romero R, Tarca AL, Gonzalez J, Draghici S, Xu Y, Dong Z, Nhan-Chang CL, Chaiworapongsa T, Lye S, Kusanovic JP, Lipovich L, et al. Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term. J Perinat Med 2010; 38: 617-643.
9. Hua R, Pease JE, Sooranna SR, Viney JM, Nelson SM, Myatt L, Bennett PR, Johnson MR. Stretch and inflammatory cytokines drive myometrial chemokine expression via NF-jB activation. Endocrinology 2012; 153: 481-491.
10. Gomez-Lopez N, Laresgoiti-Servitje E, Olson DM, Estrada-Gutierrez G, Vadillo-Ortega F. The role of chemokines in term and premature rupture of the fetal membranes: a review. Biol Reprod 2010; 82: 809-814.
11. Challis JRG, Sloboda DM, Alfaidy M, Lye SJ, Gibb W, Patel FA, Whittle WL, Newnham JP. Prostaglandins and mechanisms of preterm birth. Reproduction 2002; 124: 1-17.
12. Skinner KA, Challis JRG. Changes in the synthesis and metabolism of prostaglandins by human fetal membranes and decidua at labor. Am J Obstet Gynecol 1985; 151: 519-523.
13. Lee SE, Romero R, Park IS, Seong HS, Park CW, Yoon BH. Amniotic fluid prostaglandin concentrations increase before the onset of spontaneous labor at term. J Matern Neonatal Med 2008; 21: 89-94.
14. Durn JH, Marshall KM, Farrar D, O'Donovan P, Scally AJ, Woodward DF, Nicolaou A. Lipidomic analysis reveals prostanoid profiles in human term pregnant myometrium. Prostaglandins Leukot Essent Fatty Acids 2010; 82: 21-26.
15. Buczynski MW, Dumlao DS, Dennis EA. An integrated omics analysis of eicosanoid biology. J Lipid Res 2009; 50: 1015-1038.
16. Slater DM, Dennes WJB, Campa JS, Poston L, Bennett PR. Expression of cyclo-oxygenase types-1 and -2 in human myometrium throughout pregnancy. Mol Hum Reprod 1999; 5: 880-884.
17. Astle S, Newton R, Thornton S, Vatish M, Slater DM. Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour. Mol Hum Reprod 2007; 13: 69-75.
18. Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev 2011; 63: 471-538.
19. Leonhardt A, Glaser A, Wegmann M, Hackenberg R, Nusing RM. Expression of prostanoid receptors in human lower segment pregnant myometrium. Prostaglandins Leukot Essent Fatty Acids 2003; 69: 307-313.
20. Astle S, Thornton S, Slater DM. Identification and localization of prostaglandin E2 receptors in upper and lower segment human myometrium during pregnancy. Mol Hum Reprod 2005; 11: 279-287.
21. Groom KM, Shennan AH, Jones BA, Seed P, Bennett PR. TOCOX-a randomised, double-blind, placebo-controlled trial of rofecoxib (a COX-2-specific prostaglandin inhibitor) for the prevention of preterm delivery in women at high risk. BJOG 2005; 112: 725-730.
22. Sanchez-Ramos L. Induction of labor. Obstet Gynecol Clin N Am 2005; 32: 181-200.
23. Slater DM, Astle S, Woodcock N, Chivers JE, de Wit NCJ, Thornton S, Vatish M, Newton R. Anti-inflammatory and relaxatory effects of prostaglandin E2 in myometrial smooth muscle. Mol Hum Reprod 2006; 12: 89-97.
24. Gilroy DW, Colville-Nash PR, Willis D, Chivers J, Paul-Clark MJ, Willoughby DA. Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med 1999; 5: 698-701.
25. Clarke DL, Belvisi MG, Catley MC, Yacoub MH, Newton R, Giembycz MA. Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF. Br J Pharmacol 2004; 141: 1141-1150.
26. Brodt-Eppley J, Myatt L. Changes in expression of contractile FP and relaxatory EP2 receptors in pregnant rat myometrium during late gestation, at labor, and postpartum. Biol Reprod 1998; 59: 878-883.
27. Matsumoto T, Sagawa N, Yoshida M, Mori T, Tanaka I, Mukoyama M, Kotani M, Nakao K. The prostaglandin E2 and F2a receptor genes are expressed in human myometrium and are down-regulated during pregnancy. Biochem Biophys Res Commun 1997; 238: 838-841.
28. Smith GCS, Wu WX, Nathanielsz PW. Effects of gestational age and labor on expression of prostanoid receptor genes in baboon uterus. Biol Reprod 2001; 64: 1131-1137.
29. Grigsby PL, Sooranna SR, Adu-Amankwa B, Pitzer B, Brockman DE, Johnson MR, Myatt L. Regional expression of prostaglandin E2 and F2alpha receptors in human myometrium, amnion, and choriodecidua with advancing gestation and labor. Biol Reprod 2006; 75: 297-305.
30. Keelan JA, Blumenstein M, Helliwell RJ, Sato TA, Marvin KW, Mitchell MD. Cytokines, prostaglandins and parturition-a review. Placenta 2003; 24: S33-S46.
31. Golightly E, Jabbour HN, Norman JE. Endocrine immune interactions in human parturition. Mol Cell Endocrinol 2011; 335: 52-59.
32. Elliott CL, Slater DM, Dennes W, Poston L, Bennett PR. Interleukin-8 expression in human myometrium: changes in relation to labor onset and with gestational age. Am J Reprod Immunol 2000; 43: 272-277.
33. Sennstrom MB, Ekman G, Westergren-Thorsson G, Malmstrom A, Bystrom B, Endresen U, Mlambo N, Norman M, Stabi B, Brauner A. Human cervical ripening, an inflammatory process mediated by cytokines. Mol Hum Reprod 2000; 6: 375-381.
34. Dowd J, Laham N, Rice G, Brennecke S, Permezel M. Elevated interleukin-8 concentrations in cervical secretions are associated with preterm labour. Gynecol Obstet Invest 2001; 51: 165-168.
35. Takayama K, Garcia-Cardena G, Sukhova GK, Comander J, Gimbrone MA, Libby P. Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J Biol Chem 2002; 277: 44147-44154.
36. Ratcliffe MJ, Walding A, Shelton PA, Flaherty A, Dougall IG. Activation of E-prostanoid2 and E-prostanoid4 receptors inhibits TNF-a release from human alveolar macrophages. Eur Respir J 2007; 29: 986-994.
37. Largo R, Diez-Ortego I, Sanchez-Pernaute O, Lopez-Armada MJ, Alvarez-Soria MA, Egido J, Herrero-Beaumont G. EP2/EP4 signalling inhibits monocyte chemoattractant protein-1 production induced by interleukin 1beta in synovial fibroblasts. Ann Rheum Dis 2004; 63: 1197-1204.
38. Dey I, Giembycz MA, Chadee K. Prostaglandin E2 couples through EP4 prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines. Br J Pharmacol 2009; 156: 475-485.
39. Breyer RM, Bagdassarian CK, Myers SA, Breyer MD. Prostanoid receptors: subtypes and signalling. Annu Rev Pharmacol Toxicol 2001; 41: 661-690.
40. Regan JW. EP2 and EP4 prostanoid receptor signaling. Life Sci 2003; 74: 143-153.
41. Negishi M, Sugimoto Y, Ichikawa A. Molecular mechanisms of diverse actions of prostanoid receptors. Biochim Biophys Acta 1995; 1259: 109-119.
42. Namba T, Sugimoto Y, Negishi M, Irie A, Ushikubi F, Kakizuka A, Ito S, Ichikawa A, Narumiya S. Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature 1993; 365: 166-170.
43. Arulkumaran S, Kandola MK, Hoffman B, Hanyaloglu AC, Johnson MR, Bennett PR. The roles of prostaglandin EP1 and 3 receptors in the control of human myometrial contractility. J Clin Endo Metab 2012; 97: 489-498.
44. Khanjani S, Kandola MK, Lindstrom TM, Sooranna SR, Melchionda M, Lee YS, Terzidou V, Johnson MR, Bennett PR. NF-jB regulates a cassette of immune/inflammatory genes in human pregnant myometrium at term. J Cell Mol Med 2011; 15: 809-824.
45. Shynlova O, Tsui P, Dorogin A, Lye SJ. Monocyte chemoattractant protein-1 (CCL2) integrates mechanical and endocrine signals that mediate term and preterm labor. J Immunol 2008; 181: 1470-1479.
46. Hamilton S, Oomomian Y, Stephen G, Shynlova O, Tower CL, Garrod A, Lye SJ, Jones RL. Macrophages infiltrate the human and rat decidua during term and preterm labor: evidence that decidual inflammation precedes labor. Biol Reprod 2012; 86: 39, 1-9.
47. Dammann O, Leviton A, Gappa M, Dammann CEL. Lung and brain damage in preterm newborns, and their association with gestational age, prematurity subgroup, infection/inflammation and long term outcome. BJOG 2005; 112: 4-9.
48. Hubinont C, Debieve F. Prevention of preterm labour: 2011 update on tocolysis. J Pregnancy 2011; 2011: 941057.
49. Tang EH, Libby P, Vanhoutte PM, Xu A. Anti-inflammation therapy by activation of prostaglandin EP4 reception in cardiovascular and other inflammatory diseases. J Cardiovasc Pharmacol 2012; 59: 116-123.