Identification and localization of prostaglandin E2 receptors in upper and lower segment human myometrium during pregnancy

Molecular Human Reproduction

Volumn 11, Issue 4, 2005, Pages 279-287

  Astle, Shirley ^a   Thornton, Steven ^a,b   Slater, Donna M ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b WALSGRAVE HOSPITAL   (United Kingdom)

Author keywords

Labour; Myometrium; Nuclear; Prostaglandin E2 receptors

Indexed keywords

PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E1; PROSTAGLANDIN E2; PROSTAGLANDIN E3;

ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LABOR; MYOMETRIUM; PREGNANCY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY;

ALTERNATIVE SPLICING; DINOPROSTONE; FEMALE; HUMANS; LABOR, OBSTETRIC; MYOMETRIUM; PREGNANCY; PROTEIN ISOFORMS; RECEPTORS, PROSTAGLANDIN E;

EID: 18644364045     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/gah158     Document Type: Article

References (30)

1. Al-Matubsi HY, Eis AL, Brodt-Eppley J, MacPhee DJ, Lye S and Myatt L (2001) Expression and localization of the contractile prostaglandin F receptor in pregnant rat myometrium in late gestation, labor, and postpartum. Biol Reprod 65,1029-1037.
2. 2 subtype. J Biol Chem 269,11873-11877.
3. 2 receptors. Proc Natl Acad Sci USA 95,15792-15797.
4. 4 in the nuclear envelope. J Biol Chem 274,15719-15724.
5. 2 receptors in pregnant rat myometrium during late gestation, at labor, and postpartum. Biol Reprod 59,878-883.
6. Brodt-Eppley J and Myatt L (1999) Prostaglandin receptors in lower segment myometrium during gestation and labor. Obstet Gynecol 93,89-93.
7. Coleman RA, Smith WL and Narumiya S (1994) International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46,205-229.
8. 1 subtype. J Biol Chem 268,26767-26772.
9. Gibb W (1998) The role of prostaglandins in human parturition. Ann Med 30,235-241.
10. Gobeil F Jr, Dumont I, Marrache AM, Vazquez-Tello A, Bernier SG, Abran D, Hou X, Beauchamp MH, Quiniou C, Bouayad A et al. (2002) Regulation of eNOS expression in brain endothelial cells by perinuclear EP(3) receptors. Circ Res 90,682-689.
11. Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW and Schuster VL (1995) Identification and characterization of a prostaglandin transporter. Science 268,866-869.
12. 3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions. Mol Pharmacol 48,869-879.
13. 3 receptor subtype gene (PTGER3). Genomics 40,425-434.
14. 3 subtype isoforms expressed in human uterus. J Clin Endocrinol Metab 85,4315-4322.
15. Leonhardt A, Glaser A, Wegmann M, Hackenberg R and Nusing RM (2003) Expression of prostanoid receptors in human lower segment pregnant myometrium. Prostaglandins Leukot Essent Fatty Acids 69,307-313.
16. Lewis RB and Schulman JD (1973) Influence of acetylsalicylic acid, an inhibitor of prostaglandin synthesis, on the duration of human gestation and labour. Lancet 2,1159-1161.
17. Ma X, Wu WX and Nathanielsz PW (1999) Differential regulation of prostaglandin EP and FP receptors in pregnant sheep myometrium and endometrium during spontaneous term labor. Biol Reprod 61,1281-1286.
18. 2 alpha receptor genes are expressed in human myometrium and are down-regulated during pregnancy. Biochem Biophys Res Commun 238,838-841.
19. 3 determines G-protein specificity. Nature 365,166-170.
20. Negishi M, Sugimoto Y and Ichikawa A (1995) Molecular mechanisms of diverse actions of prostanoid receptors. Biochim Biophys Acta 1259, 109-119.
21. Regan JW, Bailey TJ, Pepperl DJ, Pierce KL, Bogardus AM, Donello JE, Fairbairn CE, Kedzie KM, Woodward DF and Gil DW (1994) Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Mol Pharmacol 46,213-220.
22. 2 to the nuclear envelope and endoplasmic reticulum. J Biol Chem 270,30749-30754.
23. 2. Eur J Biochem 228,23-30.
24. Schuster VL (1998) Molecular mechanisms of prostaglandin transport. Annu Rev Physiol 60,221-242.
25. Senior J, Marshall K, Sangha R and Clayton JK (1993) In vitro characterization of prostanoid receptors on human myometrium at term pregnancy. Br J Pharmacol 108,501-506.
26. Skinner KA and Challis JR (1985) Changes in the synthesis and metabolism of prostaglandins by human fetal membranes and decidua at labor. Am J Obstet Gynecol 151,519-523.
27. Smith GC, Baguma-Nibasheka M, Wu WX and Nathanielsz PW (1998) Regional variations in contractile responses to prostaglandins and prostanoid receptor messenger ribonucleic acid in pregnant baboon uterus. Am J Obstet Gynecol 179,1545-1552.
28. Smith GC, Wu WX and Nathanielsz PW (2001) Effects of gestational age and labor on expression of prostanoid receptor genes in baboon uterus. Biol Reprod 64,1131-1137.
29. Spencer AG, Woods JW, Arakawa T, Singer II and Smith WL (1998) Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy. J Biol Chem 273,9886-9893.
30. Wing DA, Goharkhay N, Hanna M, Naidu YM, Kovacs BW and Felix JC (2003) EP3-2 receptor mRNA expression is reduced and EP3-6 receptor mRNA expression is increased in gravid human myometrium. J Soc Gynecol Investig 10,124-129.