Roles of Cch1 and Mid1 in Morphogenesis, Oxidative Stress Response and Virulence in Candida albicans

Mycopathologia

Volumn 174, Issue 5-6, 2012, Pages 359-369

  Yu, Qilin ^a   Wang, Hui ^b   Cheng, Xinxin ^a   Xu, Ning ^a   Ding, Xiaohui ^a   Xing, Laijun ^a   Li, Mingchun ^a  

^a NANKAI UNIVERSITY   (China)

^b AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

Author keywords

Candida albicans; Cch1; Cell survival; Mid1; Virulence

Indexed keywords

ANIMALIA; CANDIDA ALBICANS; CLAVICEPS PURPUREA; FILOBASIDIELLA NEOFORMANS; FUNGI;

EID: 84869187369     PISSN: 0301486X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11046-012-9569-0     Document Type: Article

References (38)

1. Koh AY, Kohler JR, Coggshall KT, van Rooijen N, Pier GB. Mucosal damage and neutropenia are required for Candida albicans dissemination. PLoS Pathog. 2008; 4: e35.
2. Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007; 20: 133-63.
3. Schuetzer-Muehlbauer M, Willinger B, Egner R, Ecker G, Kuchler K. Reversal of antifungal resistance mediated by ABC efflux pumps from Candida albicans functionally expressed in yeast. Int J Antimicrob Agents. 2003; 22: 291-300.
4. Lo HJ, Kohler JR, DiDomenico B, Loebenberg D, Cacciapuoti A, Fink GR. Nonfilamentous C. albicans mutants are avirulent. Cell. 1997; 90: 939-49.
5. Kumamoto CA. A contact-activated kinase signals Candida albicans invasive growth and biofilm development. Proc Natl Acad Sci USA. 2005; 102: 5576-81.
6. Bahn YS, Sundstrom P. CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth, and cyclic AMP levels and is required for virulence of Candida albicans. J Bacteriol. 2001; 183(10): 3211-23.
7. Cronin SR. I'll simply die without my calcium: Ca(2+) signaling and surviving cellular stress. Mol Interv. 2002; 2: 284-5.
8. Bonilla M, Nastase KK, Cunningham KW. Essential role of calcineurin in response to endoplasmic reticulum stress. EMBO J. 2002; 21: 2343-53.
9. Bonilla M, Cunningham KW. Mitogen-activated protein kinase stimulation of Ca(2+) signaling is required for survival of endoplasmic reticulum stress in yeast. Mol Biol Cell. 2003; 14: 4296-305.
10. 2+ transport in Saccharomyces cerevisiae. J Exp Biol. 1994; 196: 157-66.
11. Liu M, Gelli A. Elongation factor 3, EF3, associates with the calcium channel Cch1 and targets Cch1 to the plasma membrane in Cryptococcus neoformans. Eukaryot Cell. 2008; 7: 1118-26.
12. Locke EG, Bonilla M, Liang L, Takita Y, Cunningham KW. A homolog of voltage-gated Ca(2+) channels stimulated by depletion of secretory Ca(2+) in yeast. Mol Cell Biol. 2000; 20: 6686-94.
13. Bormann J, Tudzynski P. Deletion of Mid1, a putative stretch-activated calcium channel in Claviceps purpurea, affects vegetative growth, cell wall synthesis and virulence. Microbiology. 2009; 155: 3922-33.
14. Liu M, Du P, Heinrich G, Cox GM, Gelli A. Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments. Eukaryot Cell. 2006; 5: 1788-96.
15. Jackson SL, Heath IB. Roles of calcium ions in hyphal tip growth. Microbiol Rev. 1993; 57: 367-82.
16. 2+/calmodulin signaling pathway on morphological development of Candida albicans. Biol Pharm Bull. 2004; 27: 1281-4.
17. 2+ gradient in the oomycete Saprolegnia ferax. Eur J Cell Biol. 1993; 60: 358-65.
18. Brand A, Shanks S, Duncan VM, Yang M, Mackenzie K, Gow NA. Hyphal orientation of Candida albicans is regulated by a calcium-dependent mechanism. Curr Biol. 2007; 17: 347-52.
19. Cyert MS. Genetic analysis of calmodulin and its targets in Saccharomyces cerevisiae. Annu Rev Genet. 2001; 35: 647-72.
20. Blankenship JR, Heitman J. Calcineurin is required for Candida albicans to survive calcium stress in serum. Infect Immun. 2005; 73: 5767-74.
21. LaFayette SL, Collins C, Zaas AK, Schell WA, Betancourt-Quiroz M, Gunatilaka AA, Perfect JR, Cowen LE. PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. PLoS Pathog. 2010; 6: e1001069.
22. Reedy JL, Filler SG, Heitman J. Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. Fungal Genet Biol. 2010; 47(2): 107-16.
23. da Silva Dantas A, Patterson MJ, Smith DA, Maccallum DM, Erwig LP, Morgan BA, et al. Thioredoxin regulates multiple hydrogen peroxide-induced signaling pathways in Candida albicans. Mol Cell Biol. 2010; 30: 4550-63.
24. Reiter TA, Rusnak F. Quantification of intracellular calcineurin activity and H2O2-induced oxidative stress. Methods Enzymol. 2002; 353: 70-81.
25. Ghosh MC, Wang X, Li S, Klee C. Regulation of calcineurin by oxidative stress. Methods Enzymol. 2003; 366: 289-304.
26. Bader T, Bodendorfer B, Schroppel K, Morschhauser J. Calcineurin is essential for virulence in Candida albicans. Infect Immun. 2003; 71: 5344-54.
27. Davis D, Wilson RB, Mitchell AP. RIM101-dependent and-independent pathways govern pH responses in Candida albicans. Mol Cell Biol. 2000; 20: 971-8.
28. Daniels KJ, Lockhart SR, Staab JF, Sundstrom P, Soll DR. The adhesin Hwp1 and the first daughter cell localize to the a/a portion of the conjugation bridge during Candida albicans mating. Mol Biol Cell. 2003; 14: 4920-30.
29. Birse CE, Irwin MY, Fonzi WA, Sypherd PS. Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans. Infect Immun. 1993; 61(9): 3648-55.
30. Alarco AM, Raymond M. The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans. J Bacteriol. 1999; 181(3): 700-8.
31. Sanglard D, Ischer F, Marchetti O, Entenza J, Bille J. Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence. Mol Microbiol. 2003; 48: 959-76.
32. Bader T, Schroppel K, Bentink S, Agabian N, Kohler G, Morschhauser J. Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain. Infect Immun. 2006; 74: 4366-9.
33. Aramburu J, Heitman J, Crabtree GR. Calcineurin: a central controller of signalling in eukaryotes. EMBO Rep. 2004; 5: 343-8.
34. 2+ -calmodulin interaction in the yeast-mycelial (Y-M) transition of Candida albicans. Mycopathologia. 1989; 108: 47-54.
35. Cruz MC, Goldstein AL, Blankenship JR, Del Poeta M, Davis D, Cardenas ME, et al. Calcineurin is essential for survival during membrane stress in Candida albicans. EMBO J. 2002; 21: 546-59.
36. Lorenz MC, Bender JA, Fink GR. Transcriptional response of Candida albicans upon internalization by macrophages. Eukaryot Cell. 2004; 3: 1076-87.
37. Hwang CS, Rhie GE, Oh JH, Huh WK, Yim HS, Kang SO. Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence. Microbiology. 2002; 148: 3705-13.
38. Martchenko M, Alarco AM, Harcus D, Whiteway M. Superoxide dismutases in Candida albicans: transcriptional regulation and functional characterization of the hyphal-induced SOD5 gene. Mol Biol Cell. 2004; 15: 456-67.