Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: Role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5

Journal of Neuroinflammation

Volumn 9, Issue , 2012, Pages

  Silva, Jharon ^a   Polesskaya, Oksana ^a   Knight, Walter ^a   Zheng, Johnny T ^a   Granger, Megan ^a   Lopez, Tenée ^b   Ontiveros, Fernando ^a   Feng, Changyong ^a   Yan, Chen ^a   Kasischke, Karl A ^c   Dewhurst, Stephen ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

^c UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Cerebrovascular reactivity; HIV 1; Hypercapnia; Phosphodiesterase 5; Tat transgenic mice

Indexed keywords

CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 5; GISADENAFIL; NITRIC OXIDE; PHOSPHODIESTERASE V; TETRAHYDROBIOPTERIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL CARBON DIOXIDE TENSION; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VESSEL REACTIVITY; BRAIN BLOOD FLOW; BRAIN CAPILLARY; CAPILLARY DENSITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HYPERCAPNIA; MALE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NONHUMAN; REACTION TIME; SIGNAL TRANSDUCTION; VASODILATATION;

EID: 84869176373     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-253     Document Type: Article

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