Reversible inhibition of fusion activity of a paramyxovirus fusion protein by an engineered disulfide bond in the membrane-proximal external region

Journal of Virology

Volumn 86, Issue 22, 2012, Pages 12397-12401

  Zokarkar, Aarohi ^a   Connolly, Sarah A ^a,c   Jardetzky, Theodore S ^b   Lamb, Robert A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DEPAUL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; MONOMER; MUTANT PROTEIN; VIRUS FUSION PROTEIN;

ARTICLE; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; DISULFIDE BOND; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; MEMBRANE PROXIMAL EXTERNAL REGION; NONHUMAN; PARAMYXOVIRUS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REDUCTION; TRIPLE HELIX; VIRUS ENVELOPE;

CELL MEMBRANE; CYSTEINE; DISULFIDES; HELA CELLS; HUMANS; MEMBRANE FUSION; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; TISSUE ENGINEERING; VIRAL FUSION PROTEINS; VIRAL PROTEINS;

PARAMYXOVIRIDAE;

EID: 84869143977     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02006-12     Document Type: Article

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