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Volumn 8, Issue 3, 2012, Pages 225-231

Gene signatures in stage II colon cancer: A clinical review

Author keywords

Adjuvant! Online; ColDx; Colon cancer; ColoPrint; Gene signatures; Guanylyl cyclase C; MSI; Numeracy; Oncotype DX RS; Predictive score; Prognostic score; Recurrence score; Stage II

Indexed keywords

ARTICLE; CANCER ADJUVANT THERAPY; CANCER GENETICS; CANCER STAGING; CLINICAL DECISION MAKING; COLON CANCER; DIAGNOSTIC TEST; GENE EXPRESSION PROFILING; GENE EXPRESSION SYSTEM; HUMAN; RECURRENCE RISK; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 84869137663     PISSN: 15563790     EISSN: 15563804     Source Type: Journal    
DOI: 10.1007/s11888-012-0132-7     Document Type: Article
Times cited : (23)

References (54)
  • 3
    • 74949122020 scopus 로고    scopus 로고
    • Revised tn categorization for colon cancer based on national survival outcomes data
    • This article updates the survival pattern of patients with colon cancer, which is the basis of changes made to the substaging in the AJCC colon cancer staging 7th edition
    • Gunderson LL, Jessup JM, Sargent DJ. Revised TN categorization for colon cancer based on national survival outcomes data. J Clin Oncol. 2010;28:264-71. This article updates the survival pattern of patients with colon cancer, which is the basis of changes made to the substaging in the AJCC colon cancer staging 7th edition.
    • (2010) J Clin Oncol. , vol.28 , pp. 264-71
    • Gunderson, L.L.1    Jessup, J.M.2    Sargent, D.J.3
  • 5
    • 6944230093 scopus 로고    scopus 로고
    • Colon cancer survival rates with new american joint committee on cancer sixth edition staging
    • O'Connell JB, Maggard MA, Ko CY. Colon cancer survival rates with new American joint committee on cancer sixth edition staging. J Natl Cancer Inst. 2004;96(19):1420.
    • (2004) J Natl Cancer Inst. , vol.96 , Issue.19 , pp. 1420
    • O'Connell, J.B.1    Maggard, M.A.2    Ko, C.Y.3
  • 6
    • 36849064682 scopus 로고    scopus 로고
    • Adjuvant chemotherapy versus observation in patients with colorectal cancer: A randomised study
    • The QUASAR Collaborative Group
    • The QUASAR Collaborative Group. Adjuvant chemotherapy versus observation in patients with colorectal cancer: A randomised study. Lancet. 2007;370:2020-9.
    • (2007) Lancet. , vol.370 , pp. 2020-9
  • 7
    • 67650315187 scopus 로고    scopus 로고
    • Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage ii or iii colon cancer in the mosaic trial
    • André T, Boni C, Navarro M. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol. 2009;27(19):3109.
    • (2009) J Clin Oncol , vol.27 , Issue.19 , pp. 3109
    • André, T.1    Boni, C.2    Navarro, M.3
  • 8
    • 34250210799 scopus 로고    scopus 로고
    • Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage ii and iii colon cancer: Results from nsabp c-07
    • Kuebler JP, Wieand S, O'Connell MJ, et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: Results from NSABP C-07. J Clin Oncol. 2007;25(16):2198.
    • (2007) J Clin Oncol , vol.25 , Issue.16 , pp. 2198
    • Kuebler, J.P.1    Wieand, S.2    O'Connell, M.J.3
  • 9
    • 77952096578 scopus 로고    scopus 로고
    • Long-term survival results of surgery alone versus surgery plus 5-fluorouracil and leucovorin for stage ii and stage iii colon cancer: Pooled analysis of nsabp c-01 through c-05. A baseline from which to compare modern adjuvant trials
    • This article is a metaanalysis of NSABP C-959-66 This article is a metaanalysi01 through C
    • Wilkinson NW, Yothers G, Lopa S. Long-term survival results of surgery alone versus surgery plus 5-fluorouracil and leucovorin for stage II and stage III colon cancer: Pooled analysis of NSABP C-01 through C-05. A baseline from which to compare modern adjuvant trials. Ann Surg Oncol. 2010;17(4):959-66. This article is a metaanalysis of NSABP C-01 through C-06 showing benefit in outcomes when 5-FU is given in addition to surgery to provide anticipated survival outcome with which to compare modern adjuvant trials.
    • (2010) Ann Surg Oncol. , vol.17 , Issue.4 , pp. 959-66
    • Wilkinson, N.W.1    Yothers, G.2    Lopa, S.3
  • 10
    • 84870736389 scopus 로고    scopus 로고
    • NCCN guidelines Version 3.2012
    • NCCN guidelines Version 3.2012. http://www.nccn.org/professionals/ physician-gls/f-guidelines.asp
  • 11
    • 80052735984 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for stage ii colon cancer with poor prognostic features
    • This article provides information that older patients with stage II colon cancer and at least one clinicopathologic risk factor do not benefit from adjuvant chemotherapy
    • O'Conner ES, Greenblatt DY, LoConte NK. Adjuvant chemotherapy for stage II colon cancer with poor prognostic features. J Clin Oncol. 2011;29(25):3381-8. This article provides information that older patients with stage II colon cancer and at least one clinicopathologic risk factor do not benefit from adjuvant chemotherapy.
    • (2011) J Clin Oncol. , vol.29 , Issue.25 , pp. 3381-8
    • O'Conner, E.S.1    Greenblatt, D.Y.2    LoConte, N.K.3
  • 12
    • 4344587783 scopus 로고    scopus 로고
    • American society of clinical oncology recommendations on adjuvant chemotherapy for stage ii colon cancer
    • Benson AB, Schrag D, Somerfield MR, et al. American society of clinical oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J Clin Oncol. 2004;22(16):3408-19.
    • (2004) J Clin Oncol. , vol.22 , Issue.16 , pp. 3408-19
    • Benson, A.B.1    Schrag, D.2    Somerfield, M.R.3
  • 13
    • 84870736818 scopus 로고    scopus 로고
    • Adjuvant! Online:
    • Adjuvant! Online: www.adjuvantonline.com
  • 14
    • 84870764618 scopus 로고    scopus 로고
    • Numeracy:
    • Numeracy: www.mayoclinic.com/calcs
  • 15
    • 77954748953 scopus 로고    scopus 로고
    • Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer
    • This article shows that stage II colon cancer patients do not benefit from adjuvant 5-FU-based therapy
    • Sargent DJ, Marsoni S, Monges G. Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer. J Clin Oncol. 2010;28 (30):3216-26. This article shows that stage II colon cancer patients do not benefit from adjuvant 5-FU-based therapy.
    • (2010) J Clin Oncol. , vol.28 , Issue.30 , pp. 3216-26
    • Sargent, D.J.1    Marsoni, S.2    Monges, G.3
  • 16
    • 60749102639 scopus 로고    scopus 로고
    • Association of gucy2c expression in lymph nodes with time to recurrence and disease-free survival in pn0 colorectal cancer
    • Waldman SA, Hyslop T, Schulz S, et al. Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer. JAMA. 2009;301(7):745-52.
    • (2009) JAMA , vol.301 , Issue.7 , pp. 745-52
    • Waldman, S.A.1    Hyslop, T.2    Schulz, S.3
  • 17
    • 83055179767 scopus 로고    scopus 로고
    • Evaluation of guanylyl cyclase c lymph node status for colon cancer staging and prognosis
    • This article shows the importance of detecting guanylyl cyclase C as a marker for metastatic disease in the lymph nodes in stage II patients without histologic evidence of positive nodes
    • Sargent DJ, Resnick MB, Meyers MO. Evaluation of Guanylyl Cyclase C lymph node status for colon cancer staging and prognosis. Ann Surg Oncol. 2011;18(12):3261-70. This article shows the importance of detecting guanylyl cyclase C as a marker for metastatic disease in the lymph nodes in stage II patients without histologic evidence of positive nodes.
    • (2011) Ann Surg Oncol. , vol.18 , Issue.12 , pp. 3261-70
    • Sargent, D.J.1    Resnick, M.B.2    Meyers, M.O.3
  • 18
    • 3042782851 scopus 로고    scopus 로고
    • Deleted in colorectal cancer protein expression as a possible predictor of response to adjuvant chemotherapy in colorectal cancer patients
    • Gal R, Sadikov E, Sulkes J, et al. Deleted in colorectal cancer protein expression as a possible predictor of response to adjuvant chemotherapy in colorectal cancer patients. Dis Colon Rectum. 2004;47(7):1216.
    • (2004) Dis Colon Rectum , vol.47 , Issue.7 , pp. 1216
    • Gal, R.1    Sadikov, E.2    Sulkes, J.3
  • 19
    • 60849123935 scopus 로고    scopus 로고
    • Evidence for cure by adjuvant therapy in colon cancer: Observations based on individual patient data from 20,898 patients on 18 randomized trials
    • Sargent DJ, Sobrero A, Grothey A, et al. Evidence for cure by adjuvant therapy in colon cancer: Observations based on individual patient data from 20,898 patients on 18 randomized trials. J Clin Oncol. 2009;27(6):872-7.
    • (2009) J Clin Oncol. , vol.27 , Issue.6 , pp. 872-7
    • Sargent, D.J.1    Sobrero, A.2    Grothey, A.3
  • 20
    • 33645750172 scopus 로고    scopus 로고
    • Tumor thymidylate synthase 1494del6 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment
    • Dotor E, Cuatrecases M, Martínez-Iniesta M, et al. Tumor thymidylate synthase 1494del6 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment. J Clin Oncol. 2006;24(10):1603-11.
    • (2006) J Clin Oncol. , vol.24 , Issue.10 , pp. 1603-11
    • Dotor, E.1    Cuatrecases, M.2    Martínez-Iniesta, M.3
  • 21
    • 0032521205 scopus 로고    scopus 로고
    • Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: A southwest oncology group study
    • Ahnen DJ, Feigl P, Quan G. Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: A Southwest Oncology Group study. Cancer Res. 1998;58:1149-58.
    • (1998) Cancer Res. , vol.58 , pp. 1149-58
    • Ahnen, D.J.1    Feigl, P.2    Quan, G.3
  • 22
    • 0033986545 scopus 로고    scopus 로고
    • Soontrapornchai p. P53 gene mutation, microsatellite instability and adjuvant chemotherapy: Impact on survival of 388 patients with dukes' c colon carcinoma
    • Elsaleh H, Powell B, Soontrapornchai P. p53 gene mutation, microsatellite instability and adjuvant chemotherapy: Impact on survival of 388 patients with Dukes' C colon carcinoma. Oncology. 2000;58:52-9.
    • (2000) Oncology. , vol.58 , pp. 52-9
    • Elsaleh, H.1    Powell, B.2
  • 23
    • 24944525406 scopus 로고    scopus 로고
    • Determination of tp53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage iii colon cancer patients
    • Westra JL, Schaapveld M, Hollema H. Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. J Clin Oncol. 2005;23:5635-43.
    • (2005) J Clin Oncol. , vol.23 , pp. 5635-43
    • Westra, J.L.1    Schaapveld, M.2    Hollema, H.3
  • 24
    • 77949274921 scopus 로고    scopus 로고
    • Stage-specific prognostic value of molecular markers in colon cancer: Results of the translational study on the petacc 3-eortc 40993-sakk 60-00 trial
    • This abstract provides information that molecular markers in stage II and III colon cancer have stage-specific prognostic information and may represent different diseases rather than sequential steps in the evolution of colon cancer
    • Roth AD, Tejpar S, Yan P. Stage-specific prognostic value of molecular markers in colon cancer: Results of the translational study on the PETACC 3-EORTC 40993-SAKK 60-00 trial. J Clin Oncol. 2009;27(4002):169s. This abstract provides information that molecular markers in stage II and III colon cancer have stage-specific prognostic information and may represent different diseases rather than sequential steps in the evolution of colon cancer.
    • (2009) J Clin Oncol. , vol.27 , Issue.4002
    • Roth, A.D.1    Tejpar, S.2    Yan, P.3
  • 25
    • 0038002279 scopus 로고    scopus 로고
    • Tumor microsatelliteinstability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
    • Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatelliteinstability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003;349:247-57.
    • (2003) N Engl J Med. , vol.349 , pp. 247-57
    • Ribic, C.M.1    Sargent, D.J.2    Moore, M.J.3
  • 26
    • 24644515996 scopus 로고    scopus 로고
    • Prognostic and predictive relevance of microsatellite instability in colorectal cancer
    • Storojeva I, Boulay JL, Heinimann K. Prognostic and predictive relevance of microsatellite instability in colorectal cancer. Oncol Rep. 2005;14:241-9.
    • (2005) Oncol Rep. , vol.14 , pp. 241-9
    • Storojeva, I.1    Boulay, J.L.2    Heinimann, K.3
  • 27
    • 10744228074 scopus 로고    scopus 로고
    • Use of 5-fluorouracil and survival in patients with microsatellite- unstable colorectal cancer
    • Carethers JM, Smith EJ, Behling CA, et al. Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer. Gastroenterology. 2004;126:394-401.
    • (2004) Gastroenterology. , vol.126 , pp. 394-401
    • Carethers, J.M.1    Smith, E.J.2    Behling, C.A.3
  • 28
    • 0342545499 scopus 로고    scopus 로고
    • Standardized approach for microsatellite instability detection in colorectal carcinomas
    • González-García I, Moreno V, Navarro M. Standardized approach for microsatellite instability detection in colorectal carcinomas. J Natl Cancer Inst. 2000;92:544-9.
    • (2000) J Natl Cancer Inst. , vol.92 , pp. 544-9
    • González-García, I.1    Moreno, V.2    Navarro, M.3
  • 29
    • 1442308342 scopus 로고    scopus 로고
    • Gene expression profiling of colon cancer by dna microarrays and correlation with histoclinical parameters
    • Bertucci F, Salas S, Eysteries S, et al. Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters. Oncogene. 2004;23:1377-91.
    • (2004) Oncogene. , vol.23 , pp. 1377-91
    • Bertucci, F.1    Salas, S.2    Eysteries, S.3
  • 30
    • 2442684455 scopus 로고    scopus 로고
    • Gene expression profiles and molecular markers to predict recurrence of dukes' b colon cancer
    • Wang Y, Jatkoe T, Zhang Y. Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer. J Clin Oncol. 2004;22:1564-71.
    • (2004) J Clin Oncol. , vol.22 , pp. 1564-71
    • Wang, Y.1    Jatkoe, T.2    Zhang, Y.3
  • 31
    • 33750593381 scopus 로고    scopus 로고
    • Stage ii colon cancer prognosis prediction by tumor gene expression profiling
    • Barrier A, Boelle PY, Roser F. Stage II colon cancer prognosis prediction by tumor gene expression profiling. J Clin Oncol. 2006;24:4685-91.
    • (2006) J Clin Oncol. , vol.24 , pp. 4685-91
    • Barrier, A.1    Boelle, P.Y.2    Roser, F.3
  • 32
    • 20644443287 scopus 로고    scopus 로고
    • Molecular staging for survival prediction of colorectal cancer patients
    • Eschrich S, Yang I, Bloom G. Molecular staging for survival prediction of colorectal cancer patients. J Clin Oncol. 2005;23:3526-35.
    • (2005) J Clin Oncol. , vol.23 , pp. 3526-35
    • Eschrich, S.1    Yang, I.2    Bloom, G.3
  • 33
    • 77957582401 scopus 로고    scopus 로고
    • Relationship between tumor gene expression and recurrence in four independent studies of patients with stage ii/iii colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin
    • This article details the process of gene selection and validation to develop the 12-gene OncotypeDX Recurrence Score from formalin-fixed paraffin embedded tissue
    • O'Connell MJ, Lavery I, Yothers G. Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin. J Clin Oncol. 2010;28(25):3937-44. This article details the process of gene selection and validation to develop the 12-gene OncotypeDX Recurrence Score from formalin-fixed paraffin embedded tissue.
    • (2010) J Clin Oncol. , vol.28 , Issue.25 , pp. 3937-44
    • O'Connell, M.J.1    Lavery, I.2    Yothers, G.3
  • 34
    • 0001554828 scopus 로고
    • The classification of cancer of the rectum
    • Dukes CE. The classification of cancer of the rectum. J Pathol Bact. 1932;35:323-32.
    • (1932) J Pathol Bact. , vol.35 , pp. 323-32
    • Dukes, C.E.1
  • 35
    • 0000352810 scopus 로고
    • The spread of rectal cancer and its effect on prognosis
    • Dukes CE, Bussey HJ. The spread of rectal cancer and its effect on prognosis. Br J Cancer. 1958;12:309-20.
    • (1958) Br J Cancer. , vol.12 , pp. 309-20
    • Dukes, C.E.1    Bussey, H.J.2
  • 36
    • 83355166957 scopus 로고    scopus 로고
    • Validation study of a quantitative multigene reverse transcriptase- polymerase chain reaction assay for assessment of recurrence risk in patients with stage ii colon cancer
    • This article describes the external validation of the 12-gene OncotypeDX Recurrence Score in the QUASAR and CALGB 9581 trials
    • Gray RG, Quirke P, Handley K. Validation study of a quantitative multigene reverse transcriptase-polymerase chain reaction assay for assessment of recurrence risk in patients with stage II colon cancer. J Clin Oncol. 2011;29(35):4611-9. This article describes the external validation of the 12-gene OncotypeDX Recurrence Score in the QUASAR and CALGB 9581 trials.
    • (2011) J Clin Oncol. , vol.29 , Issue.35 , pp. 4611-9
    • Gray, R.G.1    Quirke, P.2    Handley, K.3
  • 37
    • 0037010411 scopus 로고    scopus 로고
    • Dna markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: A molecular study
    • Barratt PL, Seymour MT, Stenning SP, et al. DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: A molecular study. Lancet. 2002;360:1381-91.
    • (2002) Lancet. , vol.360 , pp. 1381-91
    • Barratt, P.L.1    Seymour, M.T.2    Stenning, S.P.3
  • 38
    • 0037464338 scopus 로고    scopus 로고
    • Role of plateletderived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity
    • de Bruin M, van Capel T, Van der Born K, et al. Role of plateletderived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity. Br J Cancer. 2003;88:957-64.
    • (2003) Br J Cancer. , vol.88 , pp. 957-64
    • De Bruin, M.1    Van Capel, T.2    Van Der Born, K.3
  • 39
    • 12944293119 scopus 로고    scopus 로고
    • Prognostic role of thymidine synthase, thymidine phosphorylase/platelet- derived endothelial cell growth factor and proliferation markers in colorectal cancer
    • van Triest B, Pinedo HM, Blaauwgeers JL, et al. Prognostic role of thymidine synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor and proliferation markers in colorectal cancer. Clin Cancer Res. 2000;6:1063-72.
    • (2000) Clin Cancer Res. , vol.6 , pp. 1063-72
    • Van Triest, B.1    Pinedo, H.M.2    Blaauwgeers, J.L.3
  • 40
    • 33645013092 scopus 로고    scopus 로고
    • Screening for dihyrodropyrimidine dehydrogenase deficiency: To do or not to do, that's the question
    • van Kuilenburg AB. Screening for dihyrodropyrimidine dehydrogenase deficiency: To do or not to do, that's the question. Cancer Invest. 2006;24:215-7.
    • (2006) Cancer Invest. , vol.24 , pp. 215-7
    • Van Kuilenburg, A.B.1
  • 41
    • 11244258378 scopus 로고    scopus 로고
    • Prospective clinical trials using a pharmacogenetic/pharmacogenomic approach
    • Peters GJ, Smorenburg CH, Van Groeningen CJ. Prospective clinical trials using a pharmacogenetic/pharmacogenomic approach. J Chemother. 2004;16(4):25-30.
    • (2004) J Chemother. , vol.16 , Issue.4 , pp. 25-30
    • Peters, G.J.1    Smorenburg, C.H.2    Van Groeningen, C.J.3
  • 42
    • 0034048729 scopus 로고    scopus 로고
    • Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
    • Salonga D, Danenberg KD, Johnson M, et al. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res. 2000;6:1322-7.
    • (2000) Clin Cancer Res. , vol.6 , pp. 1322-7
    • Salonga, D.1    Danenberg, K.D.2    Johnson, M.3
  • 43
    • 0037312517 scopus 로고    scopus 로고
    • Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expression in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer
    • Ichikawa W, Uetake H, Shirota Y, et al. Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expression in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Clin Cancer Res. 2003;9:786-91.
    • (2003) Clin Cancer Res. , vol.9 , pp. 786-91
    • Ichikawa, W.1    Uetake, H.2    Shirota, Y.3
  • 44
    • 84870759922 scopus 로고    scopus 로고
    • Validation of the 12-gene colon cancer recurrence score (rs) in nsabp c-07 as a predictor of recurrence in stage ii and iii colon cancer patients treated with 5-fu/lv (fu) and 5-fu/lv+oxaliplatin (fu+ox)
    • Poster Discussion Session. Abstract #3512. This abstract provides results of validation study of OncotypeDX Recurrence Score (RS) on NSABP C-07 patients showing that the RS is prognostic of outcomes in patients treated with 5-FU and degree of benefit from oxaliplatin is a function of risk
    • O'Connell MJ, Lee M, Lopatin M, et al.: Validation of the 12-gene colon cancer recurrence score (RS) in NSABP C-07 as a predictor of recurrence in stage II and III colon cancer patients treated with 5-FU/LV (FU) and 5-FU/LV+oxaliplatin (FU+Ox). Being presented at American Society of Clinical Oncology June 1-5th 2012. Poster Discussion Session. Abstract #3512. This abstract provides results of validation study of OncotypeDX Recurrence Score (RS) on NSABP C-07 patients showing that the RS is prognostic of outcomes in patients treated with 5-FU and degree of benefit from oxaliplatin is a function of risk.
    • Being presented at American Society of Clinical Oncology June 1-5th 2012
    • O'Connell, M.J.1    Lee, M.2    Lopatin, M.3
  • 45
    • 79951506562 scopus 로고    scopus 로고
    • Gene expression signature to improve prognosis prediction of stage ii and iii colorectal cancer
    • This article describes the process of development of the 18-gene ColoPrint assay using Agilent 44K oligonucleotide assay from fresh frozen tissue
    • Salazar R, Roepman P, Capella G. Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer. J Clin Oncol. 2011;29(1):17-24. This article describes the process of development of the 18-gene ColoPrint assay using Agilent 44K oligonucleotide assay from fresh frozen tissue.
    • (2011) J Clin Oncol. , vol.29 , Issue.1 , pp. 17-24
    • Salazar, R.1    Roepman, P.2    Capella, G.3
  • 46
    • 84922668990 scopus 로고    scopus 로고
    • Clinical and technical validation of genomic classifier (coloprint) for predicting outcomes in stage ii colon cancer
    • abstr 384. This abstract provides the validation study for the 18-gene ColoPrint
    • Tabernero J, Moreno V, Rosenberg R. Clinical and technical validation of genomic classifier (ColoPrint) for predicting outcomes in stage II colon cancer. J Clin Oncol. 2012;30(4):abstr 384. This abstract provides the validation study for the 18-gene ColoPrint.
    • (2012) J Clin Oncol. , vol.30 , pp. 4
    • Tabernero, J.1    Moreno, V.2    Rosenberg, R.3
  • 47
    • 83355174077 scopus 로고    scopus 로고
    • Development and independent validation of a prognostic assay for stage ii colon cancer using formalin-fixed paraffin-embedded tissue
    • This article provides the development and validation of the ColDx which is a 634-gene microarray analysis of formalin fixed paraffin embedded tissue
    • Kennedy RD, Bylesjo M, Kerr P. Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue. J Clin Oncol. 2011;29 (35):4620-8. This article provides the development and validation of the ColDx which is a 634-gene microarray analysis of formalin fixed paraffin embedded tissue.
    • (2011) J Clin Oncol. , vol.29 , Issue.35 , pp. 4620-8
    • Kennedy, R.D.1    Bylesjo, M.2    Kerr, P.3
  • 48
    • 9744231436 scopus 로고    scopus 로고
    • Interplay of insulinlike growth factor-ii, insulin-like growth factor-i, insulin-like growth factor-i receptor, cox-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis
    • Nosho K, Yamamoto H, Taniguchi H, et al. Interplay of insulinlike growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis. Clin Cancer Res. 2004;10:7950-7.
    • (2004) Clin Cancer Res. , vol.10 , pp. 7950-7
    • Nosho, K.1    Yamamoto, H.2    Taniguchi, H.3
  • 49
    • 0030024536 scopus 로고    scopus 로고
    • High levels of transforming growth factor beta 1 in patients with colorectal cancer: Association with disease progression
    • Tsushima H, Kawata S, Tamura S, et al. High levels of transforming growth factor beta 1 in patients with colorectal cancer: Association with disease progression. Gastroenterology. 1996;110:375-82.
    • (1996) Gastroenterology. , vol.110 , pp. 375-82
    • Tsushima, H.1    Kawata, S.2    Tamura, S.3
  • 50
    • 30944466823 scopus 로고    scopus 로고
    • Increased expression of high mobility group box 1 (hmgb1) is associated with an elevated level of the antiapoptotic c-iap2 protein in human colon carcinomas
    • Volp K, Brezniceanu ML, Bosser S, et al. Increased expression of high mobility group box 1 (HMGB1) is associated with an elevated level of the antiapoptotic c-IAP2 protein in human colon carcinomas. Gut. 2006;55:234-42.
    • (2006) Gut. , vol.55 , pp. 234-42
    • Volp, K.1    Brezniceanu, M.L.2    Bosser, S.3
  • 51
    • 27144468959 scopus 로고    scopus 로고
    • A gene expression signature of genetic instability in colon cancer
    • Giacomini CP, Leung SY, Chen X, et al. A gene expression signature of genetic instability in colon cancer. Cancer Res. 2005;65:9200-5.
    • (2005) Cancer Res. , vol.65 , pp. 9200-5
    • Giacomini, C.P.1    Leung, S.Y.2    Chen, X.3
  • 52
    • 75749154080 scopus 로고    scopus 로고
    • Association between disease-free survival and overall survival when survival is prolonged after recurrence in patients receiving cytotoxic adjuvant therapy for colon cancer: Simulations based on the 20,800 patient accent data set
    • de Gramont A, Hubbard J, Shi Q, et al. Association between disease-free survival and overall survival when survival is prolonged after recurrence in patients receiving cytotoxic adjuvant therapy for colon cancer: Simulations based on the 20,800 patient ACCENT data set. J Clin Oncol. 2012;28(3):460-5.
    • (2012) J Clin Oncol. , vol.28 , Issue.3 , pp. 460-5
    • De Gramont, A.1    Hubbard, J.2    Shi, Q.3
  • 53
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van't Veer LJ, Dai H, van de Vijver MJ. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415:530-6.
    • (2002) Nature. , vol.415 , pp. 530-536
    • Van't Veer, L.J.1    Dai, H.2    Van De Vijver, M.J.3
  • 54
    • 33751193656 scopus 로고    scopus 로고
    • Converting a breast cancer microarray signature into a high-throughput diagnostic test
    • Glas AM, Floore A, Delahaye LJ, et al. Converting a breast cancer microarray signature into a high-throughput diagnostic test. BMC Genomics. 2006;7:278.
    • (2006) BMC Genomics , vol.7 , pp. 278
    • Glas, A.M.1    Floore, A.2    Delahaye, L.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.