Modification of one epitope-flanking amino acid allows for the induction of friend retrovirus-specific CD8+ T cells by adenovirus-based immunization

Journal of Virology

Volumn 86, Issue 22, 2012, Pages 12422-12425

  Gödel, Philipp ^a   Windmann, Sonja ^a   Dietze, Kirsten K ^a   Dittmer, Ulf ^a   Bayer, Wibke ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; DNA VACCINE; EPITOPE; GAG PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN; SCAFFOLD PROTEIN; THIOREDOXIN;

ADENOVIRUS; ARTICLE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CELL PROTECTION; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; DRUG EFFICACY; ENZYME ACTIVITY; FRIEND LEUKEMIA; FRIEND LEUKEMIA VIRUS; GENETIC IMMUNIZATION; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; VIRUS LOAD;

ANIMALS; CAPSID; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES; FRIEND MURINE LEUKEMIA VIRUS; GENE PRODUCTS, GAG; IMMUNIZATION; MICE; MODELS, GENETIC; PEPTIDES; RETROVIRIDAE; VACCINATION; VACCINES, ADENOVIRUS; VACCINES, DNA; VIRAL VACCINES;

ADENOVIRIDAE; FRIEND MURINE LEUKEMIA VIRUS; MUS;

EID: 84869137351     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01607-12     Document Type: Article

References (26)

1. Ahlers JD, Belyakov IM, Matsui S, Berzofsky JA. 2001. Mechanisms of cytokine synergy essential for vaccine protection against viral challenge. Int. Immunol. 13:897-908.
2. Ahlers JD, Dunlop N, Alling DW, Nara PL, Berzofsky JA. 1997. Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs: granulocyte-macrophage colony-stimulating factor and TNF-alpha synergize with IL-12 to enhance induction of cytotoxic T lymphocytes. J. Immunol. 158:3947-3958.
3. Bayer W, Schimmer S, Hoffmann D, Dittmer U, Wildner O. 2008. Evaluation of the Friend virus model for the development of improved adenovirus-vectored anti-retroviral vaccination strategies. Vaccine 26:716-726.
4. Bayer W, et al. 2010. Vaccination with an adenoviral vector that encodes and displays a retroviral antigen induces improved neutralizing antibody and CD4+ T-cell responses and confers enhanced protection. J. Virol. 84:1967-1976.
5. Bertini R, et al. 1999. Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells. J. Exp. Med. 189:1783-1789.
6. Blum H, Rollinghoff M, Gessner A. 1996. Expression and co-cytokine function of murine thioredoxin/adult T cell leukaemia-derived factor (ADF). Cytokine 8:6-13.
7. Bolesta E, et al. 2006. Increased level and longevity of protective immune responses induced by DNA vaccine expressing the HIV-1 Env glycoprotein when combined with IL-21 and IL-15 gene delivery. J. Immunol. 177:177-191.
8. Chakraborty K, et al. 2006. Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies. Biochem. J. 399:483-491.
9. Chen W, Qin H, Chesebro B, Cheever MA. 1996. Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors. J. Virol. 70:7773-7782.
10. Dittmer U, Brooks DM, Hasenkrug KJ. 1999. Requirement for multiple lymphocyte subsets in protection by a live attenuated vaccine against retroviral infection. Nat. Med. 5:189-193.
11. Dittmer U, Werner T, Kraft AR. 2008. Co-immunization of mice with a retroviral DNA vaccine and GITRL-encoding plasmid augments vaccineinduced protection against retrovirus infection. Viral Immunol. 21:459-467
12. Evans LH, Dresler S, Kabat D. 1977. Synthesis and glycosylation of polyprotein precursors to the internal core proteins of Friend murine leukemia virus. J. Virol. 24:865-874.
13. Hartman ZC, et al. 2007. Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. J. Virol. 81:1796-1812.
14. He TC, et al. 1998. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. U. S. A. 95:2509-2514.
15. Kron MW, et al. 2011. High-capacity adenoviral vectors circumvent the limitations of DeltaE1 and DeltaE1/DeltaE3 adenovirus vectors to induce multispecific transgene product-directed CD8 T-cell responses. J. Gene Med. 13:648-657.
16. Livingston BD, et al. 2001. Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines. Vaccine 19:4652-4660.
17. Lundegaard C, et al. 2008. NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11. Nucleic Acids Res. 36:W509-W512.
18. McCaffrey AP, et al. 2008. The host response to adenovirus, helperdependent adenovirus, and adeno-associated virus in mouse liver. Mol. Ther. 16:931-941.
19. Miyazawa M, Nishio J, Chesebro B. 1992. Protection against Friend retrovirus-induced leukemia by recombinant vaccinia viruses expressing the gag gene. J. Virol. 66:4497-4507.
20. Nielsen M, Lundegaard C, Lund O, Kesmir C. 2005. The role of the proteasome in generating cytotoxic T cell epitopes: insights obtained from improved predictions of proteasomal cleavage. Immunogenetics 57:33-41.
21. Nilsson M, et al. 2004. Development of an adenoviral vector system with adenovirus serotype 35 tropism; efficient transient gene transfer into primary malignant hematopoietic cells. J. Gene Med. 6:631-641.
22. Ohlen C, et al. 2002. CD8+ T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function. J. Exp. Med. 195:1407-1418.
23. Rubartelli A, Bajetto A, Allavena G, Wollman E, Sitia R. 1992. Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway. J. Biol. Chem. 267:24161-24164.
24. Rubio I, et al. 2009. Potent anti-HPV immune responses induced by tandem repeats of the HPV16 L2 (20-38) peptide displayed on bacterial thioredoxin. Vaccine 27:1949-1956.
25. Schepers K, et al. 2002. Differential kinetics of antigen-specific CD4+ and CD8+ T cell responses in the regression of retrovirus-induced sarcomas. J. Immunol. 169:3191-3199.
26. Zelinskyy G, Kraft AR, Schimmer S, Arndt T, Dittmer U. 2006. Kinetics of CD8+ effector T cell responses and induced CD4+ regulatory T cell responses during Friend retrovirus infection. Eur. J. Immunol. 36:2658-2670.