Duodenal reductase activity and spleen iron stores are reduced and erythropoiesis is abnormal in Dcytb knockout mice exposed to hypoxic conditions

Journal of Nutrition

Volumn 142, Issue 11, 2012, Pages 1929-1934

  Choi, Jeehyea ^a   Masaratana, Patarabutr ^a,b   Latunde Dada, Gladys O ^a   Arno, Matthew ^a   Simpson, Robert J ^a   McKie, Andrew T ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

DUODENAL CYTOCHROME B; HEMOGLOBIN; IRON; MESSENGER RNA; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ERYTHROPOIESIS; HYPOXIA; IRON ABSORPTION; IRON BLOOD LEVEL; IRON DEFICIENCY; IRON METABOLISM; KNOCKOUT MOUSE; LIVER; MEAN CORPUSCULAR HEMOGLOBIN; MOUSE; NONHUMAN; PREGNANCY; RETICULOCYTE COUNT; SPLEEN; WILD TYPE;

ANEMIA, IRON-DEFICIENCY; ANIMAL FEED; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; ANOXIA; CYTOCHROME B GROUP; DIET; DUODENUM; ERYTHROPOIESIS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IRON; MALE; MICE; MICE, KNOCKOUT; OXIDOREDUCTASES; OXYGEN; PREGNANCY; RANDOM ALLOCATION; SPLEEN;

ANIMALIA; MUS;

EID: 84869128204     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.112.160358     Document Type: Article

References (27)

1. Crane FL, Sun I, Clark M, Grebing C, Low H. Transplasma-membrane redox systems in growth and development. Biochim Biophys Acta. 1985, 811, 233-64.
2. Wollenberg P, Rummel W. Dependence of intestinal iron-absorption on the valency state of iron. Naunyn Schmiedebergs Arch Pharmacol. 1987, 336, 578-82.
3. Raja KB, Simpson R, Peters T. Investigation of a role for reduction in ferric iron uptake by mouse duodenum. Biochim Biophys Acta. 1992, 1135, 141-6.
4. Gunshin H, Mackenzie B, Berger U, Gunshin Y, Romero M, Boron W, Nussberger S, Gollan JL, Hediger MA. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997, 388, 482-8.
5. Fleming MD, Trenor C, Su M, Foernzler D, Beier D, Dietrich W, Andrews NC. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet. 1997, 16, 383-6.
6. McKie AT, Barrow D, Latunde-Dada G, Rolfs A, Sager G, Mudaly E, Mudaly M, Richardson C, Barlow D, Bomford A, et al. An ironregulated ferric reductase associated with the absorption of dietary iron. Science. 2001, 291, 1755-9.
7. Latunde-Dada GO, Van der Westhuizen J, Vulpe C, Anderson G, Simpson R, McKie A. Molecular and functional roles of duodenal cytochrome B (dcytb) in iron metabolism. Blood Cells Mol Dis. 2002, 29, 356-60.
8. Frazer DM, Wilkins S, Becker E, Vulpe C, McKie A, Trinder D, Anderson GJ. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology. 2002, 123, 835-44.
9. Dupic F, Fruchon S, Bensaid M, Loreal O, Brissot P, Borot N, Roth MP, Coppin H. Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice. Gut. 2002, 51, 648-53.
10. Zoller H, Theurl I, Koch R, McKie A, Vogel W, Weiss G. Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis. Gastroenterology. 2003, 125, 746-54.
11. Muckenthaler M, Roy C, Custodio A, Minana B, deGraaf J, Montross L, Andrews NC, Hentze MW. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet. 2003, 34, 102-7.
12. Latunde-Dada GO, Vulpe C, Anderson G, Simpson R, McKie A. Tissuespecific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis. Biochim Biophys Acta. 2004, 1690, 169-76.
13. Millard KN, Frazer D, Wilkins S, Anderson G. Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat. Gut. 2004, 53, 655-60.
14. Collins JF, Franck C, Kowdley K, Ghishan F. Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 2005, 288, G964-71.
15. Li AC, Warley A, Thoree V, Simpson R, Mckie A, Kodjabashia K, Thompson RPH, Powell JJ. Immunolocalization of duodenal cytochrome B, a relationship with circulating markers of iron status. Eur J Clin Invest. 2006, 36, 890-8.
16. Latunde-Dada GO, Simpson R, McKie A. Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells. J Nutr. 2008, 138, 991-5.
17. Gunshin H, Starr C, DiRenzo C, Fleming M, Jin J, Greer E, Sellers VM, Galica SM, Andrews NC. Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood. 2005, 106, 2879-83.
18. Ohgami RS, Campagna D, Greer E, Antiochos B, McDonald A, Chen J, Sharp JJ, Fujiwara Y, Barker JE, Fleming MD. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet. 2005, 37, 1264-9.
19. Simpson EM, Linder C, Sargent E, Davisson M, Mobraaten L, Sharp J. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat Genet. 1997, 16, 19-27.
20. Simpson RJ. Dietary iron levels and hypoxia independently affect iron absorption in mice. J Nutr. 1996, 126, 1858-64.
21. Chaudhury C, Kim J, Mehnaz S, Wani M, Oberyszyn T, Bronson C, Mohanty S, Hayton WL, Robinson JM, Anderson CL. Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation. J Nutr. 2006, 136, 2993-8.
22. Simpson RJ, Debnam E, Beaumont N, Bahram S, Schumann K, Srai S. Duodenal mucosal reductase in wild-type and hfe knockout mice on iron adequate, iron deficient, and iron rich feeding. Gut. 2003, 52, 510-3.
23. Courselaud B, Troadec M, Fruchon S, Ilyin G, Borot N, Leroyer P, Coppin H, Brissot P, Roth MP, Loreal O. Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Blood Cells Mol Dis. 2004, 32, 283-9.
24. National Centre for Biotechnology Information of the USA [Internet] [cited 2011 Dec]. Available from, http://www.ncbi.nlm.nih.gov/geo.
25. Taylor M, Qu A, Anderson E, Matsubara T, Martin A, Gonzalez F, Shah YM. Hypoxia-inducible factor-2 alpha mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology. 2011, 140, 2044-55.
26. Su D, May J, Koury M, Asard H. Human erythrocyte membranes contain a cytochrome b(561) that may be involved in extracellular ascorbate recycling. J Biol Chem. 2006, 281, 39852-9.
27. Dupic F, Fruchon S, Bensaid M, Borot N, Radosavljevic M, Loreal O, Brissot P, Gilfillan S, Bahram S, Coppin H, et al. Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains. Gastroenterology. 2002, 122, 745-51.