메뉴 건너뛰기




Volumn 39, Issue 1, 2013, Pages 44-50

Adjuvant trastuzumab in elderly with HER-2 positive breast cancer: A systematic review of randomized controlled trials

Author keywords

Adjuvant treatment; Breast cancer; Elderly patients; Geriatric oncology; Systematic review; Trastuzumab

Indexed keywords

ANTHRACYCLINE; CARBOPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; FLUOROURACIL; NAVELBINE; PACLITAXEL; TRASTUZUMAB;

EID: 84869092866     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2012.03.009     Document Type: Review
Times cited : (67)

References (42)
  • 1
    • 79955560616 scopus 로고    scopus 로고
    • Early breast cancer in the older woman
    • Ghandhi S., Verma S. Early breast cancer in the older woman. The Oncologist 2011, 16(4):479-485.
    • (2011) The Oncologist , vol.16 , Issue.4 , pp. 479-485
    • Ghandhi, S.1    Verma, S.2
  • 2
    • 36549075573 scopus 로고    scopus 로고
    • Management of breast cancer in elderly individuals: recommendations of the international society of geriatric oncology
    • Wildiers H., Kunkler I., Biganzoli L., et al. Management of breast cancer in elderly individuals: recommendations of the international society of geriatric oncology. Lancet Oncol 2007, 8(12):1101-1115.
    • (2007) Lancet Oncol , vol.8 , Issue.12 , pp. 1101-1115
    • Wildiers, H.1    Kunkler, I.2    Biganzoli, L.3
  • 3
    • 84869089427 scopus 로고    scopus 로고
    • Cancer incidence, mortality and prevalence worldwide. IARC Cancer Base No5, version 2.0. Lyon: IARC Press GLOBOCAN
    • Ferlay J, Bray F, Pisani P, Parkin DM. Cancer incidence, mortality and prevalence worldwide. IARC Cancer Base No5, version 2.0. Lyon: IARC Press GLOBOCAN; 2004.
    • (2004)
    • Ferlay, J.1    Bray, F.2    Pisani, P.3    Parkin, D.M.4
  • 4
    • 0034607235 scopus 로고    scopus 로고
    • Tumor characteristics and clinical outcome of elderly women with breast cancer
    • Diab S.G., Elledge R.M., Clark G.M. Tumor characteristics and clinical outcome of elderly women with breast cancer. J Natl Cancer Inst 2000, 92(7):550-556.
    • (2000) J Natl Cancer Inst , vol.92 , Issue.7 , pp. 550-556
    • Diab, S.G.1    Elledge, R.M.2    Clark, G.M.3
  • 5
    • 4444258770 scopus 로고    scopus 로고
    • Breast carcinoma in elderly women: features of disease presentation, choice of local and systemic treatments compared with younger postmenopausal patients
    • Gennari R., Curigliano G., Rotmensz N., et al. Breast carcinoma in elderly women: features of disease presentation, choice of local and systemic treatments compared with younger postmenopausal patients. Cancer 2004, 101(6):1302-1310.
    • (2004) Cancer , vol.101 , Issue.6 , pp. 1302-1310
    • Gennari, R.1    Curigliano, G.2    Rotmensz, N.3
  • 6
    • 79959505506 scopus 로고    scopus 로고
    • Coming of age: breast cancer in seniors
    • Muss H. Coming of age: breast cancer in seniors. Oncologist 2011, 16(suppl1):79-87.
    • (2011) Oncologist , vol.16 , Issue.SUPPL.1 , pp. 79-87
    • Muss, H.1
  • 7
    • 80054982747 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for breast cancer in older women: emerging evidence to aid in decision making
    • Kimmick G. Adjuvant chemotherapy for breast cancer in older women: emerging evidence to aid in decision making. Curr Treat Options Oncol 2011, 10.1007/s11864-011-0159-
    • (2011) Curr Treat Options Oncol
    • Kimmick, G.1
  • 8
    • 53449096848 scopus 로고    scopus 로고
    • Challenges in treating older cancer patients: breast cancer
    • Wildiers H. Challenges in treating older cancer patients: breast cancer. Ann Oncol 2008, vii(suppl7):99-103.
    • (2008) Ann Oncol , vol.7 , Issue.SUPPL.7 , pp. 99-103
    • Wildiers, H.1
  • 9
    • 33747797001 scopus 로고    scopus 로고
    • Geriatric assessment for oncologists: rationale and future directions
    • Hurria A., Lachs M.S., Cohen H.J., et al. Geriatric assessment for oncologists: rationale and future directions. Crit Rev Oncol Hematol 2006, 59(3):211-217.
    • (2006) Crit Rev Oncol Hematol , vol.59 , Issue.3 , pp. 211-217
    • Hurria, A.1    Lachs, M.S.2    Cohen, H.J.3
  • 10
    • 70349434784 scopus 로고    scopus 로고
    • Perspectives and attitudes on the use of adjuvant chemotherapy and trastuzumab in older adults with HER-2+ breast cancer: a survey of oncologists
    • Hurria A., Wong F., Pal S., et al. Perspectives and attitudes on the use of adjuvant chemotherapy and trastuzumab in older adults with HER-2+ breast cancer: a survey of oncologists. Oncologist 2009, 14(9):883-890.
    • (2009) Oncologist , vol.14 , Issue.9 , pp. 883-890
    • Hurria, A.1    Wong, F.2    Pal, S.3
  • 11
    • 34249829868 scopus 로고    scopus 로고
    • Breast cancer in the elderly
    • Crivellari D., Aapro M., Leonard R., et al. Breast cancer in the elderly. J Clin Oncol 2007, 25(14):1882-1890.
    • (2007) J Clin Oncol , vol.25 , Issue.14 , pp. 1882-1890
    • Crivellari, D.1    Aapro, M.2    Leonard, R.3
  • 12
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2 - positive breast cancer
    • Piccard-Gebhart M.J., Procter M., Leyland-Jones B., et al. Trastuzumab after adjuvant chemotherapy in HER2 - positive breast cancer. N Engl J Med 2005, 353(16):1659-1672.
    • (2005) N Engl J Med , vol.353 , Issue.16 , pp. 1659-1672
    • Piccard-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 13
    • 79952041937 scopus 로고    scopus 로고
    • Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomized controlled trial
    • Gianni L., Gelber R., Azambuja E., et al. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomized controlled trial. Lancet Oncol 2011, 12(3):236-244.
    • (2011) Lancet Oncol , vol.12 , Issue.3 , pp. 236-244
    • Gianni, L.1    Gelber, R.2    Azambuja, E.3
  • 14
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond E.H., Perez E.A., Bryant J., et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005, 353(16):1673-1684.
    • (2005) N Engl J Med , vol.353 , Issue.16 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 15
    • 80052728749 scopus 로고    scopus 로고
    • Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analyses of data from N9831 and NSABP B-31. J Clin Oncol 2011; published on line july 18, 2011 as.
    • Perez EA, Romond EH, Suman VJ, et al. Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analyses of data from N9831 and NSABP B-31. J Clin Oncol 2011; published on line july 18, 2011 as http://dx.doi.org/10.1200/JCO.2011.35.0868.
    • Perez, E.A.1    Romond, E.H.2    Suman, V.J.3
  • 16
    • 33344478381 scopus 로고    scopus 로고
    • Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
    • Joensuu H., Kellokumpu-Lehtinen P., Bono P., et al. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med 2006, 354(8):809-820.
    • (2006) N Engl J Med , vol.354 , Issue.8 , pp. 809-820
    • Joensuu, H.1    Kellokumpu-Lehtinen, P.2    Bono, P.3
  • 17
    • 74949141693 scopus 로고    scopus 로고
    • Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trial
    • Spielmann M., Roché H., Delozier T., et al. Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trial. J Clin Oncol 2009, 27(36):6129-6134.
    • (2009) J Clin Oncol , vol.27 , Issue.36 , pp. 6129-6134
    • Spielmann, M.1    Roché, H.2    Delozier, T.3
  • 18
    • 80053539103 scopus 로고    scopus 로고
    • Adjuvant trastuzumab in HER2-positive breast cancer
    • Slamon D., Eiermann W., Robert N., et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med 2011, 365(14):1273-1283.
    • (2011) N Engl J Med , vol.365 , Issue.14 , pp. 1273-1283
    • Slamon, D.1    Eiermann, W.2    Robert, N.3
  • 19
    • 0023484789 scopus 로고
    • Quantitative methods in the review of epidemiologic literature
    • Greenland S. Quantitative methods in the review of epidemiologic literature. Epidemiol Rev. 1987, 9:1-30.
    • (1987) Epidemiol Rev. , vol.9 , pp. 1-30
    • Greenland, S.1
  • 20
    • 0000694159 scopus 로고
    • Transformations related to the angular and the square root
    • Freeman M.F., Tukey J.W. Transformations related to the angular and the square root. Ann Math Stat 1950, 21:607-611.
    • (1950) Ann Math Stat , vol.21 , pp. 607-611
    • Freeman, M.F.1    Tukey, J.W.2
  • 21
    • 84952529285 scopus 로고
    • The inverse of the Freeman-Tukey double arcsine transformation
    • Miller J J. The inverse of the Freeman-Tukey double arcsine transformation. Am Stat 1978, 32:138.
    • (1978) Am Stat , vol.32 , pp. 138
    • Miller, J.J.1
  • 22
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • DerSimonian R., Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986, 7(3):177-188.
    • (1986) Control Clin Trials , vol.7 , Issue.3 , pp. 177-188
    • DerSimonian, R.1    Laird, N.2
  • 23
    • 34548531901 scopus 로고    scopus 로고
    • Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial
    • Suter T.M., Procter M., van Veldhuisen D.J., et al. Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial. J Clin Oncol 2007, 25(25):3859-3865.
    • (2007) J Clin Oncol , vol.25 , Issue.25 , pp. 3859-3865
    • Suter, T.M.1    Procter, M.2    van Veldhuisen, D.J.3
  • 24
    • 29744442709 scopus 로고    scopus 로고
    • Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node positive, human epidermal growth factor receptor 2- over expressing breast cancer: NSABP B-31
    • Tan-chiu E., Yothers G., Romond E., et al. Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node positive, human epidermal growth factor receptor 2- over expressing breast cancer: NSABP B-31. J Clin Oncol 2005, 23(31):7811-7819.
    • (2005) J Clin Oncol , vol.23 , Issue.31 , pp. 7811-7819
    • Tan-chiu, E.1    Yothers, G.2    Romond, E.3
  • 25
    • 41649083764 scopus 로고    scopus 로고
    • Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial
    • Perez E.A., Suman V.J., Davidson N.E., et al. Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol 2008, 26(8):1231-1238.
    • (2008) J Clin Oncol , vol.26 , Issue.8 , pp. 1231-1238
    • Perez, E.A.1    Suman, V.J.2    Davidson, N.E.3
  • 26
    • 84870531356 scopus 로고    scopus 로고
    • Surveillance Epidemiology and End Results Cancer Statistics Review. Accessed June 21, at
    • Surveillance Epidemiology and End Results Cancer Statistics Review. Accessed June 21, 2011, at http://seer.cancer.gov/csr/1975_2005/results_merged/sect_04_breast.pdf.
    • (2011)
  • 27
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group
    • Early Breast Cancer Trialists' Collaborative Group Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005, 365(9472):1687-1717.
    • (2005) Lancet , vol.365 , Issue.9472 , pp. 1687-1717
  • 28
    • 27244434470 scopus 로고    scopus 로고
    • Effect of screening and adjuvant therapy on mortality from breast cancer
    • Berry D.A., Cronin K.A., Plevritis S.K., et al. Effect of screening and adjuvant therapy on mortality from breast cancer. N Engl J Med 2005, 353(17):1784-1792.
    • (2005) N Engl J Med , vol.353 , Issue.17 , pp. 1784-1792
    • Berry, D.A.1    Cronin, K.A.2    Plevritis, S.K.3
  • 29
    • 0026639451 scopus 로고
    • Chemotherapy of metastatic breast cancer in the elderly: the Piedmont Oncology Association experience
    • Christman K., Muss H.B., Case L.D., Stanley V. Chemotherapy of metastatic breast cancer in the elderly: the Piedmont Oncology Association experience. JAMA 1992, 268(1):57-62.
    • (1992) JAMA , vol.268 , Issue.1 , pp. 57-62
    • Christman, K.1    Muss, H.B.2    Case, L.D.3    Stanley, V.4
  • 30
    • 0029996460 scopus 로고    scopus 로고
    • Doxorubicin based chemotherapy in elderly patients with metastatic breast cancer: tolerance and outcome
    • Ibrahim N.K., Frye D.K., Buzdar A.U., Walters R.S., Hortobagyi G.N. Doxorubicin based chemotherapy in elderly patients with metastatic breast cancer: tolerance and outcome. Arch Intern Med 1996, 156(8):882-888.
    • (1996) Arch Intern Med , vol.156 , Issue.8 , pp. 882-888
    • Ibrahim, N.K.1    Frye, D.K.2    Buzdar, A.U.3    Walters, R.S.4    Hortobagyi, G.N.5
  • 31
    • 34548484358 scopus 로고    scopus 로고
    • Toxicity of older and younger patients treated with adjuvant chemotherapy for node-positive breast cancer: the cancer and leukemia group B Experience
    • Muss H.B., Berry D.A., Cirrincione C., et al. Toxicity of older and younger patients treated with adjuvant chemotherapy for node-positive breast cancer: the cancer and leukemia group B Experience. J Clin Oncol 2007, 25(24):3699-3704.
    • (2007) J Clin Oncol , vol.25 , Issue.24 , pp. 3699-3704
    • Muss, H.B.1    Berry, D.A.2    Cirrincione, C.3
  • 32
    • 20044388527 scopus 로고    scopus 로고
    • Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer
    • Muss H.B., Woolf S., Berry D., et al. Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer. JAMA 2005, 293(9):1073-1081.
    • (2005) JAMA , vol.293 , Issue.9 , pp. 1073-1081
    • Muss, H.B.1    Woolf, S.2    Berry, D.3
  • 33
    • 0033619959 scopus 로고    scopus 로고
    • Underrepresentation of 65years of age or older in cancer-treatment trials
    • Hutchins L.F., Unger J.M., Crowley J.J., Coltman C.A., Albain K.S. Underrepresentation of 65years of age or older in cancer-treatment trials. N Engl J Med 1999, 341(27):2061-2067.
    • (1999) N Engl J Med , vol.341 , Issue.27 , pp. 2061-2067
    • Hutchins, L.F.1    Unger, J.M.2    Crowley, J.J.3    Coltman, C.A.4    Albain, K.S.5
  • 34
    • 0037306409 scopus 로고    scopus 로고
    • Treatment of operable breast cancer in the elderly: a randomised clinical trial EORTC 10850 comparing modified radical mastectomy with tumorectomy plus tamoxifen
    • Fentiman I.S., Van Zijl J., Karydas I., et al. Treatment of operable breast cancer in the elderly: a randomised clinical trial EORTC 10850 comparing modified radical mastectomy with tumorectomy plus tamoxifen. Eur J Cancer 2003, 39(3):300-308.
    • (2003) Eur J Cancer , vol.39 , Issue.3 , pp. 300-308
    • Fentiman, I.S.1    Van Zijl, J.2    Karydas, I.3
  • 35
    • 0037304997 scopus 로고    scopus 로고
    • Treatment of operable breast cancer in the elderly: a randomised clinical trial EORTC 10851 comparing tamoxifen alone with modified radical mastectomy
    • Fentiman I.S., Christiaens M.R., Paridaens R., et al. Treatment of operable breast cancer in the elderly: a randomised clinical trial EORTC 10851 comparing tamoxifen alone with modified radical mastectomy. Eur J Cancer 2003, 39(3):309-316.
    • (2003) Eur J Cancer , vol.39 , Issue.3 , pp. 309-316
    • Fentiman, I.S.1    Christiaens, M.R.2    Paridaens, R.3
  • 36
    • 0024536351 scopus 로고
    • Breast cancer in aging women. A population-based study of contrasts in stage, surgery, and survival
    • Yanick R., Ries L.G., Yates J.W. Breast cancer in aging women. A population-based study of contrasts in stage, surgery, and survival. Cancer 1989, 63(5):976-981.
    • (1989) Cancer , vol.63 , Issue.5 , pp. 976-981
    • Yanick, R.1    Ries, L.G.2    Yates, J.W.3
  • 37
    • 0036197284 scopus 로고    scopus 로고
    • Results of adjuvant treatments in breast cancer patients over 70 years old: the IBCSG experience. International Breast Cancer Study Group
    • Crivellari D. Results of adjuvant treatments in breast cancer patients over 70 years old: the IBCSG experience. International Breast Cancer Study Group. Tumori 2002, 88(1 Suppl 1):S81-2.
    • (2002) Tumori , vol.88 , Issue.1 SUPPL 1
    • Crivellari, D.1
  • 38
    • 67349248085 scopus 로고    scopus 로고
    • Cardiac toxicity with anti-HER-2 therapies - what have we learned so far?
    • de Azambuja E., Bedard P.L., Suter T., Piccart-Gebhart M. Cardiac toxicity with anti-HER-2 therapies - what have we learned so far?. Targ Oncol 2009, 4(2):77-88.
    • (2009) Targ Oncol , vol.4 , Issue.2 , pp. 77-88
    • de Azambuja, E.1    Bedard, P.L.2    Suter, T.3    Piccart-Gebhart, M.4
  • 39
    • 77955284228 scopus 로고    scopus 로고
    • Longer-terrm assessment of trastuzumab-related cardiac adverse events is the Herceptin Adjuvant (HERA) trial
    • Procter M., Suter T.M., de Azambumja E., et al. Longer-terrm assessment of trastuzumab-related cardiac adverse events is the Herceptin Adjuvant (HERA) trial. J Clin Oncol 2010, 28(20):3422-3428.
    • (2010) J Clin Oncol , vol.28 , Issue.20 , pp. 3422-3428
    • Procter, M.1    Suter, T.M.2    de Azambumja, E.3
  • 40
    • 80052704591 scopus 로고    scopus 로고
    • Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study
    • Hurria A., Togawa K., Supriya M.G., et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol 2011, 29:3457-3465.
    • (2011) J Clin Oncol , vol.29 , pp. 3457-3465
    • Hurria, A.1    Togawa, K.2    Supriya, M.G.3
  • 41
    • 84856789786 scopus 로고    scopus 로고
    • Trastuzumab-related cardiotoxicity in the elderly: a role for cardiovascular risk factors
    • Aug 9. [Epub ahead of print].
    • Serrano C, Cortés J, De Mattos-Arruda L, et al. Trastuzumab-related cardiotoxicity in the elderly: a role for cardiovascular risk factors. Ann Oncol 2011 Aug 9. [Epub ahead of print].
    • (2011) Ann Oncol
    • Serrano, C.1    Cortés, J.2    De Mattos-Arruda, L.3
  • 42
    • 34548533485 scopus 로고    scopus 로고
    • Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer
    • Pinder M.C., Duan Z., Goodwin J.S., et al. Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer. J Clin Oncol 2007, 25:3808-3815.
    • (2007) J Clin Oncol , vol.25 , pp. 3808-3815
    • Pinder, M.C.1    Duan, Z.2    Goodwin, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.