Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 12, 2012, Pages 1715-1721

  Araki, Nobutaka ^a   Tsuruoka, Shuichi ^a,b   Hasegawa, Gohki ^a   Yanagihara, Hayato ^a   Omasa, Takeshi ^c   Enosawa, Shin ^d   Yamazoe, Yasushi ^e   Fujimura, Akio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

Author keywords

cytochrome; drug interaction; furanocoumarin; grapefruit juice; NADPH cytochrome reductase

Indexed keywords

6',7' DIHYDROXYBERGAMOTTIN; CARBON MONOXIDE; CYTOCHROME P450 3A4; FUROCOUMARIN DERIVATIVE; KETOCONAZOLE; MESSENGER RNA; NIFEDIPINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG;

ABSORPTION; ARTICLE; BINDING ASSAY; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG OXIDATION; DRUG SCREENING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; GENE EXPRESSION; GRAPEFRUIT JUICE; HUMAN; HUMAN CELL; MICROSOME; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

CITRUS PARADISI; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FOOD-DRUG INTERACTIONS; HEP G2 CELLS; HUMANS; KETOCONAZOLE; MODELS, BIOLOGICAL; NADPH-FERRIHEMOPROTEIN REDUCTASE; NIFEDIPINE; PLANT EXTRACTS; PSORALENS; RNA, MESSENGER;

EID: 84869091998     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2012.01562.x     Document Type: Article

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