Increase in interleukin-8 production from circulating neutrophils upon antibiotic therapy in cystic fibrosis patients

Journal of Cystic Fibrosis

Volumn 11, Issue 6, 2012, Pages 518-524

  Montemurro, Pasqualina ^a   Mariggiò, Maria A ^a   Barbuti, Giovanna ^a   Cassano, Amalia ^a   Vincenti, Alessandra ^a   Serio, Gabriella ^a   Guerra, Lorenzo ^a   Diana, Anna ^a   Santostasi, Teresa ^a   Polizzi, Angela ^a   Fumarulo, Ruggiero ^a   Casavola, Valeria ^a   Manca, Antonio ^a   Conese, Massimo ^b  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF FOGGIA   (Italy)

Author keywords

Antibiotics; Apoptosis; Blood neutrophils; Cytokines; Reactive oxygen species

Indexed keywords

AMIKACIN; AZITHROMYCIN; CEFTAZIDIME; CIPROFLOXACIN; COTRIMOXAZOLE; CYTOKINE; INTERLEUKIN 8; ITRACONAZOLE; LEVOFLOXACIN; MEROPENEM; MINOCYCLINE; REACTIVE OXYGEN METABOLITE; TOBRAMYCIN; VORICONAZOLE;

ADOLESCENT; ADULT; ANTIBIOTIC THERAPY; APOPTOSIS; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOFLUOROMETRY; CYTOKINE RELEASE; DISEASE EXACERBATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; LUNG FIBROSIS; MALE; MYCOSIS; NEUTROPHIL; SCHOOL CHILD; SPECTROPHOTOMETRY;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; APOPTOSIS; BIOLOGICAL MARKERS; CHILD; CYSTIC FIBROSIS; DRUG MONITORING; FEMALE; HUMANS; INTERLEUKIN-8; MALE; NEUTROPHILS; PILOT PROJECTS; PNEUMONIA, BACTERIAL; PULMONARY ASPERGILLOSIS; REACTIVE OXYGEN SPECIES; YOUNG ADULT;

EID: 84869085676     PISSN: 15691993     EISSN: 18735010     Source Type: Journal    
DOI: 10.1016/j.jcf.2012.04.010     Document Type: Article

References (39)

1. Davis P.B., Drumm M., Konstan M.W. Cystic fibrosis. Am J Respir Crit Care Med 1996, 154:1229-1256.
2. Boucher R.C. Evidence for airway surface dehydration as the initiating event in CF airway disease. J Intern Med 2007, 261:5-16.
3. Watt A.P., Courtney J., Moore J., Ennis M., Elborn J.S. Neutrophil cell death, activation and bacterial infection in cystic fibrosis. Thorax 2005, 60:659-664.
4. Vandivier R.W., Fadok V.A., Hoffmann P.R., Bratton D.L., Penvari C., Brown K.K., et al. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest 2002, 109:661-670.
5. Vandivier R.W., Richens T.R., Horstmann S.A., deCathelineau A.M., Ghosh M., Reynolds S.D., et al. Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol 2009, 297:L677-L686.
6. Tabary O., Corvol H., Boncoeur E., Chadelat K., Fitting C., Cavaillon J.M., et al. Adherence of airway neutrophils and inflammatory response are increased in CF airway epithelial cell-neutrophil interactions. Am J Physiol Lung Cell Mol Physiol 2006, 290:L588-L596.
7. Quinn D.J., Weldon S., Taggart C.C. Antiproteases as therapeutics to target inflammation in cystic fibrosis. Open Respir Med J 2010, 4:20-31.
8. Hartl D., Latzin P., Hordijk P., Marcos V., Rudolph C., Woischnik M., et al. Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Nat Med 2007, 13:1423-1430.
9. Bianchi S.M., Prince L.R., McPhillips K., Allen L., Marriott H.M., Taylor G.W., et al. Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa. Am J Respir Crit Care Med 2008, 177:35-43.
10. Hayes E., Pohl K., McElvaney N.G., Reeves E.P. The cystic fibrosis neutrophil: a specialized yet potentially defective cell. Arch Immunol Ther Exp (Warsz) 2011, 59:97-112.
11. Taggart C., Coakley R.J., Greally P., Canny G., O'Neill S.J., McElvaney N.G. Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8. Am J Physiol Lung Cell Mol Physiol 2000, 278:L33-L41.
12. Koller D.Y., Urbanek R., Gotz M. Increased degranulation of eosinophil and neutrophil granulocytes in cystic fibrosis. Am J Respir Crit Care Med 1995, 152:629-633.
13. Corvol H., Fitting C., Chadelat K., Jacquot J., Tabary O., Boule M., et al. Distinct cytokine production by lung and blood neutrophils from children with cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 2003, 284:L997-L1003.
14. Saak A., Schonfeld W., Knoller J., Steinkamp G., von der Hardt H., Konig W. Generation and metabolism of leukotrienes in granulocytes of patients with cystic fibrosis. Int Arch Allergy Appl Immunol 1990, 93:227-236.
15. Witko-Sarsat V., Allen R.C., Paulais M., Nguyen A.T., Bessou G., Lenoir G., et al. Disturbed myeloperoxidase-dependent activity of neutrophils in cystic fibrosis homozygotes and heterozygotes, and its correction by amiloride. J Immunol 1996, 157:2728-2735.
16. Fruhwirth M., Ruedl C., Ellemunter H., Bock G., Wolf H. Flow-cytometric evaluation of oxidative burst in phagocytic cells of children with cystic fibrosis. Int Arch Allergy Immunol 1998, 117:270-275.
17. Witko-Sarsat V., Halbwachs-Mecarelli L., Sermet-Gaudelus I., Bessou G., Lenoir G., Allen R.C., et al. Priming of blood neutrophils in children with cystic fibrosis: correlation between functional and phenotypic expression of opsonin receptors before and after platelet-activating factor priming. J Infect Dis 1999, 179:151-162.
18. Russell K.J., McRedmond J., Mukherji N., Costello C., Keatings V., Linnane S., et al. Neutrophil adhesion molecule surface expression and responsiveness in cystic fibrosis. Am J Respir Crit Care Med 1998, 157:756-761.
19. McKeon D.J., Condliffe A.M., Cowburn A.S., Cadwallader K.C., Farahi N., Bilton D., et al. Prolonged survival of neutrophils from patients with Delta F508 CFTR mutations. Thorax 2008, 63:660-661.
20. Moriceau S., Lenoir G., Witko-Sarsat V. In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: evidence for an innate neutrophil disturbance. J Innate Immun 2010, 2:260-266.
21. Moriceau S., Kantari C., Mocek J., Davezac N., Gabillet J., Guerrera I.C., et al. Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients. J Immunol 2009, 182:7254-7263.
22. Rosenfeld M., Emerson J., Williams-Warren J., Pepe M., Smith A., Montgomery A.B., et al. Defining a pulmonary exacerbation in cystic fibrosis. J Pediatr 2001, 139:359-365.
23. Doring G., Conway S.P., Heijerman H.G., Hodson M.E., Hoiby N., Smyth A., et al. Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus. Eur Respir J 2000, 16:749-767.
24. Boyum A. Isolation of lymphocytes, granulocytes and macrophages. Scand J Immunol 1976, (Suppl. 5):9-15.
25. Terada L.S., Johansen K.A., Nowbar S., Vasil A.I., Vasil M.L. Pseudomonas aeruginosa hemolytic phospholipase C suppresses neutrophil respiratory burst activity. Infect Immun 1999, 67:2371-2376.
26. Haslett C., Guthrie L.A., Kopaniak M.M., Johnston R.B., Henson P.M. Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide. Am J Pathol 1985, 119:101-110.
27. Vaisman N., Kerasin E., Hahn T., Trifon S., Voet H., Tabachnik E. Increased neutrophil chemiluminescence production in patients with cystic fibrosis. Metabolism 1994, 43:719-722.
28. McKeon D.J., Cadwallader K.A., Idris S., Cowburn A.S., Pasteur M.C., Barker H., et al. Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation. Eur Respir J 2010, 35:1264-1272.
29. Brockbank S., Downey D., Elborn J.S., Ennis M. Effect of cystic fibrosis exacerbations on neutrophil function. Int Immunopharmacol 2005, 5:601-608.
30. Becerra M.C., Eraso A.J., Albesa I. Comparison of oxidative stress induced by ciprofloxacin and pyoverdin in bacteria and in leukocytes to evaluate toxicity. Luminescence 2003, 18:334-340.
31. Reato G., Cuffini A.M., Tullio V., Mandras N., Roana J., Banche G., et al. Immunomodulating effect of antimicrobial agents on cytokine production by human polymorphonuclear neutrophils. Int J Antimicrob Agents 2004, 23:150-154.
32. Koch C.C., Esteban D.J., Chin A.C., Olson M.E., Read R.R., Ceri H., et al. Apoptosis, oxidative metabolism and interleukin-8 production in human neutrophils exposed to azithromycin: effects of Streptococcus pneumoniae. J Antimicrob Chemother 2000, 46:19-26.
33. Jensen P.O., Moser C., Kharazmi A., Presler T., Koch C., Hoiby N. Increased serum concentration of G-CSF in cystic fibrosis patients with chronic Pseudomonas aeruginosa pneumonia. J Cyst Fibros 2006, 5:145-151.
34. Laterveer L., Lindley I.J., Heemskerk D.P., Camps J.A., Pauwels E.K., Willemze R., et al. Rapid mobilization of hematopoietic progenitor cells in rhesus monkeys by a single intravenous injection of interleukin-8. Blood 1996, 87:781-788.
35. Broxmeyer H.E., Sherry B., Cooper S., Lu L., Maze R., Beckmann M.P., et al. Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. Interacting effects involving suppression, synergistic suppression, and blocking of suppression. J Immunol 1993, 150:3448-3458.
36. Cacalano G., Lee J., Kikly K., Ryan A.M., Pitts-Meek S., Hultgren B., et al. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science 1994, 265:682-684.
37. Usher L.R., Lawson R.A., Geary I., Taylor C.J., Bingle C.D., Taylor G.W., et al. Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection. J Immunol 2002, 168:1861-1868.
38. Hachiya O., Takeda Y., Miyata H., Watanabe H., Yamashita T., Sendo F. Inhibition by bacterial lipopolysaccharide of spontaneous and TNF-alpha-induced human neutrophil apoptosis in vitro. Microbiol Immunol 1995, 39:715-723.
39. Healy D.P., Silverman P.A., Neely A.N., Holder I.A., Babcock G.E. Effect of antibiotics on polymorphonuclear neutrophil apoptosis. Pharmacotherapy 2002, 22:578-585.