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Volumn 168, Issue 11, 2012, Pages 809-814

When does Parkinson's disease begin? from prodromal disease to motor signs

Author keywords

Braak staging; Non motor signs; Premotor disease

Indexed keywords

DOPAMINE; NEUROPROTECTIVE AGENT;

EID: 84869085667     PISSN: 00353787     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurol.2012.07.004     Document Type: Review
Times cited : (40)

References (54)
  • 3
    • 79960210306 scopus 로고    scopus 로고
    • Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson's disease
    • S. Bardien, S. Lesage, A. Brice, and J. Carr Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson's disease Parkinsonism Relat Disord 17 2011 501 508
    • (2011) Parkinsonism Relat Disord , vol.17 , pp. 501-508
    • Bardien, S.1    Lesage, S.2    Brice, A.3    Carr, J.4
  • 4
    • 0034961813 scopus 로고    scopus 로고
    • Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell
    • H.W. Berendse, J. Booij, C.M. Francot, P.L. Bergmans, R. Hijman, and J.C. Stoof Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell Ann Neurol 50 2001 34 41
    • (2001) Ann Neurol , vol.50 , pp. 34-41
    • Berendse, H.W.1    Booij, J.2    Francot, C.M.3    Bergmans, P.L.4    Hijman, R.5    Stoof, J.C.6
  • 5
    • 33646082266 scopus 로고    scopus 로고
    • Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
    • A. Bloch, A. Probst, H. Bissig, H. Adams, and M. Tolnay Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects Neuropathol Appl Neurobiol 32 2006 284 295
    • (2006) Neuropathol Appl Neurobiol , vol.32 , pp. 284-295
    • Bloch, A.1    Probst, A.2    Bissig, H.3    Adams, H.4    Tolnay, M.5
  • 6
    • 54249119573 scopus 로고    scopus 로고
    • Selective hyposmia in Parkinson disease: Association with hippocampal dopamine activity
    • N.I. Bohnen, S. Gedela, P. Herath, G.M. Constantine, and R.Y. Moore Selective hyposmia in Parkinson disease: association with hippocampal dopamine activity Neurosci Lett 447 2008 12 16
    • (2008) Neurosci Lett , vol.447 , pp. 12-16
    • Bohnen, N.I.1    Gedela, S.2    Herath, P.3    Constantine, G.M.4    Moore, R.Y.5
  • 8
    • 77952998970 scopus 로고    scopus 로고
    • Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson's disease
    • N.I. Bohnen, M.L. Muller, V. Kotagal, R.A. Koeppe, M.A. Kilbourn, and R.L. Albin Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson's disease Brain 133 2010 1747 1754
    • (2010) Brain , vol.133 , pp. 1747-1754
    • Bohnen, N.I.1    Muller, M.L.2    Kotagal, V.3    Koeppe, R.A.4    Kilbourn, M.A.5    Albin, R.L.6
  • 9
    • 32544442518 scopus 로고    scopus 로고
    • Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    • H. Braak, R.A. de Vos, J. Bohl, and K. Del Tredici Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology Neurosci Lett 396 2006 67 72
    • (2006) Neurosci Lett , vol.396 , pp. 67-72
    • Braak, H.1    De Vos, R.A.2    Bohl, J.3    Del Tredici, K.4
  • 11
    • 0033595339 scopus 로고    scopus 로고
    • Cardiac uptake of [123I]MIBG separates Parkinson's disease from multiple system atrophy
    • S. Braune, M. Reinhardt, R. Schnitzer, A. Riedel, and C.H. Lucking Cardiac uptake of [123I]MIBG separates Parkinson's disease from multiple system atrophy Neurology 53 1999 1020 1025
    • (1999) Neurology , vol.53 , pp. 1020-1025
    • Braune, S.1    Reinhardt, M.2    Schnitzer, R.3    Riedel, A.4    Lucking, C.H.5
  • 12
    • 32544432029 scopus 로고    scopus 로고
    • Non-motor symptoms of Parkinson's disease: Diagnosis and management
    • K.R. Chaudhuri, D.G. Healy, and A.H. Schapira Non-motor symptoms of Parkinson's disease: diagnosis and management Lancet Neurol 5 2006 235 245
    • (2006) Lancet Neurol , vol.5 , pp. 235-245
    • Chaudhuri, K.R.1    Healy, D.G.2    Schapira, A.H.3
  • 13
    • 0034659901 scopus 로고    scopus 로고
    • Sleep-related injury in the elderly - An epidemiological study in Hong Kong
    • H.F. Chiu, Y.K. Wing, L.C. Lam, S.W. Li, C.M. Lum, and T. Leung Sleep-related injury in the elderly - an epidemiological study in Hong Kong Sleep 23 2000 513 517
    • (2000) Sleep , vol.23 , pp. 513-517
    • Chiu, H.F.1    Wing, Y.K.2    Lam, L.C.3    Li, S.W.4    Lum, C.M.5    Leung, T.6
  • 15
    • 38949140221 scopus 로고    scopus 로고
    • Olfaction in Parkinson's disease
    • R.L. Doty Olfaction in Parkinson's disease Parkinsonism Relat Disord 13 Suppl. 3 2007 S225 S228
    • (2007) Parkinsonism Relat Disord , vol.13 , Issue.SUPPL. 3
    • Doty, R.L.1
  • 16
    • 0023765129 scopus 로고
    • Olfactory dysfunction in parkinsonism: A general deficit unrelated to neurologic signs, disease stage, or disease duration
    • R.L. Doty, D.A. Deems, and S. Stellar Olfactory dysfunction in parkinsonism: a general deficit unrelated to neurologic signs, disease stage, or disease duration Neurology 38 1988 1237 1244
    • (1988) Neurology , vol.38 , pp. 1237-1244
    • Doty, R.L.1    Deems, D.A.2    Stellar, S.3
  • 17
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: Substantia nigra regional selectivity
    • J.M. Fearnley, and A.J. Lees Ageing and Parkinson's disease: substantia nigra regional selectivity Brain 114 1991 2283 2301
    • (1991) Brain , vol.114 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 18
    • 79955018192 scopus 로고    scopus 로고
    • The patients' perception of prodromal symptoms before the initial diagnosis of Parkinson's disease
    • A. Gaenslen, I. Swid, I. Liepelt-Scarfone, J. Godau, and D. Berg The patients' perception of prodromal symptoms before the initial diagnosis of Parkinson's disease Mov Disord 26 2011 653 658
    • (2011) Mov Disord , vol.26 , pp. 653-658
    • Gaenslen, A.1    Swid, I.2    Liepelt-Scarfone, I.3    Godau, J.4    Berg, D.5
  • 19
    • 33646025535 scopus 로고    scopus 로고
    • Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases
    • J.F. Gagnon, R.B. Postuma, S. Mazza, J. Doyon, and J. Montplaisir Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases Lancet Neurol 5 2006 424 432
    • (2006) Lancet Neurol , vol.5 , pp. 424-432
    • Gagnon, J.F.1    Postuma, R.B.2    Mazza, S.3    Doyon, J.4    Montplaisir, J.5
  • 20
    • 79957617156 scopus 로고    scopus 로고
    • Milestones in PD genetics
    • T. Gasser, J. Hardy, and Y. Mizuno Milestones in PD genetics Mov Disord 26 2011 1042 1048
    • (2011) Mov Disord , vol.26 , pp. 1042-1048
    • Gasser, T.1    Hardy, J.2    Mizuno, Y.3
  • 22
    • 50049104725 scopus 로고    scopus 로고
    • Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: A case-control study
    • D.G. Healy, M. Falchi, S.S. O'Sullivan, V. Bonifati, A. Durr, and S. Bressman Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study Lancet Neurol 7 2008 583 590
    • (2008) Lancet Neurol , vol.7 , pp. 583-590
    • Healy, D.G.1    Falchi, M.2    O'Sullivan, S.S.3    Bonifati, V.4    Durr, A.5    Bressman, S.6
  • 23
    • 14944354884 scopus 로고    scopus 로고
    • Sydney Multicenter Study of Parkinson's disease: Non-L-dopa-responsive problems dominate at 15 years
    • M.A. Hely, J.G. Morris, W.G. Reid, and R. Trafficante Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years Mov Disord 20 2005 190 199
    • (2005) Mov Disord , vol.20 , pp. 190-199
    • Hely, M.A.1    Morris, J.G.2    Reid, W.G.3    Trafficante, R.4
  • 24
    • 41149173996 scopus 로고    scopus 로고
    • The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years
    • M.A. Hely, W.G. Reid, M.A. Adena, G.M. Halliday, and J.G. Morris The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years Mov Disord 23 2008 837 844
    • (2008) Mov Disord , vol.23 , pp. 837-844
    • Hely, M.A.1    Reid, W.G.2    Adena, M.A.3    Halliday, G.M.4    Morris, J.G.5
  • 25
    • 0031682676 scopus 로고    scopus 로고
    • Biochemical aspects of Parkinson's disease
    • O. Hornykiewicz Biochemical aspects of Parkinson's disease Neurology 51 1998 S2 S9
    • (1998) Neurology , vol.51
    • Hornykiewicz, O.1
  • 26
    • 0026514953 scopus 로고
    • Accuracy of clinical diagnosis of idiopathic Parkinson's disease: A clinico-pathological study of 100 cases
    • A.J. Hughes, S.E. Daniel, L. Kilford, and A.J. Lees Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases J Neurol Neurosurg Psychiatry 55 1992 181 184
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 181-184
    • Hughes, A.J.1    Daniel, S.E.2    Kilford, L.3    Lees, A.J.4
  • 27
    • 48849092336 scopus 로고    scopus 로고
    • LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: A case-control genetic study
    • M.M. Hulihan, L. Ishihara-Paul, J. Kachergus, L. Warren, R. Amouri, and R. Elango LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study Lancet Neurol 7 2008 591 594
    • (2008) Lancet Neurol , vol.7 , pp. 591-594
    • Hulihan, M.M.1    Ishihara-Paul, L.2    Kachergus, J.3    Warren, L.4    Amouri, R.5    Elango, R.6
  • 28
    • 77957970097 scopus 로고    scopus 로고
    • Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: A prospective study [corrected]
    • A. Iranzo, F. Lomena, H. Stockner, F. Valldeoriola, I. Vilaseca, and M. Salamero Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected] Lancet Neurol 9 2010 1070 1077
    • (2010) Lancet Neurol , vol.9 , pp. 1070-1077
    • Iranzo, A.1    Lomena, F.2    Stockner, H.3    Valldeoriola, F.4    Vilaseca, I.5    Salamero, M.6
  • 29
    • 33744991945 scopus 로고    scopus 로고
    • Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: A descriptive study
    • A. Iranzo, J.L. Molinuevo, J. Santamaria, M. Serradell, M.J. Marti, and F. Valldeoriola Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study Lancet Neurol 5 2006 572 577
    • (2006) Lancet Neurol , vol.5 , pp. 572-577
    • Iranzo, A.1    Molinuevo, J.L.2    Santamaria, J.3    Serradell, M.4    Marti, M.J.5    Valldeoriola, F.6
  • 30
    • 77958558412 scopus 로고    scopus 로고
    • Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms
    • T. Lebouvier, M. Neunlist, S. Bruley des Varannes, E. Coron, A. Drouard, and J.M. N'Guyen Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms PLoS One 5 2010 e12728
    • (2010) PLoS One , vol.5 , pp. 12728
    • Lebouvier, T.1    Neunlist, M.2    Bruley Des Varannes, S.3    Coron, E.4    Drouard, A.5    N'Guyen, J.M.6
  • 31
    • 27644455523 scopus 로고    scopus 로고
    • G2019S LRRK2 mutation in French and North African families with Parkinson's disease
    • S. Lesage, P. Ibanez, E. Lohmann, P. Pollak, F. Tison, and M. Tazir G2019S LRRK2 mutation in French and North African families with Parkinson's disease Ann Neurol 58 2005 784 787
    • (2005) Ann Neurol , vol.58 , pp. 784-787
    • Lesage, S.1    Ibanez, P.2    Lohmann, E.3    Pollak, P.4    Tison, F.5    Tazir, M.6
  • 32
    • 60549085946 scopus 로고    scopus 로고
    • Overview of the extranigral aspects of Parkinson disease
    • S.Y. Lim, S.H. Fox, and A.E. Lang Overview of the extranigral aspects of Parkinson disease Arch Neurol 66 2009 167 172
    • (2009) Arch Neurol , vol.66 , pp. 167-172
    • Lim, S.Y.1    Fox, S.H.2    Lang, A.E.3
  • 33
    • 0035846468 scopus 로고    scopus 로고
    • [123I]beta-CIT SPECT imaging assessment of the rate of Parkinson's disease progression
    • K. Marek, R. Innis, C. van Dyck, B. Fussell, M. Early, and S. Eberly [123I]beta-CIT SPECT imaging assessment of the rate of Parkinson's disease progression Neurology 57 2001 2089 2094
    • (2001) Neurology , vol.57 , pp. 2089-2094
    • Marek, K.1    Innis, R.2    Van Dyck, C.3    Fussell, B.4    Early, M.5    Eberly, S.6
  • 36
    • 33845920467 scopus 로고    scopus 로고
    • Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder
    • T. Miyamoto, M. Miyamoto, Y. Inoue, Y. Usui, K. Suzuki, and K. Hirata Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder Neurology 67 2006 2236 2238
    • (2006) Neurology , vol.67 , pp. 2236-2238
    • Miyamoto, T.1    Miyamoto, M.2    Inoue, Y.3    Usui, Y.4    Suzuki, K.5    Hirata, K.6
  • 37
    • 0344096591 scopus 로고    scopus 로고
    • Abnormal performance on the PD test battery by asymptomatic first-degree relatives
    • E.B. Montgomery Jr., K.B. Baker, K. Lyons, and W.C. Koller Abnormal performance on the PD test battery by asymptomatic first-degree relatives Neurology 52 1999 757 762
    • (1999) Neurology , vol.52 , pp. 757-762
    • Montgomery, Jr.E.B.1    Baker, K.B.2    Lyons, K.3    Koller, W.C.4
  • 38
    • 0031898680 scopus 로고    scopus 로고
    • Measuring the rate of progression and estimating the preclinical period of Parkinson's disease with [18F]dopa PET
    • P.K. Morrish, J.S. Rakshi, D.L. Bailey, G.V. Sawle, and D.J. Brooks Measuring the rate of progression and estimating the preclinical period of Parkinson's disease with [18F]dopa PET J Neurol Neurosurg Psychiatry 64 1998 314 319
    • (1998) J Neurol Neurosurg Psychiatry , vol.64 , pp. 314-319
    • Morrish, P.K.1    Rakshi, J.S.2    Bailey, D.L.3    Sawle, G.V.4    Brooks, D.J.5
  • 40
    • 58149242840 scopus 로고    scopus 로고
    • Progression of dopaminergic dysfunction in a LRRK2 kindred: A multitracer PET study
    • R. Nandhagopal, E. Mak, M. Schulzer, J. McKenzie, S. McCormick, and V. Sossi Progression of dopaminergic dysfunction in a LRRK2 kindred: a multitracer PET study Neurology 71 2008 1790 1795
    • (2008) Neurology , vol.71 , pp. 1790-1795
    • Nandhagopal, R.1    Mak, E.2    Schulzer, M.3    McKenzie, J.4    McCormick, S.5    Sossi, V.6
  • 42
  • 44
    • 77950601138 scopus 로고    scopus 로고
    • Olfactory testing combined with dopamine transporter imaging as a method to detect prodromal Parkinson's disease
    • M.M. Ponsen, D. Stoffers, E. Wolters, J. Booij, and H.W. Berendse Olfactory testing combined with dopamine transporter imaging as a method to detect prodromal Parkinson's disease J Neurol Neurosurg Psychiatry 81 2010 396 399
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , pp. 396-399
    • Ponsen, M.M.1    Stoffers, D.2    Wolters, E.3    Booij, J.4    Berendse, H.W.5
  • 45
    • 33645836498 scopus 로고    scopus 로고
    • Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder
    • R.B. Postuma, A.E. Lang, J. Massicotte-Marquez, and J. Montplaisir Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder Neurology 66 2006 845 851
    • (2006) Neurology , vol.66 , pp. 845-851
    • Postuma, R.B.1    Lang, A.E.2    Massicotte-Marquez, J.3    Montplaisir, J.4
  • 46
  • 47
    • 0029878953 scopus 로고    scopus 로고
    • Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder
    • C.H. Schenck, S.R. Bundlie, and M.W. Mahowald Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder Neurology 46 1996 388 393
    • (1996) Neurology , vol.46 , pp. 388-393
    • Schenck, C.H.1    Bundlie, S.R.2    Mahowald, M.W.3
  • 48
    • 0345121261 scopus 로고    scopus 로고
    • REM behavior disorder (RBD): Delayed emergence of parkinsonism and/or dementia in 65% of older men initially diagnosed with idiopathic RBD, and an analysis of the minimum & maximum tonic and/or phasic electromyographic abnormalities found during REM sleep
    • C.H. Schenck, S.R. Bundlie, and M.W. Mahowald REM behavior disorder (RBD): delayed emergence of parkinsonism and/or dementia in 65% of older men initially diagnosed with idiopathic RBD, and an analysis of the minimum & maximum tonic and/or phasic electromyographic abnormalities found during REM sleep Sleep 26 2003 A316
    • (2003) Sleep , vol.26 , pp. 316
    • Schenck, C.H.1    Bundlie, S.R.2    Mahowald, M.W.3
  • 49
    • 77953390617 scopus 로고    scopus 로고
    • Parkinson's at risk syndrome: Can Parkinson's disease be predicted?
    • M.B. Stern, and A. Siderowf Parkinson's at risk syndrome: can Parkinson's disease be predicted? Mov Disord 25 Suppl. 1 2010 S89 S93
    • (2010) Mov Disord , vol.25 , Issue.SUPPL. 1
    • Stern, M.B.1    Siderowf, A.2
  • 50
    • 11244260421 scopus 로고    scopus 로고
    • Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT
    • K. Stiasny-Kolster, Y. Doerr, J.C. Moller, H. Hoffken, T.M. Behr, and W.H. Oertel Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT Brain 128 2005 126 137
    • (2005) Brain , vol.128 , pp. 126-137
    • Stiasny-Kolster, K.1    Doerr, Y.2    Moller, J.C.3    Hoffken, H.4    Behr, T.M.5    Oertel, W.H.6
  • 51
    • 60049092646 scopus 로고    scopus 로고
    • The association between smoking and smell and taste impairment in the general population
    • M.M. Vennemann, T. Hummel, and K. Berger The association between smoking and smell and taste impairment in the general population J Neurol 255 2008 1121 1126
    • (2008) J Neurol , vol.255 , pp. 1121-1126
    • Vennemann, M.M.1    Hummel, T.2    Berger, K.3
  • 54
    • 8844233579 scopus 로고    scopus 로고
    • Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
    • A. Zimprich, S. Biskup, P. Leitner, P. Lichtner, M. Farrer, and S. Lincoln Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology Neuron 44 2004 601 607
    • (2004) Neuron , vol.44 , pp. 601-607
    • Zimprich, A.1    Biskup, S.2    Leitner, P.3    Lichtner, P.4    Farrer, M.5    Lincoln, S.6


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