The plasma leptin/adiponectin ratio predicts first cardiovascular event in men: A prospective nested case-control study

European Journal of Internal Medicine

Volumn 23, Issue 8, 2012, Pages 755-759

  Kappelle, Paul J W H ^a   Dullaart, Robin P F ^a   Van Beek, André P ^a   Hillege, Hans L ^a   Wolffenbuttel, Bruce H R ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Adiponectin; Cardiovascular disease; Leptin; Leptin adiponectin ratio; Total cholesterol HDL cholesterol ratio

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; TRIACYLGLYCEROL;

ADULT; AGED; CARDIOVASCULAR RISK; CASE CONTROL STUDY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; HAZARD RATIO; HUMAN; HYPERTENSION; INSULIN SENSITIVITY; MALE; MICROALBUMINURIA; PROSPECTIVE STUDY; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; REVIEW; SMOKING; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

EID: 84869082500     PISSN: 09536205     EISSN: 18790828     Source Type: Journal    
DOI: 10.1016/j.ejim.2012.06.013     Document Type: Article

References (33)

1. Y. Matsusawa, T. Funahashi, and I. Shimomura Adiponectin and metabolic syndrome Arterioscler Thromb Vasc Biol 24 2004 29 33 (Pubitemid 38082408)
2. Y.H. Yu, and H.N. Ginsberg Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue Circ Res 96 2005 1042 1052 (Pubitemid 40791376)
3. J. Beltowski Leptin and atherosclerosis Atherosclerosis 189 2006 47 60 (Pubitemid 44441296)
4. T. Ronti, G. Lupattelli, and E. Mannarino The endocrine function of adipose tissue: an update Clin Endocrinol (Oxf) 64 2006 355 365
5. G.M. Dallinga-Thie, and R.P.F. Dullaart Do genome-wide association scans provide additional information on the variation of plasma adiponectin concentrations? Atherosclerosis 208 2010 328 329
6. N. Sattar, G. Wannamethee, N. Sarwar, J. Chernova, D.A. Lawlor, and A. Kelly Leptin and coronary heart disease: prospective study and systematic review J Am Coll Cardiol 53 2009 167 175
7. N. Sattar, G. Wannamethee, N. Sarwar, J. Tchernova, L. Cherry, and A.M. Wallace Adiponectin and coronary heart disease: a prospective study and meta-analysis Circulation 114 2006 623 629 (Pubitemid 44252303)
8. I.A. Ku, R. Farzaneh-Far, E. Vittinghoff, M.H. Zhang, B. Na, and M.A. Whooley Association of low leptin with cardiovascular events and mortality in patients with stable coronary artery disease: The Heart and Soul Study Atherosclerosis 217 2011 503 508
9. J.M. Dekker, T. Funahashi, G. Nijpels, S. Pilz, C.D. Stehouwer, and M.B. Snijder Prognostic value of adiponectin for cardiovascular disease and mortality J Clin Endocrinol Metab 93 2008 1489 1496 (Pubitemid 351519753)
10. Satoh N., M. Naruse, T. Usui, T. Tagami, T. Suganami, and K. Yamada Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients Diabetes Care 27 2004 2488 2490 (Pubitemid 39281406)
11. K. Kotani, N. Sakane, K. Saiga, and Y. Kurozawa Leptin:adiponectin ratio as an atherosclerotic index in patients with type 2 diabetes: relationship of the index to carotid intima-media thickness Diabetologia 48 2005 2684 2686 (Pubitemid 41738239)
12. G.D. Norata, S. Raselli, L. Grigore, K. Garlaschelli, E. Dozio, and P. Magni Leptin:adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery Stroke 38 2007 2844 2846 (Pubitemid 47494027)
13. N. Takamura, N. Hayashida, K. Hagane, K. Kadota, H. Yamasaki, and N. Abiru Leptin to high-molecular-weight adiponectin ratio is independently correlated with carotid intima-media thickness in men, but not in women Biomarkers 15 2010 340 344
14. R.P.F. Dullaart, P.J. Kappelle, and G.M. Dallinga-Thie Carotid intima media thickness is associated with plasma adiponectin but not with the leptin:adiponectin ratio independently of metabolic syndrome Atherosclerosis 211 2010 393 396
15. S. Bevan, K. Meidtner, M. Lorenz, M. Sitzer, P.J. Grant, and H.S. Markus Adiponectin level as a consequence of genetic variation, but not leptin level or leptin:adiponectin ratio, is a risk factor for carotid intima-media thickness Stroke 42 2011 1510 1514
16. M. Karakas, A. Zierer, C. Herder, J. Baumert, C. Meisinger, and W. Koenig Leptin, adiponectin, their ratio and risk of coronary heart disease: results from the MONICA/KORA Augsburg Study 1984-2002 Atherosclerosis 209 2010 220 225
17. G.K. Shetty, P.A. Economides, E.S. Horton, C.S. Mantzoros, and A. Veves Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes Diabetes Care 27 2004 2450 2457 (Pubitemid 39281400)
18. A. Ble, B.G. Windham, S. Bandinelli, D.D. Taub, S. Volpato, and B. Bartali Relation of plasma leptin to C-reactive protein in older adults (from the Invecchiare nel Chianti study) Am J Cardiol 96 2005 991 995 (Pubitemid 41362526)
19. R.P.F. Dullaart, R. de Vries, W.J. Sluiter, and H.A. Voorbij High plasma C-reactive protein (CRP) is related to low paraoxonase-I (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus Clin Endocrinol (Oxf) 70 2009 221 226
20. F.M. Finucane, J. Luan, N.J. Wareham, S.J. Sharp, S. O'Rahilly, and B. Balkau Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals Diabetologia 52 2009 2345 2349
21. S.E. Borggreve, H.L. Hillege, G.M. Dallinga-Thie, P.E. de Jong, B.H.R. Wolffenbuttel, and D.E. Grobbee High plasma cholesteryl ester transfer protein levels may favour reduced incidence of cardiovascular events in men with low triglycerides Eur Heart J 28 2007 1012 1018 (Pubitemid 47343914)
22. O.S. Miettinen Design of sampling from the base O.S.M. Miettinen, Theoretical epidemiology 1985 John Wiley & Sons New York 69 83
23. P.J.W.H. Kappelle, R.T. Gansevoort, J.L. Hillege, B.H.R. Wolffenbuttel, and R.P.F. Dullaart Apolipoprotein B/A-I and total cholesterol/high-density lipoprotein cholesterol ratios both predict cardiovascular events in the general population independently of nonlipid risk factors, albuminuria and C-reactive protein J Intern Med 269 2011 232 242
24. R.P.F. Dullaart, R. de Vries, A. van Tol, and W.J. Sluiter Lower plasma adiponectin is a marker of increased intima-media thickness associated with type 2 diabetes mellitus and with male gender Eur J Endocrinol 156 2007 387 394 (Pubitemid 46554507)
25. H.J. Lambers Heerspink, A.H. Brantsma, D. de Zeeuw, S.J. Bakker, P.E. de Jong, and R.T. Gansevoort Albuminuria assessed from first-morning-void urine samples versus 24-hour urine collections as a predictor of cardiovascular morbidity and mortality Am J Epidemiol 168 2008 897 905
26. W. Rathmann, and C. Herder Adiponectin and cardiovascular mortality: evidence for reverse epidemiology Horm Metab Res 39 2007 1 2 (Pubitemid 46535148)
27. B. Vergès, J.M. Petit, L. Duvillard, G. Dautin, E. Florentin, and F. Galland Adiponectin is an important determinant of apoA-I catabolism Arterioscler Thromb Vasc Biol 26 2006 1364 1369 (Pubitemid 44305383)
28. D.C. Chan, G.F. Watts, T.W. Ng, Y. Uchida, N. Sakai, and S. Yamashita Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism Clin Chem 51 2005 578 585 (Pubitemid 40300234)
29. G.F. Diercks, A.J. van Boven, H.L. Hillege, W.M. Janssen, J.A. Kors, and P.E. de Jong Microalbuminuria is independently associated with ischaemic electrocardiographic abnormalities in a large non-diabetic population. The PREVEND (Prevention of REnal and Vascular ENdstage Disease) study Eur Heart J 21 2000 1922 1927
30. C.D. Stehouwer, and Y.M. Smulders Microalbuminuria and risk for cardiovascular disease: analysis of potential mechanisms J Am Soc Nephrol 17 2006 2106 2111 (Pubitemid 44141899)
31. The Emerging Risk Factors Collaboration Major lipids, apolipoproteins, and risk of vascular disease JAMA 302 2009 1993 2000
32. W.A. van der Steeg, S.M. Boekholdt, E.A. Stein, K. El-Harchaoui, E.S. Stroes, and M.S. Sandhu Role of the apolipoprotein B-apolipoprotein A-I ratio in cardiovascular risk assessment: a case-control analysis in EPIC-Norfolk Ann Intern Med 146 2007 640 648 (Pubitemid 351650519)
33. M.J. McQueen, S. Hawken, X. Wang, S. Ounpuu, A. Sniderman, and J. Probstfield Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study Lancet 372 2008 224 233 (Pubitemid 351978112)