A comparison of the safety of olanzapine and haloperidol in combination with benzodiazepines in emergency department patients with acute agitation

Journal of Emergency Medicine

Volumn 43, Issue 5, 2012, Pages 790-797

  Wilson, Michael P ^a   MacDonald, Kai ^a   Vilke, Gary M ^a   Feifel, David ^a  

^a UCSD MEDICAL CENTER   (United States)

Author keywords

benzodiazepine; haloperidol; olanzapine; psychiatric emergencies

Indexed keywords

ALCOHOL; BENZODIAZEPINE; DIAZEPAM; HALOPERIDOL; LORAZEPAM; MIDAZOLAM; OLANZAPINE;

ACUTE DISEASE; AGITATION; COMPARATIVE STUDY; CONFERENCE PAPER; DRUG SAFETY; EMERGENCY WARD; FEMALE; HUMAN; HYPOTENSION; INGESTION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; OXYGEN SATURATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; VITAL SIGN;

ACUTE DISEASE; ADULT; ALCOHOLIC INTOXICATION; ANALYSIS OF VARIANCE; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; BLOOD PRESSURE; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; EMERGENCY SERVICE, HOSPITAL; FEMALE; HALOPERIDOL; HUMANS; MALE; MIDDLE AGED; OXYGEN; PSYCHOMOTOR AGITATION; RETROSPECTIVE STUDIES;

EID: 84869081829     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2011.01.024     Document Type: Conference Paper

References (21)

1. K.S. MacDonald, M.P. Wilson, and A. Minassian A retrospective analysis of intramuscular haloperidol and olanzapine in the treatment of agitation in drug and alcohol-using patients Gen Hosp Psychiatry 32 2010 443 445
2. M.H. Allen, G.W. Currier, D.H. Hughes, M. Reyes-Harde, and J.P. Docherty Expert consensus guideline series: treatment of behavioral emergencies J Psychiatr Pract 11 Suppl 1 2005 1 88
3. G. Huf, J. Alexander, M.H. Allen, and N.S. Raveendran Haloperidol plus promethazine for psychosis-induced aggression Cochrane Database Syst Rev 3 2009 CD005146
4. J. Battaglia, S. Moss, and J. Rush Haloperidol, lorazepam, or both for psychotic agitation? A multicenter, prospective, double-blind, emergency department study Am J Emerg Med 15 1997 335 340
5. G. D'Onofrio, B. Becker, and R.H. Woolard The impact of alcohol, tobacco, and other drug use and abuse in the emergency department Emerg Med Clin North Am 24 2006 925 967
6. Zyprexa (olanzapine) package insert 2005 Lilly Research Laboratories Indianapolis
7. L.H. Zacher, and J. Roche-Desilets Hypotension secondary to the combination of intramuscular olanzapine and intramuscular lorazepam J Clin Psychiatry 66 2005 1614 1615
8. M.P. Wilson, K.S. MacDonald, G.M. Vilke, and D. Feifel Potential complications of combining intramuscular olanzapine with benzodiazepines in emergency department patients J Emerg Med 2010 2010 Jun 12 [Epub ahead of print]
9. E.H. Gilbert, S.R. Lowenstein, J. Koziol-McLain, D.C. Barta, and J. Steiner Chart reviews in emergency medicine: where are the methods? Ann Emerg Med 27 1996 305 308
10. A. Worster, R.D. Bledsoe, P. Cleve, C. Fernandes, S. Upadhye, and K. Eva Reassessing the methods of medical record review studies in emergency medicine research Ann Emerg Med 45 2005 448 451
11. G.M. Vilke, and M.P. Wilson Agitation: what every emergency physician should know Emerg Med Rep 30 2009 1 12 Available at www.emreports.com
12. M. Martel, A. Sterzinger, and J. Miner Management of acute undifferentiated agitation in the emergency department: a randomized double-blind trial of droperidol, ziprasidone, and midazolam Acad Emerg Med 12 2005 1167 1172
13. F. Nobay, B.C. Simon, and M.A. Levitt A prospective, double-blind, randomized trial of midazolam versus haloperidol versus lorazepam in the chemical restraint of violent and severely agitated patients Acad Emerg Med 11 2004 744 749
14. J.C. Knott, D.M. Taylor, and D.J. Castle Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department Ann Emerg Med 47 2006 61 67
15. A. Breier, K. Meehan, and M. Birkett A double-blind, placebo-controlled dose response comparison of intramuscular olanzapine and haloperidol in the treatment of acute agitation in schizophrenia Arch Gen Psychiatry 59 2002 441 448
16. C.M. Beasley, S.H. Hamilton, and A.M. Crawford Olanzapine vs. haloperidol: acute-phase results of the international double-blind olanzapine trial Eur Neuropsycopharmacol 7 1997 125 137
17. A.I. Green, J.A. Liberman, and R.M. Jamer Olanzapine and haloperidol in first episode psychosis: two-year data Schizophr Res 86 2006 234 243
18. V. Villari, P. Rocca, and V. Fonzo Oral risperidone, olanzapine and quetiapine versus haloperidol in psychotic agitation Prog Neuropsychopharmacol Biol Psychiatry 32 2008 405 413
19. P. Wright, M. Birkett, and S.R. David Double-blind, placebo-controlled comparison of intramuscular olanzapine and intramuscular haloperidol in the treatment of agitation in schizophrenia Am J Psychiatry 7 2001 1149 1151
20. P. Wright, S.R. Lindborg, and M. Birkett Intramuscular olanzapine and intramuscular haloperidol in acute schizophrenia: antipsychotic efficacy and extrapyramidal safety during the first 24 hours of treatment Can J Psychiatry 48 2003 716 721
21. S. Leucht, C. Corves, D. Arbter, R.R. Engel, C. Li, and J.M. Davis Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis Lancet 373 2009 31 41