Gentamicin in Combination with Ascorbic Acid Regulates the severity of Staphylococcus aureus Infection-Induced Septic Arthritis in Mice

Scandinavian Journal of Immunology

Volumn 76, Issue 6, 2012, Pages 528-540

  Mal, P ^a   Dutta, S ^a   Bandyopadhyay, D ^a   Dutta, K ^b   Basu, A ^b   Bishayi, B ^a  

^a UNIVERSITY OF CALCUTTA   (India)

^b NATIONAL BRAIN RESEARCH CENTRE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CATALASE; CYCLOOXYGENASE 2; GAMMA INTERFERON; GENTAMICIN; GLUTATHIONE; INTERLEUKIN 10; INTERLEUKIN 6; MYELOPEROXIDASE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL ARTHRITIS; BLOOD; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFICACY; ENZYME ACTIVITY; HEART; KIDNEY PARENCHYMA; LIVER; MALE; MONOTHERAPY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SPLEEN; STAPHYLOCOCCUS INFECTION; SYNOVIAL FLUID LEVEL; SYNOVIUM;

ANIMALS; ARTHRITIS, INFECTIOUS; ASCORBIC ACID; CELLS, CULTURED; DISEASE PROGRESSION; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; GENTAMICINS; HUMANS; INTERFERON-GAMMA; MALE; MICE; OXIDATIVE STRESS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84869019460     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2012.02766.x     Document Type: Article

References (44)

1. Abdelnour A, Bremell T, Holmdahl R, Tarkowski A. Role of T lymphocytes in experimental Staphylococcus aureus arthritis. Scand J Immunol 1994;39:403-8.
2. Guzik TJ, Korbut R, Guzik TA. Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol 2003;54:469-87.
3. Goldenberg DL, Reed JI. Bacterial arthritis. N Engl J Med 1985;312:764-71.
4. McCord JM. Oxygen derived free radicals. New Horiz 1993;1:70-6.
5. Knight JA. Review: free radicals, antioxidants, and the immune system. Ann Clin Lab Sci 2000;30:145-57.
6. Goldenberg DL, Cohen AS. Synovial membrane histopathology in the differential diagnosis of rheumatoid arthritis, gout, pseudogout, systemic lupus erythematosus, infectious arthritis and degenerative joint disease. Medicine (Baltimore) 1978;57:239-52.
7. Canvin JMG, Goutcher PSC, Hagig M, Gemmell CG, Sturrock RD. Persistence of Staphylococcus aureus as detected by polymerase chain reaction in the synovial fluid of a patient with septic arthritis. Br J Rheumatol 1997;36:203-6.
8. Foster TJ. Immune evasion by staphylococci. Nat Rev Microbiol 2005;3:948-58.
9. Warner A, Bencosme A, Healy D et al. Prognostic role of antioxidant enzymes in sepsis: preliminary assessment. Clin Chem 1995;41 (S):867-71.
10. Blickwede MK, Oehmcke MRS, Miller LS, Cheung AL, Herwald H, Foster S, Medina E. Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model. Am J Pathol 2008;173:1657-68.
11. Sakiniene E, Collins LV. Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus aureus induced septic arthritis. Arthritis Res 2002;4:196-200.
12. Tarkowski A, Wagner H. Arthritis and sepsis caused by Staphylococcus aureus: can the tissue injury be reduced by modulating the host's immune system. Mol Med Today 1998;4:15-8.
13. Lara GJ, Foster SJ. Anti-Staphylococcus aureus immunotherapy: current status and prospects. Cur Opin Pharmacol 2009;9:552-7.
14. Nizet V. Understanding how leading bacterial pathogens subvert innate immunity to reveal novel therapeutic targets. Mol Mech Allergy Clin Immunol 2007;120:13-22.
15. Tarkowski A, Bokarewa M, Collins LV, Gjertsson I, Hultgren OH, Jin T. Current status of pathogenetic mechanisms in staphylococcal arthritis. FEMS Microbiol Lett 2002;217:125-32.
16. Tarkowski A. Infectious arthritis. Best Pract Res Clin Rheumatol 2006;20:1029-44.
17. Shiu MK, Chee HT, Magdalena D, John XW. Endotoxin increases ascorbate recycling and concentration in mouse liver. J Nutr 2005;135:2411-6.
18. Smith RL, Schurman DJ, Kajiyama G, Mell M, Gilkerson E. The effect of antibiotics on the destruction of cartilage in experimental infectious arthritis. J Bone Joint Surg Am 1987;69:1063-8.
19. Gemmell CG. Antibiotics and the expression of staphylococcal virulence. J Anitimicrob Chemother 1985;36:283-91.
20. Lucke M, Wildemann B, Sadoni S et al. Systemic versus local application of gentamicin in prophlylaxis of implant - related osteomyelitis in a rat model. Bone 2005;36:770-8.
21. Sandberg A, Jonas HR, Hessler RL, Skov JB, Niels FM. Intracellular activity of antibiotics against Staphylococcus aureus in a mouse peritonitis model. Antimicrob Agents Chemother 2009;53:1874-83.
22. Lescun TB, Ward MP, Adams SB. Gentamicin concentrations in synovial fluid and joint tissues during intravenous administration or continuous intra-articular infusion of the tarsocrural joint of clinically normal horses. Am J Vet Res 2006;67:409-16.
23. Raheem B, Kherani KS. Septic arthritis in patients with pre-existing inflammatory arthritis. Can Med Assoc J 2007;176:1605-8.
24. Sen R, Das D, Bishayi B. Staphylococcal catalase regulates its virulence and induces arthritis in catalase deficient mice. Ind J Physiol Pharmacol 2009;53:307-17.
25. Yao L, Berman JW, Stephen MF, Franklin DL. Correlation of histopathologic and bacteriologic changes with cytokine expression in an experimental murine model of bacteremic Staphylococcus aureus infection. Infect Immun 1997;65:3889-95.
26. Merle AS, Overton JW. In Vivo antagonism between gentamicin and chloramphenicol in neutropenic mice. J Infect Dis 1973;128:247-50.
27. Gallin JI, Elin RJ, Hubert RT, Fauci AS, Kaliner MA, Wolff SM. Efficacy of ascorbic acid in Chediak-Higashi syndrome (CHS): studies in humans and mice. Blood 1979;53:226-34.
28. Hultgren O, Eugster HP, Sedgwick JD, Korner H, Tarkowski A. TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus. J Immunol 1998;161:5937-42.
29. Burchill MA, Nardelli DT, Douglas M et al. Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi. Infect Immun 2003;71:3437-42.
30. Ronald AD. Curative effects of Tobramycin or Gentamycin therapy on mouse arthritis caused by Mycoplasma pulmonis Antimicrob. Agents Chemother 1981;20:321-6.
31. Majumdar S, Dutta K, Manna SK, Basu A, Bishayi B. Possible protective role of Chloramphenicol in TSST-1 and Coagulase-positive Staphylococcus aureus-induced septic arthritis with altered levels of inflammatory mediators. Inflammation 2011;34:269-82.
32. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Follin Phenol Reagent. J Biol Chem 1951;193:265-75.
33. Chattopadhyay A, Biswas S, Bandyopadhyay D, Sarkar C, Datta AG. Effect of isoproterenol on lipid peroxidation and antioxidant enzymes of myocardial tissue of mice and protection by quinidine. Mol Cell Biochem 2003;245:43-9.
34. Sedlak J, Lindsay RH. Estimation of total protein bound and non-protein sulfhydryl groups in tissue with Ellman's Reagent. Anal Biochem 1968;25:192-205.
35. Martin JP Jr, Dailey M, Sugarman E. Negative and positive assays of superoxide dismutase based on hematoxylin autooxidation. Archives Biochem Biophys 1987;255:3229-336.
36. Beers RF, Sizer IW. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 1952;195:133-40.
37. Dutta K, Mishra MK, Nazmi A. Minocycline differentially modulates macrophage mediated peripheral immune response following Japanese encephalitis virus infection. Immunobiology 2010;215:884-93.
38. Das D, Das A. Analysis of variance. In: Das D, ed. Statistics in Biology and Psychology. Calcutta: Academic Publisher, 2005: 280-93.
39. Verdrengh M, Tarkowski A. Role of neutrophils in experimental septicemia and septic arthritis induced by Staphylococcus aureus. Infect Immun 1997;65:2517-21.
40. Drevets DA, Canono BP, Leenen PJ, Campbell PA. Gentamicin kills intracellular Listeria. Infect Immun 1994;62:2222-8.
41. Seral C, Bambeke VF, Tulkens PM. Quantitative analysis of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) activities against intracellular Staphylococcus aureus in mouse J774 macrophages. Infect Immun 2003;47:2283-92.
42. h2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production. Int Immunol 2002;14:201-12.
43. Zhi Yong S, Yuan Lin D, Xiao Hong W. Bacterial translocation and multiple system organ failure in bowel ischemia and reperfusion. J Trauma 1992;32:148-53.
44. Pullerits R, Bokarewa M, Jonsson IM, Verdrengh M, Tarkowski A. Extracellular cytochrome c, a mitochondrial apoptosis-related protein, induces arthritis. Rheumatology 2005;44:32-9.