메뉴 건너뛰기




Volumn 7, Issue 11, 2012, Pages

Inhibition of 5′-UTR RNA Conformational Switching in HIV-1 Using Antisense PNAs

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; GENOMIC RNA; GUANINE; PEPTIDE NUCLEIC ACID; POLYADENYLIC ACID; PROTEIN SL1; UNCLASSIFIED DRUG; URIDINE; ANTISENSE OLIGONUCLEOTIDE; BUFFER; HETERODUPLEX; MESSENGER RNA; VIRUS RNA;

EID: 84869013594     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049310     Document Type: Article
Times cited : (5)

References (61)
  • 1
    • 0017078219 scopus 로고
    • Mapping of poly(A) sequences in the electron microscope reveals unusual structure of type C oncornavirus RNA molecules
    • Bender W, Davidson N, (1976) Mapping of poly(A) sequences in the electron microscope reveals unusual structure of type C oncornavirus RNA molecules. Cell 7: 595-607.
    • (1976) Cell , vol.7 , pp. 595-607
    • Bender, W.1    Davidson, N.2
  • 3
    • 0027176378 scopus 로고
    • Maturation of dimeric viral RNA of Moloney murine leukemia virus
    • Fu W, Rein A, (1993) Maturation of dimeric viral RNA of Moloney murine leukemia virus. J Virol 67: 5443-5449.
    • (1993) J Virol , vol.67 , pp. 5443-5449
    • Fu, W.1    Rein, A.2
  • 4
    • 0025598002 scopus 로고
    • Cis elements and trans-acting factors involved in the RNA dimerization of the human immunodeficiency virus HIV-1
    • Darlix JL, Gabus C, Nugeyre MT, Clavel F, Barre-Sinoussi F, (1990) Cis elements and trans-acting factors involved in the RNA dimerization of the human immunodeficiency virus HIV-1. J Mol Biol 216: 689-699.
    • (1990) J Mol Biol , vol.216 , pp. 689-699
    • Darlix, J.L.1    Gabus, C.2    Nugeyre, M.T.3    Clavel, F.4    Barre-Sinoussi, F.5
  • 5
    • 0242502660 scopus 로고    scopus 로고
    • HIV-1 reverse transcription: a brief overview focused on structure-function relationships among molecules involved in initiation of the reaction
    • Gotte M, Li X, Wainberg MA, (1999) HIV-1 reverse transcription: a brief overview focused on structure-function relationships among molecules involved in initiation of the reaction. Arch Biochem Biophys 365: 199-210.
    • (1999) Arch Biochem Biophys , vol.365 , pp. 199-210
    • Gotte, M.1    Li, X.2    Wainberg, M.A.3
  • 6
    • 0030366242 scopus 로고    scopus 로고
    • Structure and function of the human immunodeficiency virus leader RNA
    • Berkhout B, (1996) Structure and function of the human immunodeficiency virus leader RNA. Prog. Nucleic Acids Res. Mol Biol 54: 1-34.
    • (1996) Prog. Nucleic Acids Res. Mol Biol , vol.54 , pp. 1-34
    • Berkhout, B.1
  • 7
    • 0026647836 scopus 로고
    • The human immunodeficiency virus type 1 packaging signal and major splice donor region have a conserved stable secondary structure
    • Harrison GP, Lever AM, (1992) The human immunodeficiency virus type 1 packaging signal and major splice donor region have a conserved stable secondary structure. J Virol 66: 4144-4153.
    • (1992) J Virol , vol.66 , pp. 4144-4153
    • Harrison, G.P.1    Lever, A.M.2
  • 8
    • 0031777343 scopus 로고    scopus 로고
    • Functional analysis of the core human immunodeficiency virus type 1 packaging signal in a permissive cell line
    • Harrison GP, Miele G, Hunter E, Lever AM, (1998) Functional analysis of the core human immunodeficiency virus type 1 packaging signal in a permissive cell line. J Virol 72: 5886-5896.
    • (1998) J Virol , vol.72 , pp. 5886-5896
    • Harrison, G.P.1    Miele, G.2    Hunter, E.3    Lever, A.M.4
  • 9
    • 0027479628 scopus 로고
    • Functional sites in the 5' region of human immunodeficiency virus type 1 RNA form defined structural domains
    • Baudin F, Marquet R, Isel C, Darlix JL, Ehresmann B, et al. (1993) Functional sites in the 5' region of human immunodeficiency virus type 1 RNA form defined structural domains. J Mol Biol 229: 382-397.
    • (1993) J Mol Biol , vol.229 , pp. 382-397
    • Baudin, F.1    Marquet, R.2    Isel, C.3    Darlix, J.L.4    Ehresmann, B.5
  • 10
    • 0035038089 scopus 로고    scopus 로고
    • Two alternating structures of the HIV-1 leader RNA
    • Huthoff H, Berkhout B, (2001) Two alternating structures of the HIV-1 leader RNA. RNA 7: 143-157.
    • (2001) RNA , vol.7 , pp. 143-157
    • Huthoff, H.1    Berkhout, B.2
  • 12
    • 4544337311 scopus 로고    scopus 로고
    • A riboswitch regulates RNA dimerization and packaging in human immunodeficiency virus type 1 virions
    • Ooms M, Huthoff H, Russell R, Liang C, Berkhout B, (2004) A riboswitch regulates RNA dimerization and packaging in human immunodeficiency virus type 1 virions. J Virol 78: 10814-10819.
    • (2004) J Virol , vol.78 , pp. 10814-10819
    • Ooms, M.1    Huthoff, H.2    Russell, R.3    Liang, C.4    Berkhout, B.5
  • 13
    • 0038176532 scopus 로고    scopus 로고
    • A novel long distance base-pairing interaction in human immunodeficiency virus type 1 RNA occludes the Gag start codon
    • Abbink TE, Berkhout B, (2003) A novel long distance base-pairing interaction in human immunodeficiency virus type 1 RNA occludes the Gag start codon. J Biol Chem 278: 11601-11611.
    • (2003) J Biol Chem , vol.278 , pp. 11601-11611
    • Abbink, T.E.1    Berkhout, B.2
  • 14
    • 9144247039 scopus 로고    scopus 로고
    • First snapshots of the HIV-1 RNA structure in infected cells and in virions
    • Paillart JC, Dettenhofer M, Yu XF, Ehresmann C, Ehresmann B, et al. (2004) First snapshots of the HIV-1 RNA structure in infected cells and in virions. J Biol Chem 279: 48397-48403.
    • (2004) J Biol Chem , vol.279 , pp. 48397-48403
    • Paillart, J.C.1    Dettenhofer, M.2    Yu, X.F.3    Ehresmann, C.4    Ehresmann, B.5
  • 15
    • 40549122277 scopus 로고    scopus 로고
    • Role of the 5' TAR stem-loop and the U5-AUG duplex in dimerization of HIV-1 genomic RNA
    • Song R, Kafaie J, Laughrea M, (2008) Role of the 5' TAR stem-loop and the U5-AUG duplex in dimerization of HIV-1 genomic RNA. Biochemistry 47: 3283-3293.
    • (2008) Biochemistry , vol.47 , pp. 3283-3293
    • Song, R.1    Kafaie, J.2    Laughrea, M.3
  • 16
    • 0028239204 scopus 로고
    • Identification of the primary site of the human immunodeficiency virus type 1 RNA dimerization in vitro
    • Skripkin E, Paillart JC, Marquet R, Ehresmann B, Ehresmann C, (1994) Identification of the primary site of the human immunodeficiency virus type 1 RNA dimerization in vitro. Proc Natl Acad Sci U S A 91: 4945-4949.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 4945-4949
    • Skripkin, E.1    Paillart, J.C.2    Marquet, R.3    Ehresmann, B.4    Ehresmann, C.5
  • 17
    • 0027996464 scopus 로고
    • Mutational analysis of the bipartite dimer linkage structure of human immunodeficiency virus type 1 genomic RNA
    • Paillart JC, Marquet R, Skripkin E, Ehresmann B, Ehresmann C, (1994) Mutational analysis of the bipartite dimer linkage structure of human immunodeficiency virus type 1 genomic RNA. J Biol Chem 269: 27486-27493.
    • (1994) J Biol Chem , vol.269 , pp. 27486-27493
    • Paillart, J.C.1    Marquet, R.2    Skripkin, E.3    Ehresmann, B.4    Ehresmann, C.5
  • 18
    • 0028027708 scopus 로고
    • A 19-nucleotide sequence upstream of the 5' major splice donor is part of the dimerization domain of human immunodeficiency virus 1 genomic RNA
    • Laughrea M, Jette L, (1994) A 19-nucleotide sequence upstream of the 5' major splice donor is part of the dimerization domain of human immunodeficiency virus 1 genomic RNA. Biochemistry 33: 13464-13474.
    • (1994) Biochemistry , vol.33 , pp. 13464-13474
    • Laughrea, M.1    Jette, L.2
  • 20
    • 0029868164 scopus 로고    scopus 로고
    • A kissing complex together with a stable dimer is involved in the HIV-1Lai RNA dimerization process in vitro
    • Muriaux D, Fosse P, Paoletti J, (1996) A kissing complex together with a stable dimer is involved in the HIV-1Lai RNA dimerization process in vitro. Biochemistry 35: 5075-5082.
    • (1996) Biochemistry , vol.35 , pp. 5075-5082
    • Muriaux, D.1    Fosse, P.2    Paoletti, J.3
  • 21
    • 77957681610 scopus 로고    scopus 로고
    • Formation of immature and mature genomic RNA dimers in wild-type and protease-inactive HIV-1: differential roles of the Gag polyprotein, nucleocapsid proteins NCp15, NCp9, NCp7, and the dimerization initiation site
    • Jalalirad M, Laughrea M, (2010) Formation of immature and mature genomic RNA dimers in wild-type and protease-inactive HIV-1: differential roles of the Gag polyprotein, nucleocapsid proteins NCp15, NCp9, NCp7, and the dimerization initiation site. Virology 407: 225-236.
    • (2010) Virology , vol.407 , pp. 225-236
    • Jalalirad, M.1    Laughrea, M.2
  • 22
    • 84860773256 scopus 로고    scopus 로고
    • Dominant role of the 5' TAR bulge in dimerization of HIV-1 genomic RNA, but no evidence of TAR-TAR kissing during in vivo virus assembly
    • Jalalirad M, Saadatmand J, Laughrea M, (2012) Dominant role of the 5' TAR bulge in dimerization of HIV-1 genomic RNA, but no evidence of TAR-TAR kissing during in vivo virus assembly. Biochemistry 51: 3744-3758.
    • (2012) Biochemistry , vol.51 , pp. 3744-3758
    • Jalalirad, M.1    Saadatmand, J.2    Laughrea, M.3
  • 23
    • 0018304892 scopus 로고
    • Structure, replication, and recombination of retrovirus genomes: some unifying hypotheses
    • Coffin JM, (1979) Structure, replication, and recombination of retrovirus genomes: some unifying hypotheses. J Gen Virol 42: 1-26.
    • (1979) J Gen Virol , vol.42 , pp. 1-26
    • Coffin, J.M.1
  • 24
    • 21744452846 scopus 로고    scopus 로고
    • The HIV-1 leader RNA conformational switch regulates RNA dimerization but does not regulate mRNA translation
    • Abbink TE, Ooms M, Haasnoot PC, Berkhout B, (2005) The HIV-1 leader RNA conformational switch regulates RNA dimerization but does not regulate mRNA translation. Biochemistry 44: 9058-9066.
    • (2005) Biochemistry , vol.44 , pp. 9058-9066
    • Abbink, T.E.1    Ooms, M.2    Haasnoot, P.C.3    Berkhout, B.4
  • 25
    • 34247121777 scopus 로고    scopus 로고
    • The availability of the primer activation signal (PAS) affects the efficiency of HIV-1 reverse transcription initiation
    • Ooms M, Cupac D, Abbink TE, Huthoff H, Berkhout B, (2007) The availability of the primer activation signal (PAS) affects the efficiency of HIV-1 reverse transcription initiation. Nucleic Acids Res 35: 1649-1659.
    • (2007) Nucleic Acids Res , vol.35 , pp. 1649-1659
    • Ooms, M.1    Cupac, D.2    Abbink, T.E.3    Huthoff, H.4    Berkhout, B.5
  • 26
    • 62149126297 scopus 로고    scopus 로고
    • Destabilization of the TAR hairpin leads to extension of the polyA hairpin and inhibition of HIV-1 polyadenylation
    • Vrolijk MM, Harwig A, Berkhout B, Das AT, (2009) Destabilization of the TAR hairpin leads to extension of the polyA hairpin and inhibition of HIV-1 polyadenylation. Retrovirology 6: 13.
    • (2009) Retrovirology , vol.6 , pp. 13
    • Vrolijk, M.M.1    Harwig, A.2    Berkhout, B.3    Das, A.T.4
  • 27
    • 48149098589 scopus 로고    scopus 로고
    • Destabilization of the TAR hairpin affects the structure and function of the HIV-1 leader RNA
    • Vrolijk MM, Ooms M, Harwig A, Das AT, Berkhout B, (2008) Destabilization of the TAR hairpin affects the structure and function of the HIV-1 leader RNA. Nucleic Acids Res 36: 4352-4363.
    • (2008) Nucleic Acids Res , vol.36 , pp. 4352-4363
    • Vrolijk, M.M.1    Ooms, M.2    Harwig, A.3    Das, A.T.4    Berkhout, B.5
  • 28
    • 40849123031 scopus 로고    scopus 로고
    • High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states
    • Wilkinson KA, Gorelick RJ, Vasa SM, Guex N, Rein A, et al. (2008) High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states. PLoS Biol 6: e96.
    • (2008) PLoS Biol , vol.6
    • Wilkinson, K.A.1    Gorelick, R.J.2    Vasa, S.M.3    Guex, N.4    Rein, A.5
  • 29
    • 68449092202 scopus 로고    scopus 로고
    • Architecture and secondary structure of an entire HIV-1 RNA genome
    • Watts JM, Dang KK, Gorelick RJ, Leonard CW, Bess JW Jr, et al. (2009) Architecture and secondary structure of an entire HIV-1 RNA genome. Nature 460: 711-716.
    • (2009) Nature , vol.460 , pp. 711-716
    • Watts, J.M.1    Dang, K.K.2    Gorelick, R.J.3    Leonard, C.W.4    Bess Jr., J.W.5
  • 31
    • 14844359526 scopus 로고    scopus 로고
    • Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably?
    • Russell RS, Liang C, Wainberg MA, (2004) Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably? Retrovirology 1: 23.
    • (2004) Retrovirology , vol.1 , pp. 23
    • Russell, R.S.1    Liang, C.2    Wainberg, M.A.3
  • 32
    • 0037379439 scopus 로고    scopus 로고
    • Possible role of dimerization in human immunodeficiency virus type 1 genome RNA packaging
    • Sakuragi J, Ueda S, Iwamoto A, Shioda T, (2003) Possible role of dimerization in human immunodeficiency virus type 1 genome RNA packaging. J Virol 77: 4060-4069.
    • (2003) J Virol , vol.77 , pp. 4060-4069
    • Sakuragi, J.1    Ueda, S.2    Iwamoto, A.3    Shioda, T.4
  • 33
    • 34547102008 scopus 로고    scopus 로고
    • HIV-1 viral RNA is selected in the form of monomers that dimerize in a three-step protease-dependent process; the DIS of stem-loop 1 initiates viral RNA dimerization
    • Song R, Kafaie J, Yang L, Laughrea M, (2007) HIV-1 viral RNA is selected in the form of monomers that dimerize in a three-step protease-dependent process; the DIS of stem-loop 1 initiates viral RNA dimerization. J Mol Biol 371: 1084-1098.
    • (2007) J Mol Biol , vol.371 , pp. 1084-1098
    • Song, R.1    Kafaie, J.2    Yang, L.3    Laughrea, M.4
  • 34
    • 0029861557 scopus 로고    scopus 로고
    • A dual role of the putative RNA dimerization initiation site of human immunodeficiency virus type 1 in genomic RNA packaging and proviral DNA synthesis
    • Paillart JC, Berthoux L, Ottmann M, Darlix JL, Marquet R, et al. (1996) A dual role of the putative RNA dimerization initiation site of human immunodeficiency virus type 1 in genomic RNA packaging and proviral DNA synthesis. J Virol 70: 8348-8354.
    • (1996) J Virol , vol.70 , pp. 8348-8354
    • Paillart, J.C.1    Berthoux, L.2    Ottmann, M.3    Darlix, J.L.4    Marquet, R.5
  • 35
    • 0029796006 scopus 로고    scopus 로고
    • Role of the DIS hairpin in replication of human immunodeficiency virus type 1
    • Berkhout B, van Wamel JL, (1996) Role of the DIS hairpin in replication of human immunodeficiency virus type 1. J Virol 70: 6723-6732.
    • (1996) J Virol , vol.70 , pp. 6723-6732
    • Berkhout, B.1    van Wamel, J.L.2
  • 36
    • 0038784872 scopus 로고    scopus 로고
    • The dimer initiation sequence stem-loop of human immunodeficiency virus type 1 is dispensable for viral replication in peripheral blood mononuclear cells
    • Hill MK, Shehu-Xhilaga M, Campbell SM, Poumbourios P, Crowe SM, et al. (2003) The dimer initiation sequence stem-loop of human immunodeficiency virus type 1 is dispensable for viral replication in peripheral blood mononuclear cells. J Virol 77: 8329-8335.
    • (2003) J Virol , vol.77 , pp. 8329-8335
    • Hill, M.K.1    Shehu-Xhilaga, M.2    Campbell, S.M.3    Poumbourios, P.4    Crowe, S.M.5
  • 37
    • 0034074812 scopus 로고    scopus 로고
    • Impact of human immunodeficiency virus type 1 RNA dimerization on viral infectivity and of stem-loop B on RNA dimerization and reverse transcription and dissociation of dimerization from packaging
    • Shen N, Jette L, Liang C, Wainberg MA, Laughrea M, (2000) Impact of human immunodeficiency virus type 1 RNA dimerization on viral infectivity and of stem-loop B on RNA dimerization and reverse transcription and dissociation of dimerization from packaging. J Virol 74: 5729-5735.
    • (2000) J Virol , vol.74 , pp. 5729-5735
    • Shen, N.1    Jette, L.2    Liang, C.3    Wainberg, M.A.4    Laughrea, M.5
  • 38
    • 0034791054 scopus 로고    scopus 로고
    • Role of stem B, loop B, and nucleotides next to the primer binding site and the kissing-loop domain in human immunodeficiency virus type 1 replication and genomic-RNA dimerization
    • Shen N, Jette L, Wainberg MA, Laughrea M, (2001) Role of stem B, loop B, and nucleotides next to the primer binding site and the kissing-loop domain in human immunodeficiency virus type 1 replication and genomic-RNA dimerization. J Virol 75: 10543-10549.
    • (2001) J Virol , vol.75 , pp. 10543-10549
    • Shen, N.1    Jette, L.2    Wainberg, M.A.3    Laughrea, M.4
  • 39
    • 0035264640 scopus 로고    scopus 로고
    • Role of distal zinc finger of nucleocapsid protein in genomic RNA dimerization of human immunodeficiency virus type 1; no role for the palindrome crowning the R-U5 hairpin
    • Laughrea M, Shen N, Jette L, Darlix JL, Kleiman L, et al. (2001) Role of distal zinc finger of nucleocapsid protein in genomic RNA dimerization of human immunodeficiency virus type 1; no role for the palindrome crowning the R-U5 hairpin. Virology 281: 109-116.
    • (2001) Virology , vol.281 , pp. 109-116
    • Laughrea, M.1    Shen, N.2    Jette, L.3    Darlix, J.L.4    Kleiman, L.5
  • 40
    • 0344406983 scopus 로고    scopus 로고
    • Template dimerization promotes an acceptor invasion-induced transfer mechanism during human immunodeficiency virus type 1 minus-strand synthesis
    • Balakrishnan M, Roques BP, Fay PJ, Bambara RA, (2003) Template dimerization promotes an acceptor invasion-induced transfer mechanism during human immunodeficiency virus type 1 minus-strand synthesis. J Virol 77: 4710-4721.
    • (2003) J Virol , vol.77 , pp. 4710-4721
    • Balakrishnan, M.1    Roques, B.P.2    Fay, P.J.3    Bambara, R.A.4
  • 41
    • 0036888914 scopus 로고    scopus 로고
    • RNA structure and packaging signals in the 5' leader region of the human immunodeficiency virus type 1 genome
    • Clever JL, Miranda D Jr, Parslow TG, (2002) RNA structure and packaging signals in the 5' leader region of the human immunodeficiency virus type 1 genome. J Virol 76: 12381-12387.
    • (2002) J Virol , vol.76 , pp. 12381-12387
    • Clever, J.L.1    Miranda Jr., D.2    Parslow, T.G.3
  • 42
    • 0030899860 scopus 로고    scopus 로고
    • Mutations in the kissing-loop hairpin of human immunodeficiency virus type 1 reduce viral infectivity as well as genomic RNA packaging and dimerization
    • Laughrea M, Jette L, Mak J, Kleiman L, Liang C, et al. (1997) Mutations in the kissing-loop hairpin of human immunodeficiency virus type 1 reduce viral infectivity as well as genomic RNA packaging and dimerization. J Virol 71: 3397-3406.
    • (1997) J Virol , vol.71 , pp. 3397-3406
    • Laughrea, M.1    Jette, L.2    Mak, J.3    Kleiman, L.4    Liang, C.5
  • 43
    • 0029804315 scopus 로고    scopus 로고
    • Mechanisms of inhibition of in vitro dimerization of HIV type I RNA by sense and antisense oligonucleotides
    • Skripkin E, Paillart JC, Marquet R, Blumenfeld M, Ehresmann B, et al. (1996) Mechanisms of inhibition of in vitro dimerization of HIV type I RNA by sense and antisense oligonucleotides. J Biol Chem 271: 28812-28817.
    • (1996) J Biol Chem , vol.271 , pp. 28812-28817
    • Skripkin, E.1    Paillart, J.C.2    Marquet, R.3    Blumenfeld, M.4    Ehresmann, B.5
  • 44
    • 0032413255 scopus 로고    scopus 로고
    • Oligonucleotide-mediated inhibition of genomic RNA dimerization of HIV-1 strains MAL and LAI: a comparative analysis
    • Lodmell JS, Paillart JC, Mignot D, Ehresmann B, Ehresmann C, et al. (1998) Oligonucleotide-mediated inhibition of genomic RNA dimerization of HIV-1 strains MAL and LAI: a comparative analysis. Antisense Nucleic Acid Drug Dev 8: 517-529.
    • (1998) Antisense Nucleic Acid Drug Dev , vol.8 , pp. 517-529
    • Lodmell, J.S.1    Paillart, J.C.2    Mignot, D.3    Ehresmann, B.4    Ehresmann, C.5
  • 45
    • 0037205458 scopus 로고    scopus 로고
    • In vitro evidence that the untranslated leader of the HIV-1 genome is an RNA checkpoint that regulates multiple functions through conformational changes
    • Berkhout B, Ooms M, Beerens N, Huthoff H, Southern E, et al. (2002) In vitro evidence that the untranslated leader of the HIV-1 genome is an RNA checkpoint that regulates multiple functions through conformational changes. J Biol Chem 277: 19967-19975.
    • (2002) J Biol Chem , vol.277 , pp. 19967-19975
    • Berkhout, B.1    Ooms, M.2    Beerens, N.3    Huthoff, H.4    Southern, E.5
  • 46
    • 33747046408 scopus 로고    scopus 로고
    • Targeting the HIV-1 RNA leader sequence with synthetic oligonucleotides and siRNA: chemistry and cell delivery
    • Turner JJ, Fabani M, Arzumanov AA, Ivanova G, Gait MJ, (2006) Targeting the HIV-1 RNA leader sequence with synthetic oligonucleotides and siRNA: chemistry and cell delivery. Biochim Biophys Acta 1758: 290-300.
    • (2006) Biochim Biophys Acta , vol.1758 , pp. 290-300
    • Turner, J.J.1    Fabani, M.2    Arzumanov, A.A.3    Ivanova, G.4    Gait, M.J.5
  • 47
    • 0027364174 scopus 로고
    • PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules
    • Egholm M, Buchardt O, Christensen L, Behrens C, Freier SM, et al. (1993) PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules. Nature 365: 566-568.
    • (1993) Nature , vol.365 , pp. 566-568
    • Egholm, M.1    Buchardt, O.2    Christensen, L.3    Behrens, C.4    Freier, S.M.5
  • 48
    • 0027338249 scopus 로고
    • Peptide nucleic acids and their potential applications in biotechnology
    • Buchardt O, Egholm M, Berg RH, Nielsen PE, (1993) Peptide nucleic acids and their potential applications in biotechnology. Trends Biotechnol 11: 384-386.
    • (1993) Trends Biotechnol , vol.11 , pp. 384-386
    • Buchardt, O.1    Egholm, M.2    Berg, R.H.3    Nielsen, P.E.4
  • 49
    • 84855586204 scopus 로고    scopus 로고
    • Targeting RNA polymerase primary sigma70 as a therapeutic strategy against methicillin-resistant Staphylococcus aureus by antisense peptide nucleic acid
    • Bai H, Sang G, You Y, Xue X, Zhou Y, et al. (2012) Targeting RNA polymerase primary sigma70 as a therapeutic strategy against methicillin-resistant Staphylococcus aureus by antisense peptide nucleic acid. PLoS One 7: e29886.
    • (2012) PLoS One , vol.7
    • Bai, H.1    Sang, G.2    You, Y.3    Xue, X.4    Zhou, Y.5
  • 51
    • 0343334678 scopus 로고
    • Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues
    • Agrawal S, Ikeuchi T, Sun D, Sarin PS, Konopka A, et al. (1989) Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues. Proc Natl Acad Sci U S A 86: 7790-7794.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 7790-7794
    • Agrawal, S.1    Ikeuchi, T.2    Sun, D.3    Sarin, P.S.4    Konopka, A.5
  • 52
    • 0003799787 scopus 로고
    • Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides
    • Goodchild J, Agrawal S, Civeira MP, Sarin PS, Sun D, et al. (1988) Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides. Proc Natl Acad Sci U S A 85: 5507-5511.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 5507-5511
    • Goodchild, J.1    Agrawal, S.2    Civeira, M.P.3    Sarin, P.S.4    Sun, D.5
  • 53
    • 0030904762 scopus 로고    scopus 로고
    • Inhibition of HIV type 1 RNA dimerization by antisense DNA corresponding to the 17-nucleotide sequence downstream from the splice donor site of HIV type 1 RNA
    • Zhang S, Hara H, Kaji H, Kaji A, (1997) Inhibition of HIV type 1 RNA dimerization by antisense DNA corresponding to the 17-nucleotide sequence downstream from the splice donor site of HIV type 1 RNA. AIDS Res Hum Retroviruses 13: 865-873.
    • (1997) AIDS Res Hum Retroviruses , vol.13 , pp. 865-873
    • Zhang, S.1    Hara, H.2    Kaji, H.3    Kaji, A.4
  • 54
    • 10044234020 scopus 로고    scopus 로고
    • Locked nucleic acid containing antisense oligonucleotides enhance inhibition of HIV-1 genome dimerization and inhibit virus replication
    • Elmen J, Zhang HY, Zuber B, Ljungberg K, Wahren B, et al. (2004) Locked nucleic acid containing antisense oligonucleotides enhance inhibition of HIV-1 genome dimerization and inhibit virus replication. FEBS Lett 578: 285-290.
    • (2004) FEBS Lett , vol.578 , pp. 285-290
    • Elmen, J.1    Zhang, H.Y.2    Zuber, B.3    Ljungberg, K.4    Wahren, B.5
  • 55
    • 0037372281 scopus 로고    scopus 로고
    • Dimerization and template switching in the 5' untranslated region between various subtypes of human immunodeficiency virus type 1
    • Andersen ES, Jeeninga RE, Damgaard CK, Berkhout B, Kjems J, (2003) Dimerization and template switching in the 5' untranslated region between various subtypes of human immunodeficiency virus type 1. J Virol 77: 3020-3030.
    • (2003) J Virol , vol.77 , pp. 3020-3030
    • Andersen, E.S.1    Jeeninga, R.E.2    Damgaard, C.K.3    Berkhout, B.4    Kjems, J.5
  • 56
    • 0037155223 scopus 로고    scopus 로고
    • In vitro evidence for a long range pseudoknot in the 5'-untranslated and matrix coding regions of HIV-1 genomic RNA
    • Paillart JC, Skripkin E, Ehresmann B, Ehresmann C, Marquet R, (2002) In vitro evidence for a long range pseudoknot in the 5'-untranslated and matrix coding regions of HIV-1 genomic RNA. J Biol Chem 277: 5995-6004.
    • (2002) J Biol Chem , vol.277 , pp. 5995-6004
    • Paillart, J.C.1    Skripkin, E.2    Ehresmann, B.3    Ehresmann, C.4    Marquet, R.5
  • 57
    • 80054114304 scopus 로고    scopus 로고
    • NMR detection of structures in the HIV-1 5'-leader RNA that regulate genome packaging
    • Lu K, Heng X, Garyu L, Monti S, Garcia EL, et al. (2011) NMR detection of structures in the HIV-1 5'-leader RNA that regulate genome packaging. Science 334: 242-245.
    • (2011) Science , vol.334 , pp. 242-245
    • Lu, K.1    Heng, X.2    Garyu, L.3    Monti, S.4    Garcia, E.L.5
  • 59
    • 0028986869 scopus 로고
    • Dimerization of HIV-1Lai RNA at low ionic strength. An autocomplementary sequence in the 5' leader region is evidenced by an antisense oligonucleotide
    • Muriaux D, Girard PM, Bonnet-Mathoniere B, Paoletti J, (1995) Dimerization of HIV-1Lai RNA at low ionic strength. An autocomplementary sequence in the 5' leader region is evidenced by an antisense oligonucleotide. J Biol Chem 270: 8209-8216.
    • (1995) J Biol Chem , vol.270 , pp. 8209-8216
    • Muriaux, D.1    Girard, P.M.2    Bonnet-Mathoniere, B.3    Paoletti, J.4
  • 60
    • 0033953843 scopus 로고    scopus 로고
    • The leader of the HIV-1 RNA genome forms a compactly folded tertiary structure
    • Berkhout B, van Wamel JL, (2000) The leader of the HIV-1 RNA genome forms a compactly folded tertiary structure. RNA 6: 282-295.
    • (2000) RNA , vol.6 , pp. 282-295
    • Berkhout, B.1    van Wamel, J.L.2
  • 61
    • 0034903425 scopus 로고    scopus 로고
    • Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription
    • Berkhout B, Vastenhouw NL, Klasens BI, Huthoff H, (2001) Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription. RNA 7: 1097-1114.
    • (2001) RNA , vol.7 , pp. 1097-1114
    • Berkhout, B.1    Vastenhouw, N.L.2    Klasens, B.I.3    Huthoff, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.