-
1
-
-
41749113108
-
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
-
Asangani IA, et al. 2008. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27:2128-2136.
-
(2008)
Oncogene
, vol.27
, pp. 2128-2136
-
-
Asangani, I.A.1
-
2
-
-
6344231276
-
Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun
-
Bitomsky N, Bohm M, Klempnauer KH. 2004. Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun. Oncogene 23:7484-7493.
-
(2004)
Oncogene
, vol.23
, pp. 7484-7493
-
-
Bitomsky, N.1
Bohm, M.2
Klempnauer, K.H.3
-
3
-
-
49649102818
-
siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression
-
Bitomsky N, Wethkamp N, Marikkannu R, Klempnauer KH. 2008. siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression. Oncogene 27:4820-4829.
-
(2008)
Oncogene
, vol.27
, pp. 4820-4829
-
-
Bitomsky, N.1
Wethkamp, N.2
Marikkannu, R.3
Klempnauer, K.H.4
-
4
-
-
60149088848
-
Origins and mechanisms of miRNAs and siRNAs
-
Carthew RW, Sontheimer EJ. 2009. Origins and mechanisms of miRNAs and siRNAs. Cell 136:642-655.
-
(2009)
Cell
, vol.136
, pp. 642-655
-
-
Carthew, R.W.1
Sontheimer, E.J.2
-
5
-
-
22244467087
-
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
-
Chan JA, Krichevsky AM, Kosik KS. 2005. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 65:6029-6033.
-
(2005)
Cancer Res
, vol.65
, pp. 6029-6033
-
-
Chan, J.A.1
Krichevsky, A.M.2
Kosik, K.S.3
-
6
-
-
0042524204
-
Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis
-
Chen Y, et al. 2003. Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis. J. Pathol. 200:640-646.
-
(2003)
J. Pathol.
, vol.200
, pp. 640-646
-
-
Chen, Y.1
-
7
-
-
82255185653
-
Identifying transcriptional start sites of human microRNAs based on high-throughput sequencing data
-
Chien CH, et al. 2011. Identifying transcriptional start sites of human microRNAs based on high-throughput sequencing data. Nucleic Acids Res. 39:9345-9356.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 9345-9356
-
-
Chien, C.H.1
-
8
-
-
0022520577
-
Heterogeneous nuclear ribonucleoproteins, role inRNAsplicing
-
Choi YD, Grabowski PJ, Sharp PA, Dreyfuss G. 1986. Heterogeneous nuclear ribonucleoproteins: role inRNAsplicing. Science 231:1534-1539.
-
(1986)
Science
, vol.231
, pp. 1534-1539
-
-
Choi, Y.D.1
Grabowski, P.J.2
Sharp, P.A.3
Dreyfuss, G.4
-
9
-
-
42449086890
-
Interaction of heterogeneous nuclear ribonucleoprotein C1/C2 with a novel cis-regulatory element within p53 mRNA as a response to cytostatic drug treatment
-
Christian KJ, Lang MA, Raffalli-Mathieu F. 2008. Interaction of heterogeneous nuclear ribonucleoprotein C1/C2 with a novel cis-regulatory element within p53 mRNA as a response to cytostatic drug treatment. Mol. Pharmacol. 73:1558-1567.
-
(2008)
Mol. Pharmacol.
, vol.73
, pp. 1558-1567
-
-
Christian, K.J.1
Lang, M.A.2
Raffalli-Mathieu, F.3
-
10
-
-
0033598712
-
Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation
-
Cmarik JL, et al. 1999. Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc. Natl. Acad. Sci. U. S. A. 96:14037-14042.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 14037-14042
-
-
Cmarik, J.L.1
-
11
-
-
77952948062
-
Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB
-
Connolly EC, Van Doorslaer K, Rogler LE, Rogler CE. 2010. Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB. Mol. Cancer Res. 8:691-700.
-
(2010)
Mol. Cancer Res.
, vol.8
, pp. 691-700
-
-
Connolly, E.C.1
Van Doorslaer, K.2
Rogler, L.E.3
Rogler, C.E.4
-
12
-
-
50849104285
-
Mechanisms of microRNA deregulation in human cancer
-
Deng S, Calin GA, Croce CM, Coukos G, Zhang L. 2008. Mechanisms of microRNA deregulation in human cancer. Cell Cycle 7:2643-2646.
-
(2008)
Cell Cycle
, vol.7
, pp. 2643-2646
-
-
Deng, S.1
Calin, G.A.2
Croce, C.M.3
Coukos, G.4
Zhang, L.5
-
13
-
-
33750325725
-
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
-
Dorrello NV, et al. 2006. S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 314:467-471.
-
(2006)
Science
, vol.314
, pp. 467-471
-
-
Dorrello, N.V.1
-
14
-
-
42249090353
-
miR-21 gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism
-
Fujita S, et al. 2008. miR-21 gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J. Mol. Biol. 378: 492-504.
-
(2008)
J. Mol. Biol.
, vol.378
, pp. 492-504
-
-
Fujita, S.1
-
15
-
-
77449149671
-
PDCD4 gene silencing in gliomas is associated with 5=CpG island methylation and unfavourable prognosis
-
Gao F, et al. 2009. PDCD4 gene silencing in gliomas is associated with 5=CpG island methylation and unfavourable prognosis. J. Cell. Mol. Med. 13:4257-4267.
-
(2009)
J. Cell. Mol. Med.
, vol.13
, pp. 4257-4267
-
-
Gao, F.1
-
16
-
-
38149139712
-
Frequent loss of PDCD4 expression in human glioma, possible role in the tumorigenesis of glioma
-
Gao F, et al. 2007. Frequent loss of PDCD4 expression in human glioma: possible role in the tumorigenesis of glioma. Oncol. Rep. 17:123-128.
-
(2007)
Oncol. Rep.
, vol.17
, pp. 123-128
-
-
Gao, F.1
-
17
-
-
33751163757
-
MicroRNA expression and function in cancer
-
Garzon R, Fabbri M, Cimmino A, Calin GA, Croce CM. 2006. MicroRNA expression and function in cancer. Trends Mol. Med. 12:580-587.
-
(2006)
Trends Mol. Med.
, vol.12
, pp. 580-587
-
-
Garzon, R.1
Fabbri, M.2
Cimmino, A.3
Calin, G.A.4
Croce, C.M.5
-
18
-
-
79959977098
-
Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo
-
Gaur AB, Holbeck SL, Colburn NH, Israel MA. 2011. Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo. Neuro Oncol. 13:580-590.
-
(2011)
Neuro Oncol
, vol.13
, pp. 580-590
-
-
Gaur, A.B.1
Holbeck, S.L.2
Colburn, N.H.3
Israel, M.A.4
-
19
-
-
2342501442
-
Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells
-
Goke R, et al. 2004. Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells. Ann. N. Y. Acad. Sci. 1014:220-221.
-
(2004)
Ann. N. Y. Acad. Sci.
, vol.1014
, pp. 220-221
-
-
Goke, R.1
-
20
-
-
67650538055
-
Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion
-
Huang TH, et al. 2009. Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. J. Biol. Chem. 284:18515-18524.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 18515-18524
-
-
Huang, T.H.1
-
21
-
-
23844555119
-
MicroRNA gene expression deregulation in human breast cancer
-
Iorio MV, et al. 2005. MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65:7065-7070.
-
(2005)
Cancer Res
, vol.65
, pp. 7065-7070
-
-
Iorio, M.V.1
-
22
-
-
79954575702
-
Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation
-
Jin X, et al. 2011. Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation. Cancer Res. 71:3066-3075.
-
(2011)
Cancer Res
, vol.71
, pp. 3066-3075
-
-
Jin, X.1
-
23
-
-
68149165414
-
HuR recruits let-7/RISC to repress c-Myc expression
-
Kim HH, et al. 2009. HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev. 23:1743-1748.
-
(2009)
Genes Dev
, vol.23
, pp. 1743-1748
-
-
Kim, H.H.1
-
24
-
-
0037219006
-
Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner
-
Kim JH, et al. 2003. Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner. Mol. Cell. Biol. 23:708-720.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 708-720
-
-
Kim, J.H.1
-
26
-
-
67449104909
-
The tumour suppressor Pdcd4, recent advances in the elucidation of function and regulation
-
Lankat-Buttgereit B, Goke R. 2009. The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation. Biol. Cell 101:309-317.
-
(2009)
Biol. Cell
, vol.101
, pp. 309-317
-
-
Lankat-Buttgereit, B.1
Goke, R.2
-
27
-
-
1142273385
-
Pdcd4 inhibits growth of tumor cells by suppression of carbonic anhydrase type II
-
Lankat-Buttgereit B, et al. 2004. Pdcd4 inhibits growth of tumor cells by suppression of carbonic anhydrase type II. Mol. Cell. Endocrinol. 214: 149-153.
-
(2004)
Mol. Cell. Endocrinol.
, vol.214
, pp. 149-153
-
-
Lankat-Buttgereit, B.1
-
28
-
-
77953249227
-
hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies
-
Lee EK, et al. 2010. hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat. Struct. Mol. Biol. 17:732-739.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 732-739
-
-
Lee, E.K.1
-
29
-
-
34447270490
-
Tumor suppressor Pdcd4 inhibits invasion/ intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors
-
Leupold JH, et al. 2007. Tumor suppressor Pdcd4 inhibits invasion/ intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors. Oncogene 26:4550-4562.
-
(2007)
Oncogene
, vol.26
, pp. 4550-4562
-
-
Leupold, J.H.1
-
30
-
-
67849103555
-
MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme
-
Li Y, et al. 2009. MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme. Brain Res. 1286:13-18.
-
(2009)
Brain Res
, vol.1286
, pp. 13-18
-
-
Li, Y.1
-
31
-
-
33645732219
-
Molecular pathology of malignant gliomas
-
Louis DN. 2006. Molecular pathology of malignant gliomas. Annu. Rev. Pathol. 1:97-117.
-
(2006)
Annu. Rev. Pathol.
, vol.1
, pp. 97-117
-
-
Louis, D.N.1
-
32
-
-
34249316905
-
RNA-binding proteins, modular design for efficient function
-
Lunde BM, Moore C, Varani G. 2007. RNA-binding proteins: modular design for efficient function. Nat. Rev. Mol. Cell. Biol. 8:479-490.
-
(2007)
Nat. Rev. Mol. Cell. Biol.
, vol.8
, pp. 479-490
-
-
Lunde, B.M.1
Moore, C.2
Varani, G.3
-
33
-
-
77955425756
-
Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis
-
Michlewski G, Caceres JF. 2010. Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. Nat. Struct. Mol. Biol. 17: 1011-1018.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 1011-1018
-
-
Michlewski, G.1
Caceres, J.F.2
-
34
-
-
55049119136
-
Posttranscriptional regulation of miRNAs harboring conserved terminal loops
-
Michlewski G, Guil S, Semple CA, Caceres JF. 2008. Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Mol. Cell 32: 383-393.
-
(2008)
Mol. Cell
, vol.32
, pp. 383-393
-
-
Michlewski, G.1
Guil, S.2
Semple, C.A.3
Caceres, J.F.4
-
35
-
-
29244472037
-
Akt phosphorylates and regulates Pdcd4 tumor suppressor protein
-
Palamarchuk A, et al. 2005. Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. Cancer Res. 65:11282-11286.
-
(2005)
Cancer Res
, vol.65
, pp. 11282-11286
-
-
Palamarchuk, A.1
-
36
-
-
0027411587
-
hnRNP proteins, localization and transport between the nucleus and the cytoplasm
-
Pinol-Roma S, Dreyfuss G. 1993. hnRNP proteins: localization and transport between the nucleus and the cytoplasm. Trends Cell Biol. 3:151-155.
-
(1993)
Trends Cell Biol
, vol.3
, pp. 151-155
-
-
Pinol-Roma, S.1
Dreyfuss, G.2
-
37
-
-
77956453805
-
Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma
-
Reis PP, et al. 2010. Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma. Mol. Cancer 9:238.
-
(2010)
Mol. Cancer
, vol.9
, pp. 238
-
-
Reis, P.P.1
-
38
-
-
33750600178
-
MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior
-
Roldo C, et al. 2006. MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. J. Clin. Oncol. 24:4677-4684.
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 4677-4684
-
-
Roldo, C.1
-
39
-
-
20944435993
-
Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells
-
Shetty S. 2005. Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells. Mol. Cell. Biochem. 272:107-118.
-
(2005)
Mol. Cell. Biochem.
, vol.272
, pp. 107-118
-
-
Shetty, S.1
-
40
-
-
34247495591
-
miR-21-mediated tumor growth
-
Si ML, et al. 2007. miR-21-mediated tumor growth. Oncogene 26:2799-2803.
-
(2007)
Oncogene
, vol.26
, pp. 2799-2803
-
-
Si, M.L.1
-
41
-
-
67649277689
-
The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs
-
Trabucchi M, et al. 2009. The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature 459:1010-1014.
-
(2009)
Nature
, vol.459
, pp. 1010-1014
-
-
Trabucchi, M.1
-
42
-
-
80052041185
-
MicroRNA regulation by RNA-binding proteins and its implications for cancer
-
van Kouwenhove M, Kedde M, Agami R. 2011. MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat. Rev. Cancer 11:644-656.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 644-656
-
-
van Kouwenhove, M.1
Kedde, M.2
Agami, R.3
-
43
-
-
33144490646
-
A microRNA expression signature of human solid tumors defines cancer gene targets
-
Volinia S, et al. 2006. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc. Natl. Acad. Sci. U. S. A. 103: 2257-2261.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 2257-2261
-
-
Volinia, S.1
-
44
-
-
84855860369
-
Tumour suppressive function and modulation of programmed cell death 4 (PDCD4) in ovarian cancer
-
doi, 10.1371/journal.pone.0030311
-
Wei N, Liu SS, Chan KK, Ngan HY. 2012. Tumour suppressive function and modulation of programmed cell death 4 (PDCD4) in ovarian cancer. PLoS One 7:e30311. doi:10.1371/journal.pone.0030311.
-
(2012)
PLoS One
, vol.7
-
-
Wei, N.1
Liu, S.S.2
Chan, K.K.3
Ngan, H.Y.4
-
45
-
-
70350087561
-
Loss of programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancer
-
Wei NA, et al. 2009. Loss of programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancer. Mol. Cancer 8:70.
-
(2009)
Mol. Cancer
, vol.8
, pp. 70
-
-
Wei, N.A.1
-
46
-
-
32044459728
-
Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion
-
Yang HS, et al. 2006. Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. Mol. Cell. Biol 26:1297-1306.
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 1297-1306
-
-
Yang, H.S.1
-
47
-
-
79951500251
-
The ATM kinase induces microRNA biogenesis in the DNA damage response
-
Zhang X, Wan G, Berger FG, He X, Lu X. 2011. The ATM kinase induces microRNA biogenesis in the DNA damage response. Mol. Cell 41:371-383.
-
(2011)
Mol. Cell
, vol.41
, pp. 371-383
-
-
Zhang, X.1
Wan, G.2
Berger, F.G.3
He, X.4
Lu, X.5
-
48
-
-
77952963826
-
Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3
-
Zhou X, et al. 2010. Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3. Oncol. Rep. 24:195-201.
-
(2010)
Oncol. Rep.
, vol.24
, pp. 195-201
-
-
Zhou, X.1
-
49
-
-
40249092910
-
MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
-
Zhu S, et al. 2008. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res. 18:350-359.
-
(2008)
Cell Res
, vol.18
, pp. 350-359
-
-
Zhu, S.1
|