Serological identification of Tektin5 as a cancer/testis antigen and its immunogenicity

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Hanafusa, Tadashi ^a   Mohamed, Ali E A ^b,e   Domae, Shohei ^c   Nakayama, Eiichi ^d   Ono, Toshiro ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b Damanhour University   (Egypt)

^c OKAYAMA UNIVERSITY   (Japan)

^d KAWASAKI UNIVERSITY OF MEDICAL WELFARE   (Japan)

^e Batterjee Medical College for Sciences and Technology   (Saudi Arabia)

Author keywords

CT antigen; SEREX; TEKT5

Indexed keywords

CANCER TESTIS ANTIGEN; COMPLEMENTARY DNA; MESSENGER RNA;

A KINASE ANCHORINA PROTEIN 3 GENE; ADULT; ANTIBODY DETECTION; ARTICLE; CANCER LOCALIZATION; COLON CANCER; CONTROLLED STUDY; DISEASE MARKER; DNA ISOLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; IMMUNOGENICITY; MAJOR CLINICAL STUDY; MOLECULAR CLONING; ONCOGENE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROLOGY; TEKTIN5 GENE;

ANTIBODY FORMATION; ANTIGENS, NEOPLASM; CLONING, MOLECULAR; DNA, COMPLEMENTARY; HUMANS; MALE; MICROTUBULE PROTEINS; NEOPLASMS; SEROLOGIC TESTS; TESTIS; TRANSCRIPTOME;

EID: 84868705063     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-520     Document Type: Article

References (26)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012, 62:10-29. 10.3322/caac.20138, 22237781.
2. Scanlan MJ, Güre AO, Jungbluth AA, Old LJ, Chen YT. Cancer/testis antigens: an expanding family of targets for cancer immunotherapy. Immunol Rev 2002, 188:22-32. 10.1034/j.1600-065X.2002.18803.x, 12445278.
3. Jungbluth AA, Chen YT, Stockert E, Busam KJ, Kolb D, Iversen K, Coplan K, Williamson B, Altorki N, Old LJ. Immunohistochemical analysis of NY-ESO-1 antigen expression in normal and malignant human tissues. Int J Cancer 2001, 92:856-860. 10.1002/ijc.1282, 11351307.
4. Güre AO, Türeci O, Sahin U, Tsang S, Scanlan MJ, Jäger E, Knuth A, Pfreundschuh M, Old LJ, Chen YT. SSX: a multigene family with several members transcribed in normal testis and human cancer. Int J Cancer 1997, 72:965-971. 10.1002/(SICI)1097-0215(19970917)72:6<965::AID-IJC8>3.0.CO;2-N, 9378559.
5. Türeci O, Sahin U, Zwick C, Koslowski M, Seitz G, Pfreundschuh M. Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens. Proc Natl Acad Sci USA 1998, 95:5211-5216. 10.1073/pnas.95.9.5211, 20240, 9560255.
6. Chen YT, Scanlan MJ, Sahin U, Türeci O, Güre AO, Tsang S, Williamson B, Stockert E, Pfreundschuh M, Old LJ. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci USA 1997, 94:1914-1918. 10.1073/pnas.94.5.1914, 20017, 9050879.
7. Ali Eldib AM, Ono T, Shimono M, Kaneko M, Nakagawa K, Tanaka R, Noguchi Y, Nakayama E. Immunoscreening of a cDNA library from a lung cancer cell line using autologous patient serum: Identification of XAGE-1b as a dominant antigen and its immunogenicity in lung adenocarcinoma. Int J Cancer 2004, 108:558-563. 10.1002/ijc.11587, 14696120.
8. Domae S, Nakamura Y, Nakamura Y, Uenaka A, Wada H, Nakata M, Oka M, Kishimoto K, Tsukamoto G, Yoshihama Y, Matsuoka J, Gochi A, Kohno S, Saika T, Sasaki A, Nakayama E, Ono T. Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity. Int J Cancer 2009, 124:2347-2352. 10.1002/ijc.24220, 19165854.
9. Steffen W, Linck RW. Evidence for tektins in centrioles and axonemal microtubules. Proc Natl Acad Sci USA 1988, 85:2643-2647. 10.1073/pnas.85.8.2643, 280054, 3282233.
10. Amos LA. The tektin family of microtubule-stabilizing proteins. Genome Biol 2008, 9:229. 2530864, 18671835.
11. Hanafusa T, Mohamed AE, Kitaoka K, Ohue Y, Nakayama E, Ono T. Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies. Cancer Lett 2011, 301:57-62. 10.1016/j.canlet.2010.10.024, 21094583.
12. Beene DL, Scott JD. A-kinase anchoring proteins take shape. Curr Opin Cell Biol 2007, 19:192-198. 10.1016/j.ceb.2007.02.011, 17317140.
13. Hoshi N, Langeberg LK, Scott JD. Distinct enzyme combinations in AKAP signalling complexes permit functional diversity. Nat Cell Biol 2005, 7:1066-1073.
14. Vijayaraghavan S, Liberty GA, Mohan J, Winfrey VP, Olson GE, Carr DW. Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. Mol Endocrinol 1999, 13:705-717. 10.1210/me.13.5.705, 10319321.
15. Hasegawa K, Ono T, Matsushita H, Shimono M, Noguchi Y, Mizutani Y, Kodama J, Kudo T, Nakayama E. A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis. Int J Cancer 2004, 108:86-90. 10.1002/ijc.11565, 14618620.
16. Linck RW, Albertini DF, Kenney DM, Langevin GL. Tektin filaments: chemically unique filaments of sperm flagellar microtubules. Prog Clin Biol Res 1982, 80:127-132.
17. Roy A, Yan W, Burns KH, Matzuk MM. Tektin3 encodes an evolutionarily conserved putative testicular microtubules-related protein expressed preferentially in male germ cells. Mol Reprod Dev 2004, 67:295-302. 10.1002/mrd.20025, 14735490.
18. Cao W, Ijiri TW, Huang AP, Gerton GL. Characterization of a novel tektin member, TEKT5, in mouse sperm. J Androl 2011, 32:55-69. 10.2164/jandrol.109.009456, 20378928.
19. Murayama E, Yamamoto E, Kaneko T, Shibata Y, Inai T, Iida H. Tektin5, a new Tektin family member, is a component of the middle piece of flagella in rat spermatozoa. Mol Reprod Dev 2008, 75:650-658. 10.1002/mrd.20804, 17924527.
20. Takiguchi H, Murayama E, Kaneko T, Kurio H, Toshimori K, Iida H. Characterization and subcellular localization of Tektin 3 in rat spermatozoa. Mol Reprod Dev 2011, 78:611-620. 10.1002/mrd.21352, 21744413.
21. Xu M, Zhou Z, Cheng C, Zhao W, Tang R, Huang Y, Wang W, Xu J, Zeng L, Xie Y, Mao Y. Cloning and characterization of a novel human TEKTIN1 gene. Int J Biochem Cell Biol 2001, 33:1172-1182. 10.1016/S1357-2725(01)00089-9, 11606253.
22. Wolkowicz MJ, Naaby-Hansen S, Gamble AR, Reddi PP, Flickinger CJ, Herr JC. Tektin B1 demonstrates flagellar localization in human sperm. Biol Reprod 2002, 66:241-250. 10.1095/biolreprod66.1.241, 11751288.
23. Stockert E, Jäger E, Chen YT, Scanlan MJ, Gout I, Karbach J, Arand M, Knuth A, Old LJ. A survey of the humoral immune response of cancer patients to a panel of human tumor antigens. J Exp Med 1998, 187:1349-1354. 10.1084/jem.187.8.1349, 2212223, 9547346.
24. Jäger E, Nagata Y, Gnjatic S, Wada H, Stockert E, Karbach J, Dunbar PR, Lee SY, Jungbluth A, Jäger D, Arand M, Ritter G, Cerundolo V, Dupont B, Chen YT, Old LJ, Knuth A. Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses. Proc Natl Acad Sci USA 2000, 97:4760-4765. 10.1073/pnas.97.9.4760, 18306, 10781081.
25. Gnjatic S, Nishikawa H, Jungbluth AA, Güre AO, Ritter G, Jäger E, Knuth A, Chen YT, Old LJ. NY-ESO-1: review of an immunogenic tumor antigen. Adv Cancer Res 2006, 95:1-30.
26. Uenaka A, Wada H, Isobe M, Saika T, Tsuji K, Sato E, Sato S, Noguchi Y, Kawabata R, Yasuda T, Doki Y, Kumon H, Iwatsuki K, Shiku H, Monden M, Jungbluth AA, Ritter G, Murphy R, Hoffman E, Old LJ, Nakayama E. T cell immunomonitoring and tumor responses in patients immunized with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein. Cancer Immun 2007, 7:9. 2935756, 17441676.