Antidiabetic effect of Eclipta alba associated with the inhibition of alpha-glucosidase and aldose reductase

Natural Product Research

Volumn 26, Issue 24, 2012, Pages 2363-2367

  Jaiswal, Natasha ^a   Bhatia, Vikram ^a   Srivastava, Swayam Prakash ^a   Srivastava, Arvind Kumar ^a   Tamrakar, Akhilesh Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

aldose reductase; alpha glucosidase; diabetes mellitus; Eclipta alba

Indexed keywords

ACARBOSE; ALCOHOL; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; ALPHA GLUCOSIDASE; ANTIDIABETIC AGENT; CREATININE; ECLIPTA ALBA EXTRACT; GLUCOSE; HEMOGLOBIN A1C; INSULIN; METFORMIN; QUERCETIN; UREA; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; DOSE RESPONSE; DRUG EFFECT; ECLIPTA; ECLIPTA ALBA; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HYPERGLYCEMIA; IC 50; INSULIN BLOOD LEVEL; MEDICINAL PLANT; NONHUMAN; RAT; RENAL PROTECTION; SINGLE DRUG DOSE; STREPTOZOCIN DIABETES; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL;

ADMINISTRATION, ORAL; ALDEHYDE REDUCTASE; ALPHA-GLUCOSIDASES; ANIMALS; BLOOD GLUCOSE; CREATININE; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ECLIPTA; HYPOGLYCEMIC AGENTS; INDIA; INHIBITORY CONCENTRATION 50; INSULIN; LENS, CRYSTALLINE; PLANT EXTRACTS; RATS; UREA; URIC ACID;

ANIMALIA; ECLIPTA PROSTRATA; RATTUS;

EID: 84868695818     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2012.662648     Document Type: Article

References (14)

1. Ananthi, J, Prakasam, A, and, Pugalendi, KV. 2003. Antihyperglycemic activity of Eclipta alba leaf on alloxan-induced diabetic rats. The Yale Journal of Biology and Medicine, 76: 97-102. (Pubitemid 40990778)
2. Aurell, M, and, Bjrck, S. 1992. Determinants of progressive renal disease in diabetes mellitus. Kidney International, 36: 38-42.
3. Bedekar, A, Shah, K, and, Koffas, M. 2010. Natural products for type II diabetes treatment. Advances in Applied Microbiology, 71: 21-73.
4. Bischoff, H. 1994. Pharmacology of alpha-glucosidase inhibition. European Journal of Clinical Investigation, 3: 3-10.
5. Bopanna, KN, and, Rathod, SP. 1997. Antidiabetic and antihyperlipademic effects of neem seed kernel powder on alloxon diabetic rabbits. Indian Journal of Pharmacology, 29: 162-167. (Pubitemid 27296934)
6. Carper, DA, Wistow, G, Nishimura, C, Graham, C, Wanatable, K, Fujii, Y, Hayashi, O. 1989. A superfamily of NADPH-dependent reductases in eukaryotes and prokaryotes. Experimental Eye Research, 49: 377-388. (Pubitemid 19239396)
7. Grover, JK, Yadav, S, and, Vats, V. 2002. Medicinal plants of India with antidiabetic potential. Journal of Ethnopharmacology, 81: 81-100. (Pubitemid 34518472)
8. King, H, Aubert, RE, and, Herman, WH. 1998. Global burden of diabetes. Diabetes Care, 21: 1414-1431.
9. Kinoshita, JH. 1990. A thirty-year journey in the polyol pathway. Experimental Eye Research, 50: 563-573.
10. Nishimura, YC. 1998. Aldose reductase in glucose toxicity: a potential target for the prevention of diabetic complications. Pharmacological Review, 50: 21-34.
11. Sangeeta, RK, and, Ralph, AD. 2007. The Insulin resistance syndrome: physiological considerations. Diabetes and Vascular Disease Research, 4: 13-19.
12. Singh, B, Saxena, AK, Chandan, BK, Agrawal, SG, and, Anand, KK. 2001. Invivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian Journal of Physiology and Pharmacology, 45: 435-441. (Pubitemid 33026896)
13. Stuart, AR, Gulve, EA, and, Wang, M. 2004. Chemistry and biochemistry of type 2 diabetes. Chemical Reviews, 104: 1255-1282.
14. Tamrakar, AK, Yadav, PP, Tiwari, P, Maurya, R, and, Srivastava, AK. 2008. Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits. Journal of Ethnopharmacology, 18: 435-439.