QSAR, docking and in vitro studies for anti-inflammatory activity of cleomiscosin A methyl ether derivatives

European Journal of Pharmaceutical Sciences

Volumn 47, Issue 5, 2012, Pages 952-964

  Sharma, Shelly ^a   Chattopadhyay, Sunil Kumar ^a   Yadav, Dharmendra Kumar ^a   Khan, Feroz ^a   Mohanty, Shilpa ^a   Maurya, Anil ^a   Bawankule, Dnyaneshwar Umrao ^a  

^a CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

Author keywords

Anti inflammatory activity; Cleomiscosin A methyl ether; Novel polyhalogenated derivative; QSAR

Indexed keywords

( 3,5,2' TRICHLORO)CLEIOMISCOSIN A METHYL ETHER; ( 3,5,5' TRIIODO)CLEOMISCOSIN A METHYL ETHER; ( 3,5,5',6' TETRABROMO)CLEOMISCOSIN A METHYL ETHER; ( 5,6' DICHLORO)CLEOMISCOSIN A METHYL ETHER; ( 5,6' DIIODO)CLEOMISCOSIN A METHYL ETHER; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 9' METHYL ESTER CLEOMISCOSIN A METHYL ETHER; ANTIINFLAMMATORY AGENT; CLEOMISCOSIN A METHYL ETHER DERIVATIVE; CYTOKINE; DICLOFENAC; ETHER DERIVATIVE; INTERLEUKIN 1BETA; INTERLEUKIN 6; POLYHALO DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOASSAY; CELL CULTURE; CELL ISOLATION; CELL VIABILITY; COLUMN CHROMATOGRAPHY; COMPUTER MODEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PENETRATION; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; IC 50; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; MOLECULAR DOCKING; MOLECULE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; COUMARINS; CYTOKINES; FEMALE; MACROPHAGES, PERITONEAL; METHYL ETHERS; MICE; MOLECULAR DOCKING SIMULATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84868688248     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.09.008     Document Type: Article

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