The metabolic response of Candida albicans to farnesol under hyphae-inducing conditions

FEMS Yeast Research

Volumn 12, Issue 8, 2012, Pages 879-889

  Han, Ting Li ^a   Cannon, Richard D ^b   Villas Bôas, Silas G ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Candida albicans; Farnesol; Filamentous growth; Metabolomics; Quorum sensing molecules

Indexed keywords

FARNESOL;

ARTICLE; CANDIDA ALBICANS; CARBON METABOLISM; FUNGUS HYPHAE; LIPID METABOLISM; MASS FRAGMENTOGRAPHY; METABOLOMICS; NONHUMAN; UPREGULATION;

BIOMASS; CANDIDA ALBICANS; CARBON; CULTURE MEDIA; FARNESOL; FATTY ACIDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENE EXPRESSION REGULATION, FUNGAL; HYPHAE; METABOLOME; METABOLOMICS; MORPHOGENESIS; QUORUM SENSING; SIGNAL TRANSDUCTION; UP-REGULATION;

CANDIDA ALBICANS; FUNGI;

EID: 84868633557     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2012.00837.x     Document Type: Article

References (42)

1. Abe S, Tsunashima R, Iijima R, Yamada T, Maruyama N, Hisajima T, Abe Y, Oshima H & Yamazaki M (2009) Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress. Microbiol Immunol 53: 323-330.
2. Aggio RBM, Ruggiero K & Villas-Bôas SG (2010) Pathway activity profiling (papi): From the metabolite profile to the metabolic pathway activity. Bioinformatics 26: 2969-2976.
3. Albuquerque P & Casadevall A (2012) Quorum sensing in fungi-a review. Med Mycol 50: 1-9.
4. Alem MAS, Oteef MDY, Flowers TH & Douglas LJ (2006) Production of tyrosol by Candida albicans biofilms and its role in quorum sensing and biofilm development. Eukaryot Cell 5: 1770-1779.
5. Aoki S & Ito-Kuwa S (1982) Respiration of Candida albicans in relation to its morphogenesis. Plant Cell Physiol 23: 721-726.
6. Cao YY, Cao YB, Xu Z, Ying K, Li Y, Xie Y, Zhu ZY, Chen WS & Jiang YY (2005) cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesol. Antimicrob Agents Chemother 49: 584-589.
7. Cho T, Aoyama T, Toyoda M, Nakayama H, Chibana H & Kaminishi H (2007) Transcriptional changes in Candida albicans genes by both farnesol and high cell density at an early stage of morphogenesis in N-acetyl-D-glucosamine medium. Jpn J Med Mycol 48: 159-167.
8. Davis-Hanna A, Piispanen AE, Stateva LI & Hogan DA (2008) Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. Mol Microbiol 67: 47-62.
9. Deveau A & Hogan DA (2011) Linking quorum sensing regulation and biofilm formation by Candida albicans. Methods Mol Biol 692: 219-233.
10. Fairn GD, MacDonald K & McMaster CR (2007) A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway. J Biol Chem 282: 4868-4874.
11. Hall RA, Turner KJ, Chaloupka J, Cottier F, de Sordi L, Sanglard D, Levin LR, Buck J & Mühlschlegel FA (2011) The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans. Eukaryot Cell 10: 1034-1042.
12. Han TL, Cannon RD & Villas-Bôas SG (2011) The metabolic basis of Candida albicans morphogenesis and quorum sensing. Fungal Genet Biol 48: 747-763.
13. Han TL, Cannon RD & Villas-Bôas SG (2012) Metabolome analysis during the morphological transition of Candida albicans. Metabolomics, doi: 10.1007/s11306-012-0416-6.
14. Holmes AR & Shepherd MG (1987) Proline-induced germ-tube formation in Candida albicans: role of proline uptake and nitrogen metabolism. J Gen Microbiol 133: 3219-3228.
15. Hornby JM, Jensen EC, Lisec AD, Tasto JJ, Jahnke B, Shoemaker R, Dussault P & Nickerson KW (2001) Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl Environ Microbiol 67: 2982-2992.
16. Kebaara BW, Langford ML, Navarathna DHMLP, Dumitru R, Nickerson KW & Atkin AL (2008) Candida albicans Tup1 is involved in farnesol-mediated inhibition of filamentous-growth induction. Eukaryot Cell 7: 980-987.
17. Land GA, McDonald WC, Stjernholm RL & Friedman L (1975) Factors affecting filamentation in Candida albicans: changes in respiratory activity of Candida albicans during filamentation. Infect Immun 12: 119-127.
18. Liu P, Deng B, Long CA & Min X (2009) Effect of farnesol on morphogenesis in the fungal pathogen Penicillium expansum. Ann Microbiol 59: 33-38.
19. Maidan MM, Thevelein JM & Van Dijck P (2005) Carbon source induced yeast-to-hypha transition in Candida albicans is dependent on the presence of amino acids and on the G-protein-coupled receptor Gpr1. Biochem Soc Trans 33: 291-293.
20. Montserrat M-G, Perumal P, Mekala S, Nombela C, Chaffin WL & Gil C (2009) Proteomic analysis of cytoplasmic and surface proteins from yeast cells, hyphae, and biofilms of Candida albicans. Proteomics 9: 2230-2252.
21. Moran C, Grussemeyer CA, Spalding JR, Benjamin DK Jr & Reed SD (2010) Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections. Am J Infect Control 38: 78-80.
22. Mosel DD, Dumitru R, Hornby JM, Atkin AL & Nickerson KW (2005) Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum. Appl Environ Microbiol 71: 4938-4940.
23. Navarathna DHMLP, Hornby JM, Hoerrmann N, Parkhurst AM, Duhamel GE & Nickerson KW (2005) Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis. J Antimicrob Chemother 56: 1156-1159.
24. Pfaller MA & Diekema DJ (2007) Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 20: 133-163.
25. Reynolds R & Braude AI (1956) The filament inducing property of blood for Candida albicans; its nature and significance. Clin Res Proc 4: 40.
26. Rozpȩdowska E, Galafassi S, Johansson L, Hagman A, Piškur J & Compagno C (2011) Candida albicans - a pre-whole genome duplication yeast - is predominantly aerobic and a poor ethanol producer. FEMS Yeast Res 11: 285-291.
27. Sato T, Watanabe T, Mikami T & Matsumoto T (2004) Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascade. Biol Pharm Bull 27: 751-752.
28. Scheper MA, Shirtliff ME, Meiller TF, Peters BM & Jabra-Rizk MA (2008) Farnesol, a fungal quorum-sensing molecule triggers apoptosis in human oral squamous carcinoma cells. Neoplasia 10: 954-963.
29. Semighini CP, Hornby JM, Dumitru R, Nickerson KW & Harris SD (2006) Farnesol-induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi. Mol Microbiol 59: 753-764.
30. Shirtliff ME, Krom BP, Meijering RAM, Peters BM, Zhu J, Scheper MA, Harris ML & Jabra-Rizk MA (2009) Farnesol-induced apoptosis in Candida albicans. Antimicrob Agents Chemother 53: 2392-2401.
31. Smart KF, Aggio RBM, Van Houtte JR & Villas-Bôas SG (2010) Analytical platform for metabolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatography-mass spectrometry. Nat Protoc 5: 1709-1729.
32. Smith DA, Nicholls S, Morgan BA, Brown AJP & Quinn J (2004) A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans. Mol Biol Cell 15: 4179-4190.
33. Veiga A, Arrabaça JD & Loureiro-Dias MC (2000) Cyanide-resistant respiration is frequent, but confined to yeasts incapable of aerobic fermentation. FEMS Microbiol Lett 190: 93-97.
34. Verduyn C, Postma E, Scheffers WA & Van Dijken JP (1992) Effect of benzoic acid on metabolic fluxes in yeasts: a continuous-culture study on the regulation of respiration and alcoholic fermentation. Yeast 8: 501-517.
35. Watanabe T, Ogasawara A, Mikami T & Matsumoto T (2006) Hyphal formation of Candida albicans is controlled by electron transfer system. Biochem Biophys Res Commun 348: 206-211.
36. Weber K, Sohr R, Schulz B, Fleischhacker M & Ruhnke M (2008) Secretion of E, E-farnesol and biofilm formation in eight different Candida species. Antimicrob Agents Chemother 52: 1859-1861.
37. Weber K, Schulz B & Ruhnke M (2010) The quorum-sensing molecule E, E-farnesol - Its variable secretion and its impact on the growth and metabolism of Candida species. Yeast 27: 727-739.
38. Westwater C, Balish E & Schofield DA (2005) Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance. Eukaryot Cell 4: 16540-16610.
39. Whiteway M & Oberholzer U (2004) Candida morphogenesis and host-pathogen interactions. Curr Opin Microbiol 7: 350-357.
40. Wickham H (2009) ggplot2: Elegant Graphics for Data Analysis. Springer, New York.
41. Yamaguchi H (1974) Dimorphism in Candida albicans. I. Morphology dependent changes in cellular content of macromolecules and respiratory activity. J Gen Appl Microbiol 20: 87-99.
42. Zhang JG & Fariss MW (2002) Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity. Biochem Pharmacol 63: 751-754.