Interleukin-6-174 G/C polymorphism is not associated with IL-6 expression and susceptibility to sporadic colon cancer

DNA and Cell Biology

Volumn 29, Issue 4, 2010, Pages 177-182

  Čačev, Tamara ^a   Jokić, Mladen ^a   Lončar, Božo ^b   Križanac, Šimun ^b   Kapitanović, Sanja ^a  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b University of Zagreb   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; MESSENGER RNA;

ADULT; AGED; ARTICLE; CANCER SUSCEPTIBILITY; COLON CANCER; CONTROLLED STUDY; DNA BASE COMPOSITION; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; COLON TUMOR; CYTOPLASM; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; COLONIC NEOPLASMS; CYTOPLASM; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 77951214540     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2009.0950     Document Type: Article

References (24)

1. Bonafe, M., Olivieri, F., Cavallone, L., Giovagnetti, S., Marchegiani, F., Cardelli, M., Pieri, C., Marra, M., Antonicelli, R., Lisa, R., Rizzo, M.R., Paolisso, G., Monti, D., and Franceschi, C. (2001). A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur J Immunol 31, 2357-2361.
2. De Michelle, A., Martin, A.M., Mick, R., Gor, P., Wray, L., Klein-Cabral, M., Athanasiadis, G., Colligan, T., Stadtmauer, E., and Weber, B. (2003). Interleukin-6-174 G/C polymorphism is associated with improved outcome in high risk breast cancer. Cancer Res 63, 8051-8056.
3. Endler, G., Marsik, C., Joukhadar, C., Marculescu, R., Mayr, F., Mannhalter, C., Wagner, O.F., and Jilma, B. (2004). The interleukin-6-174 G/C promoter polymorphism does not determine plasma interleukin-6 concentrations in experimental endotoxemia in humans. Clin Chem 50, 195-200.
4. Fishman, D., Faulds, G., Jeffery, R., Mohamed-Ali, V., Yudkin, J.S., Humphries, S., and Woo, P. (1998). The effect of novel polymorphism in the interleukin-6 (IL-6) gene on IL-6 transcription and serum IL-6 levels, and association with systemic-onset juvenile chronic arthritis. J Clin Investig 102, 1369-1376.
5. Gabay, C. (2006). Interleukin-6 and chronic inflammation. Arthritis Res Ther 8(Supp 2), S3.
6. Haukim, N., Bidwell, J.L., Smith, A.J.P., Keen, L.J., Gallagher, G., Kimberly, R., Huizinga, T., McDermott, M.F., Oksenberg, J., McNicholl, J., Pociot, F., Hardt, C., and D'Alfonso, S. (2002). Cytokine gene polymorphism in human disease: on-line databases. Genes Immun 3(Suppl 2), 313-330.
7. Heikkila, K., Ebrahim, S., and Lawlor, D.A. (2008). Systematic review of the association between circulating interleukin-6 (IL-6) and cancer. Eur J Cancer 44, 937-945.
8. Hodge, D.R., Hurt, E.M., and Farrar, W.L. (2005). The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 41, 2502-2512.
9. Hollegaard, M.V., and Bidwell, J.L. (2006). Cytokine gene polymorphism in human disease: on-line databases. Genes Immun 7(Suppl 3), 269-276.
10. Hong, D.S., Angelo, L.S., and Kurzrack, R. (2007). Interleukin-6 and its receptor in cancer. Cancer 110, 1911-1928.
11. Kotnis, A., Sarin, R., and Mulherkar, R. (2005). Genotype, phenotype and cancer: role of low penetrance genes and environment in tumour susceptibility. J Biosci 30, 93-102.
12. Landi, S., Moreno, V., Gioia-Patricola, L., Guino, E., Navarro, M., de Oca, J., Capella, G., and Canzian, F. (2003). Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer. Cancer Res 63, 3560-3566.
13. Lieb, W., Pavlik, R., Erdmann, J., Mayer, B., Holmer, S.R., Fischer, M., Baessler, A., Hengstenberg, C., Loewel, H., Doering, A., Riegger, G.A., and Schunkert, H. (2004). No association of interleukin-6 gene polymorphism (-174 G/C) with myocardial infarction or traditional cardiovascular risk factors. Int J Cardiol 97, 205-212.
14. Naccarati, A., Pardini, B., Hemminki, K., and Vodicka, P. (2007). Sporadic colorectal cancer and individual susceptibility: a review of the association studies investigating the role of DNA repair genetic polymorphisms. Mutat Res 635, 118-145.
15. Naugler, W.E., and Karin, M. (2008). The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med 14, 109-119.
16. Reyes-Gibby, C.C., Wu, X., Spitz, M., Kurzrock, R., Fisch, M., Bruera, E., and Shete, S. (2008). Molecular epidemiology, cancer related symptoms, and cytokine pathway. Lancet Oncol 9, 777-785.
17. Ries, L.A.G., Melbert, D., Krapcho, M., Stinchcomb, D.G., Howlader, N., Horner, M.J., Mariotto, A., Miller, B.A., Feuer, E.J., Altekruse, S.F., Lewis, D.R., Clegg, L., Eisner, M.P., Reichman, M., and Edwards, B.K., eds. (2007). SEER Cancer Statistics Review, 1975-2005 (National Cancer Institute, Bethesda, MD).
18. Schafer, Z.T., and Brugge, J.S. (2007). IL-6 involvement in epithelial cancers. J Clin Invest 117, 3660-3663.
19. Slattery, M.L., Wolff, R.K., Herrick, J.S., Caan, B.J., and Potter, J.D. (2007). IL6 genotypes and colon and rectal cancer. Cancer Causes Control 18, 1095-1105.
20. Spaventi, R., Pecur, L., Pavelic, K., Pavelic, Z.P., Spaventi, S., and Stambrook, P.J. (1994). Human tumour bank in Croatia: a possible model for a small bank as a part of future European tumour bank network. Eur J Cancer 30A, 419.
21. Terry, C.F., Loukaci, V., and Green, F.R. (2000). Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem Mol Biol 275, 18138-18144.
22. Theodoropoulos, G., Papaconstantinou, I., Felekouras, E., Nikiteas, N., Karakitsos, P., Panoussopoulos, D., Lazaris, A., Patsouris, E., Bramis, J., and Gazouli, M. (2006). Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer. World J Gastroenterol 12, 5037-5043.
23. Vogelstein, B., and Kinzler, K.W. (2004). Cancer genes and the pathways they control. Nat Med 10, 789-799.
24. Wieser, F., Fabjani, G., Tempfer, C., Schneeberger, C., Sator, M., Huber, J., and Wenzl, R. (2003). Analysis of an interleukin 6 gene promoter polymorphism in women with endometriosis by pyrosequencing. J Soc Gynecol Investig 10, 32-36.