Effect of insulin infusion on spillover of meal-derived fatty acids

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 11, 2012, Pages 4201-4205

  Muthusamy, Kalpana ^a   Nelson, Robert H ^a   Singh, Ekta ^a   Vlazny, Danielle ^a   Smailovic, Almira ^a   Miles, John M ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHYLOMICRON; FATTY ACID; GLUCOSE; INSULIN; PLACEBO; SODIUM CHLORIDE; TRIACYLGLYCEROL; TRIOLEIN;

ADULT; ARTICLE; CLINICAL ARTICLE; DRUG EFFICACY; DRUG MECHANISM; DYSLIPIDEMIA; FATTY ACID BLOOD LEVEL; FATTY ACID SYNTHESIS; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID DIET; LIPOLYSIS; MALE; OBESITY; PRIORITY JOURNAL; REGULATORY MECHANISM; STEADY STATE;

ADULT; BLOOD GLUCOSE; FATTY ACIDS, NONESTERIFIED; HUMANS; INSULIN; LIPOLYSIS; MALE; MEALS; OBESITY; OVERWEIGHT;

EID: 84868628522     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-1468     Document Type: Article

References (23)

1. Boden G, Chen X, Ruiz J, White JV, Rossetti L 1994 Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93:2438-2446 (Pubitemid 24177157)
2. Lewis GF, Uffelman KD, Szeto LW, Weller B, Steiner G 1995 Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J Clin Invest 95:158-166
3. Steinberg HO, Tarshoby M, Monestel R, Hook G, Cronin J, Johnson A, Bayazeed B, Baron AD 1997 Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 100:1230-1239 (Pubitemid 27386309)
4. Grekin RJ, Vollmer AP, Sider RS 1995 Pressor effects of portal venous oleate infusion. A proposed mechanism for obesity hypertension. Hypertension 26:193-198
5. Stojiljkovic MP, Zhang D, Lopes HF, Lee CG, Goodfriend TL, Egan BM 2001 Hemodynamic effects of lipids in humans. Am J Physiol 280:R1674-R1679
6. Coppack SW, Jensen MD, Miles JM 1994 The in vivo regulation of lipolysis in humans. J Lipid Res 35:177-193
7. Miles JM, Park YS, Walewicz D, Russell-Lopez C, Windsor S, Isley WL, Coppack SW, Harris WS 2004 Systemic and forearm triglyceride metabolism: fate of lipoprotein lipase-generated glycerol and free fatty acids. Diabetes 53:521-527 (Pubitemid 38270618)
8. Nelson RH, Basu R, Johnson CM, Rizza RA, Miles JM 2007 Splanchnic spillover of extracellular lipase-generated fatty acids in overweight and obese humans. Diabetes 56:2878-2884 (Pubitemid 350223621)
9. Ruge T, Hodson L, Cheeseman J, Dennis AL, Fielding BA, Humphreys SM, Frayn KN, Karpe F 2009 Fasted to fed trafficking of fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage. J Clin Endocrinol Metab 94:1781-1788
10. Nelson RH, Edgerton DS, Basu R, Roesner JC, Cherrington AD, Miles JM 2007 Triglyceride uptake and lipoprotein lipase-generated fatty acid spillover in the splanchnic bed of dogs. Diabetes 56:1850-1855 (Pubitemid 47025458)
11. Park Y, Grellner WJ, Harris WS, Miles JM 2000 A new method for the study of chylomicron kinetics in vivo. AmJ Physiol 279:E1258-E1263
12. Miles JM, Ellman MG, McClean KL, Jensen MD 1987 Validation of a new method for determination of free fatty acid turnover. Am J Physiol 252:E431-E438
13. Jensen MD, Heiling VJ, Miles JM 1990 Measurement of non-steady-state free fatty acid turnover. Am J Physiol 258:E103-E108 (Pubitemid 20068586)
14. Persson XM, Blachnio-Zabielska AU, Jensen MD 2010 Rapid measurement of plasma free fatty acid concentration and isotopic enrichment using LC/MS. J Lipid Res 51:2761-2765
15. Riggs D 1968 The mathematical approach to physiological problems: a critical primer. Baltimore, MD: Williams and Wilkins
16. Jensen MD, Caruso M, Heiling V, Miles JM 1989 Insulin regulation of lipolysis in nondiabetic and IDDM subjects. Diabetes 38:1595-1601 (Pubitemid 20006686)
17. Bolinder J, Kager L, Ostman J, Arner P 1983 Differences at the receptor and postreceptor levels between human omental and subcutaneous adipose tissue in the action of insulin on lipolysis. Diabetes 32:117-123 (Pubitemid 13180343)
18. Meek SE, Nair KS, Jensen MD 1999 Insulin regulation of regional free fatty acid metabolism. Diabetes 48:10-14 (Pubitemid 29019346)
19. Wang H, Eckel RH 2009 Lipoprotein lipase: from gene to obesity. Am J Physiol 297:E271-E288
20. Nelson R, Vlazny D, Smailovic A, Miles J 24 August 2012 Intravenous niacin acutely improves the efficiency of dietary fat storage in lean and obese humans. Diabetes 10.2337/db12-0236
21. Nguyen TT, Hernández Mijares A, Johnson C, Jensen MD 1996 Postprandial leg and splanchnic fatty acid metabolism in nonobese men and women. Am J Physiol 271:E965-E972 (Pubitemid 27030589)
22. Ravussin E, Smith SR 2002 Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus. Ann NY Acad Sci 967:363-378 (Pubitemid 34721922)
23. Evans K, Burdge GC, Wootton SA, Clark ML, Frayn KN 2002 Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle. Diabetes 51:2684-2690 (Pubitemid 34970919)