Central QCT reveals lower volumetric BMD and stiffness in premenopausal women with idiopathic osteoporosis, regardless of fracture history

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 11, 2012, Pages 4244-4252

  Cohen, Adi ^a   Lang, Thomas F ^b   McMahon, Donald J ^a   Liu, X Sherry ^a   Guo, X Edward ^a   Zhang, Chiyuan ^a   Stein, Emily M ^a   Dempster, David W ^c   Young, Polly ^a   Saeed, Isra ^b   Lappe, Joan M ^d   Recker, Robert R ^d   Shane, Elizabeth ^a  

^a College of Physicians and Surgeons ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HELEN HAYES HOSPITAL   (United States)

^d CREIGHTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BONE DENSITY; BONE FRAGILITY; BONE STIFFNESS; BONE STRENGTH; BONE STRUCTURE; CENTRAL QUANTITATIVE COMPUTER ASSISTED TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; FINITE ELEMENT ANALYSIS; FRAGILITY FRACTURE; HIP; HUMAN; IDIOPATHIC OSTEOPOROSIS; LUMBAR SPINE; MEDICAL HISTORY; MUSCULOSKELETAL STIFFNESS; PREDICTIVE VALUE; PREMENOPAUSE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; THREE DIMENSIONAL IMAGING;

ADOLESCENT; ADULT; BONE AND BONES; BONE DENSITY; FEMALE; FINITE ELEMENT ANALYSIS; FRACTURES, BONE; HUMANS; MIDDLE AGED; OSTEOPOROSIS; PREMENOPAUSE;

EID: 84868624315     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-2099     Document Type: Article

References (21)

1. Adams J, Bishop N 2008 DXA in adults and children. In: Rosen CJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. Chap 29. Washington, DC: American Society for Bone and Mineral Research; 152-158
2. Cohen A, Shane E 2008 Premenopausal osteoporosis. In: Rosen CJ, ed. Primer on the metabolic bone diseases and other disorders of bone and mineral metabolism. Washington, DC: American Society for Bone and Mineral Research; 289-293
3. Kahn AA, Syed Z 2004 Bone densitometry in premenopausal women: synthesis and review. J Clin Densitom 7:85-92 (Pubitemid 38223469)
4. Gourlay ML, Brown SA 2004 Clinical considerations in premenopausal osteoporosis. Arch Intern Med 164:603-614 (Pubitemid 38392974)
5. Lewiecki EM 2004 Low bone mineral density in premenopausal women. South Med J 97:544-550 (Pubitemid 38802767)
6. Lewiecki EM, Gordon CM, Baim S, Leonard MB, Bishop NJ, Bianchi ML, Kalkwarf HJ, Langman CB, Plotkin H, Rauch F, Zemel BS, Binkley N, Bilezikian JP, Kendler DL, Hans DB, Silverman S 2008 International Society for Clinical Densitometry 2007 adult and pediatric official positions. Bone 43:1115-1121
7. Cohen A, Recker RR, Lappe J, Dempster DW, Cremers S, McMahon DJ, Stein EM, Fleischer J, Rosen CJ, Rogers H, Staron RB, Lemaster J, Shane E 2012 Premenopausal women with idiopathic low-trauma fractures and/or low bone mineral density. Osteoporos Int 23:171-182
8. Cohen A, Dempster DW, Recker RR, Stein EM, Lappe JM, Zhou H, Wirth AJ, van Lenthe GH, Kohler T, Zwahlen A, Müller R, Rosen CJ, Cremers S, Nickolas TL, McMahon DJ, Rogers H, Staron RB, LeMaster J, Shane E 2011 Abnormal bone microarchitecture and evidence of osteoblast dysfunction in premenopausal women with idiopathic osteoporosis. J Clin Endocrinol Metab 96:3095-3105
9. Cohen A, Liu XS, Stein EM, McMahon DJ, Rogers HF, Lemaster J, Recker RR, Lappe JM, Guo XE, Shane E 2009 Bone microarchitecture and stiffness in premenopausal women with idiopathic osteoporosis. J Clin Endocrinol Metab 94:4351-4360
10. Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A 2004 Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res 19:1006-1012 (Pubitemid 41103458)
11. Lang TF, Leblanc AD, Evans HJ, Lu Y 2006 Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight. J Bone Miner Res 21:1224-1230 (Pubitemid 44128335)
12. Black DM, Bouxsein ML, Marshall LM, Cummings SR, Lang TF, Cauley JA, Ensrud KE, Nielson CM, Orwoll ES 2008 Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT. J Bone Miner Res 23:1326-1333 (Pubitemid 352040188)
13. Cheng X, Li J, Lu Y, Keyak J, Lang T 2007 Proximal femoral density and geometry measurements by quantitative computed tomography: association with hip fracture. Bone 40:169-174 (Pubitemid 44839321)
14. Liu XS, Cohen A, Shane E, Yin PT, Stein EM, Rogers H, Kokolus SL, McMahon DJ, Lappe JM, Recker RR, Lang T, Guo XE 2010 Bone density, geometry, microstructure, and stiffness: relationships between peripheral and central skeletal sites assessed by DXA, HRpQCT, and cQCT in premenopausal women. J Bone Miner Res 25:2229-2238
15. Crawford RP, Cann CE, Keaveny TM 2003 Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography. Bone 33:744-750 (Pubitemid 37222401)
16. Keyak JH, Kaneko TS, Tehranzadeh J, Skinner HB 2005 Predicting proximal femoral strength using structural engineering models. Clin Orthop Relat Res:219-228 (Pubitemid 41099091)
17. Kopperdahl DL, Morgan EF, Keaveny TM 2002 Quantitative computed tomography estimates of the mechanical properties of human vertebral trabecular bone. J Orthop Res 20:801-805 (Pubitemid 34823001)
18. Hui SL, Slemenda CW, Johnston Jr CC 1988 Age and bone mass as predictors of fracture in a prospective study. J Clin Invest 81:1804-1809
19. Leib ES 2005 Treatment of low bone mass in premenopausal women: when may it be appropriate? Curr Osteoporos Rep 3:13-18
20. Licata AA 2000 "Does she or doesn't she . . . have osteoporosis?" The use and abuse of bone densitometry. Endocr Pract 6:336-337
21. Lindsay R 1994 Bone mass measurement for premenopausal women. Osteoporos Int 4:39-41