Glutathione conjugation of busulfan produces a hydroxyl radical-trapping dehydroalanine metabolite

Xenobiotica

Volumn 42, Issue 12, 2012, Pages 1170-1177

  Peer, Cody J ^a   Younis, Islam R ^a,b   Leonard, Stephen S ^c   Gannett, Peter M ^a   Minarchick, Valerie C ^c   Kenyon, Allison J ^c   Rojanasakul, Yon ^a   Callery, Patrick S ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Busulfan; Carbon centered radical; Dehydroalanine; EPR; Glutathione; Hydroxyl radical; Metabolite

Indexed keywords

ANTIOXIDANT; BUSULFAN; CARBON; DEHYDROALANINE; FREE RADICAL; GAMMA GLUTAMYLDEHYDROALANYLGLYCINE; GLUTATHIONE; GLYCINE DERIVATIVE; HYDROXYL RADICAL; SCAVENGER; THIOL; TRIPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG METABOLISM; ELECTRON SPIN RESONANCE; ELIMINATION REACTION; FENTON REACTION; GLUTATHIONE METABOLISM; PHASE 2 CLINICAL TRIAL (TOPIC);

ALANINE; ANTIOXIDANTS; BIOCATALYSIS; BUSULFAN; CHROMATOGRAPHY, LIQUID; CYCLIC N-OXIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; KINETICS; OXIDATION-REDUCTION; PYRIDINES; TANDEM MASS SPECTROMETRY;

EID: 84868616918     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2012.696740     Document Type: Article

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