Anticatabolic activity of alpha-ketoglutaric acid in growing rats

Italian Journal of Animal Science

Volumn 11, Issue 3, 2012, Pages 279-284

  Prandini, Aldo ^a   Morlacchini, Mauro ^b   Sigolo, Samantha ^a   Fiorentini, Lucia ^a   Gallo, Antonio ^a  

^a UNIVERSITÀ CATTOLICA DEL SACRO CUORE   (Italy)

^b CERZOO   (Italy)

Author keywords

Alpha ketoglutaric acid; Free amino acids; Intestinal morphology; Nitrogen balance; Rat

Indexed keywords

ANIMALIA; RATTUS;

EID: 84868604567     PISSN: 15944077     EISSN: None     Source Type: Journal    
DOI: 10.4081/ijas.2012.e52     Document Type: Article

References (40)

1. AOAC, e. Official Methods of Analysis, 16th ed., Association of Official Analytical Chemists, Arlington, VA, USA.
2. Bergen, W.G., Wu, G., 2009. Intestinal nitrogen recycling and utilization in health and disease. J. Nutr. 139:821-825.
3. Beza, R., 1986. Studies on nitrogen metabolism in rats of different age fed on a protein free diet. Arch. Anim. Nutr. 36:341-350.
4. Blarzino, C., Coccia, R., Pensa, B., Cini, C., De Marco, C., 1994. Selenomethionine as a substrate for glutamine transaminase. Biochem. Mol. Biol. Int. 32:79-86.
5. Blomqvist, B.I., Harrarqvist, F., Von der Decken, A., Wernerman, J., 1995. Glutamine and aketoglutarate prevent the decrease in muscle free glutamine concentration and influence protein synthesis after total hip replacement. Metabolism 44:1215-1222.
6. Chawalibog, A., Sawosz, E., Niemiec, T., Grodzik, M., Thorbek, G., 2008. Nitrogen excretion in rats on a protein-free diet and during starvation. Arch. Anim. Nutr. 62:82-85.
7. Chen, L., Li, P., Wang, J., Li, X., Gao, H., Yin, Y., Hou, Y., Wu, G., 2009. Catabolism of nutritionally essential amino acids in developing porcine enterocytes. Amino Acids 37:143-152.
8. Cynober, L., 2004. Ornithine a-ketoglutarate as a potent precursor of arginine and nitric oxide: a new job for an old friend. J. Nutr. 134:2858-2862.
9. Cynober, L., Coudray-Lucas, C., De Bandt, J.P., Guechot, J., Aussel, C., Salvucci, M., Giboudeau, J., 1990. Action of ornithine alpha-ketoglutarate, ornithine hydrochloride and calcium alpha-ketoglutarate on plasma and hormonal patterns in healthy subjects. J. Am. Coll. Nutr. 9:2-12.
10. Cynober, L.A., 1999. The use of alpha-ketoglutarate salts in clinical nutrition and metabolic care. Curr. Opin. Clin. Nutr. 2:33-38.
11. Dönmez, N., Karsli, M.A., 2004. Effects of protein restriction on the live weight gain and some blood parameters in mature and immature rats. YYU Vet. Fak. Derg. 15:83-86.
12. Drozdowski, L., Thomson, A.B.R., 2006. Intestinal mucosal adaptation. W. J. Gastr. 12:4614-4627.
13. Dumas, F., De Bandt, J.P., Colomb, V., Le Boucher, J., Coudray-Lucas, C., Lavie, S., Brousse, N., Ricour, C., Cynober, L., Goulet, O., 1998. Enteral Ornithine a-ketoglutarate enhances intestinal adaptation to massive resection in rats. Metabolism 47:1366-1371.
14. Filip, R., Pierzynowski, S.G., 2007. The role of glutamine and a-ketoglutarate in gut metabolism and the potential application in medicine and nutrition. J. Clin. Res. 1:9-15.
15. Filip, R., Wdowiak, L., Harrison, A.P., Pierzynowski, S.G., 2008. Dietary supplementation with phytohemagglutinin in combination with a-ketoglutarate limits the excretion of nitrogen via urinary tract. Ann. Agr. Env. Med. 15:309-315.
16. Griffiths, R.D., 2001. The evidence for glutamine use in the critically-ill. Proc. Nutr. Soc. 60:403-410.
17. Hou, Y., Wang, L., Ding, B., Liu, Y., Zhu, H., Liu, J., Li, Y., Kang, O., Yin, Y., Wu, G., 2011. Alpha-ketoglutarate and intestinal function. Front. Biosci. 16:1186-1196.
18. Jeevanandam, M., Ali, M.R., Ramias, L., Schiller, W.R., 1991. Efficiency of ornithine-alpha ketoglutarate (OKGA) as a dietary supplement in growing rats. Clin. Nutr. 10: 55-161.
19. Jeevanandam, M., Holaday, N.J., Petersen, S.C., 1996. Ornithine-a-ketoglutarate (OKG) supplementation is more effective than its component salts in traumatized rats. J. Nutr. 126:2141-2150.
20. Kern, M., Beuttenmuller, D., Diehl, S., McCormick, C., Ambrose, M., 2002. The effects of protein repletion at varied levels on the growth and nutritional status of protein restricted rats. Nutr. Res. 22:957-963.
21. Koehnle, T.J., Russell, M.C., Morin, A.S., Erecius, L.F., Gietzen, W., 2004. Diets deficient in indispensable amino acids rapidly decrease the concentration of the limiting amino acid in the anterior piriform cortex of rats. J. Nutr. 134: 2365-2371.
22. Le Floc'h, N., Meziere, N., Seve, B., 1999. Whole blood and plasma amino acid transfers across the portal drained viscera and liver of the pig. Reprod. Nutr. Dev. 39:433-442.
23. Lobley, G., Hoskin, S.O., McNeil, C.J., 2001. Glutamine in animal science and production. J. Nutr. 131(Suppl.9):2525-2531.
24. Martillotti, F., Antongiovanni, M., Rizzi, L., Santi, E., Bittante, G., 1987. Metodi di analisi per la valutazione degli alimenti di interesse zootecnico. CNR-IPRA Publ., Roma, Italy.
25. Montoya, C.A., Leterme, P., Lalles, J.P., 2006. A protein diet alters small intestinal architecture and digestive enzyme activities in rats. Reprod. Nutr. Dev. 46:49-56.
26. Moukarzel, A.A., Coulet, O., Salas, J.S., Marti-Henneberg, C., Buckman, A.L., Cynober, L., Rappaport, R., Ricour, C., 1994. Growth retardation in children receiving longterm total parenteral nutrition: effects of ornithine a-ketoglutarate. Am. J. Clin. Nutr. 60:408-413.
27. Nielsen, K., Koudrup, J., Elsner, P., Joul, A., Jensen, E.S., 1994. Casein and soya-bean protein have different effects on whole body protein turnover at the same nitrogen balance. Brit. J. Nutr. 72:69-81.
28. Nordgren, A., Karlsson, T., Wiklund, L., 2002. Glutamine concentration and tissue exchange with intravenously administered a-ketoglutaric acid and ammonium: a dose-response study in the pig. Nutr. 18:496-504.
29. Pierzynowski, S.G., Sjodin, A., 1998. Perspectives of glutamine and its derivates as feed additives for farm animals. J. Anim. Sci. 7:79-91.
30. Piva, A., Prandini, A., Fiorentini, L., Morlacchini, M., Galvano, F., Luchansky, J.B., 2002. Tributyrin and lactitol synergistically enhanced the trophic status of the intestinal mucosa and reduced histamine levels in the gut of nursery pigs. J. Anim. Sci. 80:670-680.
31. Pluske, J.R., Williams, I.H., Aherne, F.X., 1996. Villous height and crypt depth in piglets in response to increases in the intake of cows' milk after weaning. Anim. Sci. 62:145-158.
32. Reeds, P.J., Douglas, G.B., 2001. Glutamine and the bowel. J. Nutr. 131:2505-2508.
33. Riedel, E., Nundel, M., Hampl, H., 1996. Alphaketoglutarate application in hemodialysis patients improves amino acid metabolism. Nephron 74:261-265.
34. Sant'Ana, D.M., Molinari, S.L., Miranda-Neto, M.H., 2001. Effects of protein and vitamin B deficiency on blood parameters and myenteric neurons of the colon of rats. Arq. Neuro-Psiquiat. 59:493-498.
35. SAS, 2003. Guide for Personal Computers, ver. 9.13. SAS Institute Inc., Cary, NC, USA.
36. Schmidt, H., Martindale, R., 2003. Nutraceuticals in critical care nutrition. pp 245-264 in: L. Cynober and F.A. Moore (eds.) Nutrition and Critical Care, Nestlé Workshop Series Clinical & Performance Program, vol. 8, Nestec Ltd., Vevey/S Karger AG, Basel, Switzerland.
37. Stein, W.H., Moore, S., 1954. Procedure for the chromatographic determination of amino acids on four pen per cent cross-linked sulfonated polystyrene resins. J. Biol. Chem. 211:893-906.
38. Storm, E., Orskov, E.R., 1984. The nutritive value of rumen microorganisms in ruminants: the limiting amino acids of microbial protein in growing sheep determined by a new approach. Brit. J. Nutr. 57:613-622.
39. Xi, P.B., Jiang, Z.Y., Zheng, C., Lin, Y., Wu, G., 2011. Regulation of protein metabolism by glutamine: implications for nutrition and health. Front. Biosci. 16:578-597.
40. Yao, K., Yin, Y., Li, X., Xi, P., Wang, J., Lei, J., Hou, Y., Wu, G., 2011. Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells. Amino acids 42:2491-2500.