Improvement bioreactor production of cytotoxic saponins in Astragalus membranaceus by combined control of the bioprocess

Comptes Rendus de L'Academie Bulgare des Sciences

Volumn 65, Issue 10, 2012, Pages 1447-1454

  Ionkov, Todor ^a   Ionkova, Iliana ^b   Momekov, Georgi ^b   Sasheva, Pavlina ^b  

^a TECHNICAL UNIVERSITY OF SOFIA   (Bulgaria)

^b MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Astragalus membranaceus; Bioreactor; Combined control of the bioprocess; Cytotoxic activity; Hairy roots; Saponins (astragalo sides)

Indexed keywords

EID: 84868583103     PISSN: 13101331     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Krasteva I., S. Nikolov, M. Kaloga, G. Mayer. Z. Naturforsch., 61b, 2006, No 9, 1166-1169.
2. Rios L. J., P. G. Waterman. Phytoterapy Research, 11, 1997, No 6, 411-418.
3. Ionkova I., G. Momekov, P. Proksch. Fitoterapia (Ital), 81, 2010, No 5, 447-451.
4. Mossman T. J. Immunol. Methods, 16, 1983, No 65 (1-2), 55-63.
5. Konstantinov S. M., H. Eibl, M. R. Berger. Br. J. Haematol., 107, 1999, No 2, 365-380.
6. Chu D. T., J. R. Liu, W. Wong. The in vitro potentiation of LAK cell cytotoxi- city in cancer and AIDS patients induced by F3-a fractionated extract of Astragalus membranaceus, Zhonghua Zhong Liu Za Zhi, 16, 1994, No 3, 167-171.
7. Klamt F., D. T. Passos, M. A. Castro, D. P. Gelain, I. Grivicich, J. C. Moreira. Toxicol. in vitro, 22, 2008, No 4, 873-878.
8. Ishikawa T., H. Nakagawa. J. Exp. Ther. Oncol., 8, 2009, No 1, 5-24.