Are 25 antibodies better than 1?

Blood

Volumn 120, Issue 18, 2012, Pages 3627-3628

  Cuker, Adam ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; FC RECEPTOR; HEMOGLOBIN; RHESUS D ANTIBODY; RHESUS D ANTIGEN; ROZROLIMUPAB;

ANTIGEN BINDING; AUTOIMMUNE THROMBOCYTOPENIA; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG POTENCY; DRUG TOLERANCE; ERYTHROCYTE; HEADACHE; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; MUTATION; NOTE; PHAGOCYTOSIS; POLAND; PRIORITY JOURNAL; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

EID: 84868581760     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-09-452771     Document Type: Note

References (9)

1. Robak T, Windyga J, Trelinski J, et al. Rozrolimupab, a mixture of 25 recombinant human monoclonal RhD antibodies, in the treatment of primary immune thrombocytopenia. Blood. 2012;120(18):3670-3676.
2. Despotovic JM, Lambert MP, Herman JH, et al. RhIG for the treatment of immune thrombocytopenia: consensus and controversy. Transfusion. 2012;52(5):1126-1136.
3. Kumpel BM. Efficacy or RhD monoclonal antibodies in clinical trials as replacement therapy for prophylactic anti-D immunoglobulin: more questions than answers. Vox Sang. 2007;93(2):99-111. (Pubitemid 47228499)
4. Godeau B, Oksenhendler E, Brossard Y, et al. Treatment of chronic autoimmune thrombocytopenic purpura with monoclonal anti-D. Transfusion. 1996;36(4):328-330. (Pubitemid 26141058)
5. Wagner FF. Rhesus Base. http://www.uniulm.de/~fwagner/RH/RB/. Accessed September 2, 2012.
6. Chou ST, Westhoff CM. Molecular biology of the Rh system: clinical considerations for transfusion in sickle cell disease. Hematology Am Soc Hematol Educ Program. 2009;2009:178-184.
7. Kjaersgaard M, Aslam R, Kim M, et al. Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets. Blood. 2007;110(4):1359-1361. (Pubitemid 47281437)
8. Chang TY, Siegel DL. Genetic and immunological properties of phage-displayed human anti-Rh(D) antibodies: implications for Rh(D) epitope topology. Blood. 1998;91(8):3066-3078. (Pubitemid 28227561)
9. Pedersen MW, Jacobsen HJ, Koefoed K, et al. Sym004: a novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy. Cancer Res. 2010;70(2):588-597.