Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets

Blood

Volumn 110, Issue 4, 2007, Pages 1359-1361

  Kjaersgaard, Mimi ^a   Aslam, Rukhsana ^b,c   Kim, Michael ^c   Speck, Edwin R ^b,c   Freedman, John ^b,d,e   Stewart, Donald I H ^f   Wiersma, Erik J ^f   Semple, John W ^b,d,e  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b CANADIAN BLOOD SERVICES   (Canada)

^c Toronto Platelet Immunobiology Group   (Canada)

^d ST MICHAEL'S HOSPITAL   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f Department of Research ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; IMMUNOGLOBULIN G3; MOANTI D ANTIBODY; MONOCLONAL ANTIBODY; RHESUS D ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; FLUORESCENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL;

EID: 34548048157     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-03-079848     Document Type: Article

References (25)

1. Cines DB, Blanchette VS. Immune thrombocytopenic purpura. N Engl J Med. 2002;346:995-1008.
2. Blanchette V. Childhood chronic immune thrombocytopenic purpura (ITP). Blood Rev. 2002;16:23-26.
3. Salama A, Kiefel V, Amberg R, Mueller-Eckhardt C. Treatment of autoimmune thrombocytopenic purpura with rhesus antibodies [anti-Rh0(D)]. Blut. 1984;49:29-35.
4. Andrew M, Blanchette VS, Adams M, et al. A multicenter study of the treatment of childhood chronic idiopathic thrombocytopenic purpura with anti-D. J Pediatr. 1992;120:522-527.
5. Scaradavou A, Woo B, Woloski BM, et al. Intravenous anti-D treatment of immune thrombocytopenic purpura: experience in 272 patients. Blood. 1997;89:2689-2700.
6. Avent ND, Reid ME. The Rh blood group system: a review. Blood. 2000;95:375-387.
7. Cartron JP, Rouillac C, Le Van KC, Mouro I, Colin Y. Tentative model for the mapping of D epitopes on the RhD polypeptide. Transfus Clin Biol. 1996;3:497-503.
8. Flegal WA. Molecular genetics of RH and it clinical application. Transfus Clin Biol. 2006;13:4-12.
9. Kumpel BM, Poole GD, Bradley BA. Human monoclonal anti-D antibodies. I. Their production, serology, and quantitation and potential use a blood grouping reagents. Br J Haematol. 1989;71:125-129.
10. Kumpel BM, Goodrick J, Pamphilon DH, et al. Human Rh D monoclonal antibodies (BRAD-3 and BRAD-5) cause accelerated clearance of Rh D+ red blood cells and suppression of Rh D immunization in Rh D- volunteers. Blood. 1995;86:1701-1709.
11. Nickerson L, Wiersma EJ. Epitope mapping of four monoclonal antibodies specific for the human RhD antigen. Immunol Lett. 2002;80:33-39.
12. Beliard R. Monoclonal anti-D antibodies to prevent alloimmunization: lessons from clinical trials. Transfus Clin Biol. 2006;13:58-64.
13. Kumpel BM, Beliard R, Brossard Y, et al. Section 1C: assessment of the functional activity and IgG Fc receptor utilisation of 64 IgG Rh monoclonal antibodies. Coordinators report. Transfus Clin Biol. 2002;9:45-53.
14. Godeau B, Oksenhendler E, Brossard Y, et al. Treatment of chronic autoimmune thrombocytopenic purpura with monoclonal anti-D. Transfusion. 1996;36:328-330.
15. Engelfriet CP, Reesink HW, Bussel J, et al. The treatment of patients with autoimmune thrombocytopenia with intravenous IgG-anti-D. Vox Sanguinus. 1999;76:250-255.
16. Semple JW, Kim M, Lazarus AH, Freedman J. Gammaglobulins prepared from the sera of multiparous women bind anti-HLA antibodies and inhibit an established in vivo human alloimmune response. Blood. 2002;100:1055-1059.
17. Semple JW, Aslam R, Kim M, Speck ER, Freedman J. Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG opsonized platelets. Blood. 2007;109:4803-4805. .
18. Wiener E, Mawas F, Dellow RA, et al. A major role of class I Fc gamma receptors in immunoglobulin G anti-D mediated red blood cell destruction by fetal mononuclear phagocytes. Obstet Gynecol. 1995;86:157-162.
19. Miescher S, Spycher MO, Amstutz H, et al. A single recombinant anti-RhD IgG prevents RhD immunization: association of RhD-positive red blood cell clearance rate with polymorphisms in the Fc-RIIA and Fc-RIIIA genes. Blood. 2004;103:4028-4035.
20. Coopamah MD, Freedman J, Semple JW. Anti-D (WinRhoSDF™) initially stimulates an Fc-dependent leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin 1 receptor antagonist. Blood. 2003;102:2862-2867.
21. Hadley AG, Kumpel BM. Synergistic effect of blending IgG1 and IgG3 monoclonal anti-D in promoting the metabolic response of monocytes to sensitized red cells. Immunology. 1989;67:550-552.
22. Armstrong-Fisher SS, McCann MC, Downing I, et al. Evaluation of a panel of human monoclonal antibodies to D and exploration of the synergistic effects of blending IgG1 and IgG3 antibodies on their in vitro biological function. Transfusion. 1999;39:1005-1012.
23. Nielson LK, Green TH, Norderhaug L, Sandlie I, Dziegiel MH. Functional in vitro studies of recombinant immunoglobulin G and immunoglobulin A anti-D. Transfusion. 2007;47:306-315.
24. Dijstelbloem HM, van de Winkel JG, Kallenberg CG. Inflammation in autoimmunity: receptors for IgG revisited. Trends Immunol. 2001;22:510-516.
25. Christiaansen JE, Burnside SS, Sears DW. Apparent sensitivity of human K lymphocytes to the spatial orientation and organization of target cell-bound antibodies as measured by the efficiency of antibody-dependent cellular cytotoxicity (ADCC). J Immunol. 1987;138:2236-2243.