Detection of PAX8 and p53 is beneficial in recognizing metastatic carcinomas in pelvic washings, especially in cases with suspicious cytology

Gynecologic Oncology

Volumn 127, Issue 3, 2012, Pages 595-600

  Xiang, Li ^a,b   Zheng, Wenxin ^a,b,c   Kong, Beihua ^a  

^a SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

M llerian origin of metastatic carcinomas; p53; PAX8; Pelvic washings

Indexed keywords

PROTEIN P53; TRANSCRIPTION FACTOR PAX8;

ADULT; AGED; ARTICLE; CYTOLOGY; CYTOPATHOLOGY; ENDOMETRIUM CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; METASTASIS; OVARY CARCINOMA; PELVIC WASHING; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PAIRED BOX TRANSCRIPTION FACTORS; PELVIC NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84868552777     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2012.08.028     Document Type: Article

References (31)

1. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics, 2012 CA Cancer J Clin 62 2012 10 29
2. F. Ensani, F. Nematizadeh, and G. Irvanlou Accuracy of immunohistochemistry in evaluation of malignant pleural and peritoneal effusions Pol J Pathol 62 2011 95 100
3. J.A. Blake, M. Thomas, J.A. Thompson, R. White, and M. Ziman Perplexing Pax: from puzzle to paradigm Dev Dyn 237 2008 2791 2803
4. J. Li, N. Abushahin, S. Pang, L. Xiang, S.K. Chambers, and O. Fadare Tubal origin of low-grade serous carcinoma Mod Pathol 24 2011 1488 1499
5. A.R. Laury, R. Perets, H. Piao, J.F. Krane, J.A. Barletta, and C. French A comprehensive analysis of PAX8 expression in human epithelial tumors Am J Surg Pathol 35 2011 816 826
6. A.R. Laury, J.L. Hornick, R. Perets, J.F. Krane, J. Corson, and R. Drapkin PAX8 reliably distinguishes ovarian serous tumors from malignant mesothelioma Am J Surg Pathol 34 2010 627 635
7. N.J. Bowen, S. Logani, E.B. Dickerson, L.B. Kapa, M. Akhtar, and B.B. Benigno Emerging roles for PAX8 in ovarian cancer and endosalpingeal development Gynecol Oncol 104 2007 331 337
8. K.H. Vousden, and X. Lu Live or let die: the cell's response to p53 Nat Rev Cancer 2 2002 594 604
9. L. Jia, Y. Liu, X. Yi, A. Miron, C.P. Crum, and B. Kong Endometrial glandular dysplasia with frequent p53 gene mutation: a genetic evidence supporting its precancer nature for endometrial serous carcinoma Clin Cancer Res 14 2008 2263 2269
10. A.G. Chiesa-Vottero, A. Malpica, M.T. Deavers, R. Broaddus, G.J. Nuovo, and E.G. Silva Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma Int J Gynecol Pathol 26 2007 328 333
11. R. Salani, R. Kurman, R. Giuntoli II, G. Gardner, R. Bristow, and T.L. Wang Assessment of TP53 mutation using purified tissue samples of ovarian serous carcinomas reveals a higher mutation rate than previously reported and does not correlate with drug resistance Int J Gynecol Cancer 18 2008 487 491
12. R. McKnight, C. Cohen, and M.T. Siddiqui Utility of paired box gene 8 (PAX8) expression in fluid and fine-needle aspiration cytology Cancer Cytopathol 118 2010 298 302
13. S. Salvador, B. Gilks, M. Köbel, D. Huntsman, B. Rosen, and D. Miller The fallopian tube: primary site of most pelvic high-grade serous carcinomas Int J Gynecol Cancer 19 2009 58
14. U. Guth, D.J. Huang, G. Bauer, M. Stieger, E. Wight, and G. Singer Metastatic patterns at autopsy in patients with ovarian carcinoma Cancer 110 2007 1272 1280
15. M.G. del Carmen, D.M. Boruta, and J.O. Schorge Recurrent Endometrial Cancer Clin Obstet Gynecol 54 2011 266 277
16. P.J. Eifel, J. Ross, M. Hendrickson, R.S. Cox, R. Kempson, and A. Martinez Adenocarcinoma of the endometrium analysis of 256 cases with disease limited to the uterine corpus: treatment comparisons Cancer 52 1983 1026 1031
17. M.E. Sherman, P. Bitterman, N.B. Rosenshein, G. Delgado, and R.J. Kurman Uterine serous carcinoma. A morphologically diverse neoplasm with unifying clinicopathologic features Am J Surg Pathol 16 1992 600
18. W. Zheng, L. Xiang, O. Fadare, and B. Kong A proposed model for endometrial serous carcinogenesis Am J Surg Pathol 35 2011 e1 e14
19. A. Poleev, F. Wendler, H. Fickenscher, M.S. Zannini, K. Yaginuma, and C. Abbott Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors Eur J Biochem 228 1995 899 911
20. C.M. Haynes, A.R. Sangoi, and R.K. Pai PAX8 is expressed in pancreatic well-differentiated neuroendocrine tumors and in extrapancreatic poorly differentiated neuroendocrine carcinomas in fine-needle aspiration biopsy specimens Cancer Cytopathol 119 2011 193 201
21. Y. Hu, A. Hartmann, C. Stoehr, S. Zhang, M. Wang, and D. Tacha PAX8 is expressed in the majority of renal epithelial neoplasms: an immunohistochemical study of 223 cases using a mouse monoclonal antibody J Clin Pathol 65 2012 254 256
22. D. Tacha, D. Zhou, and L. Cheng Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study Appl Immunohistochem Mol Morphol 19 2011 293 299
23. N.L. Eberhardt, S.K.G. Grebe, B. McIver, and H.V. Reddi The role of the PAX8/PPAR [gamma] fusion oncogene in the pathogenesis of follicular thyroid cancer Mol Cell Endocrinol 321 2010 50 56
24. D. Nonaka, L. Chiriboga, and R.A. Soslow Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas Am J Surg Pathol 32 2008 1566 1571
25. A.H. Brunner, P. Riss, G. Heinze, E. Meltzow, and H. Brustmann Immunoexpression of PAX 8 in endometrial cancer: relation to high-grade carcinoma and p53 Int J Gynecol Pathol 30 2011 569 575
26. G.X. Tong, K. Devaraj, D. Hamele-Bena, W.M. Yu, A. Turk, and X. Chen Pax8: a marker for carcinoma of Müllerian origin in serous effusions Diagn Cytopathol 39 2011 562 566
27. C.P. Crum, R. Drapkin, A. Miron, T.A. Ince, M. Muto, and D.W. Kindelberger The distal fallopian tube: a new model for pelvic serous carcinogenesis Curr Opin Obstet Gynecol 19 2007 3 9
28. C.P. Crum, R. Drapkin, D. Kindelberger, F. Medeiros, A. Miron, and Y. Lee Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer Clin Med Res 5 2007 35 44
29. E.A. Jarboe, A.K. Folkins, R. Drapkin, T.A. Ince, E.S. Agoston, and C.P. Crum Tubal and ovarian pathways to pelvic epithelial cancer: a pathological perspective Histopathology 53 2008 127 138
30. C.P. Crum Intercepting pelvic cancer in the distal fallopian tube: theories and realities Mol Oncol 3 2009 165 170
31. X. Zhang, S.X. Liang, L. Jia, N. Chen, O. Fadare, and P.E. Schwartz Molecular identification of Latent precancers for endometrial serous carcinoma in benign-appearing endometrium Am J Pathol 174 2009 2000 2006