PAX8 is expressed in the majority of renal epithelial neoplasms: An immunohistochemical study of 223 cases using a mouse monoclonal antibody

Journal of Clinical Pathology

Volumn 65, Issue 3, 2012, Pages 254-256

  Hu, Yingchuan ^a   Hartmann, Arndt ^b   Stoehr, Christine ^b   Zhang, Shaobo ^a   Wang, Mingsheng ^a   Tacha, David ^c   Montironi, Rodolfo ^d   Lopez Beltran, Antonio ^e   Cheng, Liang ^a  

^a INDIANA UNIVERSITY   (United States)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c Biocare Medical   (United States)

^d UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^e UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY PAX8; TRANSCRIPTION FACTOR PAX8; UNCLASSIFIED DRUG;

ARTICLE; CLEAR CELL CARCINOMA; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; ONCOCYTOMA; PAPILLARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOMA, OXYPHILIC; ANIMALS; ANTIBODIES, MONOCLONAL; BIOPSY; CARCINOMA, PAPILLARY; CARCINOMA, RENAL CELL; EPITHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; MICE; PAIRED BOX TRANSCRIPTION FACTORS; PREDICTIVE VALUE OF TESTS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84862785535     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2011-200508     Document Type: Article

References (16)

1. Tacha D, Zhou D, Cheng L. Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study. Appl Immunohistochem Mol Morphol 2011;19:293-9.
2. Laury AR, Perets R, Piao H, et al. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol 2011;35:816-26.
3. Tong GX, Yu WM, Beaubier NT, et al. Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study. Mod Pathol 2009;22:1218-27.
4. Bubendorf L. High-throughput microarray technologies: from genomics to clinics. Eur Urol 2001;40:231-8.
5. Singer K, Kastenberger M, Gottfried E, et al. Warburg phenotype in renal cell carcinoma: high expression of glucose-transporter 1 (GLUT-1) correlates with low CD8(+) T-cell infiltration in the tumor. Int J Cancer 2011;128:2085-95.
6. Eble JN, Sauter G, Epstein JI, et al. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon: IARC Press, 2004.
7. Bowen NJ, Logani S, Dickerson EB, et al. Emerging roles for PAX8 in ovarian cancer and endosalpingeal development. Gynecol Oncol 2007;104:331-7.
8. Nonaka D, Chiriboga L, Soslow RA. Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. Am J Surg Pathol 2008;32:1566-71.
9. Nonaka D, Tang Y, Chiriboga L, et al. Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms. Mod Pathol 2008;21:192-200.
10. Tong GX, Weeden EM, Hamele-Bena D, et al. Expression of PAX8 in nephrogenic adenoma and clear cell adenocarcinoma of the lower urinary tract: evidence of related histogenesis? Am J Surg Pathol 2008;32:1380-7.
11. Chi N, Epstein JA. Getting your Pax straight: Pax proteins in development and disease. Trends Genet 2002;18:41-7.
12. Poleev A, Fickenscher H, Mundlos S, et al. PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. Development 1992;116:611-23.
13. Dressler GR. The cellular basis of kidney development. Annu Rev Cell Dev Biol 2006;22:509-29.
14. Bouchard M, Souabni A, Mandler M, et al. Nephric lineage specification by Pax2 and Pax8. Genes Dev 2002;16:2958-70.
15. Narlis M, Grote D, Gaitan Y, et al. Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. J Am Soc Nephrol 2007;18:1121-9.
16. Blake JA, Thomas M, Thompson JA, et al. Perplexing Pax: from puzzle to paradigm. Dev Dyn 2008;237:2791-803.