Cytokine production in immortalized porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus

Veterinary Immunology and Immunopathology

Volumn 150, Issue 3-4, 2012, Pages 213-220

  Lee, Yoo Jin ^a   Lee, Changhee ^a  

^a Kyungpook National University   (South Korea)

Author keywords

Cytokines; Immortalized PAMs; Immune response genes; PRRSV

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; ALPHA INTERFERON; ALVEOLAR MACROPHAGE CHEMOTACTIC FACTOR 1; BETA INTERFERON; CHEMOKINE; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; INTERFERON REGULATORY FACTOR 9; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; PROTEIN KINASE R; RANTES; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTERIVIRUS; ARTERIVIRUS INFECTION; ARTICLE; CELL IMMORTALIZATION; CYTOKINE PRODUCTION; GENOTYPE; IMMUNE RESPONSE; IN VITRO STUDY; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PROTEIN EXPRESSION; VIRUS ISOLATION;

ANIMALS; CELLS, CULTURED; CYTOKINES; MACROPHAGES, ALVEOLAR; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SWINE;

PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE; SUS;

EID: 84868471714     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2012.09.007     Document Type: Article

References (48)

1. Ait-Ali T., Wilson A.D., Westcott D.G., Clapperton M., Waterfall M., Mellencamp M.A., Drew T.W., Bishop S.C., Archibald A.L. Innate immune responses to replication of porcine reproductive and respiratory syndrome virus in isolated swine alveolar macrophages. Viral Immunol. 2007, 20:105-118.
2. Albina E. Epidemiology of porcine reproductive and respiratory syndrome (PRRS): an overview. Vet. Microbiol. 1997, 55:309-316.
3. Albina E., Carrat C., Charley B. Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus. J. Interferon Cytokine Res. 1998, 18:485-490.
4. Borca M.V., Gudmundsdottir I., Fernández-Sainzb I.J., Holinkab L.G., Risatti G.R. Patterns of cellular gene expression in swine macrophages infected with highly virulent classical swine fever virus strain Brescia. Virus Res. 2008, 138:89-96.
5. Cavanagh D. Nidovirales: a new order comprising Coronaviridae and Arteriviridae. Arch. Virol. 1997, 142:629-633.
6. Chang H.C., Peng Y.T., Chang H.L., Chaung H.C., Chung W.B. Phenotypic and functional modulation of bone marrow-derived dendritic cells by porcine reproductive and respiratory syndrome virus. Vet. Microbiol. 2008, 129:281-293.
7. Chiou M.T., Jeng C.R., Chueh L.L., Cheng C.H., Pang V.F. Effects of porcine reproductive and respiratory syndrome virus (isolate tw91) on porcine alveolar macrophages in vitro. Vet. Microbiol. 2000, 71:9-25.
8. Choi C., Chae C. Expression of tumor necrosis factor-alpha is associated with apoptosis in lungs of pigs experimentally infected with porcine reproductive and respiratory syndrome virus. Res. Vet. Sci. 2002, 72:45-49.
9. Dawson H.D., Beshah E., Nishi S., Solano-Aguilar G., Morimoto M., Zhao A., Madden K.B., Ledbetter T.K., Dubey J.P., Shea-Donohue T., Lunney J.K., Urban J.F. Localized multigene expression patterns support an evolving Th1/Th2-like paradigm in response to infections with Toxoplasma gondii and Ascaris suum. Infect. Immun. 2005, 73:1116-1128.
10. de Los Santos T., de Avila Botton S., Weiblen R., Grubman M.J. The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response. J. Virol. 2006, 80:1906-1914.
11. Duan X., Nauwynck H.J., Pensaert M.B. Effects of origin and state of differentiation and activation of monocytes/macrophages on their susceptibility to porcine reproductive and respiratory syndrome virus (PRRSV). Arch. Virol. 1997, 142:2483-2497.
12. Duan X., Nauwynck H.J., Pensaert M.B. Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV). Vet. Microbiol. 1997, 156:9-19.
13. Duvigneau J.C., Hartl R.T., Groiss S., Gemeiner M. Quantitative simultaneous multiplex real-time PCR for the detection of porcine cytokines. J. Immunol. Methods 2005, 306:16-27.
14. Flores-Mendoza L., Silva-Campa E., Reséndiz M., Osorio F.A., Hernández J. Porcine reproductive and respiratory syndrome virus infects mature porcine dendritic cells and up-regulates interleukin-10 production. Clin. Vaccine Immunol. 2008, 15:720-725.
15. Genini S., Delputte P.L., Malinverni R., Cecere M., Stella A., Nauwynck H.J., Giuffra E. Genome-wide transcriptional response of primary alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 2008, 89:2550-2564.
16. Gómez-Laguna J., Salguero F.J., Barranco I., Pallarés F.J., Rodríguez-Gómez I.M., Bernabé A., Carrasco L. Cytokine expression by macrophages in the lung of pigs infected with the porcine reproductive and respiratory syndrome virus. J. Comp. Pathol. 2010, 142:51-60.
17. Gudmundsdottir I., Risatti G.R. Infection of porcine alveolar macrophages with recombinant chimeric porcine reproductive and respiratory syndrome virus: effects on cellular gene transcription and virus growth. Virus Res. 2009, 145:145-150.
18. Johnsen C.K., Bøtner A., Kamstrup S., Lind P., Nielsen J. Cytokine mRNA profiles in bronchoalveolar cells of piglets experimentally infected in utero with porcine reproductive and respiratory syndrome virus: association of sustained expression of IFN-gamma and IL-10 after viral clearance. Viral Immunol. 2002, 15:549-556.
19. Krishnan J., Selvarajoo K., Tsuchiya M., Lee G., Choi S. Toll-like receptor signal transduction. Exp. Mol. Med. 2007, 39:421-438.
20. Kroese M.V., Zevenhoven-Dobbe J.C., Bos-de Ruijter J.N., Peeters B.P., Meulenberg J.J., Cornelissen L.A., Snijder E.J. The nsp1alpha and nsp1 papain-like autoproteinases are essential for porcine reproductive and respiratory syndrome virus RNA synthesis. J. Gen. Virol. 2008, 89:494-499.
21. Labarque G., Van Gucht S., Nauwynck H., Van Reeth K., Pensaert M. Apoptosis in the lungs of pigs infected with porcine reproductive and respiratory syndrome virus and associations with the production of apoptogenic cytokines. Vet. Res. 2003, 34:249-260.
22. Lee Y.J., Lee C. Porcine reproductive and respiratory syndrome virus replication is suppressed by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway. Virus Res. 2010, 152:50-58.
23. Lee Y.J., Park C.K., Nam E., Kim S.H., Lee O.S., Lee D.S., Lee C. Generation of a porcine alveolar macrophage cell line for the growth of porcine reproductive and respiratory syndrome virus. J. Virol. Methods 2010, 163:410-415.
24. Liu C.H., Chaung H.C., Chang H.L., Peng Y.T., Chung W.B. Expression of Toll-like receptor mRNA and cytokines in pigs infected with porcine reproductive and respiratory syndrome virus. Vet. Microbiol. 2009, 136:266-276.
25. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
26. López-Fuertes L., Campos E., Doménech N., Ezquerra A., Castro J.M., Domínguez J., Alonso F. Porcine reproductive and respiratory syndrome (PRRS) virus down-modulates TNF-alpha production in infected macrophages. Virus Res. 2000, 69:41-46.
27. Lopez O.J., Osorio F.A. Role of neutralizing antibodies in PRRSV protective immunity. Vet. Immunol. Immunopathol. 2004, 102:155-163.
28. Loving C.L., Brockmeier S.L., Ma W., Richt J.A., Sacco R.E. Innate cytokine responses in porcine macrophage populations: evidence for differential recognition of double-stranded RNA. J. Immunol. 2006, 177:8432-8439.
29. Mateu E., Diaz I. The challenge of PRRS immunology. Vet. J. 2007, 177:345-351.
30. Meulenberg J.J., Hulst M.M., de Meijer E.J., Moonen P.J.M., den Besten A., De Kluyver E.P., Wensvoort G., Moormann R.J.M. Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV. Virology 1993, 192:62-72.
31. Miller L.C., Laegreid W.W., Bono J.L., Chitko-McKown C.G., Fox J.M. Interferon type I response in porcine reproductive and respiratory syndrome virus-infected MARC-145 cells. Arch. Virol. 2004, 149:2453-2463.
32. Murtaugh M.P., Xiao Z., Zuckermann F. Immunological responses of swine to porcine reproductive and respiratory syndrome virus infection. Viral. Immunol. 2002, 15:533-547.
33. Nuemann E.J., Kliebenstein J.B., Johnson C.D., Mabry J.W., Bush E.J., Seitzinger A.H., Green A.L., Zimmerman J.J. Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States. J. Am. Vet. Med. Assoc. 2005, 227:385-392.
34. Patel D., Nan Y., Shen M., Ritthipichai K., Zhu X., Zhang Y.J. Porcine reproductive and respiratory syndrome virus inhibits type I interferon signaling by blocking STAT1/STAT2 nuclear translocation. J. Virol. 2010, 84:11045-11055.
35. Rossow K.D. Porcine reproductive and respiratory syndrome. Vet. Pathol. 1998, 35:1-20.
36. Royaee A.R., Husmann R.J., Dawson H.D., Calzada-Nova G., Schnitzlein W.M., Zuckermann F.A., Lunney J.K. Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination. Vet. Immunol. Immunopathol. 2004, 102:199-216.
37. Sagong M., Lee C. Porcine reproductive and respiratory syndrome virus nucleocapsid protein modulates interferon-β production by inhibiting IRF3 activation in immortalized porcine alveolar macrophages. Arch. Virol. 2011, 156:2187-2195.
38. Silva-Campa E., Cordoba L., Fraile L., Flores-Mendoza L., Montoya M., Hernández J. European genotype of porcine reproductive and respiratory syndrome (PRRSV) infects monocyte-derived dendritic cells but does not induce Treg cells. Virology 2010, 396:264-271.
39. Snijder E.J., Meulenberg J.J. The molecular biology of arteriviruses. J. Gen. Virol. 1998, 79:961-979.
40. Subramaniam S., Sur J.H., Kwon B., Pattnaik A.K., Osorio F.A. A virulent strain of porcine reproductive and respiratory syndrome virus does not up-regulate interleukin-10 levels in vitro or in vivo. Virus Res. 2011, 155:415-422.
41. Suradhat S., Thanawongnuwech R., Poovorawan Y. Upregulation of IL-10 gene expression in porcine peripheral blood mononuclear cells by porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 2003, 84:453-459.
42. Thanawongnuwech R., Thacker E.L., Halbur P.G. Effect of porcine reproductive and respiratory syndrome virus (PRRSV) (isolate ATCC VR-2385) infection on bactericidal activity of porcine pulmonary intravascular macrophages (PIMs): in vitro comparisons with pulmonary alveolar macrophages (PAMs). Vet. Immunol. Immunopathol. 1997, 59:323-335.
43. Thanawongnuwech R., Thacker B., Halbur P., Thacker E.L. Increased production of proinflammatory cytokines following infection with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae. Clin. Diagn. Lab. Immunol. 2004, 11:901-908.
44. Uze G., Monneron D. IL-28 and IL-29: newcomers to the interferon family. Biochimie 2007, 89:729-734.
45. Van Reeth K., Van Gucht S., Pensaert M. In vivo studies on cytokine involvement during acute viral respiratory disease of swine: troublesome but rewarding. Vet. Immunol. Immunopathol. 2002, 87:161-168.
46. Waldmann T.A. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat. Rev. Immunol. 2006, 6:595-601.
47. Wang D., Fang L., Liu L., Zhong H., Chen Q., Luo R., Liu X., Zhang Z., Chen H., Xiao S. Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-λ1 pathway. Mol. Immunol. 2011, 49:407-412.
48. Xiao S., Jia J., Mo D., Wang Q., Qin L., He Z., Zhao X., Huang Y., Li A., Yu J., Niu Y., Liu X., Chen Y. Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing. PLoS ONE 2010, 5:e11377.