Low-dose oral interferon α possibly retards the progression of idiopathic pulmonary fibrosis and alleviates associated cough in some patients

Thorax

Volumn 66, Issue 5, 2011, Pages 446-447

  Lutherer, Lorenz O ^a   Nugent, Kenneth M ^a   Schoettle, Byron W ^a   Cummins, Martin J ^b   Raj, Rishi ^a   Birring, Surinder S ^c   Jumper, Cynthia A ^a  

^a TEXAS TECH UNIVERSITY   (United States)

^b Amarillo Biosciences Inc   (United States)

^c KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON;

ADULT; AGE DISTRIBUTION; AGED; BLOOD ANALYSIS; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; COUGHING; DISEASE ASSOCIATION; DISEASE COURSE; DOSE RESPONSE; DRUG EFFICACY; FORCED VITAL CAPACITY; HUMAN; IDIOPATHIC DISEASE; LETTER; LOW DRUG DOSE; LOZENGE; LUNG FIBROSIS; LUNG FUNCTION TEST; MORTALITY; PRIORITY JOURNAL;

EID: 79954994760     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thx.2010.135947     Document Type: Letter

References (5)

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2. Jimenez SA, Freundlich B, Rosenbloom J. Selective inhibition of human diploid fibroblast collagen synthesis by interferons. J Clin Invest 1984;74:1112-16. (Pubitemid 14031053)
3. Cummins JM, Krakowka GS, Thompson CG. Systemic effects of interferons after oral administration in animals and humans. Am J Vet Res 2005;66:164-76. (Pubitemid 40214500)
4. Eid P, Meritet JF, Maury C, et al. Oromucosal interferon therapy: pharmacokinetics and pharmacodynamics. J Interferon Cytokine Res 1999;19:157-69. (Pubitemid 29109632)
5. Raj AA, Pavord DI, Birring SS. Clinical cough IV:what is the minimal important difference for the Leicester Cough Questionnaire? Handb Exp Pharmacol 2009; (187):311-20.