PNPLA3 Ile148Met variant and hepatocellular carcinoma: A matter of fat

Digestive and Liver Disease

Volumn 44, Issue 12, 2012, Pages 974-975

  Valenti, Luca ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; CANCER RISK; EPIDEMIC; FATTY LIVER; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENETICS; GENOTYPE; HUMAN; INSULIN RESISTANCE; LIPID STORAGE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; NONALCOHOLIC FATTY LIVER; NOTE; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS HEPATITIS;

CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; LIPASE; LIVER NEOPLASMS; MALE; MEMBRANE PROTEINS; OBESITY;

EID: 84868300302     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2012.08.023     Document Type: Note

References (11)

1. Baffy G., Brunt E.M., Caldwell S.H. Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. Journal of Hepatology 2012, 56:1384-1391.
2. Nahon P., Zucman-Rossi J. Single nucleotide polymorphisms and risk of hepatocellular carcinoma in cirrhosis. Journal of Hepatology 2012, 57:663-674.
3. Romeo S., Kozlitina J., Xing C., et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nature Genetics 2008, 40:1461-1465.
4. Trepo E., Guyot E., Ganne-Carrie N., et al. PNPLA3 (rs738409 C>G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis. Hepatology 2012, 55:1307-1308.
5. Nischalke H.D., Berger C., Luda C., et al. The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis. PLoS One 2012, 6:e27087.
6. Falleti E., Fabris C., Cmet S., et al. PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence. Liver International 2012, 31:1137-1143.
7. Ginanni-Corradini S., Burza M.A., Molinaro A., et al. Patatin-like phospholipase domain containing 3 sequence variant and hepatocellular carcinoma. Hepatology 2011, 53:1776.
8. Valenti L., Rumi M., Galmozzi E., et al. Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C. Hepatology 2011, 53:791-799.
9. Sookoian S., Pirola C.J. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology 2011, 53:1883-1894.
10. Graff M, North KE, Franceschini N, et al. PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: The NHLBI Family Heart Study. International Journal of Obesity (London) 2012, in press. doi:10.1038/ijo.2012.65.
11. Burza M.A., Pirazzi C., Maglio C., et al. PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals. Digestive and Liver Disease 2012, 10.1016/j.dld.2012.05.006.