Effects of extended-release injectable naltrexone on self-injurious behavior in rhesus macaques (Macaca mulatta)

Comparative Medicine

Volumn 62, Issue 3, 2012, Pages 209-217

  Kempf, Doty J ^a   Baker, Kate C ^a   Gilbert, Margaret H ^a   Blanchard, James L ^a   Dean, Reginald L ^b   Deaver, Daniel R ^b   Bohm, Rudolf P ^a  

^a TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

^b Alkermes   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NALTREXONE; NARCOTIC ANTAGONIST;

ABNORMAL BEHAVIOR; AGGRESSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; AUTOMUTILATION; BLOOD ANALYSIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; MALE; NONHUMAN; OUTCOME ASSESSMENT; RHESUS MONKEY; SINGLE DRUG DOSE; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; VIDEORECORDING; ANIMAL;

ANIMALS; MACACA MULATTA; MALE; NALTREXONE; NARCOTIC ANTAGONISTS; SELF-INJURIOUS BEHAVIOR;

EID: 84868283396     PISSN: 15320820     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (72)

1. Animal Welfare Regulations. 2008. 9 CFR §3.129.
2. Anderson JR, Chamove AS. 1980. Self-aggression and social aggression in laboratory-reared macaques. J Abnorm Psychol 89:539-550. (Pubitemid 11246140)
3. Anderson LT, Ernst M. 1994. Self-injury in Lesch-Nyhan disease. J Autism Dev Disord 24:67-81. (Pubitemid 24065611)
4. Barr CS, Newman TK, Shannon C, Parker C, Dvoskin RL, Becker ML, Schwandt M, Champoux M, Lesch KP, Goldman D, Suomi SJ, Higley JD. 2004. Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biol Psychiatr 55:733-738. (Pubitemid 38376185)
5. Bayne KA, Dexter S, Suomi S. 1992. A preliminary survey of the incidence of abnormal behavior in rhesus monkeys (Macaca mulatta) relative to housing condition. Lab Anim 21:38-46.
6. Bayne KA, Haines M, Dexter S, Woodman D, Evans C. 1995. Nonhuman primate wounding prevalence: a retrospective analysis. Lab Anim 24:40-44.
7. Bentson KL, Crockett CM, Wahl KL, Runeson EP, Bellanca RU, Lee GH, Thom JP, Montgomery HB, Yi MH, McComas JG, Ha JC. 2010. Floating limb behaviors and self-biting are associated in laboratory monkeys. Am J Primatol 72:725-733.
8. Brain KL, Haines J, Williams CL. 1998. The psychophysiology of self-mutilation: evidence of tension reduction. Arch Suicide Res 4:227-242. (Pubitemid 28291259)
9. Breese GR, Criswell HE, Duncan GE, Mueller RA. 1989. Dopamine deficiency in self-injurious behavior. Psychopharmacol Bull 25:353-357.
10. Briere J, Gil E. 1998. Self-mutilation in clinical and general population samples: prevalence, correlates, and functions. Am J Orthopsychiatr 68:609-620. (Pubitemid 28520741)
11. Browder DM, editor. 1992. Assessment of individuals with severe disabilities: an applied approach to life skills assessment. Baltimore (MD): Paul H Brookes Publishing.
12. Buitelaar JK. 1993. Self-injurious behaviour in retarded children: clinical phenomena and biological mechanisms. Acta Paedopsychiatr 56:105-111.
13. Carlezon WA, Béguin C, DiNieri JA, Baumann MH, Richards MR, Todtenkopf MS, Rothman RB, Ma Z, Lee DY, Cohen BM. 2006. Depressive-like effects of the κ-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats. J Pharmacol Exp Ther 316:440-447. (Pubitemid 41832624)
14. Cataldo MF, Harris JC. 1982. The biological basis for self-injury in the mentally retarded. Anal Interven Dev Disabil 2:21-39.
15. Crockett CM, Sackett GP, Sandman CA, Chicz-DeMet A, Bentson KL. 2007. Beta-endorphin levels in longtailed and pigtailed macaques vary by abnormal behavior raring and sex. Peptides 28:1987-1997. (Pubitemid 47419099)
16. Cross HA, Harlow HF. 1965. Prolonged and progressive effects of partial isolation on the behavior of macaque monkeys. J Exp Res Pers 1:39-49.
17. Davenport MD, Lutz CK, Teifenbacher S, Novak MA, Meyer JS. 2008. A rhesus monkey model of self-injury: effects of relocation stress on behavior and neuroendocrine function. Biol Pscychiatr 63:990-996.
18. Dean RL. 2005. The preclinical development of medisorb naltrexone, a once-a-month long-acting injection, for the treatment of alcohol dependence. Front Biosci 10:643-655.
19. Dean RL, Todtenkopf MS, Deaver DR, Arastu MF, Dong N, Reitano K, O'Driscoll K, Kriksciukaite K, Gastfriend DR. 2008. Overriding the blockade of antinociceptive actions of opioids in rats treated with extended-release naltrexone. Pharmacol Biochem Behav 89:515-522.
20. Di Nuovo SF, Buono S. 2007. Psychiatric syndromes comorbid with mental retardation: differences in cognitive and adaptive skills. J Psychiatr Res 41:795-800. (Pubitemid 46671399)
21. Ebner SR, Roitman MF, Potter DN, Rachlin AB, Chartoff EH. 2010. Depressive-like effects of the κ-opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens. Psychopharmacology (Berl) 210:241-252.
22. Favazza Simeon D, Favazza AR. 2001. Self-injurious behaviors: phenomenology and assessment, p 1-28. In: Simeon D, Hollander E, editors. Self-injurious behaviors: assessment and treatment. Washington (DC): American Psychiatric Publishing.
23. Fontenot MB, Padgett EE 3rd, Dupuy AM, Lynch CR, De Petrillo PB, Higley JD. 2005. The effects of fluoxetine and buspirone on self-injurious and stereotypic behavior in adult male rhesus macaques. Comp Med 55:67-74. (Pubitemid 41557547)
24. Goldstein M. 1989. Dopaminergic mechanisms in self-inflicting biting behavior. Psychopharmacol Bull 25:349-352.
25. Goldstein M, Kuga S, Kusano N, Meller E, Dancis J, Schwarez R. 1986. Dopamine agonist induced self-mutilative biting behavior in monkeys with unilateral ventromedial tegmental lesions of the brainstem: possible pharmacologic model for Lesch-Nyhan syndrome. Brain Res 367:114-120. (Pubitemid 16011669)
26. Harlow HF, Harlow M. 1962. The effect of rearing conditions on behavior. Bull Menninger Clin 26:213-224.
27. Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, Yeo GS, O'Rahilly S, Colmers WF, Elmquist JK, Tecott LH. 2007. Serotonin activates hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. J Neurosci 27:6956-6964. (Pubitemid 47015900)
28. Hellings JA, Warnock JK. 1994. Self-injurious behavior and serotonin in Prader-Willi syndrome. Psychopharmacol Bull 30:245-250. (Pubitemid 24331395)
29. Herman BH. 1990. A possible role of proopiomelanocortin peptides in self-injurious behavior. Prog Neuropsychopharmacol Biol Psychiatr 14:109-139.
30. Hugo C, Seier J, Mdhlulo C, Daniels W, Harvey BH, Toit DD, Wolfe-Coote SW, Nel D, Dtein DJ. 2003. Fluoxetine decreases stereotypic behavior in primates. Prog Neuropsychopharmacol Biol Psychiatr 27:639-643. (Pubitemid 36645065)
31. 11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus macaques. J Neurosci 26:4638-4643.
32. Institute for Laboratory Animal Research. 2011. Guide for the care and use of laboratory animals. Washington (DC): National Academies Press.
33. Jawed SH, Krishnan VR, Cassidy G. 1994. Self-injurious behavior and the serotonin link: 2 case illustrations and theoretical overview. Ir J Psychol Med 11:165-168.
34. Kemperman I, Russ MJ, Shearin E. 1997. Self-injurious behavior and mood regulation in borderline patients. J Pers Disord 11:146-157. (Pubitemid 27313776)
35. Klonsky ED, Oltmanns TF, Turkkeimer E. 2003. Deliberate self-harm in a nonclinical population: prevalence and psychological correlates. Am J Psychiatry 160:1501-1508. (Pubitemid 41070927)
36. Kraemer GW, Schimdt DE, Ebert MH. 1997. The behavioral neurobiology of self-injurious behavior in rhesus monkeys. Current concepts and relations to impulsive behavior in humans. Ann N Y Acad Sci 836:12-38. (Pubitemid 28044018)
37. Land BB, Bruchas MR, Lemos JC, Xu M, Melief EJ, Chavkin C. 2008. The dysphoric component of stress is encoded by activation of the dynorphin κ-opioid system. J Neurosci 28:407-414.
38. Lewis M, Baumeister A. 1982. Stereotyped mannerisms in mentally retarded persons: animal models and theoretical analyses. Int Rev Res Ment Retard 11:123-161.
39. Lewis MH, Gluck JP, Beauchamp AJ, Keresztury MF, Mailman RB. 1990. Long-term effects of early social isolation in Macaca mulatta: changes in dopamine receptor function following apomorphine challenge. Brain Res 513:67-73. (Pubitemid 20144273)
40. Lutz C, Well A, Novak M. 2003. Stereotypic and self-injurious behavior in rhesus macaques: a survey and retrospective analysis of environment and early experience. Am J Primatol 60:1-15. (Pubitemid 36708161)
41. Major CA, Kelly BJ, Novak MA, Davenport MD, Stonemetz KM, Meyer JS. 2009. The anxiogenic drug FG7142 increases self-injurious behavior in male rhesus monkeys (Macaca mulatta). Life Sci 85:753-758.
42. Marinus LM, Chase WK, Rasmussen KL, Jorgensen MJ, Novak MA. 1999. Reaction of rhesus macaques with self-injurious behavior to heart rate testing: is biting a coping strategy? Am J Primatol 49:79.
43. Markowitz PI. 1992. Effect of fluoxetine on self-injurious behavior in the developmentally disabled: a preliminary study. J Clin Psychopharmacol 12:27-31.
44. Matson JL, Minshawi NF, Gonzalez ML, Mayville SB. 2006. The relationship of comorbid behavior problems to social skills in persons with profound mental retardation. Behav Modif 30:496-506. (Pubitemid 43807415)
45. Mitchel G, Raymond E, Ruppenthal G, Harlow H. 1966. Long-term effects of total social isolation upon behavior of rhesus macaques. Psychol Rep 18:567-580.
46. Mizuno T, Yugari Y. 1975. Prophylactic effect of L-5-hydroxytrypyophan on self-mutilation in the Lesch-Nyhan syndrome. Neuropadiatrie 6:13-23.
47. New AS, Trestman RL, Mitropoulou V, Benishay DS, Coccaro E, Silverman J, Siever LJ. 1997. Serotonergic function and self-injurious behavior in personality disorder patients. Psychiatr Res 69:17-26. (Pubitemid 27139680)
48. Novak MA. 2003. Self-injurious behavior in rhesus monkeys: new insights into its etiology, physiology, and treatment. Am J Primatol 59:3-19. (Pubitemid 36280518)
49. Pfeiffer A, Brantl V, Herz A, Emrich HM. 1986. Psychotomimesis mediated by κ opiate receptors. Science 233:774-776.
50. Ribka E, Baker K. 2004. Naltrexone (naltrexone hydrochloride) as a treatment to decrease incidence and severity of self-injurious behavior in rhesus macaques (Macaca mulatta). Am J Primatol 62:44.
51. Sandman CA, Hetrick W, Taylor DV, Chicz-DeMet A. 1997. Dissociation of POMC peptides after self-injury predicts responses to centrally acting opiate blockers. Am J Ment Retard 102:182-199. (Pubitemid 27418539)
52. Sandman CA, Hetrick W, Taylor DV, Marion SD, Touchette PE, Barron JL, Martinezzi V, Steinburg RM, Crinella FM. 2000. Long-term effects of naltrexone on self-injurious behavior. Am J Ment Retard 105:103-117. (Pubitemid 30413396)
53. Sandman CA, Kemp AS. 2011. Opioid antagonists may reverse endogenous opiate 'dependence' in the treatment of self-injurious behavior. Pharmaceuticals (Basel) 4:366-381.
54. Sandman CA, Spence MA, Smith M. 1999. Proopiomelanocortin (POMC) dysregulation and response to opiate blockers. Ment Retard Dev Disabil Res Rev 5:314-321. (Pubitemid 30033620)
55. Sandman CA, Touchette P, Lenjavi M, Marion S, Chicz-DeMet A. 2003. β-Endorphin and ACTH are dissociated after self-injury in adults with developmental disabilities. Am J Ment Retard 108:414-424.
56. Sandman CA, Touchette PE, Marion SD, Chicz-Demet A. 2008. The role of proopiomelanocortin (POMC) in sequentially dependent self-injurious behavior. Dev Psychobiol 50:680-689. (Pubitemid 352748859)
57. Smith MA, McClean JM, Greene JL. 2003. Enhanced sensitivity to the antinociceptive effects of κ opioids in naltrexone-treated rats: dose- and time-dependent effects. Behav Pharmacol 14:641-647.
58. 1A receptors in juvenile rhesus monkeys measured by positron emission tomography. Biol Psychiatry 67:1146-1153.
59. Stanley B, Gameroff M, Michaleson V, Mann J. 2001. Are suicide attempters who self-mutilate a unique population? Am J Psychiatr 158:427-432. (Pubitemid 32205200)
60. Suyemoto KL. 1998. The functions of self-mutilation. Clin Psychol Rev 18:531-554. (Pubitemid 28378253)
61. Symons FJ, Thompson A, Roderiguez MC. 2004. Self-injurious behavior and the efficacy of naltrexone treatment: a quantitative synthesis. Ment Retard Dev Disabil Res Rev 10:193-200. (Pubitemid 40095894)
62. Tenneij NH, Didden R, Stoker JJ, Koot HM. 2009. Markers for aggression in inpatient treatment facilities for adults with mild to borderline intellectual disability. Res Dev Disabil 30:1248-1257.
63. Tiefenbacher S, Davenport MD, Novak MA, Poulit AL, Meyer JS. 2003. Fenfluramine challenge, self-injurious behavior, and aggression in rhesus monkeys. Physiol Behav 80:327-331. (Pubitemid 37456770)
64. Tiefenbacher S, Novak MA, Jorgenson MJ, Meyer JS. 2000. Physiological correlates of self-injurious behavior in captive, socially reared rhesus monkeys. Psychoneuroendocrinology 25:799-817. (Pubitemid 30670325)
65. Tiefenbacher S, Novak MA, Lutz CK, Meyer JS. 2005. The physiology and neurochemistry of self-injurious behavior: a nonhuman primate model. Front Biosci 10:1-11. (Pubitemid 40543011)
66. Tiefenbacher S, Novak MA, Marinus LM, William CK, Miller JA, Meyer JS. 2004. Altered hypothalamic-pituitary-adrenocortical function in rhesus monkeys (Macaca mulatta) with self-injurious behavior. Psychoneuroendocrinology 29:501-515. (Pubitemid 38121605)
67. Turner CA, Lewis MH. 2002. Dopaminergic mechanisms in self-injurious behavior and related disorders p 165-179. In: Schroder SR, Oster-Granite ML, Thompson T, editors. Self-injurious behavior: genes-brain-behavior relationships. Washington (DC): American Psychological Association.
68. Verebey K, Volavka J, Mule S, Resnick R. 1976. Naltrexone: disposition, metabolism, and effects after acute and chronic dosing. Clin Pharmacol Ther 20:315-328.
69. Wang D, Raehal KM, Bilsky EJ, Sadee W. 2001. Inverse agonists and neutral antagonists at μ opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. J Neurochem 77:1590-1600. (Pubitemid 32574494)
70. Weerts EM, Kim YK, Wand GS, Dannals RF, Lee JS, Frost JJ, McCaul ME. 2008. Differences in δ- and μ-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects. Neuropsychopharmacology 33:653-665.
71. Wentland MP, Lou R, Dehnhardt CM, Duan W, Cohen DJ, Bidlack JM. 2001. 3-Carboxamido analogues of morphine and naltrexone: synthesis and opioid receptor binding properties. Bioorg Med Chem Lett 11:1717-1721. (Pubitemid 32568305)
72. Williams KL, Holden Ko MC, Rice KC, Woods JH. 2003. Effect of opioid antagonists on hypothalamic-piruitary-adrenal activity in rhesus monkeys. Psychoneuroendocrinology 28:513-528. (Pubitemid 36411987)