The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats

Psychopharmacology

Volumn 224, Issue 2, 2012, Pages 255-262

  Alvers, Kristin M ^a   Beckmann, Joshua S ^a   Zheng, Guangrong ^a   Crooks, Peter A ^a   Dwoskin, Linda P ^a   Bardo, Michael T ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

GZ 793A; Locomotor activity; Methamphetamine; Reinstatement; Relapse; VMAT2

Indexed keywords

CIS N (2,3 DIHYDROXYPROPYL) 2,6 DI (4 METHOXYPHENETHYL)PIPERIDINE; DOPAMINE; GZ 793A; METHAMPHETAMINE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSOCIATION; CONTROLLED STUDY; DOPAMINE RELEASE; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG REEXPOSURE; DRUG RESPONSE; DRUG SELF ADMINISTRATION; DRUG SPECIFICITY; DRUG SYNTHESIS; HYPERACTIVITY; LOCOMOTION; MALE; METHAMPHETAMINE DEPENDENCE; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; RELAPSE; RISK REDUCTION;

AMPHETAMINE-RELATED DISORDERS; ANIMALS; DRUG-SEEKING BEHAVIOR; LOBELINE; MALE; METHAMPHETAMINE; RATS; RATS, SPRAGUE-DAWLEY; REINFORCEMENT (PSYCHOLOGY); STREET DRUGS; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 84868256840     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2748-3     Document Type: Article

References (35)

1. Beckmann JS, Denehy ED, Zheng G, Crooks PA, Dwoskin LP, Bardo MT (2012) The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats. Psychopharmacology (Berl) 220:395-403
2. Bossert JM, Ghitza UE, Lu L, Epstein DH, Shaham Y (2005) Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications. Eur J Pharmacol 526:36-50 (Pubitemid 41744104)
3. Carroll ME, Lac ST (1993) Autoshaping i.v. cocaine self-administration in rats: effects of nondrug alternative reinforcers on acquisition. Psychopharmacology (Berl) 110:5-12
4. Community Epidemiology Work Group (2009) Proceedings of the Community Epidemiology Work Group: Volume I. Highlights and Executive Summary (NIH Publication No. 10-7421). Bethesda, MD
5. Di Ciano P, Blaha CD, Phillips AG (1998) The relationship between dopamine oxidation currents in the nucleus accumbens and conditioned increases in motor activity in rats following repeated administration of d-amphetamine or cocaine. Eur J Neurosci 10:1113-1120 (Pubitemid 28375636)
6. Di Ciano P, Blaha CD, Phillips AG (2001) Changes in dopamine efflux associated with extinction, CS-induced and d-amphetamine-induced reinstatement of drug-seeking behavior by rats. Behav Brain Res 120:147-158 (Pubitemid 32140982)
7. Dwoskin LP, Crooks PA (2002) A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse. Biochem Pharmacol 63:89-98 (Pubitemid 34158807)
8. Elkashef A, Vocci F, Hanson G, White J, Wickes W, Tiihonen J (2008) Pharmacology of methamphetamine addiction: an update. Subst Abus 29:31-49
9. Gratton A, Wise RA (1994) Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous cocaine self-administration in rats. J Neurosci 14:4130-4146 (Pubitemid 24200538)
10. Guillot TS, Miller GW (2009) Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons. Mol Neurobiol 39:149-170
11. Harrod SB, Dwoskin LP, Crooks PA, Klebaur JE, Bardo MT (2001) Lobeline attenuates d-methamphetamine self-administration in rats. J Pharmacol Exp Ther 298:172-179 (Pubitemid 32574524)
12. Harrod SB, Dwoskin LP, Green TA, Gehrke BJ, Bardo MT (2003) Lobeline does not serve as a reinforcer in rats. Psychopharmacology (Berl) 165:397-404 (Pubitemid 36223081)
13. Horton DB, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP (2011) Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamineevoked dopamine release. J Pharmacol Exp Ther 339:286-297
14. Ito R, Dalley JW, Howes SR, Robbins TW, Everitt BJ (2000) Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats. J Neurosci 20: 7489-7495
15. Karila L, Weinstein A, Aubin HJ, Benyamina A, Reynaud M, Batki SL (2010) Pharmacological approaches to methamphetamine dependence: a focused review. Br J Clin Pharmacol 69:578-592
16. Kiyatkin EA, Stein EA (1996) Conditioned changes in nucleus accumbens dopamine signal established by intravenous cocaine in rats. Neurosci Lett 211:73-76 (Pubitemid 26244679)
17. Meyer AC, Horton DB, Neugebauer NM, Wooters TE, Nickell JR, Dwoskin LP, Bardo MT (2011) Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration. Neuropharmacology 61:849-856
18. Miller DK, Crooks PA, Teng L, Witkin JM, Munzar P, Goldberg SR, Acri JB, Dwoskin LP (2001) Lobeline inhibits the neurochemical and behavioral effects of amphetamine. J Pharmacol Exp Ther 296:1023-1034 (Pubitemid 32187378)
19. Miller DK, Crooks PA, Zheng G, Grinevich VP, Norrholm SD, Dwoskin LP (2004) Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicula monoamine transporters. J Pharmacol Exp Ther 310:1035-1045 (Pubitemid 39108925)
20. Neisewander JL, O'Dell LE, Tran-Nguyen LT, Castañeda E, Fuchs RA (1996) Dopamine overflow in the nucleus accumbens during extinction and reinstatement of cocaine self-administration behavior. Neuropharmacology 15:506-514 (Pubitemid 26389874)
21. Neugebauer NM, Harrod SB, Stairs DJ, Crooks PA, Dwoskin LP, Bardo MT (2007) Lobelane decreases methamphetamine self-administration in rats. Eur J Pharmacol 571:33-38 (Pubitemid 47284051)
22. Nickell JR, Krishnamurthy S, Norrholm S, Deaciuc G, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP (2009) Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2. J Pharmacol Exp Ther 332:612-621
23. O'Brien CP (1997) A range of research-based pharmacotherapies for addiction. Science 278:66-70 (Pubitemid 27446273)
24. Ramo DE, Brown SA (2008) Classes of substance abuse relapse situations: a comparison of adolescents and adults. Psychol Addict Behav 22:372-379
25. Ranaldi R, Pocock D, Zereik R, Wise RA (1999) Dopamine fluctuations in the nucleus accumbens during maintenance, extinction, and reinstatement of intravenous D-amphetamine self-administration. J Neurosci 19:4102-4109 (Pubitemid 29222282)
26. Rogers JL, De Santis S, See RE (2008) Extended methamphetamine self-administration enhances reinstatement of drug seeking and impairs novel object recognition in rats. Psychopharmacology (Berl) 199:615-624
27. Ross S, Peselow E (2009) The neurobiology of addictive disorders. Clin Neuropharmacol 32:269-276
28. Shaham Y, Shalev U, Lu L, de Wit H, Stewart J (2003) The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl) 168:3-20 (Pubitemid 36851158)
29. Shelton KL, Beardsley PM (2008) Effect of drug-paired exteroceptive stimulus presentations on methamphetamine reinstatement in rats. Pharmacol Biochem Behav 90:434-440
30. Sulzer D, Sonders MS, Poulsen NW, Galli A (2005) Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol 75:406-433 (Pubitemid 40834286)
31. Willuhn I, Wanat MJ, Clark JJ, Phillips PE (2010) Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse. Curr Top Behav Neurosci 3:29-71
32. Wise RA, Bozarth MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94(4):469-492
33. Wise RA, Rompre PP (1989) Brain dopamine and reward. Annu Rev Psychol 40:191-225
34. Yahyavi-Firouz-Abadi N, See RE (2009) Anti-relapse medications: preclinical models for drug addiction treatment. Pharmacol Ther 124:235-247
35. Zheng G, Dwoskin LP, Crooks PA (2006) Vesicular monoamine transporter 2: role as a novel target for drug development. AAPS J 8: E682-E692