Crotoxin, a rattlesnake toxin, induces a long-lasting inhibitory effect on phagocytosis by neutrophils

Experimental Biology and Medicine

Volumn 237, Issue 10, 2012, Pages 1219-1230

  Lima, Tatiane S ^a,b   Cataneo, Sálua C ^a   Iritus, Ana Caroline C ^a   Sampaio, Sandra C ^a   Della Casa, Maisa S ^a   Cirillo, Maria Cristina ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Actin polymerization; Crotalus durissus terrificus venom; Crotoxin; Neutrophil; Phagocytosis; Tyrosine phosphorylation

Indexed keywords

CROTALUS DURISSUS TERRIFICUS SNAKE VENOM; CROTOXIN; REACTIVE OXYGEN METABOLITE; SNAKE VENOM; TYROSINE; UNCLASSIFIED DRUG; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; ZYMOSAN;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; NEUTROPHIL; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANION EXCHANGE CHROMATOGRAPHY; CROTALUS; IMMUNOCYTOCHEMISTRY; INCUBATION TIME; INTRACELLULAR SIGNALING; MACROPHAGE; MICROSCOPY; PERITONEUM EXUDATE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CROTOXIN; HYDROGEN PEROXIDE; INFLAMMATION; LEUKOCYTE COUNT; MALE; NEUTROPHILS; PHAGOCYTOSIS; PHOSPHORYLATION; RATS; RATS, WISTAR; SUPEROXIDES;

CHINO DEL TOMATE VIRUS; CROTALUS; CROTALUS DURISSUS TERRIFICUS; RATTUS;

EID: 84868250468     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2012.012010     Document Type: Article

References (42)

1. Bercovici D, Chudzinski AM, Dias W, Esteves MI, Hirachi E, Oishi NY, Picarelli ZP, Rocha MC, Ueda CMPM, Yamanouye N, Raw I. A systematic fractionation of Crotalus durissus terrificus. Mem Inst Butantan 1987;49:69-78
2. Slotta KH, Fraenkel-Conrat H. Estudos químicos sobre os venenos ofídicos. Purificac ̧ão e cristalizac ̧ão do veneno da cobra cascavel. Mem Inst Butantan 1938;12:505-512
3. Habermann E, Breithaupt H. The crotoxin complex - an example of biochemical and pharmacological protein complementation. Toxicon 1978;16:19-30
4. Sampaio SC, Hyslop S, Fontes MRM, Prado-Frasceschi J, Zambelli VO, Magro AJ, Brigatte P, Gutierrez VP, Cury Y. Crotoxin: novel activities for a classic b-neurotoxin. Toxicon 2010;55:451-460
5. Cardoso DF, Mota I. Effect of Crotalus venom on the humoral and cellular immune response. Toxicon 1997;35:607-612
6. Rangel-Santos A, Lima C, Lopes-Ferreira M, Cardoso DF Immunosuppressive role of principal toxin (crotoxin) of Crotalus durissus terrificus venom. Toxicon 2004;44:609-616
7. Favoretto BC, Ricardi R, Silva SR, Jacysyn JF, Fernandes I, Takehara HA, Faquim-Mauro EL. Immunomodulatory effects of crotoxin isolated from Crotalus durissus terrificus venom in mice immunized with human serum albumin. Toxicon 2011;57:600-607
8. Nunes FP, Sampaio SC, Santoro ML, Sousa-e-Silva MC. Long-lasting anti-inflammatory properties of Crotalus durissus terrificus snake venom in mice. Toxicon 2007;49:1090-1098
9. Nunes FP, Zychar BC, Della-Casa MS, Sampaio SC, Goncalves LR, Cirillo MC. Crotoxin is responsible for the long-lasting anti-inflammatory effect of Crotalus durissus terrificus snake venom: involvement of formyl peptide receptors. Toxicon 2010;55:1100-1106
10. Cirillo MC, Nunes FPB, Della-Casa MS, Spadacci-Morena DD. Action on P-selectin and ICAM-1 expression contribute to potential anti-inflammatory properties of crotoxin, a toxin from rattlesnake venom. Inflamm Res Book Abstr 2011;60:83
11. Nunes FPB, Della-Casa MS, Cirillo MC. Inhibition of secretion of pro-inflammatory cytokines contributes to the long-lasting anti-inflammatory properties of crotoxin: a natural toxin from rattlesnake venom. Inflamm Res Book Abstr 2011;60:111
12. Sousa-e-Silva MCC, Gonçalves LRC, Mariano M. The venom of South American rattlesnakes inhibits macrophage functions and is endowed with anti-inflammatory properties. Mediators Inflamm 1996;5:18-23
13. Sampaio SC, Sousa-e-Silva MCC, Borelli P, Curi R, Cury Y. Crotalus durissus terrificus snake venom regulates macrophage metabolism and function. J Leukoc Biol 2001;70:551-58
14. Sampaio SC, Brigatte P, Sousa-e-Silva MCC, Dos-Santos EC, Rangel-Santos AC, Curi R, Cury Y. Contribution of crotoxin for the inhibitory effect of Crotalus durissus terrificus snake venom on macrophage function. Toxicon 2003;41:899-907
15. Sampaio SC, Santos MF, Costa EP, Rangel-Santos AC, Carneiro SM Curi R, Cury Y. Crotoxin induces actin reorganization and inhibits tyrosine phosphorylation and activity of small GTPases in rat macrophages. Toxicon 2006;47:909-919
16. Levy L. Carrageenan paw edema in the mouse. Life Sci 1969;8:601-606
17. Gill CD, Cooper D, Rosignoli M, Perretti M, Oliani SM. Inflammation-induced modulation of cellular galectin-1 and -3 expression in a model of rat peritonitis. Inflamm Res 2006;55:99-107
18. Lee WL, Harrison RE, Grinstein S. Phagocytosis by neutrophils. Microbes Infect 2003;5:1299-1306
19. Borregaard N. Neutrophils, from marrow to microbes. Immunity 2010;33:657-70
20. Flannagan RS, Jaumouillé V, Grinstein S. The cell biology of phagocytosis. Annu Rev Pathol Mech Dis 2012;7:61-98
21. Furtado MF, Colletto GMDD, Dias da Silva W. Controle de qualidade dos venenos animais e dos correspondentes antivenenos. Mem Inst Butantan 1991;53:149-159
22. Rangel-Santos A, Dos-Santos EC, Lopes-Ferreira M, Lima C, Cardoso DF, Mota I. A comparative study of biological activities of crotoxin and CB fraction of venoms from Crotalus durissus terrificus, Crotalus durissus cascavella and Crotalus durissus collilineatus. Toxicon 2004;43:801-10
23. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685
24. Lôbo-de-Araujo A, Radvanyi F. Determination of phospholipase A2 activity by a colorimetric assay using a pH indicator. Toxicon 1987;25:1181-1188
25. Rosenfeld G. Metodo rápido de coloração de esfregacços de sangue. Nocões pra ́ticas sobre corantes pancrômicos e estudos de diversos fatores. Mem Inst Butantan 1947;20:315-328
26. Corazzini R. Avaliação morfofisiológica de macrófagos peritoneais de camundongos submetidos ao choque eletrico. Dissertação de mestrado em Patologia Experimental e Comparada, Faculdade de Medicina Veterina ́ria e Zootecnia, Universidade de São Paulo, 1993
27. Pick E, Mizel D. Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader. J Immunol Methods 1981;46:211-226
28. Pick E, Keisari Y. A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J Immunol Methods 1980;38:161-170
29. Dypbukt JM, Bishop C, Brooks WM, Thong B, Eriksson H, Kettle AJ. A sensitive and selective assay for chloramine production by myeloperoxidase. Free Radic Biol Med 2005;39:1468-77
30. Zambelli VO, Sampaio SC, Sudo-Hayashi LS, Greco K, Britto LRG Alves AS, Zychar BC, Golçalves LRC, Spadaddi-Morena DD, Otton R, Della-Casa MS, Curi R, Cury Y. Crotoxin alters lymphocyte distribution in rats: involvement of adhesion molecules and lipoxygenase-derived mediators. Toxicon 2008;51:1357-1367
31. Rosenfeld G. Symptomatology, pathology and treatment of snakes bites in South America. In: Bü rchel W, Buckley E, eds. Venomous Animals and their Venoms. New York: Academic Press, 1971: 345-384
32. Glantz SA. Primer of Bio-Statistics. New York: McGraw-Hill, 1997: 65-107
33. Gomes RT, Camargo RPF, Viotti AP, Tavares AP, Revelo MP, Freitas TV. Comparison of the biodistribution of free or liposome-entrapped Crotalus durissus terrificus (South American rattlesnake) venom in mice. Comp Biochem Physiol C Toxicol Pharmacol 2002;131:295-301
34. Bradley TR, Metcalf D. The growth of mouse bone marrow cells in vitro. Aust J Biol Med Sci 1966;44:287-299
35. Metcalf D. Haemato poietic growth factors 1. Lancet 1989;1:825-827
36. Silva MT. When two is better than one: macrophages and neutron phils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system. J Leukoc Biol 2010;87:93-106
37. Minakami R, Maehara Y, Kamakura S, Kumano O, Miyano K, Suminoto H. Membrane phospholipid metabolism during phagocytosis in human neutrophils. Genes Cells 2010;15:409-424
38. Nordenfelt P, Tapper H. Phagosome dynamics during phagocytosis by neutrophils. J Leukoc Biol 2011;90:271-284
39. Vieira OV, Botelho RJ, Grinstein S. Phagosome maturation: aging gracefully. Biochem J 2002;11:425-9
40. Schymeinsky J, Mocsai A, Walzog B. Neutrophil activation via b2 integrins (CD11/CD18): molecular mechanisms and clinical implications. Thromb Haemost 2007;98:262-273
41. Glogauer M, Marchal CC, Zhu F, Worku A, Clausen BE, Foerster I, Marks P, Downey GP, Dinauer M, KwiatKowski DJ. Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol 2003;170:5652-657
42. Kim JS, Diebolds BA, Kim JI, Kim J, Lee JY. Rho is involved in superoxide formation during phagocytosis of opsonized zymosans. J Biol Chem 2004;279:21589-21597