Sex hormone changes during weight loss and maintenance in overweight and obese postmenopausal African-American and non-African-American women

Breast Cancer Research

Volumn 14, Issue 5, 2012, Pages

  Stolzenberg Solomon, Rachael Z ^a   Falk, Roni T ^a   Stanczyk, Frank ^b   Hoover, Robert N ^a   Appel, Lawrence J ^c   Ard, Jamy D ^d   Batch, Bryan C ^e   Coughlin, Janelle ^f   Han, Xu ^a   Lien, Lillian F ^e   Pinkston, Christina M ^a   Svetkey, Laura P ^g   Katki, Hormuzd A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Reproductive Endocrine Research Laboratory   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; ESTRADIOL; ESTRONE; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; SEX HORMONE;

ADULT; AFRICAN AMERICAN; AGED; ARTICLE; BLOOD SAMPLING; BODY MASS; DISEASE SEVERITY; DYSLIPIDEMIA; FEMALE; HORMONAL THERAPY; HUMAN; MAJOR CLINICAL STUDY; OBESITY; PHYSICAL ACTIVITY; POSTMENOPAUSE; PROSPECTIVE STUDY; RACE; WEIGHT CHANGE; WEIGHT REDUCTION; BLOOD; ETHNIC GROUP; ETHNOLOGY; MIDDLE AGED; OVERWEIGHT; RISK FACTOR; TIME; UNITED STATES;

AFRICAN AMERICANS; AGED; ETHNIC GROUPS; FEMALE; GONADAL STEROID HORMONES; HUMANS; MIDDLE AGED; OBESITY; OVERWEIGHT; POSTMENOPAUSE; RISK FACTORS; TIME FACTORS; UNITED STATES; WEIGHT LOSS;

EID: 84868227107     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3346     Document Type: Article

References (56)

1. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010, 303:235-241. 10.1001/jama.2009.2014, 20071471.
2. McTiernan A. Behavioral risk factors in breast cancer: can risk be modified?. Oncologist 2003, 8:326-334. 10.1634/theoncologist.8-4-326, 12897329.
3. Cummings SR, Tice JA, Bauer S, Browner WS, Cuzick J, Ziv E, Vogel V, Shepherd J, Vachon C, Smith-Bindman R, Kerlikowske K. Prevention of breast cancer in postmenopausal women: approaches to estimating and reducing risk. J Natl Cancer Inst 2009, 101:384-398. 10.1093/jnci/djp018, 2720698, 19276457.
4. Key TJ, Appleby PN, Reeves GK, Roddam A, Dorgan JF, Longcope C, Stanczyk FZ, Stephenson HE, Falk RT, Miller R, Schatzkin A, Allen DS, Fentiman IS, Key TJ, Wang DY, Dowsett M, Thomas HV, Hankinson SE, Toniolo P, Akhmedkhanov A, Koenig K, Shore RE, Zeleniuch-Jacquotte A, Berrino F, Muti P, Micheli A, Krogh V, Sieri S, Pala V, Venturelli E, et al. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 2003, 95:1218-1226.
5. DeWaard F, Schwarz F. Weight reduction and postmenopausal estrogenic effect. Acta Cytol 1964, 8:449-453.
6. Boyar AP, Rose DP, Loughridge JR, Engle A, Palgi A, Laakso K, Kinne D, Wynder EL. Response to a diet low in total fat in women with postmenopausal breast cancer: a pilot study. Nutr Cancer 1988, 11:93-99. 10.1080/01635588809513975, 3362724.
7. Prentice R, Thompson D, Clifford C, Gorbach S, Goldin B, Byar D. Dietary fat reduction and plasma estradiol concentration in healthy postmenopausal women. The Women's Health Trial Study Group. J Natl Cancer Inst 1990, 82:129-134. 10.1093/jnci/82.2.129, 2294222.
8. Heber D, Ashley JM, Leaf DA, Barnard RJ. Reduction of serum estradiol in postmenopausal women given free access to low-fat high-carbohydrate diet. Nutrition 1991, 7:137-139.
9. Crighton IL, Dowsett M, Hunter M, Shaw C, Smith IE. The effect of a low-fat diet on hormone levels in healthy pre- and postmenopausal women: relevance for breast cancer. Eur J Cancer 1992, (28A:):2024-2027.
10. Rose DP, Connolly JM, Chlebowski RT, Buzzard IM, Wynder EL. The effects of a low-fat dietary intervention and tamoxifen adjuvant therapy on the serum estrogen and sex hormone-binding globulin concentrations of postmenopausal breast cancer patients. Breast Cancer Res Treat 1993, 27:253-262. 10.1007/BF00665695, 8312583.
11. Berrino F, Bellati C, Ooldani S, Mastroianni A, Allegro G, Berselli E, Venturelli E, Cavalleri A, Cambie M, Pala V, Pasanisi P, Secreto G. DIANA trials on diet and endogenous hormones. IARC Sci Publ 2002, 156:439-444.
12. Berrino F, Bellati C, Secreto G, Camerini E, Pala V, Panico S, Allegro G, Kaaks R. Reducing bioavailable sex hormones through a comprehensive change in diet: the diet and androgens (DIANA) randomized trial. Cancer Epidemiol Biomarkers Prev 2001, 10:25-33.
13. Prentice RL, Caan B, Chlebowski RT, Patterson R, Kuller LH, Ockene JK, Margolis KL, Limacher MC, Manson JE, Parker LM, Paskett E, Phillips L, Robbins J, Rossouw JE, Sarto GE, Shikany JM, Stefanick ML, Thomson CA, Van Horn L, Vitolins MZ, Wactawski-Wende J, Wallace RB, Wassertheil-Smoller S, Whitlock E, Yano K, Adams-Campbell L, Anderson GL, Assaf AR, Beresford SA, Black HR, Brunner RL, Brzyski RG, Ford L, Gass M, Hays J, Heber D, Heiss G, Hendrix SL, Hsia J, Hubbell FA, Jackson RD, Johnson KC, Kotchen JM, LaCroix AZ, Lane DS, Langer RD, Lasser NL, Henderson MM. Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 2006, 295:629-642. 10.1001/jama.295.6.629, 16467232.
14. Carty CL, Kooperberg C, Neuhouser ML, Tinker L, Howard B, Wactawski-Wende J, Beresford SA, Snetselaar L, Vitolins M, Allison M, Budrys N, Prentice R, Peters U. Low-fat dietary pattern and change in body-composition traits in the Women's Health Initiative Dietary Modification Trial. Am J Clin Nutr 2011, 93:516-524. 10.3945/ajcn.110.006395, 3041598, 21177798.
15. Friedenreich CM, Woolcott CG, McTiernan A, Ballard-Barbash R, Brant RF, Stanczyk FZ, Terry T, Boyd NF, Yaffe MJ, Irwin ML, Jones CA, Yasui Y, Campbell KL, McNeely ML, Karvinen KH, Wang Q, Courneya KS. Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women. J Clin Oncol 2010, 28:1458-1466. 10.1200/JCO.2009.24.9557, 2849767, 20159820.
16. Tymchuk CN, Tessler SB, Barnard RJ. Changes in sex hormone-binding globulin, insulin, and serum lipids in postmenopausal women on a low-fat, high-fiber diet combined with exercise. Nutr Cancer 2000, 38:158-162. 10.1207/S15327914NC382_3, 11525592.
17. Caballero MJ, Maynar M. Effects of physical exercise on sex hormone binding globulin, high density lipoprotein cholesterol, total cholesterol and triglycerides in postmenopausal women. Endocr Res 1992, 18:261-279. 10.3109/07435809209111036, 1473520.
18. Caballero MJ, Mahedero G, Hernandez R, Alvarez JL, Rodriguez J, Rodriguez I, Maynar M. Effects of physical exercise on some parameters of bone metabolism in postmenopausal women. Endocr Res 1996, 22:131-138. 10.1080/07435809609030502, 8799692.
19. Turcato E, Zamboni M, De Pergola G, Armellini F, Zivelonghi A, Bergamo-Andreis IA, Giorgino R, Bosello O. Interrelationships between weight loss, body fat distribution and sex hormones in pre- and postmenopausal obese women. J Intern Med 1997, 241:363-372. 10.1046/j.1365-2796.1997.120129000.x, 9183303.
20. Campbell KL, Foster-Schubert KE, Alfano CM, Wang CC, Wang CY, Duggan CR, Mason C, Imayama I, Kong A, Xiao L, Bain CE, Blackburn GL, Stanczyk FZ, McTiernan A. Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial. J Clin Oncol 2012, 30:2314-2326. 10.1200/JCO.2011.37.9792, 22614972.
21. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006, 295:1549-1555. 10.1001/jama.295.13.1549, 16595758.
22. Amend K, Hicks D, Ambrosone CB. Breast cancer in African-American women: differences in tumor biology from European-American women. Cancer Res 2006, 66:8327-8330. 10.1158/0008-5472.CAN-06-1927, 16951137.
23. Svetkey LP, Stevens VJ, Brantley PJ, Appel LJ, Hollis JF, Loria CM, Vollmer WM, Gullion CM, Funk K, Smith P, Samuel-Hodge C, Myers V, Lien LF, Laferriere D, Kennedy B, Jerome GJ, Heinith F, Harsha DW, Evans P, Erlinger TP, Dalcin AT, Coughlin J, Charleston J, Champagne CM, Bauck A, Ard JD, Aicher K. Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial. JAMA 2008, 299:1139-1148. 10.1001/jama.299.10.1139, 18334689.
24. Brantley P, Appel L, Hollis J, Stevens V, Ard J, Champagne C, Elmer P, Harsha D, Myers V, Proschan M, William V, Svetkey L. Design considerations and rationale of a multi-center trial to sustain weight loss: the Weight Loss Maintenance Trial. Clin Trials 2008, 5:546-556. 10.1177/1740774508096315, 2805169, 18827047.
25. Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 1997, 336:1117-1124. 10.1056/NEJM199704173361601, 9099655.
26. Stanczyk FZ, Lee JS, Santen RJ. Standardization of steroid hormone assays: why, how, and when?. Cancer Epidemiol Biomarkers Prev 2007, 16:1713-1719. 10.1158/1055-9965.EPI-06-0765, 17855686.
27. Ranadive GN, Mistry JS, Damodaran K, Khosravi MJ, Diamandi A, Gimpel T, Castracane VD, Patel S, Stanczyk FZ. Rapid, convenient radioimmunoassay of estrone sulfate. Clin Chem 1998, 44:244-249.
28. Sodergard R, Backstrom T, Shanbhag V, Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem 1982, 16:801-810. 10.1016/0022-4731(82)90038-3, 7202083.
29. Fears TR, Ziegler RG, Donaldson JL, Falk RT, Hoover RN, Stanczyk FZ, Vaught JB, Gail MH. Reproducibility studies and interlaboratory concordance for androgen assays in female plasma. Cancer Epidemiol Biomarkers Prev 2000, 9:403-412.
30. Agurs-Collins T, Dunn BK, Browne D, Johnson KA, Lubet R. Epidemiology of health disparities in relation to the biology of estrogen receptor-negative breast cancer. Semin Oncol 2010, 37:384-401. 10.1053/j.seminoncol.2010.05.002, 20816508.
31. Setiawan VW, Haiman CA, Stanczyk FZ, Le ML, Henderson BE. Racial/ethnic differences in postmenopausal endogenous hormones: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev 2006, 15:1849-1855. 10.1158/1055-9965.EPI-06-0307, 17035391.
32. Woods MN, Barnett JB, Spiegelman D, Trail N, Hertzmark E, Longcope C, Gorbach SL. Hormone levels during dietary changes in premenopausal African-American women. J Natl Cancer Inst 1996, 88:1369-1374. 10.1093/jnci/88.19.1369, 8827014.
33. Pinheiro SP, Holmes MD, Pollak MN, Barbieri RL, Hankinson SE. Racial differences in premenopausal endogenous hormones. Cancer Epidemiol Biomarkers Prev 2005, 14:2147-2153. 10.1158/1055-9965.EPI-04-0944, 16172224.
34. McTiernan A, Wu L, Barnabei VM, Chen C, Hendrix S, Modugno F, Rohan T, Stanczyk FZ, Wang CY. Relation of demographic factors, menstrual history, reproduction and medication use to sex hormone levels in postmenopausal women. Breast Cancer Res Treat 2008, 108:217-231. 10.1007/s10549-007-9588-6, 18297397.
35. Gupta PB, Proia D, Cingoz O, Weremowicz J, Naber SP, Weinberg RA, Kuperwasser C. Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers. Cancer Res 2007, 67:2062-2071. 10.1158/0008-5472.CAN-06-3895, 17332335.
36. Rose DP, Haffner SM, Baillargeon J. Adiposity, the metabolic syndrome, and breast cancer in African-American and white American women. Endocr Rev 2007, 28:763-777. 10.1210/er.2006-0019, 17981890.
37. Palmer JR, Adams-Campbell LL, Boggs DA, Wise LA, Rosenberg L. A prospective study of body size and breast cancer in black women. Cancer Epidemiol Biomarkers Prev 2007, 16:1795-1802. 10.1158/1055-9965.EPI-07-0336, 17855697.
38. Allred DC, Brown P, Medina D. The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer. Breast Cancer Res 2004, 6:240-245. 10.1186/bcr938, 1064085, 15535853.
39. Asselin-Labat ML, Vaillant F, Sheridan JM, Pal B, Wu D, Simpson ER, Yasuda H, Smyth GK, Martin TJ, Lindeman GJ, Visvader JE. Control of mammary stem cell function by steroid hormone signalling. Nature 2010, 465:798-802. 10.1038/nature09027, 20383121.
40. Phipps AI, Chlebowski RT, Prentice R, McTiernan A, Wactawski-Wende J, Kuller LH, Adams-Campbell LL, Lane D, Stefanick ML, Vitolins M, Kabat GC, Rohan TE, Li CI. Reproductive history and oral contraceptive use in relation to risk of triple-negative breast cancer. J Natl Cancer Inst 2011, 103:470-477. 10.1093/jnci/djr030, 3057984, 21346227.
41. Palmer JR, Boggs DA, Wise LA, Ambrosone CB, Adams-Campbell LL, Rosenberg L. Parity and lactation in relation to estrogen receptor negative breast cancer in African American women. Cancer Epidemiol Biomarkers Prev 2011, 20:1883-1891. 10.1158/1055-9965.EPI-11-0465, 3179178, 21846820.
42. Cauley JA, Lui LY, Stone KL, Hillier TA, Zmuda JM, Hochberg M, Beck TJ, Ensrud KE. Longitudinal study of changes in hip bone mineral density in Caucasian and African-American women. J Am Geriatr Soc 2005, 53:183-189. 10.1111/j.1532-5415.2005.53101.x, 15673339.
43. Aloia JF. African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox. Am J Clin Nutr 2008, 88:545S-550S. 2777641, 18689399.
44. Kohler BA, Ward E, McCarthy BJ, Schymura MJ, Ries LA, Eheman C, Jemal A, Anderson RN, Ajani UA, Edwards BK. Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst 2011, 103:714-736. 10.1093/jnci/djr077, 3086878, 21454908.
45. McTiernan A, Tworoger SS, Ulrich CM, Yasui Y, Irwin ML, Rajan KB, Sorensen B, Rudolph RE, Bowen D, Stanczyk FZ, Potter JD, Schwartz RS. Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial. Cancer Res 2004, 64:2923-2928. 10.1158/0008-5472.CAN-03-3393, 15087413.
46. McTiernan A, Tworoger SS, Rajan KB, Yasui Y, Sorenson B, Ulrich CM, Chubak J, Stanczyk FZ, Bowen D, Irwin ML, Rudolph RE, Potter JD, Schwartz RS. Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trial. Cancer Epidemiol Biomarkers Prev 2004, 13:1099-1105.
47. Monninkhof EM, Velthuis MJ, Peeters PH, Twisk JW, Schuit AJ. Effect of exercise on postmenopausal sex hormone levels and role of body fat: a randomized controlled trial. J Clin Oncol 2009, 27:4492-4499. 10.1200/JCO.2008.19.7459, 19687339.
48. Kaaks R, Rinaldi S, Key TJ, Berrino F, Peeters PH, Biessy C, Dossus L, Lukanova A, Bingham S, Khaw KT, Allen NE, Bueno-de-Mesquita HB, van Gils CH, Grobbee D, Boeing H, Lahmann PH, Nagel G, Chang-Claude J, Clavel-Chapelon F, Fournier A, Thiebaut A, Gonzalez CA, Quiros JR, Tormo MJ, Ardanaz E, Amiano P, Krogh V, Palli D, Panico S, Tumino R, et al. Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition. Endocr Relat Cancer 2005, 12:1071-1082. 10.1677/erc.1.01038, 16322344.
49. James RE, Lukanova A, Dossus L, Becker S, Rinaldi S, Tjonneland A, Olsen A, Overvad K, Mesrine S, Engel P, Clavel-Chapelon F, Chang-Claude J, Vrieling A, Boeing H, Schutze M, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Krogh V, Panico S, Tumino R, Sacerdote C, Rodriguez L, Buckland G, Sanchez MJ, Amiano P, Ardanaz E, Bueno-de-Mesquita B, Ros MM, et al. Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study. Cancer Prev Res (Phila) 2011, 4:1626-1635.
50. Zeleniuch-Jacquotte A, Gu Y, Shore RE, Koenig KL, Arslan AA, Kato I, Rinaldi S, Kaaks R, Toniolo P. Postmenopausal levels of sex hormones and risk of breast carcinoma in situ: results of a prospective study. Int J Cancer 2005, 114:323-327. 10.1002/ijc.20694, 15540225.
51. Zeleniuch-Jacquotte A, Afanasyeva Y, Kaaks R, Rinaldi S, Scarmo S, Liu M, Arslan AA, Toniolo P, Shore RE, Koenig KL. Premenopausal serum androgens and breast cancer risk: a nested case-control study. Breast Cancer Res 2012, 14:R32. 10.1186/bcr3117, 22339988.
52. Woolcott CG, Shvetsov YB, Stanczyk FZ, Wilkens LR, White KK, Caberto C, Henderson BE, Le ML, Kolonel LN, Goodman MT. Plasma sex hormone concentrations and breast cancer risk in an ethnically diverse population of postmenopausal women: the Multiethnic Cohort Study. Endocr Relat Cancer 2010, 17:125-134. 10.1677/ERC-09-0211, 2880171, 19903744.
53. Missmer SA, Eliassen AH, Barbieri RL, Hankinson SE. Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women. J Natl Cancer Inst 2004, 96:1856-1865. 10.1093/jnci/djh336, 15601642.
54. Bianchini F, Kaaks R, Vainio H. Overweight, obesity, and cancer risk. Lancet Oncol 2002, 3:565-574. 10.1016/S1470-2045(02)00849-5, 12217794.
55. Kuller LH, Matthews KA, Meilahn EN. Estrogens and women's health: interrelation of coronary heart disease, breast cancer and osteoporosis. J Steroid Biochem Mol Biol 2000, 74:297-309. 10.1016/S0960-0760(00)00106-0, 11162938.
56. Friedenreich CM, Orenstein MR. Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 2002, 132:3456S-3464S.