Mutant erythropoietin without erythropoietic activity is neuroprotective against ischemic brain injury

Stroke

Volumn 43, Issue 11, 2012, Pages 3071-3077

  Gan, Yu ^a,b   Xing, Juan ^b   Jing, Zheng ^a,b   Anne Stetler, R ^b,d   Zhang, Feng ^d   Luo, Yumin ^c   Ji, Xunming ^c   Gao, Yanqin ^d   Cao, Guodong ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

Author keywords

AKT; cerebral ischemia; ERK1 2; erythropoietin; erythropoietin mutant; neuroprotection; neurotoxicity

Indexed keywords

ERYTHROPOIETIN; ISOLEUCINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUTANT PROTEIN; N METHYL DEXTRO ASPARTIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; RECOMBINANT ERYTHROPOIETIN; SERINE; STAT5 PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN NERVE CELL; BRAIN PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG SCREENING; ENZYME INHIBITION; ERYTHROPOIESIS; EXPERIMENTAL MODEL; INTRACELLULAR SIGNALING; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; THROMBOCYTE; TREATMENT OUTCOME; WILD TYPE;

ANIMALS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN; MICE; MICE, INBRED C57BL; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84868208378     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.112.663120     Document Type: Article

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