Distinct pathophysiologic mechanisms of septic acute kidney injury: Role of immune suppression and renal tubular cell apoptosis in murine model of septic acute kidney injury

Critical Care Medicine

Volumn 40, Issue 11, 2012, Pages 2997-3006

  Lee, So Young ^a,b   Lee, Yong Su ^b   Choi, Hye Min ^b   Ko, Yoon Sook ^b   Lee, Hee Young ^b   Jo, Sang Kyung ^b   Cho, Won Yong ^b   Kim, Hyoung Kyu ^b  

^a Eulji General Hospital   (South Korea)

^b Korea University College of Medicine   (South Korea)

Author keywords

acute kidney injury; apoptosis; immune suppression; ischemia reperfusion injury; regulatory t cells; sepsis

Indexed keywords

CASPASE 3; CASPASE 3 INHIBITOR; CYTOKINE; INTERLEUKIN 10;

ACUTE KIDNEY FAILURE; ACUTE KIDNEY TUBULE NECROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHEMICAL ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOSUPPRESSIVE TREATMENT; ISCHEMIA; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY TUBULE CELL; LIGATION; MALE; MOUSE; NEPHRITIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PUNCTURE; REGULATORY T LYMPHOCYTE; REPERFUSION INJURY; SEPTIC SHOCK;

ACUTE KIDNEY INJURY; ANIMALS; APOPTOSIS; CASPASE 3; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; IMMUNOSUPPRESSION; INTERLEUKIN-10; KIDNEY TUBULES; MALE; MICE; MICE, INBRED C57BL; REPERFUSION INJURY; SEPSIS; T-LYMPHOCYTES, REGULATORY;

EID: 84868208280     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31825b912d     Document Type: Article

References (31)

1. Chertow GM, Burdick E, Honour M, et al: Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 2005; 16:3365-3370
2. Uchino S, Kellum JA, Bellomo R, et al; Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators: Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA 2005; 294:813-818
3. Waikar SS, Curhan GC, Wald R, et al: Declining mortality in patients with acute renal failure, 1988 to 2002. J Am Soc Nephrol 2006; 17:1143-1150
4. Bagshaw SM, Uchino S, Bellomo R, et al; Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators: Septic acute kidney injury in critically ill patients: Clinical characteristics and outcomes. Clin J Am Soc Nephrol 2007; 2:431-439
5. Schrier RW, Wang W: Acute renal failure and sepsis. N Engl J Med 2004; 351:159-169
6. Cohen J, Carlet J: INTERSEPT: An international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 1996; 24:1431-1440
7. Abraham E: Why immunomodulatory therapies have not worked in sepsis. Intensive Care Med 1999; 25:556-566
8. Hotchkiss RS, Opal S: Immunotherapy for sepsis-a new approach against an ancient foe. N Engl J Med 2010; 363:87-89
9. Hotchkiss RS, Swanson PE, Freeman BD, et al: Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999; 27:1230-1251
10. Hotchkiss RS, Tinsley KW, Swanson PE, et al: Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci USA 1999; 96:14541-14546
11. Hotchkiss RS, Tinsley KW, Swanson PE, et al: Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol 2002; 168:2493-2500
12. Unsinger J, Kazama H, McDonough JS, et al: Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAILdependent mechanism. J Immunol 2010; 184:6766-6772
13. Gandolfo MT, Jang HR, Bagnasco SM, et al: Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury. Kidney Int 2009; 76:717-729
14. Kim MG, Lee SY, Ko YS, et al: CD4+ CD25+ regulatory T cells partially mediate the beneficial effects of FTY720, a sphingosine-1-phosphate analogue, during ischaemia/reperfusion-induced acute kidney injury. Nephrol Dial Transplant 2011; 26:111-124
15. Jaffe R, Ariel I, Beeri R, et al: Frequent apoptosis in human kidneys after acute renal hypoperfusion. Exp Nephrol 1997; 5:399-403
16. Terada Y, Inoshita S, Kuwana H, et al: Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury. Biochem Biophys Res Commun 2007; 364:1043-1049
17. Kindt N, Menzebach A, Van de Wouwer M, et al: Protective role of the inhibitor of apoptosis protein, survivin, in toxin-induced acute renal failure. FASEB J 2008; 22:510-521
18. Leemans JC, Stokman G, Claessen N, et al: Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 2005; 115:2894-2903
19. Pulskens WP, Teske GJ, Butter LM, et al: Tolllike receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury. PLoS ONE 2008; 3:e3596
20. Langenberg C, Wan L, Egi M, et al: Renal blood flow in experimental septic acute renal failure. Kidney Int 2006; 69:1996-2002
21. Brun C, Munck O: Lesions of the kidney in acute renal failure following shock. Lancet 1957; 272:603-607
22. Diaz de Leon M, Moreno SA, Gonzalez Diaz DJ, et al: Severe sepsis as a cause of acute renal failure. Nefrologia 2006; 26:439-444
23. Langenberg C, Bagshaw SM, May CN, et al: The histopathology of septic acute kidney injury: A systematic review. Crit Care 2008; 12:R38
24. Messaris E, Memos N, Chatzigianni E, et al: Apoptotic death of renal tubular cells in experimental sepsis. Surg Infect (Larchmt) 2008; 9:377-388
25. Jo SK, Cha DR, Cho WY, et al: Inflammatory cytokines and lipopolysaccharide induce Fasmediated apoptosis in renal tubular cells. Nephron 2002; 91:406-415
26. Lerolle N, Nochy D, Gu?ot E, et al: Histopathology of septic shock induced acute kidney injury: Apoptosis and leukocytic infiltration. Intensive Care Med 2010; 36:471-478
27. Wang W, Faubel S, Ljubanovic D, et al: Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice. Am J Physiol Renal Physiol 2005; 288:F997-1004
28. Brahmamdam P, Inoue S, Unsinger J, et al: Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J Leukoc Biol 2010; 88:233-240
29. Kinsey GR, Sharma R, Huang L, et al: Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury. J Am Soc Nephrol 2009; 20:1744-1753
30. Lee H, Nho D, Chung HS, et al: CD4+CD25+ regulatory T cells attenuate cisplatin-induced nephrotoxicity in mice. Kidney Int 2010; 78:1100-1109
31. Hiraki S, Ono S, Tsujimoto H, et al: Neutralization of interleukin-10 or transforming growth factor-? decreases the percentages of CD4+ CD25+ Foxp3+ regulatory T cells in septic mice, thereby leading to an improved survival. Surgery 2012; 151:313-322