Genetic risk factors in Parkinson's disease: Single gene effects and interactions of genotypes

Journal of Neurology

Volumn 259, Issue 11, 2012, Pages 2503-2505

  Göbel, Anna ^a   Macklin, Eric A ^b   Winkler, Susen ^a   Betensky, Rebecca A ^c   Klein, Christine ^a   Lohmann, Katja ^a   Simon, David K ^d  

^a UNIVERSITY OF LÜBECK   (Germany)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; TAU PROTEIN; UBIQUITIN THIOLESTERASE;

GENE INTERACTION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; LETTER; PARKINSON DISEASE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SYNAPTOSOME;

ARYLAMINE N-ACETYLTRANSFERASE; EPISTASIS, GENETIC; GENETIC DISEASES, INBORN; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; PARKINSON DISEASE; POLYMORPHISM, GENETIC; RISK FACTORS; UBIQUITIN THIOLESTERASE;

EID: 84868205698     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-012-6623-2     Document Type: Letter

References (14)

1. Gasser T, Hardy J, Mizuno Y (2011) Milestones in PD genetics. Mov Disord 26:1042-1048
2. Gibb WR, Lees AJ (1988) The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neuro-surg Psychiatry 51:745-752
3. Golab-Janowska M, Honczarenko K, Gawronska-Szklarz B, Potemkowski A (2007) The role of NAT2 gene polymorphism in aetiology of the most frequent neurodegenerative diseases with dementia. Neurol Neurochir Pol 41:388-394 (Pubitemid 350200123)
4. IPsDGC (2011) A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genet 7:e1002142
5. Ittner A, Ke YD, van Eersel J, Gladbach A, Gotz J, Ittner LM (2011) Brief update on different roles of tau in neurodegeneration. IUBMB Life 63:495-502
6. Kuznetsov IB, McDuffie M, Moslehi R (2009) A web-server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT genotype. Bioinformatics 25:1185-1186
7. Kyratzi E, Pavlaki M, Stefanis L (2008) The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells. Hum Mol Genet 17:2160-2171 (Pubitemid 351911985)
8. Lill CM RJ, McQueen MB, Kavvoura F, Bagade S, Schjeide BMM, Schjeide L, Meissner E, Zauft U, Allen NC, Tanzi R, Khoury MJ, Ionnidis JPA, Bertram L The PDGene Database. Parkinson Research Forum
9. Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC et al (2012) Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: the PDGene Database. PLoS Genet 8:e1002548
10. Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simon-Sanchez J, Schulte C, Lesage S, Sveinbjornsdottir S et al (2011) Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet 377:641-649
11. Schapira AH (2009) Etiology and pathogenesis of Parkinson disease. Neurol Clin 27:583-603
12. Stroke" NIoNDa: A multicenter, double-blind, parallel group, placebo controlled studyofcreatineinsubjects with treated Parkinson's disease (PD) long term study (LS-1). In: Identifier NCT00449865
13. Vekrellis K, Xilouri M, Emmanouilidou E, Rideout HJ, Stefanis L (2011) Pathological roles of alpha-synuclein in neurological disorders. Lancet Neurol 10:1015-1025
14. Winkler S, Konig IR, Lohmann-Hedrich K, Vieregge P, Kostic V, Klein C (2007) Role of ethnicity on the association of MAPT H1 haplotypes and subhaplotypes in Parkinson's disease. Eur J Hum Genet 15:1163-1168 (Pubitemid 350011681)