Dexamethasone treatment interferes with the pharmacokinetics of ivermectin in young cattle

Veterinary Parasitology

Volumn 190, Issue 3-4, 2012, Pages 482-488

  Areskog, Marlene ^a   Von Samson Himmelstjerna, Georg ^b   Alvinerie, Michel ^c   Sutra, Jean François ^c   Höglund, Johan ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c CEMAGREF   (France)

Author keywords

Anthelmintic resistance; Cooperia; Gastrointestinal parasites; Immunosuppression; Macrocyclic lactones; Ostertagia

Indexed keywords

DEXAMETHASONE; DEXAMETHASONE ISONICOTINATE; DEXAMETHASONE SODIUM PHOSPHATE; IVERMECTIN; UNCLASSIFIED DRUG; VONRENVET;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD CELL COUNT; CATTLE; CONTROLLED STUDY; COOPERIA ONCOPHORA; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG EFFICACY; FECES ANALYSIS; IMMUNE DEFICIENCY; JUVENILE ANIMAL; LARVAL STAGE; MALE; NEMATODIASIS; NONHUMAN; OSTERTAGIA OSTERTAGI; PLASMA CONCENTRATION-TIME CURVE; RECOMMENDED DRUG DOSE; RUMINANT STOMACH; SMALL INTESTINE;

ANIMALS; ANTHELMINTICS; ANTI-INFLAMMATORY AGENTS; CATTLE; DEXAMETHASONE; DRUG INTERACTIONS; FECES; IVERMECTIN; OSTERTAGIA; OSTERTAGIASIS; PARASITE EGG COUNT; TRICHOSTRONGYLOIDEA; TRICHOSTRONGYLOIDIASIS;

ANIMALIA; BOS; COOPERIA; COOPERIA ONCOPHORA; OSTERTAGIA; OSTERTAGIA OSTERTAGI;

EID: 84868201532     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2012.07.011     Document Type: Article

References (46)

1. Alvinerie M., Sutra J.F., Galtier P. Ivermectin in goat plasma and milk after subcutaneous injection. Ann. Rech. Vet. 1993, 24:417-421.
2. Anderson B.H., Watson D.L., Coldiz I.G. The effect of dexamethasone on some immunological parameters in cattle. Vet. Res. Commun. 1999, 23:399-413.
3. Anonymous Manual of Veterinary Parasitological Laboratory Techniques. Reference Book 418 1986, Her Majesty's Stationary Office, London, 160 pp. third ed.
4. Borgsteede F.H., Hendriks J. Identification of infective larvae of gastrointestinal nematodes in cattle. Tijdschr. Diergeneeskd. 1974, 99:103-113.
5. Cabaret J., Berrag B.B. Faecal egg count reduction test for assessing anthelmintic efficacy: average versus individually based estimations. Vet. Parasitol. 2004, 121:105-113.
6. Coles G.C., Bauer C., Borgsteede F.H.M., Geerts S., Klei T.R., Taylor M.A., Waller P.J. World Association for the Advancement of Veterinary Parasitology (WAAVP). Methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet. Parasitol. 1992, 44:35-44.
7. Coles G.C. Resistance in cattle worms. Vet. Rec. 2004, 155:312.
8. Coles G.C., Watson C.L., Anziani O.S. Ivermectin-resistant Cooperia in cattle. Vet. Rec. 2001, 148:283-284.
9. Cringoli G. FLOTAC, a novel apparatus for a multivalent faecal egg count technique. Parassitologia 2006, 48:381-384.
10. Cringoli G., Rinaldi L., Veneziano V., Capelli G., Scala A. The influence of flotation solution, sample dilution and the choice of McMaster slide area (volume) on the reliability of the McMaster technique in estimating the faecal egg counts of gastrointestinal strongyles and Dicrocoelium dendriticum in sheep. Vet. Parasitol. 2004, 123:121-131.
11. Demeler J., Küttler U., von Samson-Himmelstjerna G. Adaptation and evaluation of three different in vitro tests for the detection of resistance to anthelmintics in gastro intestinal nematodes of cattle. Vet. Parasitol. 2010, 170:61-70.
12. Demeler J., van Zeveren A.M.J., Kleinschmidt N., Vercruysse J., Höglund J., Koopmann R., Cabaret J., Claerebout E., Areskog M., von Samson-Himmelstjerna G. Monitoring the efficacy of ivermectin and albendazole against gastro intestinal nematodes of cattle in Northern Europe. Vet. Parasitol. 2009, 160:109-115.
13. De Montigny P., Shim J.S.K., Pivnichny J.V. Liquid chromatographic determination in animal plasma with trifluoroacetic anhydride and N-methylimidazole as the derivatization reagent. J. Pharm. Biomed. Anal. 1990, 8:507-511.
14. Dupuy J., Alvinerie M., Menez C., Lespine A. Interaction of anthelmintic drugs with P-glycoprotein in recombinant LLC-PK1-mdr1a cells. Chem. Biol. Interact. 2010, 186:280-286.
15. El-Abdellati A., Charlier J., Geldhof P., Levecke B., Demeler J., von Samson- Himmelstjerna G., Claerebout E., Vercruysse J. The use of a simplified faecal egg count reduction test for assessing anthelmintic efficacy on Belgian and German cattle farms. Vet. Parasitol. 2010, 169:352-357.
16. Gasbarre L.C. Effects of gastrointestinal nematode infection on the ruminant immune system. Vet. Parasitol. 1997, 72:327-343.
17. Hamid S.Y.A., Mohi Aldeen K.A. Effects of dexamethasone on leukocytes in sheep. Indian J. Vet. Med. 1992, 12:52-55.
18. Höglund J. Parasite surveillance and novel use of anthelmintics in cattle. Acta Vet. Scand. 2010, 52:2-5.
19. Kanobana K., Koets A., Bakker N., Ploeger H.W., Vervelde L. T-cell mediated immune responses in calves primary infected or re-infected with Cooperia oncophora: similar effector cells but different timing. Int. J. Parasitol. 2003, 33:1503-1514.
20. Kaplan R.M. Drug resistance in nematodes of veterinary importance: a status report. Trends Parasitol. 2004, 20:477-481.
21. Kerboeuf D., Guégnard F. Anthelmintics are substrates and activators of nematode P-glycoprotein. Antimicrob. Agents Chemother. 2011, 55:2224-2232.
22. Kochapakdee S., Pandey V.S., Pralomkarm W., Choldumrongkul S., Ngampongsai W., Lawpetchara A. Anthelmintic resistance in goat in southern Thailand. Vet. Rec. 1995, 137:124-125.
23. Larsson A., Dimander S.O., Waller A., Uggla A., Höglund J. A 3-year field evaluation of pasture rotation and supplementary feeding to control parasite infection in first-season grazing cattle - dynamics of pasture infectivity. Vet. Parasitol. 2007, 145:129-137.
24. Lifschitz A., Suarez V.H., Sallovitz J., Cristel S.L., Imperiale F., Ahoussou S., Schiavi C., Lanusse C. Cattle nematodes resistant to macrocyclic lactones: comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin. Exp. Parasitol. 2010, 125:172-178.
25. Lin J.H., Chiba M., Chen I.W., Nishime J.A., Deluna F.A., Yamazaki M., Lin Y.J. Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and P-glycoprotein induction. Drug Metab. Dispos. 1999, 27:1187-1193.
26. Lomborg S.R., Agerholm J.S., Jensen A.L., Nielsen L.R. Effects of experimental immunosuppression in cattle with persistently high antibody levels to Salmonella dublin lipopolysaccharide O-antigens. BMC Vet. Res. 2007, 3:17.
27. Matthews D., Brunsdon R.V., Vlassoff A. Effect of dexamethasone on the ability of sheep to resist reinfection with nematodes. Vet. Parasitol. 1979, 5:65-72.
28. McKenna P.B. Topically applied ivermectin and Cooperia infections in cattle. N. Z. Vet. J. 1995, 43:44.
29. Mejía M.E., Fernandez Igartúa B.M., Schmidt E.E., Cabaret J. Multispecies and multiple anthelmintic resistance on cattle nematodes in a farm in Argentina: the beginning of high resistance. Vet. Res. 2003, 34:461-467.
30. Molento M., Lifschitz A., Sallovitz J., Lanusse C., Prichard R. Influence of verapamil on the pharmacokinetics of the antiparasitic drugs ivermectin and moxidectin in sheep. Parasitol. Res. 2004, 92:121-127.
31. Newton R. Molecular mechanisms of glucocorticoid action: what is important?. Thorax 2000, 55:603-613.
32. Peña M.T., Miller J.E., Horohov D.W. Effect of dexamethasone treatment on the immune response of Gulf Coast Native lambs to Haemonchus contortus infection. Vet. Parasitol. 2004, 119:223-235.
33. Perloff M.D., Von Moltke L.L., Greenblatt D.J. Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats. Xenobiotica 2004, 34:133-150.
34. Prichard R.K. Genetic variability following selection of Haemonchus contortus with anthelmintics. Trends Parasitol. 2001, 17:445-453.
35. Roth J.A., Flaming K.P. Model systems to study immunomodulation in domestic food animals. Immunomodulation in Domestic Food Animals 1990, 21-41. Academic Press, Inc., San Diego. F. Blecha, B. Charley (Eds.).
36. Soutello R.G.V., Seno M.C.Z., Amarante A.F.T. Anthelmintic resistance in cattle nematodes in northwestern Sao Paolo State, Brazil. Vet. Parasitol. 2007, 148:360-364.
37. Stafford K., Morgan E., Coles G.C. Anthelmintic resistance in cattle. Vet. Rec. 2007, 160:671-672.
38. Suarez V.H., Cristel S.L. Anthelmintic resistance in cattle nematode in the western Pampeana region of Argentina. Vet. Parasitol. 2007, 144:111-117.
39. Sutherland I.A., Leathwick D.M. Anthelmintic resistance in nematode parasites of cattle: a global issue?. Trends Parasitol. 2011, 27:176-181.
40. Ueda K. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J. Biol. Chem. 1992, 267:24248-24252.
41. Vercruysse J., Holdswroth P., Letonja T., Barth D., Conder G., Hamamoto K., Okano K. International harmonization of anthelmintic efficacy guidelines. Vet. Parasitol. 2001, 96:171-193.
42. Vermunt J.J., West D.M., Pomroy W.E. Multiple resistance to ivermectin and oxfendazole in Cooperia species of cattle in New Zealand. Vet. Rec. 1995, 137:43-45.
43. Waghorn T.S., Leathwick D.M., Rhodes A.P., Jackson R., Pomroy W.E., West D.M., Moffat J.R. Prevalence of anthelmintic resistance on 62 beef cattle farms in the North Island of New Zealand. N. Z. Vet. J. 2006, 54:278-282.
44. West D.M., Vermunt J.J., Pomroy W.E., Bentall H.P. Inefficacy of ivermectin against Cooperia spp. infection in cattle. N. Z. Vet. J. 1994, 42:192-193.
45. Wolstenholme A.J., Fairweather I., Prichard R., von Samson-Himmelstjerna G., Sangster N.C. Drug resistance in veterinary helminthes. Trends Parasitol. 2004, 20:469-476.
46. Zeng Z., Andrew N.W., Arison B.H., Luffer-Atlas D., Wang R.W. Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes. Xenobiotica 1998, 28:313-321.