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Volumn 24, Issue 6, 2012, Pages 720-726

Allogeneic hematopoietic stem cell transplantation for multiple myeloma: Curative but not the standard of care

Author keywords

allogeneic hematopoietic stem cell transplantation; multiple myeloma; posttransplantation immunotherapy

Indexed keywords

BUSULFAN; CALCINEURIN INHIBITOR; CANCER TESTIS ANTIGEN; CYCLOPHOSPHAMIDE; FLUDARABINE; MELANOMA ANTIGEN 1; MELANOMA ANTIGEN 3; MELPHALAN;

EID: 84868200827     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0b013e328358f619     Document Type: Review
Times cited : (16)

References (41)
  • 1
    • 0026070258 scopus 로고
    • Allogeneic bone marrow transplantation in multiple myeloma
    • Gahrton G, Tura S, Ljungman P, et al. Allogeneic bone marrow transplantation in multiple myeloma. N Engl J Med 1991; 325:1267-1273.
    • (1991) N Engl J Med , vol.325 , pp. 1267-1273
    • Gahrton, G.1    Tura, S.2    Ljungman, P.3
  • 2
    • 0029039069 scopus 로고
    • Prognostic factors in allogeneic bone marrow transplantation for multiple myeloma
    • Gahrton G, Tura S, Ljungman P, et al. Prognostic factors in allogeneic bone marrow transplantation for multiple myeloma. J Clin Oncol 1995; 13:1312-1322.
    • (1995) J Clin Oncol , vol.13 , pp. 1312-1322
    • Gahrton, G.1    Tura, S.2    Ljungman, P.3
  • 3
    • 33947197286 scopus 로고    scopus 로고
    • A comparison of allografting with autografting for newly diagnosed myeloma
    • Bruno B, Rotta M, Patriarca F, et al. A comparison of allografting with autografting for newly diagnosed myeloma. N Engl J Med 2007; 356:1110-1120.
    • (2007) N Engl J Med , vol.356 , pp. 1110-1120
    • Bruno, B.1    Rotta, M.2    Patriarca, F.3
  • 4
    • 55749099328 scopus 로고    scopus 로고
    • A prospective PETHEMA study of tandem autologous transplantation versus autograft followed by reducedintensity conditioning allogeneic transplantation in newly diagnosed multiple myeloma
    • Rosiñ ol L, Pé rez-Simó n JA, Sureda A, et al. A prospective PETHEMA study of tandem autologous transplantation versus autograft followed by reducedintensity conditioning allogeneic transplantation in newly diagnosed multiple myeloma. Blood 2008; 112:3591-3593;
    • (2008) Blood , vol.112 , pp. 3591-3593
    • Rosiñol, L.1    Pérez-Simó, N.J.A.2    Sureda, A.3
  • 5
    • 58149199537 scopus 로고    scopus 로고
    • A Phase II trial of autologous stem cell transplantation followed by mini-allogeneic stem cell transplantation for the treatment of multiple myeloma: An analysis of Eastern Cooperative Oncology Group ECOG E4A98 and E1A97
    • Vesole DH, Zhang L, Flomenburg N, et al. A Phase II trial of autologous stem cell transplantation followed by mini-allogeneic stem cell transplantation for the treatment of multiple myeloma: an analysis of Eastern Cooperative Oncology Group ECOG E4A98 and E1A97. Biol Blood Marrow Transplant 2009; 15:83-91.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 83-91
    • Vesole, D.H.1    Zhang, L.2    Flomenburg, N.3
  • 6
    • 82555179157 scopus 로고    scopus 로고
    • Autologous haemopoietic stem-cell transplantation followed by allogeneic or autologous haemopoietic stem-cell transplantation in patients with multiple myeloma (BMT CTN 0102): A phase 3 biological assignment trial
    • Krishnan A, Pasquini MC, Logan B, et al. Autologous haemopoietic stem-cell transplantation followed by allogeneic or autologous haemopoietic stem-cell transplantation in patients with multiple myeloma (BMT CTN 0102): a phase 3 biological assignment trial. Lancet Oncol 2011; 12:1195-1203.
    • (2011) Lancet Oncol , vol.12 , pp. 1195-1203
    • Krishnan, A.1    Pasquini, M.C.2    Logan, B.3
  • 7
    • 0031827442 scopus 로고    scopus 로고
    • Phase I-II evaluation of rapid sequence tandem high dose melphalan with peripheral blood stem cell support in patients with multiple myeloma
    • WeaverC, Zhen B,Schwartzberg L, et al. Phase I-II evaluation of rapid sequence tandem high dose melphalan with peripheral blood stem cell support in patients with multiple myeloma. Bone Marrow Transplant 1998; 22:245-251.
    • (1998) Bone Marrow Transplant , vol.22 , pp. 245-251
    • Weaver, C.1    Zhen, B.2    Schwartzberg, L.3
  • 8
    • 0024350166 scopus 로고
    • Intensive treatment of multiple myeloma and criteria for complete remission
    • Gore M, Selby P, Viner C, et al. Intensive treatment of multiple myeloma and criteria for complete remission. Lancet Oncol 1989; 2:879-882.
    • (1989) Lancet Oncol , vol.2 , pp. 879-882
    • Gore, M.1    Selby, P.2    Viner, C.3
  • 9
    • 84858001524 scopus 로고    scopus 로고
    • Early versus delayed autologous transplantation after immunomodulatory agents-based induction thearpy in patients with newly diagnosed multiple myeloma
    • Kumar SK, Lacy MQ, Dispenzieri A, et al. Early versus delayed autologous transplantation after immunomodulatory agents-based induction thearpy in patients with newly diagnosed multiple myeloma. Cancer 2011; 118:1585-1592.
    • (2011) Cancer , vol.118 , pp. 1585-1592
    • Kumar, S.K.1    Lacy, M.Q.2    Dispenzieri, A.3
  • 10
    • 84860744403 scopus 로고    scopus 로고
    • Continuous lenalidomide treatment for newly diagnosed multiple myeloma
    • Palumbo A, Hajek R, Delforge M, et al. Continuous lenalidomide treatment for newly diagnosed multiple myeloma. N Engl J Med 2012; 366:1759-1769.
    • (2012) N Engl J Med , vol.366 , pp. 1759-1769
    • Palumbo, A.1    Hajek, R.2    Delforge, M.3
  • 11
    • 84860741191 scopus 로고    scopus 로고
    • Lenalidomide after stem-cell transplantation for multiple myeloma
    • McCarthy PL, Owzar K, Hofmeister CC, et al. Lenalidomide after stem-cell transplantation for multiple myeloma. N Engl J Med 2012; 366:1770-1781.
    • (2012) N Engl J Med , vol.366 , pp. 1770-1781
    • McCarthy, P.L.1    Owzar, K.2    Hofmeister, C.C.3
  • 12
    • 84860709392 scopus 로고    scopus 로고
    • Lenalidomide maintenance after stem-cell transplantation for multiple myeloma
    • Attal MM, Lauwers-Cances V, Marit G, et al. Lenalidomide maintenance after stem-cell transplantation for multiple myeloma. N Engl J Med 2012; 366:1782-1791.
    • (2012) N Engl J Med , vol.366 , pp. 1782-1791
    • Attal, M.M.1    Lauwers-Cances, V.2    Marit, G.3
  • 13
    • 33644920953 scopus 로고    scopus 로고
    • Standard chemotherapy compared with high-dose chemoradiotherapy for multiple myeloma: Final results of phase III US Intergroup Trial S9321
    • Barlogie B, Kyle R, Anderson K, et al. Standard chemotherapy compared with high-dose chemoradiotherapy for multiple myeloma: final results of phase III US Intergroup Trial S9321. J Clin Oncol 2006; 24:926-936.
    • (2006) J Clin Oncol , vol.24 , pp. 926-936
    • Barlogie, B.1    Kyle, R.2    Anderson, K.3
  • 14
    • 84862777140 scopus 로고    scopus 로고
    • Predictors of prolonged survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma
    • Bashir Q, Khan H, Orlowski R, et al. Predictors of prolonged survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma. Am J Hematol 2012; 87:272-276.
    • (2012) Am J Hematol , vol.87 , pp. 272-276
    • Bashir, Q.1    Khan, H.2    Orlowski, R.3
  • 15
    • 80051642093 scopus 로고    scopus 로고
    • Tandem autologous/reduced intensity conditioning allogeneic stem-cell transplantation verus autologous transplantation in myeloma: Long-term follow up
    • Björkstrand B, Iacobelli S, Hegenbart U, et al. Tandem autologous/reduced intensity conditioning allogeneic stem-cell transplantation verus autologous transplantation in myeloma: long-term follow up. J Clin Oncol 2011; 29: 3016-3022.
    • (2011) J Clin Oncol , vol.29 , pp. 3016-3022
    • Björkstrand, B.1    Iacobelli, S.2    Hegenbart, U.3
  • 16
    • 25844477041 scopus 로고    scopus 로고
    • Multiple myeloma: Diagnose and treatment
    • Rajkumar SV, Kyle R. Multiple myeloma: diagnose and treatment. Mayo Clin Proc 2005; 80:1371-1382.
    • (2005) Mayo Clin Proc , vol.80 , pp. 1371-1382
    • Rajkumar, S.V.1    Kyle, R.2
  • 17
    • 20644460600 scopus 로고    scopus 로고
    • International staging system for multiple myeloma
    • Greipp P, San Miguel J, Durie B, et al. International staging system for multiple myeloma. J Clin Oncol 2005; 23:3412-3420.
    • (2005) J Clin Oncol , vol.23 , pp. 3412-3420
    • Greipp, P.1    San Miguel, J.2    Durie, B.3
  • 18
    • 7944227334 scopus 로고    scopus 로고
    • Multiple myeloma involving central nervous system: High frequency of chromosome 17p13.1
    • Chang H, Sloan S, Li D, Keith Stewart A. Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1. Br J Haematol 2004; 127:280-284.
    • (2004) Br J Haematol , vol.127 , pp. 280-284
    • Chang, H.1    Sloan, S.2    Li, D.3    Keith Stewart, A.4
  • 19
    • 27144441760 scopus 로고    scopus 로고
    • Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32) and-17p13 in myeloma patients treated with high-dose therapy
    • Gertz MA, Lacy MQ, Dispenzieri A, et al. Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32) and-17p13 in myeloma patients treated with high-dose therapy. Blood 2005; 106:2837-2840.
    • (2005) Blood , vol.106 , pp. 2837-2840
    • Gertz, M.A.1    Lacy, M.Q.2    Dispenzieri, A.3
  • 20
    • 77957996812 scopus 로고    scopus 로고
    • Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: Prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies
    • Dimopoulos M, Kastritis E, Christoulas D, et al. Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies. Leukemia 2010; 24:1769-1778.
    • (2010) Leukemia , vol.24 , pp. 1769-1778
    • Dimopoulos, M.1    Kastritis, E.2    Christoulas, D.3
  • 21
    • 78549269073 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone for relapsed or treatment refractory multiple myeloma: The collaborative study at six institutes in Kyoto and Osaka
    • Kobayashi T, Kuroda J, Shimura K, et al. Bortezomib plus dexamethasone for relapsed or treatment refractory multiple myeloma: the collaborative study at six institutes in Kyoto and Osaka. Int J Hematol 2010; 92:579-586.
    • (2010) Int J Hematol , vol.92 , pp. 579-586
    • Kobayashi, T.1    Kuroda, J.2    Shimura, K.3
  • 22
    • 79953125606 scopus 로고    scopus 로고
    • Treatment of relapsed and refractory multiple myeloma in the era of novel agents
    • van de Donk NW, Lokhorst HM, Dimopoulos M, et al. Treatment of relapsed and refractory multiple myeloma in the era of novel agents. Cancer Treat Rev 2011; 37:266-283.
    • (2011) Cancer Treat Rev , vol.37 , pp. 266-283
    • Van De Donk, N.W.1    Lokhorst, H.M.2    Dimopoulos, M.3
  • 23
    • 84856719479 scopus 로고    scopus 로고
    • Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter international myeloma working group study
    • Kumar SK, Lee J, Lahuerta J, et al. Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group study. Leukemia 2012; 26:149-157.
    • (2012) Leukemia , vol.26 , pp. 149-157
    • Kumar, S.K.1    Lee, J.2    Lahuerta, J.3
  • 24
    • 45449104670 scopus 로고    scopus 로고
    • Reduced-intensity conditioning allogeneic SCT as salvage treatment for relapsed multiple myeloma
    • de Lavallade H, El-Cheikh J, Faucher C, et al. Reduced-intensity conditioning allogeneic SCT as salvage treatment for relapsed multiple myeloma. Bone Marrow Transplant 2008; 41:953-960.
    • (2008) Bone Marrow Transplant , vol.41 , pp. 953-960
    • De Lavallade, H.1    El-Cheikh, J.2    Faucher, C.3
  • 25
    • 84858075401 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation in multiple myeloma relapsed after autograft: A multicenter retrospective study based on donor availability
    • Patriarca F, Einsele H, Spina F, et al. Allogeneic stem cell transplantation in multiple myeloma relapsed after autograft: a multicenter retrospective study based on donor availability. Biol Blood Marrow Transplant 2012; 18:617-626.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 617-626
    • Patriarca, F.1    Einsele, H.2    Spina, F.3
  • 26
    • 84861190044 scopus 로고    scopus 로고
    • Comparable outcomes between unrelated and related donors after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation in patients with high-risk multiple myeloma
    • El-Cheikh J, Crocchiolo R, Boher J, et al. Comparable outcomes between unrelated and related donors after reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation in patients with high-risk multiple myeloma. Eur J Haematol 2012; 88:497-503.
    • (2012) Eur J Haematol , vol.88 , pp. 497-503
    • El-Cheikh, J.1    Crocchiolo, R.2    Boher, J.3
  • 27
    • 79960270124 scopus 로고    scopus 로고
    • Results of the Blood and Marrow Transplant Clinical Trials Network Protocol 0303: Low risk of chronic graftversus-host disease and relapse associated with T-cell depleted peripheral blood stem cell transplantation for acute myelogenous leukemia in first remission
    • Devine SM, Carter S, Soiffer RJ, et al. Results of the Blood and Marrow Transplant Clinical Trials Network Protocol 0303: low risk of chronic graftversus-host disease and relapse associated with T-cell depleted peripheral blood stem cell transplantation for acute myelogenous leukemia in first remission. Biol Blood Marrow Transplant 2011; 17:1343-1351.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 1343-1351
    • Devine, S.M.1    Carter, S.2    Soiffer, R.J.3
  • 28
    • 84876199112 scopus 로고    scopus 로고
    • Impact of chronic GVHD on late relapse, treatment related mortality and survival after allogeneic hematopoietic cell transplantation for hematological malignancies
    • abstract 19
    • Boyiadzis M, Klein JAM, Arora M, et al. Impact of chronic GVHD on late relapse, treatment related mortality and survival after allogeneic hematopoietic cell transplantation for hematological malignancies. Biol Blood Marrow Transplant 2012; abstract 19; 18(2).
    • (2012) Biol Blood Marrow Transplant , vol.18 , Issue.2
    • Boyiadzis, M.1    Klein, J.A.M.2    Arora, M.3
  • 29
    • 84880716897 scopus 로고    scopus 로고
    • T-cell depleted allogeneic hematopoietic stem cell transplantation with busulfan melphalan and fludarabine conditioning followed by post transplantation donor lymphocyte infusions for patients with relapsed multiple myeloma and high-risk cytogenetics. ASH Annual Meeting [abstract]
    • abstr 1992
    • Koehne G, Landau H, Hassoun H, et al. T-cell depleted allogeneic hematopoietic stem cell transplantation with busulfan, melphalan, and fludarabine conditioning followed by post transplantation donor lymphocyte infusions for patients with relapsed multiple myeloma and high-risk cytogenetics. ASH Annual Meeting [abstract]. Blood 2011; 118:abstr 1992.
    • (2011) Blood , pp. 118
    • Koehne, G.1    Landau, H.2    Hassoun, H.3
  • 30
    • 0033844816 scopus 로고    scopus 로고
    • Donor lymphocyte infusions for relapsed multiple myeloma after allogeneic stem-cell transplantation: Predictive factors for response and long-term outocme
    • Lokhorst HM, Schattenberg A, Corneliseen J, et al. Donor lymphocyte infusions for relapsed multiple myeloma after allogeneic stem-cell transplantation: predictive factors for response and long-term outocme. J Clin Oncol 2000; 18:3031-3037.
    • (2000) J Clin Oncol , vol.18 , pp. 3031-3037
    • Lokhorst, H.M.1    Schattenberg, A.2    Corneliseen, J.3
  • 31
    • 0033665539 scopus 로고    scopus 로고
    • Donor leukocyte infusions for multiple myeloma
    • Salama M, Nevill T, Marcellus D, et al. Donor leukocyte infusions for multiple myeloma. Bone Marrow Transplant 2000; 26:1179-1184.
    • (2000) Bone Marrow Transplant , vol.26 , pp. 1179-1184
    • Salama, M.1    Nevill, T.2    Marcellus, D.3
  • 32
    • 0035883066 scopus 로고    scopus 로고
    • T-cell depleted allogeneic bone marrow transplantation followed by donor lymphocyte infusion in patients with multiple myeloma: Induction of graft-versus-myeloma effect
    • Alyea E, Weller E, Schlossman R, et al. T-cell depleted allogeneic bone marrow transplantation followed by donor lymphocyte infusion in patients with multiple myeloma: induction of graft-versus-myeloma effect. Blood 2001; 98:934-939.
    • (2001) Blood , vol.98 , pp. 934-939
    • Alyea, E.1    Weller, E.2    Schlossman, R.3
  • 33
    • 67349225687 scopus 로고    scopus 로고
    • Posttransplant immunotherapy with donor-lymphocyte infusion and novel agents to upgrade partial into complete and molecular remission in allografted patients with multiple myeloma
    • Kroeger N, Badbaran A, Lioznov M, et al. Posttransplant immunotherapy with donor-lymphocyte infusion and novel agents to upgrade partial into complete and molecular remission in allografted patients with multiple myeloma. Exp Hematol 2009; 37:791-798.
    • (2009) Exp Hematol , vol.37 , pp. 791-798
    • Kroeger, N.1    Badbaran, A.2    Lioznov, M.3
  • 34
    • 84865438383 scopus 로고    scopus 로고
    • WT1-specific immune responses in patients with high-risk multiple myeloma undergoing allogeneic T cell depleted hematopoietic stem cell transplantation followed by donor lymphocyte infusions. ASH Annual Meeting 2011
    • abstr 1993
    • Tyler E, Jungbluth A, O'Reilly RJ, Koehne G. WT1-specific immune responses in patients with high-risk multiple myeloma undergoing allogeneic T cell depleted hematopoietic stem cell transplantation followed by donor lymphocyte infusions. ASH Annual Meeting 2011. Blood 2011; 118:abstr 1993.
    • (2011) Blood , pp. 118
    • Tyler, E.1    Jungbluth, A.2    O'Reilly, R.J.3    Koehne, G.4
  • 35
    • 0030656556 scopus 로고    scopus 로고
    • Cancer tumor antigens
    • Boon T, Old L. Cancer tumor antigens. Curr Opin Immunol 1997; 9:681-683.
    • (1997) Curr Opin Immunol , vol.9 , pp. 681-683
    • Boon, T.1    Old, L.2
  • 36
    • 22044451852 scopus 로고    scopus 로고
    • The cancer-testis antigens CT7 (MAGE-C') and MAGE-A3/6 are commonly expressed in multiple myeloma and correlated with plasma-cell proliferation
    • Jungbluth A, Ely S, DiLiberto M, et al. The cancer-testis antigens CT7 (MAGE-C') and MAGE-A3/6 are commonly expressed in multiple myeloma and correlated with plasma-cell proliferation. Blood 2005; 106:167-174.
    • (2005) Blood , vol.106 , pp. 167-174
    • Jungbluth, A.1    Ely, S.2    Diliberto, M.3
  • 37
    • 3042522562 scopus 로고    scopus 로고
    • Expression of cancer/testis (CT) antigens MAGE-A1, MAGE-A3, MAGE-A4, CT-7 and NY-ESO-1 in malignant gammopathies is heterogeneous and correlates with site, stage and risk status of disease
    • Dhodapkar M, Osman K, Teruya-Feldstein J, et al. Expression of cancer/testis (CT) antigens MAGE-A1, MAGE-A3, MAGE-A4, CT-7 and NY-ESO-1 in malignant gammopathies is heterogeneous and correlates with site, stage and risk status of disease. Cancer Immun 2003; 3:9-17.
    • (2003) Cancer Immun , vol.3 , pp. 9-17
    • Dhodapkar, M.1    Osman, K.2    Teruya-Feldstein, J.3
  • 38
    • 33846871255 scopus 로고    scopus 로고
    • Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation
    • Atanackovic D, Arfsten J, Cao Y, et al. Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation. Blood 2007; 109:1103-1112.
    • (2007) Blood , vol.109 , pp. 1103-1112
    • Atanackovic, D.1    Arfsten, J.2    Cao, Y.3
  • 39
    • 77952313238 scopus 로고    scopus 로고
    • Cancer-testis antigens MAGEC1/CT7 and MAGE-A3 promote the survival of multiple myeloma cells
    • Atanackovic D, Hildebrandt Y, Jadczak A, et al. Cancer-testis antigens MAGEC1/CT7 and MAGE-A3 promote the survival of multiple myeloma cells. Haematologica 2010; 95:795-893.
    • (2010) Haematologica , vol.95 , pp. 795-893
    • Atanackovic, D.1    Hildebrandt, Y.2    Jadczak, A.3
  • 40
    • 79960329490 scopus 로고    scopus 로고
    • MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of bax and maintenance of survivin
    • Nardiello T, Achim A, Jungbluth A, et al. MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of bax and maintenance of survivin. Clin Cancer Res 2011; 17:4309-4319.
    • (2011) Clin Cancer Res , vol.17 , pp. 4309-4319
    • Nardiello, T.1    Achim, A.2    Jungbluth, A.3
  • 41
    • 79959718186 scopus 로고    scopus 로고
    • Identification of MAGE-C1 (CT-7) epitopes for T-cell therapy of multiple myeloma
    • Anderson L, Cook D, Yamamoto T, et al. Identification of MAGE-C1 (CT-7) epitopes for T-cell therapy of multiple myeloma. Cancer Immunol Immunother 2011; 60:985-997.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 985-997
    • Anderson, L.1    Cook, D.2    Yamamoto, T.3


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