Effects of N-acetyl-l-cysteine on bleomycin induced oxidative stress in malignant testicular germ cell tumors

Biochimie

Volumn 94, Issue 12, 2012, Pages 2734-2739

  Cort, Aysegul ^a   Ozdemir, Evrim ^a   Timur, Mujgan ^a   Ozben, Tomris ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Bleomycin; N Acetyl l cysteine; Oxidative stress; Reactive oxygen species; Testicular cancer

Indexed keywords

8 ISOPROSTANE; ACETYLCYSTEINE; BLEOMYCIN; CARBONYL DERIVATIVE; GLUTATHIONE; HYDROGEN PEROXIDE; LIPID HYDROPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONCENTRATION (PARAMETERS); GERM CELL TUMOR; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN CARBONYLATION;

ACETYLCYSTEINE; ANTIOXIDANTS; BLEOMYCIN; CELL LINE, TUMOR; DINOPROST; FREE RADICAL SCAVENGERS; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; LIPID PEROXIDES; MALE; MUTATION; NEOPLASMS, GERM CELL AND EMBRYONAL; OXIDANTS; OXIDATIVE STRESS; PROTEIN CARBONYLATION; TESTICULAR NEOPLASMS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84868199749     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.08.015     Document Type: Article

References (32)

1. R. Bergstrom, H.O. Adami, M. Mohner, W. Zatonski, H. Storm, A. Ekbom, S. Tretli, L. Teppo, O. Akre, and T. Hakulinen Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon J. Natl. Cancer Inst. 88 1996 727 733 (Pubitemid 26195020)
2. K.A. McGlynn, S.S. Devesa, A.J. Sigurdson, L.M. Brown, L. Tsao, and R.E. Tarone Trends in the incidence of testicular germ cell tumors in the United States Cancer 97 2003 63 70 (Pubitemid 36033864)
3. S.D. Zequi, W.H. da Costa, T.B. Santana, R.L. Favaretto, C.A. Sacomani, G.C. Guimaraes, Bilateral testicular germ cell tumours: a systematic review, Br. J. Urol. Int. in press.
4. H. Umezawa, K. Maeda, T. Takeuchi, and Y. Okami New antibiotics, bleomycin A and B J. Antibiot. (Tokyo) 19 1966 200 209
5. R.A. Bayer, E.R. Gaynor, and R.I. Fisher Bleomycin in non-Hodgkin's lymphoma Semin. Oncol. 19 1992 46 52 discussion 52-43
6. J.A. Levi, D. Raghavan, V. Harvey, D. Thompson, T. Sandeman, G. Gill, R. Stuart-Harris, R. Snyder, M. Byrne, and Z. Kerestes The importance of bleomycin in combination chemotherapy for good-prognosis germ cell carcinoma. Australasian germ cell trial group J. Clin. Oncol. 11 1993 1300 1305 (Pubitemid 23199133)
7. W.G. Martin, K.M. Ristow, T.M. Habermann, J.P. Colgan, T.E. Witzig, and S.M. Ansell Bleomycin pulmonary toxicity has a negative impact on the outcome of patients with Hodgkin's lymphoma J. Clin. Oncol. 23 2005 7614 7620 (Pubitemid 46291825)
8. R.M. Burger, J. Peisach, and S.B. Horwitz Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA J. Biol. Chem. 256 1981 11636 11644
9. G.M. Ehrenfeld, L.O. Rodriguez, S.M. Hecht, C. Chang, V.J. Basus, and N.J. Oppenheimer Copper(I)-bleomycin: structurally unique complex that mediates oxidative DNA strand scission Biochemistry 24 1985 81 92 (Pubitemid 15130398)
10. R. Schreck, P. Rieber, and P.A. Baeuerle Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1 EMBO J. 10 1991 2247 2258 (Pubitemid 21905698)
11. M. Takeshita, A.P. Grollman, E. Ohtsubo, and H. Ohtsubo Interaction of bleomycin with DNA Proc. Natl. Acad. Sci. U. S. A. 75 1978 5983 5987 (Pubitemid 9093645)
12. D.T. Phelps, S.M. Deneke, D.L. Daley, and B.L. Fanburg Elevation of glutathione levels in bovine pulmonary artery endothelial cells by N-acetylcysteine Am. J. Respir. Cell. Mol. Biol. 7 1992 293 299
13. Y. Gon, S. Hashimoto, T. Nakayama, K. Matsumoto, T. Koura, I. Takeshita, and T. Horie N-Acetyl-l-cysteine inhibits bleomycin-induced interleukin-8 secretion by bronchial epithelial cells Respirology 5 2000 309 313 (Pubitemid 32049491)
14. S. De Flora, A. Izzotti, F. D'Agostini, and R.M. Balansky Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points Carcinogenesis 22 2001 999 1013 (Pubitemid 32633597)
15. A. Miyajima, J. Nakashima, M. Tachibana, K. Nakamura, M. Hayakawa, and M. Murai N-acetylcysteine modifies cis-dichlorodiammineplatinum-induced effects in bladder cancer cells Jpn. J. Cancer Res. 90 1999 565 570 (Pubitemid 29267711)
16. K.A. Conklin Cancer chemotherapy and antioxidants J. Nutr. 134 2004 3201S 3204S (Pubitemid 39470116)
17. D. Appenroth, K. Winnefeld, H. Schroter, and M. Rost Beneficial effect of acetylcysteine on cisplatin nephrotoxicity in rats J. Appl. Toxicol. 13 1993 189 192 (Pubitemid 23151257)
18. A. Cort, M. Timur, E. Ozdemir, E. Kucuksayan, and T. Ozben Synergistic anticancer activity of curcumin and bleomycin: an in vitro study using human malignant testicular germ cells Mol. Med. Rep. 5 2012 1481 1486
19. K.A. Conklin Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects Nutr. Cancer 37 2000 1 18 (Pubitemid 30650661)
20. H. Ciftci, A. Verit, M. Savas, E. Yeni, and O. Erel Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status Urology 74 2009 73 76
21. K.C. Teixeira, F.S. Soares, L.G. Rocha, P.C. Silveira, L.A. Silva, S.S. Valenca, F. Dal Pizzol, E.L. Streck, and R.A. Pinho Attenuation of bleomycin-induced lung injury and oxidative stress by N-acetylcysteine plus deferoxamine Pulm. Pharmacol. Ther. 21 2008 309 316 (Pubitemid 351312673)
22. J. Cortijo, M. Cerda-Nicolas, A. Serrano, G. Bioque, J.M. Estrela, F. Santangelo, A. Esteras, A. Llombart-Bosch, and E.J. Morcillo Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats Eur. Respir. J. 17 2001 1228 1235 (Pubitemid 32717483)
23. J. Zachwieja, M. Zaniew, W. Bobkowski, E. Stefaniak, A. Warzywoda, D. Ostalska-Nowicka, A. Dobrowolska-Zachwieja, M. Lewandowska-Stachowiak, and A. Siwinska Beneficial in vitro effect of N-acetyl-cysteine on oxidative stress and apoptosis Pediatr. Nephrol. 20 2005 725 731 (Pubitemid 40663153)
24. J. Quadrilatero, and L. Hoffman-Goetz N-Acetyl-l-cysteine prevents exercise-induced intestinal lymphocyte apoptosis by maintaining intracellular glutathione levels and reducing mitochondrial membrane depolarization Biochem. Biophys. Res. Commun. 319 2004 894 901 (Pubitemid 38739405)
25. N.A. Finn, and M.L. Kemp Pro-oxidant and antioxidant effects of N-acetylcysteine regulate doxorubicin-induced NF-kappa B activity in leukemic cells Mol. Biosyst. 8 2012 650 662
26. S.A. Park, K.S. Choi, J.H. Bang, K. Huh, and S.U. Kim Cisplatin-induced apoptotic cell death in mouse hybrid neurons is blocked by antioxidants through suppression of cisplatin-mediated accumulation of p53 but not of Fas/Fas ligand J. Neurochem. 75 2000 946 953 (Pubitemid 30660482)
27. W.E. Antholine, D.H. Petering, L.A. Saryan, and C.E. Brown Interactions among iron(II) bleomycin, Lewis bases, and DNA Proc. Natl. Acad. Sci. U. S. A. 78 1981 7517 7520 (Pubitemid 12186173)
28. M. Zafarullah, W.Q. Li, J. Sylvester, and M. Ahmad Molecular mechanisms of N-acetylcysteine actions Cell. Mol. Life Sci. 60 2003 6 20 (Pubitemid 36223114)
29. A. Maheshwari, M.M. Misro, A. Aggarwal, R.K. Sharma, and D. Nandan N-acetyl-l-cysteine counteracts oxidative stress and prevents H2O2 induced germ cell apoptosis through down-regulation of caspase-9 and JNK/c-Jun Mol. Reprod. Dev. 78 2011 69 79
30. D. Koracevic, G. Koracevic, V. Djordjevic, S. Andrejevic, and V. Cosic Method for the measurement of antioxidant activity in human fluids J. Clin. Pathol. 54 2001 356 361 (Pubitemid 32458132)
31. T. Ozben Oxidative stress and apoptosis: impact on cancer therapy J. Pharm. Sci. 96 2007 2181 2196 (Pubitemid 47477879)
32. H.S. Akbas, M. Timur, and T. Ozben Concurrent use of antioxidants in cancer therapy: an update Expert Rev. Clin. Immunol. 2 2006 931 939