White matter lesion severity in mild acute ischemic stroke patients and functional outcome after 1 year

Stroke

Volumn 43, Issue 11, 2012, Pages 3046-3051

  Leonards, Christopher O ^a   Ipsen, Nils ^a   Malzahn, Uwe ^a,d   Fiebach, Jochen B ^a   Endres, Matthias ^a,b,c   Ebinger, Martin ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Excellence Cluster NeuroCure   (Germany)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

ischemia; leukoaraiosis; outcome; white matter disease

Indexed keywords

C REACTIVE PROTEIN; CREATININE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; INSULIN;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DISABILITY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FLUID ATTENUATED INVERSION RECOVERY; FOLLOW UP; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANKIN SCALE; RATING SCALE; SCORING SYSTEM; SEX RATIO; SYSTOLIC BLOOD PRESSURE; WAHLUND AND FAZEKAS VISUAL SCALE; WAIST CIRCUMFERENCE; WHITE MATTER LESION;

AGED; BRAIN; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NERVE FIBERS, MYELINATED; RECOVERY OF FUNCTION; STROKE; TREATMENT OUTCOME;

EID: 84868198165     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.646554     Document Type: Article

References (42)

1. Counsell C, Dennis M, McDowall M, Warlow C. Predicting outcome after acute and subacute stroke: development and validation of new prognostic models. Stroke. 2002;33:1041-1047.
2. Hand P, Wardlaw J, Lindley R, Keir S. Prediction of outcome after stroke. Lancet. 2001;358:1552-1553, author reply 1553-1554.
3. Hachinski VC, Potter P, Merskey H. Leuko-araiosis. Arch Neurol. 1987;44:21-23.
4. Breteler MM, van Swieten JC, Bots ML, Grobbee DE, Claus JJ, van den Hout JH, et al. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: The Rotterdam Study. Neurology. 1994;44:1246-1252.
5. Longstreth WT Jr, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke. 1996;27:1274-1282.
6. Fu JH, Lu CZ, Hong Z, Dong Q, Luo Y, Wong KS. Extent of white matter lesions is related to acute subcortical infarcts and predicts further stroke risk in patients with first ever ischaemic stroke. J Neurol Neurosurg Psychiatry. 2005;76:793-796.
7. Hénon H, Vroylandt P, Durieu I, Pasquier F, Leys D. Leukoaraiosis more than dementia is a predictor of stroke recurrence. Stroke. 2003;34:2935-2940.
8. Inzitari D, Pracucci G, Poggesi A, Carlucci G, Barkhof F, Chabriat H, et al. Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort. BMJ. 2009;339:b2477.
9. Skoog I, Berg S, Johansson B, Palmertz B, Andreasson LA. The influence of white matter lesions on neuropsychological functioning in demented and non-demented 85-year-olds. Acta Neurol Scand. 1996;93:142-148.
10. Lopez OL, Becker JT, Reynolds CF III, Jungreis CA, Weinman S, DeKosky ST. Psychiatric correlates of MR deep white matter lesions in probable Alzheimer's disease. J Neuropsychiatr Clin Neurosci. 1997;9:246-250.
11. Briley DP, Wasay M, Sergent S, Thomas S. Cerebral white matter changes (leukoaraiosis), stroke, and gait disturbance. J Am Geriatr Soc. 1997;45:1434-1438.
12. Sakakibara R, Hattori T, Uchiyama T, Yamanishi T. Urinary function in elderly people with and without leukoaraiosis: relation to cognitive and gait function. J Neurol Neurosurg Psychiatry. 1999;67:658-660.
13. eumann-Haefelin T, Hoelig S, Berkefeld J, Fiehler J, Gass A, Humpich M, et al. Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke. Stroke. 2006;37:2463-2466.
14. Briley DP, Haroon S, Sergent SM, Thomas S. Does leukoaraiosis predict morbidity and mortality? Neurology. 2000;54:90-94.
15. Arsava EM, Rahman R, Rosand J, Lu J, Smith EE, Rost NS, et al. Severity of leukoaraiosis correlates with clinical outcome after ischemic stroke. Neurology. 2009;72:1403-1410.
16. Pantoni L, Inzitari D. New clinical relevance of leukoaraiosis. Stroke. 1998;29:543.
17. Miyao S, Takano A, Teramoto J, Takahashi A. Leukoaraiosis in relation to prognosis for patients with lacunar infarction. Stroke. 1992;23:1434-1438.
18. Koton S, Schwammenthal Y, Merzeliak O, Philips T, Tsabari R, Orion D, et al. Cerebral leukoaraiosis in patients with stroke or TIA: clinical correlates and 1-year outcome. Eur J Neurol. 2009;16:218-225.
19. Podgorska A, Hier DB, Pytlewski A, Czlonkowska A. Leukoaraiosis and stroke outcome. J Stroke Cerebrovasc Dis. 2002;11:336-340.
20. Ay H, Arsava EM, Rosand J, Furie KL, Singhal AB, Schaefer PW, et al. Severity of leukoaraiosis and susceptibility to infarct growth in acute stroke. Stroke. 2008;39:1409-1413.
21. van Straaten EC, Fazekas F, Rostrup E, Scheltens P, Schmidt R, Pantoni L, et al. Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study. Stroke. 2006;37:836-840.
22. Wahlund LO, Barkhof F, Fazekas F, Bronge L, Augustin M, Sjögren M, et al. A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke. 2001;32:1318-1322.
23. Scheltens P, Erkinjunti T, Leys D, Wahlund LO, Inzitari D, del Ser T, et al. White matter changes on CT and MRI: an overview of visual rating scales. European Task Force on Age-Related White Matter Changes. Eur Neurol. 2000;39:80-89.
24. Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology. 1993;43:1683-1689.
25. Ebinger M, Heuschmann PU, Jungehuelsing GJ, Werner C, Laufs U, Endres M. The Berlin "Cream&Sugar" Study: the prognostic impact of an oral triglyceride tolerance test in patients after acute ischaemic stroke. Int J Stroke. 2010;5:126-130.
26. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24:35-41.
27. Takahashi W, Tsukamoto Y, Takizawa S, Kawada S, Takagi S. Relationship between chronic kidney disease and white matter hyperintensities on magnetic resonance imaging. J Stroke Cerebrovasc Dis. 2012;21:18-23.
28. Fazekas F, Niederkorn K, Schmidt R, Offenbacher H, Horner S, Bertha G, et al. White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors. Stroke. 1988;19:1285-1288.
29. Kissela B, Lindsell CJ, Kleindorfer D, Alwell K, Moomaw CJ, et al. Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and race. Stroke. 2009;40:530-536.
30. Samuelsson M, Söderfeldt B, Olsson GB. Functional outcome in patients with lacunar infarction. Stroke. 1996;27:842-846.
31. Streifler JY, Eliasziw M, Benavente OR, Alamowitch S, Fox AJ, Hachinski VC, et al. Prognostic importance of leukoaraiosis in patients with symptomatic internal carotid artery stenosis. Stroke. 2002;33:1651-1655.
32. Leys D, Englund E, Del Ser T, Inzitari D, Fazekas F, Bornstein N, et al. White matter changes in stroke patients. Relationship with storke subtype and outcome. Eur Neurol. 1999;42:67-75.
33. Tei H, Uchiyama S, Usui T, Ohara K. Posterior circulation ASPECTS on diffusion-weighted MRI can be a powerful marker for predicting functional outcome. J Neurol. 2010;257:767-773.
34. Palumbo V, Boulanger JM, Hill MD, Inzitari D, Buchan AM, CASES Investigators. Leukoaraiosis and intracerebral hemorrhage after thrombolysis in acute stroke. Neurology. 2007;68:1020-1024.
35. Jørgensen HS, Nakayama H, Raaschou HO, Olsen TS. Leukoaraiosis in stroke patients. The Copenhagen Stroke Study. Stroke. 1995;26:588-592.
36. Kurumatani T, Kudo T, Ikura Y, Takeda M. White matter changes in the gerbil brain under chronic cerebral hypoperfusion. Stroke. 1998;29:1058-1062.
37. Yamauchi H, Fukuyama H, Nagahama Y, Shiozaki T, Nishizawa S, Konishi J, et al. Brain arteriolosclerosis and hemodynamic disturbance may induce leukoaraiosis. Neurology. 1999;53:1833-1838.
38. Black S, Gao F, Bilbao J. Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairment. Stroke. 2009;40:S48-S52.
39. van Dijk EJ, Prins ND, Vermeer SE, Vrooman HA, Hofman A, Koudstaal PJ, et al. C-reactive protein and cerebral small-vessel disease: the Rotterdam Scan Study. Circulation. 2005;112:900-905.
40. Mitchell GF. Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage. J Applied Physiol. 2008;105:1652-1660.
41. Carmelli D, Swan GE, Reed T, Miller B, Wolf PA, Jarvik GP, et al. Midlife cardiovascular risk factors, ApoE, and cognitive decline in elderly male twins. Neurology. 1998;50:1580-1585.
42. de Leeuw FE, de Groot JC, Bots ML, Witteman JC, Oudkerk M, Hofman A, et al. Carotid atherosclerosis and cerebral white matter lesions in a population based magnetic resonance imaging study. J Neurol. 2000;247:291-296.