Cerebrolysin administration reduces oxidative stress-induced apoptosis in limphocytes from healthy individuals

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 11, 2012, Pages 2840-2843

  Formichi, Patrizia ^a   Radi, Elena ^a   Battisti, Carla ^a   Di Maio, Giuseppe ^a   Muresanu, Dafin ^b   Federico, Antonio ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Apoptosis; Cerebrolysin; Lymphocytes

Indexed keywords

AMINO ACID; CASPASE; CEREBROLYSIN; DEOXYRIBOSE; NEUROPROTECTIVE AGENT;

ADULT; APOPTOSIS; ARTICLE; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; LYMPHOCYTE; MALE; METABOLISM; MIDDLE AGED; OXIDATIVE STRESS; PATHOLOGY;

ADULT; AMINO ACIDS; APOPTOSIS; CASPASES; CELLS, CULTURED; DEOXYRIBOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS;

SUS;

EID: 84868159191     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2012.01615.x     Document Type: Article

References (19)

1. Chen H, Tung YC, Li B, et al. Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis. Neurobiol Aging. 2007; 28: 1148-62.
2. HutterPaier B, Fruhwirth M, Grygar E, et al. Cerebrolysin(R) protects neurons from ischemia-induced loss of microtubule - associated protein 2. J Neural Transm Suppl. 1996; 46: 276.
3. Schwab M, Schaller R, Bauer R, et al. Morphofunctional effects of moderate forebrain ischemia combined with short-term hypoxia in rats - protective effects of Cerebrolysin. Exp Toxicol Pathol. 1997; 49: 29-37.
4. Tatebayashi Y, Lee MH, Li L, et al. The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease. Acta Neuropathol. 2003; 105: 225-32.
5. Satou T, Itoh T, Tamai Y, et al. Neurotrophic effects of FPF-1070 (Cerebrolysin (R)) on cultured neurons from chicken embryo dorsal root ganglia, ciliary ganglia, and sympathetic trunks. J Neural Transm. 2000; 107: 1253-62.
6. FrancisTurner L, Valouskova V. Nerve growth factor and nootropic drug Cerebrolysin but not fibroblast growth factor can reduce spatial memory impairment elicited by fimbria-fornix transection: short-term study. Neurosci Lett. 1996; 202: 193-6.
7. Ruther E, Ritter R, Apecechea M, et al. Efficacy of the peptidergic nootropic drug cerebrolysin in patients with senile dementia of the Alzheimer-type (SDAT). Pharmacopsychiatry. 1994; 27: 32-40.
8. Wei ZH, He QB, Wang H, et al. Meta-analysis: the efficacy of nootropic agent Cerebrolysin in the treatment of Alzheimer's disease. J Neural Transm. 2007; 114: 629-34.
9. Kletsas D, Barbieri D, Stathakos D, et al. The highly reducing sugar 2-deoxy-D-ribose induces apoptosis in human fibroblasts by reduced glutathione depletion and cytoskeletal disruption. Biochem Biophys Res Commun. 1998; 243: 416-25.
10. Nicoletti I, Migliorati G, Pagliacci MC, et al. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow-cytometry. J Immunol Methods. 1991; 139: 271-9.
11. Formichi P, Battisti C, Tripodi SA, et al. Apoptotic response and cell cycle transition in ataxia telangiectasia cells exposed to oxidative stress. Life Sci. 2000; 66: 1893-903.
12. Hartbauer M, Hutter-Paier B, Skofitsch G, et al. Antiapoptotic effects of the peptidergic drug Cerebrolysin on primary cultures of embryonic chick cortical neurons. J Neural Transm. 2001; 108: 459-73.
13. Gutmann B, Hutter-Paier B, Windisch M, et al. Long-term effects of cerebrolysin on spatial navigation: comparison of different treatment-schedules. Neurobiol Aging. 2002; 23: S86.
14. Onishchenko LS, Gaikova ON, Yanishevskii SN. Changes at the focus of experimental ischemic stroke treated with neuroprotective agents. Neurosci Behav Physiol. 2008; 38: 49-54.
15. Wronski R, Kronawetter S, Hutter-Paier B, et al. A brain derived peptide preparation reduces the translation dependent loss of a cytoskeletal protein in primary cultured chicken neurons. J Neural Transm Suppl. 2000; 59: 263-72.
16. Squier MKT, Miller ACK, Malkinson AM, et al. Calpain activaction in apoptosis. J Cell Physiol. 1994; 159: 229-37.
17. (R) protects cortical neurons from neurodegeneration in vitro. J Neural Transm Suppl. 1998; 53: 363-72.
18. (R) protects isolated cortical neurons from neurodegeneration after brief histotoxic hypoxia. J Neural Transm Suppl. 1998; 53: 351-61.
19. Formichi P, Radi E, Battisti C, et al. Apoptosis in CADASIL: an in vitro study of lymphocytes and fibroblasts from a cohort of Italian patients. J Cell Physiol. 2009; 219: 494-502.