Operational research and HIV policy and guidelines: Lessons from a study of patients lost to follow-up from a public antiretroviral treatment program in Cameroon

Journal of Public Health Policy

Volumn 33, Issue 4, 2012, Pages 462-477

  Mben, Jean Marc ^a   Kouanfack, Charles ^a   Essomba, Claudine Ntsama ^a   Mbougua, Jules Brice Tchatchueng ^b,c   Kenfack, Alain ^a   Tonfack, Clément Auguste Djouatsa ^a   Laborde Balen, Gabrièle ^d   Bourgeois, Anke ^c,e   Biwolé Sida, Magloire ^a,f   Delaporte, Eric ^c,e   Laurent, Christian ^c  

^a YAOUNDÉ CENTRAL HOSPITAL   (Cameroon)

^b UNIVERSITY OF YAOUNDÉ I   (Cameroon)

^c INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

^d French Ministry of Foreign Affairs   (Cameroon)

^e MONTPELLIER UNIVERSITY HOSPITAL   (France)

^f MINISTRY OF PUBLIC HEALTH   (Cameroon)

Author keywords

Africa; antiretroviral; HIV; lost to follow up; operational research

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADULT; ARTICLE; CAMEROON; FEMALE; FOLLOW UP; HEALTH CARE DELIVERY; HEALTH CARE POLICY; HEALTH SERVICES RESEARCH; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KAPLAN MEIER METHOD; MALE; MORTALITY; ORGANIZATION AND MANAGEMENT; PRACTICE GUIDELINE; PROPORTIONAL HAZARDS MODEL; STATISTICS;

ADULT; ANTI-HIV AGENTS; CAMEROON; DELIVERY OF HEALTH CARE; FEMALE; HEALTH POLICY; HEALTH SERVICES RESEARCH; HIV INFECTIONS; HUMANS; KAPLAN-MEIER ESTIMATE; LOST TO FOLLOW-UP; MALE; PRACTICE GUIDELINES AS TOPIC; PROPORTIONAL HAZARDS MODELS;

EID: 84868155376     PISSN: 01975897     EISSN: 1745655X     Source Type: Journal    
DOI: 10.1057/jphp.2012.31     Document Type: Article

References (46)

1. Foreit, J., Schmid, B., Korenromp, E., Low-Beer, D. and Xueref, S. (2008) Guide to operational research in programs supported by the Global Fund,WorldHealth Organization and The Global Fund To Fight AIDS, Tuberculosis and Malaria, http://www.who.int/hiv/pub/operational/or-guide-gf.pdf, accessed 30 August 2011.
2. Cooper, D. et al.(2007) The Sydney Declaration: A call to scale up research. Lancet 370(9581): 7-8. (Pubitemid 47017450)
3. Zachariah, R. et al.(2009) Operational research in low-income countries: What, why, and how? Lancet Infectious Diseases 9(11): 711-717.
4. Katzenstein, D., Koulla-Shiro, S., Laga, M. and Moatti, J.P. (2010) Learning and doing: Operational research and access to HIV treatment in Africa. AIDS 24(Supplement 1): S1-S4.
5. Jaffar, S. et al.(2010) Health services strengthening in Africa - Research is a key component Tropical Medicine & International Health 15(11): 1270-1273.
6. Gray, J. (2010) Global health experts seek to transform programs through implementation science, Fogarty International Center, http://www.fic.nih.gov/ news/globalhealthmatters/pages/ 0410-implementation.aspx, accessed 5 December 2011.
7. Dabis, F., Bazin, B. and Delfraissy, J.F. (2011) Implementation and operational research in francophone Africa. Introduction. Journal of Acquired Immune Deficiency Syndrome 57(Supplement 1): S1-S2.
8. Braitstein, P. et al.(2006) Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: Comparison between low-income and high-income countries. Lancet 367(9513): 817-824.
9. Bisson, G.P. et al.(2008) Overestimates of survival after HAART: Implications for global scale-up efforts. PLoS One 3(3): E1725.
10. Brinkhof, M.W. et al.(2008) Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countries. Bulletin of the World Health Organization 86(7): 559-567. (Pubitemid 351931216)
11. Fox, M.P. and Rosen, S. (2010) Patient retention in antiretroviral therapy programs up to three years on treatment in sub-Saharan Africa, 2007-2009: Systematic review. Tropical Medicine& International Health 15(Supplement 1): 1-15.
12. WHO, UNAIDS, and UNICEF. (2011) Global HIV/AIDS response. Epidemic update and health sector progress towards universal access. Geneva. Progress report 2011, http:// whqlibdoc.who.int/publications/2011/9789241502986-eng.pdf, accessed 19 July 2012.
13. Institut National de la Statistique. (2012) Enque○te De'mographique et de Santé et al Indicateurs Multiples EDS-MICS 2011. Yaoundé. Rapport pre'liminaire sur la pre'valence du VIH, http:// www.statistics- cameroon.org/downloads/EDS-MICS11/DHSMICS-2011-preliminary-report-VIH.pdf, accessed 19 July 2012.
14. Harries, A.D., Zachariah, R., Lawn, S.D. and Rosen, S. (2010) Strategies to improve patient retention on antiretroviral therapy in sub-Saharan Africa. Tropical Medicine & International Health 15(Supplement 1): 70-75.
15. Rubin, D.B. (1987) Multiple Imputation for Nonresponse in Surveys. New York: Wiley
16. Egger, M. et al.(2011) Correcting mortality for loss to follow-up: A nomogram applied to antiretroviral treatment programmes in sub-Saharan Africa. PLoS Medicine 8(1): E1000390.
17. Brinkhof, M.W. et al.(2010) Adjusting mortality for loss to follow-up: Analysis of five ART programmes in sub-Saharan Africa. PLoS One 5(11): E14149.
18. Henriques, J. et al.(2012) Comparison of methods to correct survival estimates and survival regression analysis on a large HIVAfrican cohort. PLoS One 7(2): E31706.
19. Yiannoutsos, C.T. et al.(2008) Sampling-based approaches to improve estimation of mortality among patient dropouts: Experience from a large PEPFAR-funded program in western Kenya PLoS One 3(12): E3843.
20. Yu, J.K. et al.(2007) True outcomes for patients on antiretroviral therapy who are 'lost to follow-up' in Malawi. Bulletin of the World Health Organization 85(7): 550-554. (Pubitemid 47041634)
21. Weigel, R. et al.(2011) Outcomes and associated risk factors of patients traced after being lost to follow-up from antiretroviral treatment in Lilongwe, Malawi. BMC Infectious Diseases 11: 31.
22. McGuire, M. et al.(2010)Vital status of pre-ARTand ART patients defaulting from care in rural Malawi. Tropical Medicine & International Health 15(Supplement 1): 55-62.
23. Dalal, R.P. et al.(2008) Characteristics and outcomes of adult patients lost to follow-up at an antiretroviral treatment clinic in Johannesburg, South Africa. Journal of Acquired Immune Deficiency Syndrome 47(1): 101-107. (Pubitemid 351619376)
24. Geng, E.H. et al.(2010) Understanding reasons for and outcomes of patients lost to follow-up in antiretroviral therapy programs in Africa through a sampling-based approach. Journal of Acquired Immune Deficiency Syndrome 53(3): 405-411.
25. Brinkhof, M.W., Pujades-Rodriguez, M. and Egger, M. (2009) Mortality of patients lost to follow-up in antiretroviral treatment programmes in resource-limited settings: Systematic review and meta-analysis. PLoS One 4(6): E5790.
26. Severe, P. et al.(2010) Early versus standard antiretroviral therapy for HIV-infected adults in Haiti. The New England Journal of Medicine 363(3): 257-265.
27. Kitahata, M.M. et al.(2009) Effect of early versus deferred antiretroviral therapy for HIV on survival. The New England Journal of Medicine 360(18): 1815-1826.
28. Sterne, J.A. et al.(2009) Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: A collaborative analysis of 18 HIV cohort studies. Lancet 373(9672): 1352-1363.
29. Walensky, R.P. et al.(2009) When to start antiretroviral therapy in resource-limited settings Annals of Internal Medicine 151(3): 157-166.
30. Cohen, M.S. et al.(2011) Prevention of HIV-1 infection with early antiretroviral therapy. The New England Journal of Medicine 365(6): 493-505.
31. Writing Committee for the CASCADE Collaboration. (2011) Timing of HAART initiation and clinical outcomes in human immunodeficiency virus type 1 seroconverters. Archives of Internal Medicine 171(17): 1560-1569.
32. Menon, S. (2010) Early initiation of antiretroviral therapy and universal HIV testing in sub-Saharan Africa: Has WHO offered a milestone for HIV prevention? Journal of Public Health Policy 31(4): 385-400.
33. Laurent, C. (2010) Commentary: Early antiretroviral therapy for HIV infection in sub-Saharan Africa, a challenging new step. Journal of Public Health Policy 31(4): 401-406.
34. Ministry of Public Health. (2010) Directives nationales de prise en charge par les antire'troviraux des personnes (adultes et adolescents) infecte'es par le VIH. Yaoundé, Cameroon: Ministry of Public Health
35. Ministry of Public Health. (2007) Directives nationales de prise en charge des personnes vivant avec le VIH par les antire'troviraux. Yaoundé, Cameroon: Ministry of Public Health
36. World Health Organization. (2010) Antiretroviral Therapy for HIV Infection in Adults and Adolescents: Recommendations for a public health approach
37. Ministry of Public Health. (2004) Plan de de'centralisation de la prise en charge par les antire'troviraux au Cameroun (2004-2005). Yaoundé, Cameroon: Ministry of Public Health
38. Eboko, F., Abé, C. and Laurent, C. (2010) Accés décentralisé au traitement du VIH/sida Evaluation de l'expérience camerounaise. Paris, France: Agence nationale de recherches sur le sida et les hépatites virales
39. Boyer, S. et al.(2010) Scaling up access to antiretroviral treatment for HIV infection: The impact of decentralization of healthcare delivery in Cameroon. AIDS 24(Supplement 1): S5-S15.
40. Forster, M. et al.(2008) Electronic medical record systems, data quality and loss to follow-up: Survey of antiretroviral therapy programmes in resource-limited settings. Bulletin of theWorld Health Organization 86(12): 939-947.
41. Laborde-Balen, G. et al.(2011) Mise en oeuvre d'un programme de suivi-e'valuation des patients sous traitement antire'troviral dans un ho○ pital de re'fe'rence et un ho○ pital de district rural au Cameroun. 16th International Conference on AIDS and STIs in Africa (ICASA 2011), Addis Ababa, Ethiopa (abstract WEAE0705).
42. Jahn, A. et al.(2008) Population-level effect of HIV on adult mortality and early evidence of reversal after introduction of antiretroviral therapy in Malawi. Lancet 371(9624): 1603-1611. (Pubitemid 351626844)
43. Mermin, J. et al.(2008) Mortality in HIV-infected Ugandan adults receiving antiretroviral treatment and survival of their HIV-uninfected children: A prospective cohort study. Lancet 371(9614): 752-759. (Pubitemid 351297773)
44. Badri, M., Wilson, D. and Wood, R. (2002) Effect of highly active antiretroviral therapy on incidence of tuberculosis in South Africa: A cohort study. Lancet 359(9323): 2059-2064. (Pubitemid 34680968)
45. Montaner, J.S. et al.(2010) Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: A population-based study. Lancet 376(9740): 532-539.
46. Laurent, C. and Delaporte, E. (2001) Epidemiology of HIV infection in sub-Saharan Africa AIDS Reviews 3(2): 59-66. (Pubitemid 33121190)