LC determination and pharmacokinetic study of the main phenolic components of Portulaca oleracea L. extract in rat plasma after oral administration

Natural Product Research

Volumn 26, Issue 23, 2012, Pages 2247-2250

  Cheng, Zhongzhe ^a   Wang, Dong ^a   Zhang, Wenjie ^a   Du, Yang ^a   Wang, Yunjiao ^a   Zhai, Yanjun ^a   Ying, Xixiang ^a   Kang, Tingguo ^a  

^a LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

HPLC; pharmacokinetics; Portulaca oleracea L. extract; rat plasma

Indexed keywords

COUMARIC ACID; FERULIC ACID; HESPERIDIN; PORTULACA OLERACEA EXTRACT; UNCLASSIFIED DRUG; VITEXIN; VITEXIN 2'' RHAMNOSIDE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF QUANTITATION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PORTULACA OLERACEA; RAT; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS;

ADMINISTRATION, ORAL; ANIMALS; APIGENIN; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARIC ACIDS; HESPERIDIN; PHENOLS; PLANT EXTRACTS; PORTULACA; RATS; REPRODUCIBILITY OF RESULTS;

PORTULACA OLERACEA; RATTUS;

EID: 84868154715     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2011.648193     Document Type: Article

References (7)

1. Chan, K., Islam, M.W., Kamil, M., Radhakrishnan, R., Zakaria, M.N., Habibullah, M., & Attas, A. (2000). The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. Sativa (Haw.) Celak. Journal of Ethnopharmacology, 73, 445-451.
2. Cui, Y., Li, Q., Zhang, M., Liu, Z., Yin, W., Liu, W., . . ., Bi, K. (2010). LC-MS determination and pharmacokinetics of p-coumaric acid in rat plasma after oral administration of p-coumaric acid and freeze-dried red wine. Journal of Agricultural and Food Chemistry, 58, 12083-12088.
3. Jin, M.J., Kim, U., Kim, I.S., Kim, Y., Kim, D.H., Han, S.B., . . ., Yoo, H.H. (2010). Effects of gut microflora on pharmacokinetics of hesperidin: A study on non-antibiotic and pseudo-germ-free rats. Journal of Toxicology and Environmental Health, Part A, 73, 1441-1450.
4. Manach, C., Morand, C., Gil-Izquierdo, A., Bouteloup-Demange, C., & Remesy, C. (2003). Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. European Journal of Clinical Nutrition, 57, 235-242. (Pubitemid 36240474)
5. Meng, Z., Wang, W., Xing, D.M., Lei, F., Lan, J.Q., & Du, L.J. (2006). Pharmacokinetic study of p-coumaric acid in mouse after oral administration of extract of Ananas comosus L. leaves. Biomedical Chromatography, 20, 951-955. (Pubitemid 44430555)
6. The Pharmacopoeia Commission of PRC (2010). The Pharmacopoeia of the People's Republic of China (Part 1, p. 46). Beijing: China Medical Science and Technology Press.
7. Zhao, Z., Egashira, Y., & Sanada, H. (2004). Ferulic acid is quickly absorbed from rat stomach as the free form and then conjugated mainly in liver. Journal of Nutrition, 134, 3083-3088. (Pubitemid 39470088)